Evidence for a periaqueductal gray-nucleus retroambiguus-spinal cord pathway in the rat.

abstract：:Sodium-dependent high-affinity amino-acid transporters play crucial roles in terminating synaptic transmission in the central nervous system (CNS). However, there is lack of information about the mechanisms underlying the regulation of amino-acid transport by fast-acting neuromodulators, like ATP. Here, we investigate...

journal_title：Neuroscience

authors： Barros-Barbosa AR,Lobo MG,Ferreirinha F,Correia-de-Sá P,Cordeiro JM

更新日期：2015-10-15 00:00:00

abstract：:Mature neurons contain two distinct regulated secretory pathways, characterized electron microscopically by so-called large dense core vesicles and small synaptic vesicles, respectively. Each vesicle type is characterized by vesicle-specific proteins, such as the granins (chromogranins/secretogranins) for the matrix o...

journal_title：Neuroscience

authors： Tixier-Vidal A,Barret A,Faivre-Bauman A,Huttner W,Wiedenmann B

更新日期：1992-01-01 00:00:00

abstract：:A lesion of the entorhinal cortex produces a loss of more than 80% of the synapses in the outer molecular layer of the hippocampus in the rat. However, this synaptic loss is transient. Beginning a few days after denervation, new synapses are formed, virtually replacing the lost inputs within two months. Synaptic remod...

journal_title：Neuroscience

authors： Parent A,Poirier J,Baccichet A,Quirion R

更新日期：1994-08-01 00:00:00

abstract：:The noradrenergic nerve terminals and their vesicle populations have been subject to much ultrastructural research which has served to support and extend data from biochemical analysis and pharmacological-physiological experiments. Although a great deal of information has been collected, there are still many problems ...

journal_title：Neuroscience

authors： Thureson-Klein A

更新日期：1983-10-01 00:00:00

abstract：:The distribution of the diadenosine tetraphosphate high-affinity binding sites has been studied in rat brain by an autoradiographic method using [3H]diadenosine tetraphosphate as the ligand. The binding characteristics are comparable to those described in studies performed on rat brain synaptosomes. White matter is de...

journal_title：Neuroscience

authors： Rodríguez-Pascual F,Cortes R,Torres M,Palacios JM,Miras-Portugal MT

更新日期：1997-03-01 00:00:00

abstract：:Phospholipids and cholesterol were found to be the main lipids in mature and immature neuroblastoma cells. The ratios for the total cholesterol/phospholipids in these undifferentiated and differentiated cells were 0.33 and 0.52, respectively. The ratios of 0.45 and 0.62 were obtained with corresponding plasma membrane...

journal_title：Neuroscience

authors： Gulaya NM,Volkov GL,Klimashevsky VM,Govseeva NN,Melnik AA

更新日期：1989-01-01 00:00:00

abstract：:Previous studies found that prostaglandins in skeletal muscle play a role in evoking the exercise pressor reflex; however the role played by prostaglandins in the spinal transmission of the reflex is not known. We determined, therefore, whether or not spinal blockade of cyclooxygenase (COX) activity and/or spinal bloc...

journal_title：Neuroscience

authors： Stone AJ,Copp SW,Kaufman MP

更新日期：2014-09-26 00:00:00

abstract：:Scratching inhibits pruritogen-evoked responses of neurons in the superficial dorsal horn, implicating a spinal site for scratch inhibition of itch. We investigated if scratching differentially affects neurons depending on whether they are activated by itchy vs. painful stimuli, and if the degree of inhibition depends...

journal_title：Neuroscience

authors： Nishida K,Takechi K,Akiyama T,Carstens MI,Carstens E

更新日期：2013-10-10 00:00:00

abstract：:Intracellular recordings were performed in a pontine slice preparation of the rat brain containing the locus coeruleus. The enzymatically stable P2-purinoceptor agonist alpha,beta-methylene ATP increased the firing rate without altering the amplitude or shape of action potentials; the afterhyperpolarization following ...

journal_title：Neuroscience

authors： Harms L,Finta EP,Tschöpl M,Illes P

更新日期：1992-06-01 00:00:00

abstract：:Undifferentiated PC12 cells undergo apoptosis, via a calcium-induced calcium release mechanism, when the calcium-binding protein purified from bovine brain (native S100) is present in micromolar concentration in the medium. This process begins when S100 binds to specific membrane binding sites and involves up to 50% o...

