The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy.

abstract：:The effects of acute application of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNFalpha) on levels of intracellular Ca(2+) ([Ca(2+)]i) and on whole-cell outward and inward K(+) currents were studied in cultured human microglia. TNFalpha elicited a linear increase in [Ca(2+)]i to a plateau level in micr...

journal_title：Neuroscience

authors： McLarnon JG,Franciosi S,Wang X,Bae JH,Choi HB,Kim SU

更新日期：2001-01-01 00:00:00

abstract：:Inhibitory serotonergic and cholecystokinergic mechanisms in the lateral parabrachial nucleus and central GABAergic mechanisms are involved in the regulation of water and NaCl intake. In the present study we investigated if the GABA(A) receptors in the lateral parabrachial nucleus are involved in the control of water,...

journal_title：Neuroscience

authors： Callera JC,Oliveira LB,Barbosa SP,Colombari DS,De Luca LA Jr,Menani JV

更新日期：2005-01-01 00:00:00

abstract：:A long-term induction of Fos-related antigens has been shown in neurons after brain injury, suggesting that Fos-related antigens are involved in enhancing the transcription of genes related to the process of regeneration and repair. In the present study, we report that levels of Fos-related antigen-2 are elevated in s...

journal_title：Neuroscience

authors： Pennypacker KR,Yang X,Gordon MN,Benkovic S,Miller D,O'Callaghan JP

更新日期：2000-01-01 00:00:00

abstract：:An important reaction in rodent models of persistent pain is for the animal to turn and bite/lick the source of discomfort (autotomy). Comparatively little is known about the supraspinal pathways which mediate this reaction. Since autotomy requires co-ordinated control of the head and mouth, it is possible that basal ...

journal_title：Neuroscience

authors： Wang S,Redgrave P

更新日期：1997-12-01 00:00:00

abstract：:Locomotor networks after spinal cord injury (SCI) are shaped by training-activated proprioceptive and cutaneous inputs. Nociception from injured tissues may alter these changes but has largely been overlooked. The objective of the present study was to ascertain whether lumbar muscle inflammation hinders locomotion rec...

journal_title：Neuroscience

authors： Jeffrey-Gauthier R,Piché M,Leblond H

更新日期：2017-09-17 00:00:00

abstract：:Dorsal vagal complex (DVC) AMPK regulation of food intake in the estradiol-treated ovariectomized (OVX) female rat is energy state-dependent. Here, RT-PCR array technology was used to identify estradiol-sensitive AMPK-regulated DVC signal transduction pathways that exhibit differential reactivity to sensor activation ...

journal_title：Neuroscience

authors： Ibrahim BA,Alenazi FSH,Briski KP

更新日期：2015-01-22 00:00:00

abstract：:It has recently been reported that the degeneration of retinal ganglion cells induced by transection of the optic nerve in the neonatal rat is due to an active process of apoptosis, as opposed to passive necrosis. Here we tested whether the administration of the trophic factor nerve growth factor could prevent the apo...

journal_title：Neuroscience

authors： Rabacchi SA,Ensini M,Bonfanti L,Gravina A,Maffei L

更新日期：1994-12-01 00:00:00

abstract：:Intracellular recordings were made from submucous plexus neurons of the guinea-pig cecum maintained in vitro. Histamine (0.3-10 microM) produced a dose-dependent membrane depolarization (congruent to 13 mV with 3 microM) in about 28% of the cells tested; most of these cells showed a prominent calcium-activated potassi...

journal_title：Neuroscience

authors： Tokimasa T,Akasu T

更新日期：1989-01-01 00:00:00

abstract：:Migration of neurons is a key step in the formation of the central nervous system, and an increase in internal Ca(2+) concentration has been shown to increase the rate of migration of granule cells along radial glial processes in slices of postnatal cerebellum. In embryonic spinal cord, the non-radial migration of aut...

journal_title：Neuroscience

authors： Wetts R,Vaughn JE

更新日期：2000-01-01 00:00:00

abstract：:Microtubule-associated protein 1B is a major constituent of the neuronal cytoskeleton during the early stages of development. This protein and its phosphorylated isoform, microtubule-associated protein 1B-P, defined by the monoclonal antibody 1B-P [Boyne L. J. et al. (1995) J. Neurosci. Res. 40, 439-450], are present ...

journal_title：Neuroscience

authors： Ma D,Connors T,Nothias F,Fischer I

更新日期：2000-01-01 00:00:00

abstract：:Inflammation is an important event in ischemic injury. These immune responses begin with the expression of pro-inflammatory genes modulating transcription factors, such as nuclear factor-κB (NF-κB), activator protein-1 (AP-1), and signal transducers and activator of transcription-1 (STAT-1). The 70-kDa heat shock prot...

