Depolarization of rat locus coeruleus neurons by adenosine 5'-triphosphate.


:Intracellular recordings were performed in a pontine slice preparation of the rat brain containing the locus coeruleus. The enzymatically stable P2-purinoceptor agonist alpha,beta-methylene ATP increased the firing rate without altering the amplitude or shape of action potentials; the afterhyperpolarization following a spike was not changed either. When locus coeruleus neurons were hyperpolarized by current injection in order to prevent spontaneous firing, alpha,beta-methylene ATP produced depolarization and a slight increase in the apparent input resistance. A combined application of kynurenic acid and bicuculline methiodide failed to alter the alpha,beta-methylene ATP-induced depolarization, and tetrodotoxin only slightly depressed it. A gradual shift of the membrane potential by hyperpolarizing current injection led to a corresponding decrease, but no abolition or reversal of the alpha,beta-methylene ATP effect. In the hyperpolarized region, the current-voltage curve of alpha,beta-methylene ATP came into close approximation with, but did not cross, the control curve. Elevation of the external K+ concentration, or the intracellular application of Cs+ by diffusion from the microelectrode, depressed the response to alpha,beta-methylene ATP; external tetraethylammonium was also inhibitory. External Ba2+ and Cs+ had no effect or only slightly decreased the alpha,beta-methylene ATP-induced depolarization. A low Na+, or a low Ca2+ high Mg2+ medium, as well as the presence of Co2+ in the medium, markedly reduced or even abolished the depolarization by alpha,beta-methylene ATP. ATP itself did not produce consistent changes in the membrane potential or input resistance. However, in the presence of the P1-purinoceptor antagonist 8-cyclopentyl-1,3-dipropylxanthine, ATP consistently increased the firing rate and evoked an inward current. In conclusion, P2-purinoceptor activation appears to depolarize locus coeruleus neurons by inhibiting a persistent potassium current, and at the same time opening calcium-sensitive sodium channels or calcium-sensitive non-selective cationic channels.






Harms L,Finta EP,Tschöpl M,Illes P





Has Abstract


1992-06-01 00:00:00














  • Differential expression of synapsin genes during early zebrafish development.

    abstract::Synapsins are a family of synaptic vesicle (SV)-associated phosphoproteins that have been identified in several vertebrates and invertebrates. We report here the cloning and expression of synapsin family genes in the zebrafish Danio rerio. We identified the complete coding sequence of synapsin 3, which is not present ...


    pub_type: 杂志文章


    authors: Garbarino G,Costa S,Pestarino M,Candiani S

    更新日期:2014-11-07 00:00:00

  • A paleostriatal-thalamic-telencephalic path in pigeons.

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    pub_type: 杂志文章


    authors: Kitt CA,Brauth SE

    更新日期:1982-01-01 00:00:00

  • Phenotypic characterization of orofacial movement topography in mutants with disruption of amino acid mechanisms: glutamate N2A/B/D [GluRε1/2/4] subtypes and the GABA synthesizing enzyme GAD65.

    abstract::To investigate the role of glutamate receptor subtypes and GABA in orofacial function, six individual topographies of orofacial movement, both spontaneous and induced by the dopamine D1-like receptor agonist [R/S]-3-methyl-6-chloro-7,8-dihydroxy-1-[3-methyl-phenyl]-2,3,4,5-tetrahydro-1H-3-benzazepine (SKF 83959), were...


    pub_type: 杂志文章


    authors: Tomiyama K,Kato R,Hara Y,Kobayashi M,Mishina M,Yanagawa Y,Kinsella A,Koshikawa N,Waddington JL

    更新日期:2013-10-10 00:00:00

  • Functional recovery of stepping in rats after a complete neonatal spinal cord transection is not due to regrowth across the lesion site.

    abstract::Rats receiving a complete spinal cord transection (ST) at a neonatal stage spontaneously can recover significant stepping ability, whereas minimal recovery is attained in rats transected as adults. In addition, neonatally spinal cord transected rats trained to step more readily improve their locomotor ability. We hypo...