journal_title：Neuroscience

authors： Fulle S,Mariggiò MA,Belia S,Petrelli C,Ballarini P,Guarnieri S,Fanò G

更新日期：1999-03-01 00:00:00

abstract：:The role of nitric oxide (NO) in post-ischemic cerebral infarction has been extensively examined, but few studies have investigated its role on the neurological deficit. In the present study, we investigated the effect of spermine on the temporal evolution of infarct volume, NO production and neurological deficit usin...

journal_title：Neuroscience

authors： Shirhan MD,Moochhala SM,Ng PY,Lu J,Ng KC,Teo AL,Yap E,Ng I,Hwang P,Lim T,Sitoh YY,Rumpel H,Jose R,Ling E

更新日期：2004-01-01 00:00:00

abstract：:Transgenic mice with overexpression of the caspase-inhibitor, X-chromosome-linked inhibitor of apoptosis protein (XIAP) in Purkinje cell (PC) and in retinal bipolar cells (RBCs) were produced to study the regulation of cell death. Unexpectedly, an increased neurodegeneration was observed in the PCs in these L7-XIAP mi...

journal_title：Neuroscience

authors： Korhonen L,Hansson I,Maugras C,Wehrle R,Kairisalo M,Borgkvist A,Jokitalo E,Sotelo C,Fisone G,Dusart I,Lindholm D

更新日期：2008-10-15 00:00:00

abstract：:Rates of cerebral glucose utilization were measured by means of the autoradiographic 2-deoxy-D[1-14C]glucose technique in the rat brain in order to determine the metabolic effects of unilateral intranigral application of the GABAA agonist muscimol upon the substantia nigra and its targets. Intranigral injection of 1.5...

journal_title：Neuroscience

authors： Savaki HE,Raos VC,Dermon CR

更新日期：1992-10-01 00:00:00

abstract：:Rats receiving a complete spinal cord transection (ST) at a neonatal stage spontaneously can recover significant stepping ability, whereas minimal recovery is attained in rats transected as adults. In addition, neonatally spinal cord transected rats trained to step more readily improve their locomotor ability. We hypo...

journal_title：Neuroscience

authors： Tillakaratne NJ,Guu JJ,de Leon RD,Bigbee AJ,London NJ,Zhong H,Ziegler MD,Joynes RL,Roy RR,Edgerton VR

更新日期：2010-03-10 00:00:00

abstract：:I have prepared a number of monoclonal antibodies to chromaffin cell membranes. One of these antibodies recognizes a number of antigenically related proteins that are present in all tissues examined. In the adrenal, these proteins are completely excluded from chromaffin granules but are present in other subcellular me...

journal_title：Neuroscience

authors： Pruss RM

更新日期：1987-07-01 00:00:00

abstract：:Neuropathic pain resulting from spinal cord injury is often accompanied by maladaptive plasticity of the central nervous system, including the opioid receptor-rich periaqueductal gray (PAG). Evidence suggests that sensory signaling via the PAG is robustly modulated by dopamine D1- and D2-like receptors, but the effect...

journal_title：Neuroscience

authors： Voulalas PJ,Ji Y,Jiang L,Asgar J,Ro JY,Masri R

更新日期：2017-02-20 00:00:00

abstract：:Microelectrode recordings were made from 5-10 micron dia axons of adult rat spinal cord in vitro. Action potentials in response to electrical stimulation were recorded intracellularly and electrical characteristics of the axons were examined by injecting current pulses through a bridge circuit. All action potentials l...

journal_title：Neuroscience

authors： Blight AR,Someya S

更新日期：1985-05-01 00:00:00

abstract：:In the glomerular layer of the rat main olfactory bulb, we previously reported three chemically defined interneuron groups: GABA-like immunoreactive, calretinin-immunoreactive and Calbindin-D28k-immunoreactive groups [Kosaka K. et al. (1995) Neurosci. Res. 23, 73-88]. In the present study, we analysed the structural f...

journal_title：Neuroscience

authors： Kosaka K,Toida K,Margolis FL,Kosaka T

更新日期：1997-02-01 00:00:00

abstract：:The present study seeks to identify effects of a common genetic polymorphism in the human nicotinic alpha4beta2 receptor on components of the cognitive event-related potentials in auditory and visual modalities. The same sense thymine-to-cytosine polymorphism (c.1629T-C; Ser543Ser) was shown to preferentially modulate...

journal_title：Neuroscience

authors： Espeseth T,Endestad T,Rootwelt H,Reinvang I

更新日期：2007-07-29 00:00:00

abstract：:Neurotransmitter and headache target localization in the trigeminal ganglia (TG) might increase the understanding of sites of action, and mechanisms related to headache therapy. The overall aim of the study was to investigate the presence of migraine targets in the TG with particular emphasis on pituitary adenylate cy...