journal_title：Neuroscience

authors： Kim JY,Yenari MA,Lee JE

更新日期：2015-02-12 00:00:00

abstract：:The involvement of nitric oxide in neurodegenerative processes still remains incompletely characterized. Although nitric oxide has been reported to be an important mediator in neuronal degeneration in different models of cell death involving NMDA-receptor activation, increasing evidence for protective mechanisms has b...

journal_title：Neuroscience

authors： Lautenschlager M,Onufriev MV,Gulyaeva NV,Harms C,Freyer D,Sehmsdorf U,Ruscher K,Moiseeva YV,Arnswald A,Victorov I,Dirnagl U,Weber JR,Hörtnagl H

更新日期：2000-01-01 00:00:00

abstract：:We have shown that transgenic transient axonal glycoprotein (TAG)/F3 mice, in which the mouse axonal glycoprotein F3/contactin was misexpressed from a regulatory region of the gene encoding the transient axonal glycoprotein TAG-1, exhibit a transient disruption of cerebellar granule and Purkinje cell development [Deve...

journal_title：Neuroscience

authors： Coluccia A,Tattoli M,Bizzoca A,Arbia S,Lorusso L,De Benedictis L,Buttiglione M,Cuomo V,Furley A,Gennarini G,Cagiano R

更新日期：2004-01-01 00:00:00

abstract：:An in vitro slice preparation of combined hippocampus and entorhinal cortex from adult rats was used to study the modalities of generation and propagation, as well as the pharmacological properties of the epileptiform activity induced by the muscarinic agonist pilocarpine (10 microM). Simultaneous field potentials rec...

journal_title：Neuroscience

authors： Nagao T,Alonso A,Avoli M

更新日期：1996-05-01 00:00:00

abstract：:Within the D2-class of dopamine receptors, the D2 and D3 subtypes share the highest degree of similarity in their primary structure. However, the extent to which these two receptor subtypes have similar or different functional properties is unclear. The present study used gene targeting to generate mice deficient for ...

journal_title：Neuroscience

authors： Jung MY,Skryabin BV,Arai M,Abbondanzo S,Fu D,Brosius J,Robakis NK,Polites HG,Pintar JE,Schmauss C

更新日期：1999-01-01 00:00:00

abstract：:Kinetic properties of synaptic depression were analysed for excitatory postsynaptic potentials in neuron number 3 in the right pallial ganglion of Helix pomatia. It was observed that long-term depression did not only suppress the amplitudes of excitatory postsynaptic potentials but also changed the kinetics of short-t...

journal_title：Neuroscience

authors： Christoffersen GR,Schilhab TS

更新日期：1996-08-01 00:00:00

abstract：:The effect of etomidate, an imidazole general anesthetic, on GABAA receptor function was studied in cultured hippocampal neurons. At a clinically relevant concentration of 4.1 microM, etomidate shifts the GABA dose response to the left (ED50 shift from 10.2 to 5.2 microM), with no change in the maximum current evoked ...

journal_title：Neuroscience

authors： Yang J,Uchida I

更新日期：1996-07-01 00:00:00

abstract：:Field and intracellular potentials were recorded from CA1 pyramidal stratum in submerged slices (at 33 degrees). During "normal" oxygenation (95% O2 + 5% CO2), tonic depression of population spikes and field excitatory postsynaptic potentials by endogenous adenosine was demonstrated by (i) the marked enhancement by th...

journal_title：Neuroscience

authors： Zhu PJ,Krnjević K

更新日期：1994-11-01 00:00:00

abstract：:Plethodontid salamanders display intricate courtship behaviors. Proteinaceous courtship pheromones were recently discovered in the submandibular (mental) gland of the male Plethodon shermani, the red-legged salamander. Behavioral studies showed that these male pheromones are delivered by direct contact to the female s...

journal_title：Neuroscience

authors： Laberge F,Feldhoff RC,Feldhoff PW,Houck LD

更新日期：2008-01-24 00:00:00

abstract：:The influence of intra-arterial injections of 5-hydroxytryptamine, histamine and prostaglandin E2 on afferent impulse activity of mesenteric nerves of small intestine was studied. In anaesthetized cats 5-hydroxytryptamine (10(-5)-10(-4) M) and histamine (10(-5)-10(-3) M) were shown to increase the impulse activity in ...