    pub_type: 杂志文章


    authors: Tillakaratne NJ,Guu JJ,de Leon RD,Bigbee AJ,London NJ,Zhong H,Ziegler MD,Joynes RL,Roy RR,Edgerton VR

    更新日期:2010-03-10 00:00:00

  • Gene expression profile analysis of epilepsy-associated gangliogliomas.

    abstract::Gangliogliomas (GG) constitute the most frequent tumor entity in young patients undergoing surgery for intractable epilepsy. The histological composition of GG, with the presence of dysplastic neurons, corroborates their maldevelopmental origin. However, their histogenesis, the pathogenetic relationship with other dev...


    pub_type: 杂志文章


    authors: Aronica E,Boer K,Becker A,Redeker S,Spliet WG,van Rijen PC,Wittink F,Breit T,Wadman WJ,Lopes da Silva FH,Troost D,Gorter JA

    更新日期:2008-01-02 00:00:00

  • Changes in immunoreactivity for growth associated protein-43 suggest reorganization of synapses on spinal sympathetic neurons after cord transection.

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    pub_type: 杂志文章


    authors: Weaver LC,Cassam AK,Krassioukov AV,Llewellyn-Smith IJ

    更新日期:1997-11-01 00:00:00

  • Maternal High-fat Diet Programs Offspring Emotional Behavior in Adulthood.

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    authors: Winther G,Elfving B,Müller HK,Lund S,Wegener G

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  • Distribution of two types of monoamine oxidase-containing neurons in the cat medulla oblongata demonstrated by an improved histochemical method.

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    pub_type: 杂志文章


    authors: Kitahama K,Kimura H,Maeda T,Jouvet M

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  • Deficits in cortico-striatal synaptic plasticity and behavioral habituation in rats with portacaval anastomosis.

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    pub_type: 杂志文章


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    更新日期:2005-01-01 00:00:00

  • Latent inhibition is spared by N-methyl-D-aspartate (NMDA)-induced ventral hippocampal lesions, but is attenuated following local activation of the ventral hippocampus by intracerebral NMDA infusion.

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    pub_type: 杂志文章


    authors: Pouzet B,Zhang WN,Weiner I,Feldon J,Yee BK

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    pub_type: 杂志文章


    authors: Toldi J,Fehér O,Feuer L

    更新日期:1984-11-01 00:00:00

  • Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload.

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    pub_type: 杂志文章


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  • Glutamate-dependent translational regulation in cultured Bergmann glia cells: involvement of p70S6K.

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    pub_type: 杂志文章


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  • Evidence for beta corticomuscular coherence during human standing balance: Effects of stance width, vision, and support surface.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Thureson-Klein A

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    pub_type: 杂志文章


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    更新日期:1998-08-01 00:00:00

  • Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice.

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    pub_type: 杂志文章


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  • Overexpression of nuclear FUS induces neuronal cell death.

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    pub_type: 杂志文章


    authors: Suzuki H,Matsuoka M

    更新日期:2015-02-26 00:00:00

  • Repeated i.v. cocaine exposure produces long-lasting behavioral sensitization in pregnant adults, but behavioral tolerance in their offspring.

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    pub_type: 杂志文章


    authors: Stanwood GD,Levitt P

    更新日期:2003-01-01 00:00:00

  • Potassium ion- and nitric oxide-induced exocytosis from populations of hippocampal synapses during synaptic maturation in vitro.

    abstract::The development of mechanisms of neurotransmitter release is an important component in the formation of functional synaptic connections. Synaptic neurotransmitter release can be modulated by nitric oxide, a compound shown to have a variety of physiologic functions in the nervous system. The goal of this study was to d...


    pub_type: 杂志文章


    authors: Sporns O,Jenkinson S

    更新日期:1997-10-01 00:00:00

  • N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia.

    abstract:INTRODUCTION:Electrophysiological responses to auditory stimuli have provided a useful means of elucidating mechanisms and evaluating treatments in psychiatric disorders. Deficits in gating during paired-click tasks and lack of mismatch negativity following deviant stimuli have been well characterized in patients with ...