journal_title：Neuroscience

authors： Frederiksen SD,Warfvinge K,Ohlsson L,Edvinsson L

更新日期：2018-11-21 00:00:00

abstract：:The central nervous system responds to diverse neurologic injuries with a vigorous activation of astrocytes. While this phenomenon is found in many different species, its function is obscure. Understanding the molecular profile characteristic of reactive astrocytes should help define their function. The purpose of thi...

journal_title：Neuroscience

authors： Eddleston M,Mucke L

更新日期：1993-05-01 00:00:00

abstract：:In the adult CNS, GABA is the predominant inhibitory neurotransmitter, mediating the hyperpolarization of membrane potential and regulating the glutamatergic activity. In the immature CNS, on the other hand, GABA mediates depolarization and is involved in controlling morphogenesis. This developmental shift in GABA act...

journal_title：Neuroscience

authors： Takayama C,Inoue Y

更新日期：2006-12-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) produced in the medial preoptic region (MPO) in response to immune signals is generally accepted to play a major role in triggering the illness response, a complex of physiological and behavioral changes induced by infection or injury. Hyperalgesia is now thought to be an important component of...

journal_title：Neuroscience

authors： Heinricher MM,Neubert MJ,Martenson ME,Gonçalves L

更新日期：2004-01-01 00:00:00

abstract：:GABA neurones in the dorsal raphe nucleus (DRN) influence ascending 5-hydroxytryptamine (5-HT) neurones but are not physiologically or anatomically characterised. Here, in vivo juxtacellular labelling methods in urethane-anaesthetised rats were used to establish the neurochemical and morphological identity of a fast-f...

journal_title：Neuroscience

authors： Allers KA,Sharp T

更新日期：2003-01-01 00:00:00

abstract：:Most functional imaging studies of memory retrieval investigate memory for standardized laboratory stimuli. However, naturally acquired autobiographical memories differ from memories of standardized stimuli in important ways. Neuroimaging studies of natural memories may reveal distinctive patterns of brain activation ...

journal_title：Neuroscience

authors： Maddock RJ,Garrett AS,Buonocore MH

更新日期：2001-01-01 00:00:00

abstract：:It appears likely that, in analogy to the synaptic development of sensory and motor cortices, which critically depends on sensory or motor stimulation (Rosenzweig and Bennett, 1996), the synaptic development of limbic cortical regions are modulated by early postnatal cognitive and emotional experiences. The very first...

journal_title：Neuroscience

authors： Helmeke C,Poeggel G,Braun K

更新日期：2001-01-01 00:00:00

abstract：:Adverse environments during early life may lead to different neurophysiological and behavioral consequences, including depression and learning and memory deficits that persist into adulthood. Previously, we demonstrated that exposure to an enriched environment during adolescence mitigates the cognitive impairment obse...

journal_title：Neuroscience

authors： Cordier JM,Aguggia JP,Danelon V,Mir FR,Rivarola MA,Mascó D

更新日期：2021-01-15 00:00:00

abstract：:We have previously demonstrated that progesterone significantly increases the rate of myelination in organotypic slice cultures of 7-day-old rat and mouse cerebellum. Here, we show that progesterone (20microM) stimulates the proliferation of oligodendrocyte precursors in cultured cerebellar slices of 7-day-old rats. T...

journal_title：Neuroscience

authors： Ghoumari AM,Baulieu EE,Schumacher M

更新日期：2005-01-01 00:00:00

abstract：:Our study examined how different housing conditions modulated the acquisition of a spatial reference memory task and also, a reversal task in the 4-radial arm water maze (4-RAWM). The animals were randomly assigned to standard or enriched cages, and, as a type of complementary stimulation along with the environmental ...

journal_title：Neuroscience

authors： Sampedro-Piquero P,Zancada-Menendez C,Begega A

更新日期：2015-10-29 00:00:00

abstract：:Neurons in the region of dorsomedial hypothalamus are involved in the organization of the physiological responses to emotional stress. We have recently shown that the cardiovascular response evoked by activation of dorsomedial hypothalamus neurons is largely dependent on a synaptic relay with the lateral/dorsolateral ...

journal_title：Neuroscience

authors： da Silva LG Jr,Menezes RC,Villela DC,Fontes MA

更新日期：2006-01-01 00:00:00