journal_title：Neuroscience

authors： Akoev GN,Filippova LV,Sherman NO

更新日期：1996-04-01 00:00:00

abstract：:Temporal and spatial characteristics of hippocampal neuronal network activation are modified during epileptiform afterdischarges. We developed a beta burst stimulation protocol to investigate subregional variations and substrates of rhythmic population spike discharges in vivo in urethane anesthetized Wistar rat hippo...

journal_title：Neuroscience

authors： Mikkonen JE,Penttonen M

更新日期：2005-01-01 00:00:00

abstract：:Human Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32kDa (DARPP-32, also known as PPP1R1B) gene codes for different transcripts that are mainly translated into two DARPP-32 protein isoforms, full length (fl)-DARPP-32 and truncated (t)-DARPP. The t-DARPP lacks the first 36 residues at the N-terminal,...

journal_title：Neuroscience

authors： Straccia M,Carrere J,Rosser AE,Canals JM

更新日期：2016-10-01 00:00:00

abstract：:Resident microglia are involved in immune responses of the central nervous system and may contribute to neuronal degeneration and death. Here, we tested in adult rats whether injection of bacterial lipopolysaccharide (which causes inflammation and microglial activation) just above the substantia nigra, results in the ...

journal_title：Neuroscience

authors： Lu X,Bing G,Hagg T

更新日期：2000-01-01 00:00:00

abstract：:Estrogen exerts many of its receptor-mediated neuroprotective functions through the activation of various intracellular signal transduction pathways including the mitogen activating protein kinase (MAPK), phospho inositol-3 kinase and protein kinase C pathways. Here we have used a hippocampal slice culture model of ka...

journal_title：Neuroscience

authors： Goodenough S,Schleusner D,Pietrzik C,Skutella T,Behl C

更新日期：2005-01-01 00:00:00

abstract：:The nucleus retroambiguus in the cat has been shown to receive strong projections from the periaqueductal gray and to send fibres to distinct motoneuronal cell groups in brainstem and spinal cord. The nucleus retroambiguus plays a role in the production of vocalization and possibly copulatory (lordosis and mounting) b...

journal_title：Neuroscience

authors： Holstege G,Kerstens L,Moes MC,Vanderhorst VG

更新日期：1997-09-01 00:00:00

abstract：:Cholesterol is an essential substance for maintaining normal structure and function of the brain. But unfortunately, a long-term high-cholesterol diet can lead to a variety of pathological changes of the brain such as β-amyloid (Aβ) accumulation, Tau hyperphosphorylation, reactive gliosis, neuroinflammation, neuronal ...

journal_title：Neuroscience

authors： Chen YL,Wang LM,Chen Y,Gao JY,Marshall C,Cai ZY,Hu G,Xiao M

更新日期：2016-03-01 00:00:00

abstract：:We have recently identified a third subtype of glutamate vesicular transporter (VGLUT) named VGLUT3. In the present study, we provide a detailed account of the regional and cellular distributions of VGLUT3 in the rat brain, using specific nucleotide probes and antisera. The distribution of VGLUT3 protein was compared ...

journal_title：Neuroscience

authors： Herzog E,Gilchrist J,Gras C,Muzerelle A,Ravassard P,Giros B,Gaspar P,El Mestikawy S

更新日期：2004-01-01 00:00:00

abstract：:I.v. injection of secretin activates neurons in brain areas controlling autonomic function and emotion. Peripheral administration of secretin inhibits gastric functions through a central mechanism that is mediated by vagal dependent pathways. We investigated whether the vagus nerve is involved in i.p. injection of sec...

journal_title：Neuroscience

authors： Yang H,Wang L,Wu SV,Tay J,Goulet M,Boismenu R,Czimmer J,Wang Y,Wu S,Ao Y,Taché Y

更新日期：2004-01-01 00:00:00

abstract：:PACAP1-38, a ubiquitous and multifunctional regulator has been in the focus of neurotoxicity research due to its impressive neuroprotective potential. Although the literature extensively demonstrated its repressive effect on the apoptotic machinery in neurodegenerative models, there is a striking absence of analysis o...

journal_title：Neuroscience

authors： Nyisztor Z,Denes V,Kovacs-Valasek A,Hideg O,Berta G,Gabriel R

更新日期：2018-08-10 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons and leads to death a few years after symptom onset. Despite its high morbidity and mortality, its underlying pathogenic mechanisms still remain poorly understood. Although there is increasing evidence for sign...

journal_title：Neuroscience

authors： Konsolaki E,Koropouli E,Tsape E,Pothakos K,Zagoraiou L

更新日期：2020-12-01 00:00:00