    pub_type: 杂志文章


    authors: Ehrlichman RS,Gandal MJ,Maxwell CR,Lazarewicz MT,Finkel LH,Contreras D,Turetsky BI,Siegel SJ

    更新日期:2009-01-23 00:00:00

  • Expression of pannexin1 in the CNS of adult mouse: cellular localization and effect of 4-aminopyridine-induced seizures.

    abstract::The expression pattern of pannexin1, a gene coding for a protein that forms gap junction channels, was studied as both mRNA and protein in the CNS of adult mouse. Pannexin1 was widely expressed in the CNS by neuronal cell types but not glial cells, except for Bergmann glial cells of the cerebellar cortex. Cells positi...


    pub_type: 杂志文章


    authors: Zappalà A,Cicero D,Serapide MF,Paz C,Catania MV,Falchi M,Parenti R,Pantò MR,La Delia F,Cicirata F

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  • Distribution and kainate-mediated induction of the DNA mismatch repair protein MSH2 in rat brain.

    abstract::DNA repair is one of the most essential systems for maintaining the inherited nucleotide sequence of genomic DNA over time. Repair of DNA damage would be particularly important in neurons, because these cells are among the longest-living cells in the body. MSH2 is one of the proteins which are involved in the recognit...


    pub_type: 杂志文章


    authors: Belloni M,Uberti D,Rizzini C,Ferrari-Toninelli G,Rizzonelli P,Jiricny J,Spano P,Memo M

    更新日期:1999-01-01 00:00:00

  • Er81 is expressed in a subpopulation of layer 5 neurons in rodent and primate neocortices.

    abstract::Laminar organization is a fundamental cytoarchitecture in mammalian CNS and a striking feature of the neocortex. ER81, a transcription factor, has recently been utilized as a marker of cells in the layer 5 of the neocortex. We further pursued the distribution of ER81 to investigate the identity of the ER81-expressing ...


    pub_type: 杂志文章


    authors: Yoneshima H,Yamasaki S,Voelker CC,Molnár Z,Christophe E,Audinat E,Takemoto M,Nishiwaki M,Tsuji S,Fujita I,Yamamoto N

    更新日期:2006-01-01 00:00:00

  • Dopamine profoundly suppresses excitatory transmission in neonatal rat hippocampus via phosphatidylinositol-linked D1-like receptor.

    abstract::Dopamine modulates synaptic transmission in various brain regions. The disorder of dopamine system may be related to neurodevelopmental dysfunction. However, the action of dopamine on synaptic transmission during development is largely unknown. We studied the effect of dopamine on GABAergic and glutamatergic transmiss...


    pub_type: 杂志文章


    authors: Noriyama Y,Ogawa Y,Yoshino H,Yamashita M,Kishimoto T

    更新日期:2006-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Reuter EM,Marinovic W,Beikoff J,Carroll TJ

    更新日期:2018-03-15 00:00:00

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    pub_type: 杂志文章


    authors: Reimers-Kipping S,Hevers W,Pääbo S,Enard W

    更新日期:2011-02-23 00:00:00

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    pub_type: 杂志文章


    authors: Wei H,Qin ZH,Senatorov VV,Wei W,Wang Y,Qian Y,Chuang DM

    更新日期:2001-01-01 00:00:00

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    abstract::The hypothesis that attention deficits induced by the hypofunction of N-methyl d-aspartate (NMDA) receptors in the prefrontal cortex (PFC) might be associated with increased glutamate release and changes in the phosphorylation of the cyclic adenosine monophosphate response element-binding protein on serine 133 (p-S(13...


    pub_type: 杂志文章


    authors: Pozzi L,Baviera M,Sacchetti G,Calcagno E,Balducci C,Invernizzi RW,Carli M

    更新日期:2011-03-10 00:00:00

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    pub_type: 杂志文章


    authors: Li L,Hao JX,Fredholm BB,Schulte G,Wiesenfeld-Hallin Z,Xu XJ

    更新日期:2010-10-27 00:00:00