当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: involvement of BDNF?

Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: involvement of BDNF?

Abstract：

:Stroke is a leading cause of death and disability in industrialized countries. Although surviving patients exhibit a certain degree of restoration of function attributable to brain plasticity, the majority of stroke survivors has to struggle with persisting deficits. In order to potentiate post-stroke recovery, several rehabilitation therapies have been undertaken and many experimental studies have reported that brain-derived neurotrophic factor (BDNF) is central to many facets of neuroplastic processes. However, although BDNF role in brain plasticity is well characterized through strategies that manipulate its content, the involvement of this neurotrophin in spontaneous post-stroke recovery remains to be clarified. Besides, while the neuroplastic role of BDNF is restricted to its mature form, most studies investigating the proper effect of ischemia on post-stroke BDNF metabolism focused on mRNA or total protein expressions. In addition, these studies are mainly performed in brain regions collected either at or around the lesion site. Therefore, the objective of the present study was to investigate in both hemispheres, the long-term expression (up to one month) of both pro- and mature BDNF forms in rats subjected to photothrombotic ischemia. These assessments were performed in the cortex and in the hippocampus, two regions known to subserve functional recovery after stroke and were coupled to the study of synaptophysin expression, a marker of synaptogenesis. Our study reports that stroke induces an early and transient increase (4h) in mature BDNF expression in the cortex of both hemispheres that was associated with a delayed rise (30d) in synaptophysin levels ipsilateraly. In both hippocampal territories, the pattern of mature BDNF expression shows a more delayed increase (from 8 to 30d), which coincides with the evolution of synaptophysin expression. Interestingly, in these hippocampal territories, pro-BDNF levels evolve differently suggesting a differential gene regulation between the two hemispheres. While highlighting the complexity of changes in BDNF metabolism after stroke, our data suggest that BDNF involvement in spontaneous post-stroke plasticity is region-dependent.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Madinier A,Bertrand N,Rodier M,Quirié A,Mossiat C,Prigent-Tessier A,Marie C,Garnier P

doi

10.1016/j.neuroscience.2012.11.054

subject

Has Abstract

pub_date

2013-02-12 00:00:00

pages

169-81

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(12)01165-7

journal_volume

231

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Transient receptor potential vanilloid 1-immunopositive neurons in the mouse are more prevalent within colon afferents compared to skin and muscle afferents.

    abstract：:Previous studies in our laboratories found that isolectin B(4)(IB(4))-positive polymodal nociceptors in the mouse do not express transient receptor potential vanilloid 1 (TRPV1), nor does deletion of TRPV1 compromise the ability of these afferents to detect thermal stimuli. Considering that IB(4)-positive afferents ac...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.02.015

    authors： Christianson JA,McIlwrath SL,Koerber HR,Davis BM

    更新日期：2006-06-19 00:00:00

  • The localization of nitric oxide synthase in the rat eye and related cranial ganglia.

    abstract：:Nitric oxide synthase is the biosynthetic enzyme for the free radical neurotransmitter nitric oxide. Using an affinity-purified antiserum, nitric oxide synthase was found to be localized to peripheral ocular nerve fibers, related cranial ganglia, and the retina of the rat. In the eye, nitric oxide synthase-like immuno...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90393-t

    authors： Yamamoto R,Bredt DS,Snyder SH,Stone RA

    更新日期：1993-05-01 00:00:00

  • Calcium-induced long-term potentiation in the hippocampus.

    abstract：:The effect of a transient increase in extracellular calcium concentration on the Schaffer collateral-commissural evoked excitatory postsynaptic potential and population spike responses of CAI pyramidal neurons was investigated using the rat in vitro hippocampal slice preparation. Brief exposure of slices (5-10 min) to...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(82)90254-8

    authors： Turner RW,Baimbridge KG,Miller JJ

    更新日期：1982-06-01 00:00:00

  • Selective changes in angiotensin II AT1 and AT2 receptor subtypes in the rat superior colliculus following eye enucleation.

    abstract：:In the brain of young (two weeks old) rats, angiotensin II receptors (AT2 receptors) are found in brain nuclei which receive and integrate direct visual input from the retina, the suprachiasmatic nuclei (containing only AT1 receptors), the lateral geniculate nuclei (containing AT2 receptors) and the superior colliculu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90460-x

    authors： Michels KM,Heemskerk FM,Saavedra JM

    更新日期：1994-02-01 00:00:00

  • Patterns of activation and de-activation associated with cue-guided spatial navigation: A whole-brain, voxel-based study.

    abstract：:Functional imaging studies have implicated the hippocampus and parahippocampal gyrus in cue-guided spatial navigation, but also many other regions. Furthermore, little is known about de-activations that take place during performance of navigation tasks, something that is of interest given that the hippocampus is a com...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.06.029

    authors： Salgado-Pineda P,Landin-Romero R,Pomes A,Spanlang B,Sarró S,Salvador R,Slater M,McKenna PJ,Pomarol-Clotet E

    更新日期：2017-09-01 00:00:00

  • A role for the neural cell adhesion molecule in a late, consolidating phase of glycoprotein synthesis six hours following passive avoidance training of the young chick.

    abstract：:We have investigated the effect of intracranial injections of the amnestic anti-metabolite, 2-deoxygalactose, and antibodies to the neural cell adhesion molecule on retention of a one-trial passive avoidance task in chicks. Groups of chicks received bilateral intracranial injections of 10 mumol/hemisphere 2-deoxygalac...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90519-l

    authors： Scholey AB,Rose SP,Zamani MR,Bock E,Schachner M

    更新日期：1993-07-01 00:00:00

  • Spinal Circuits Mediate a Stretch Reflex Between the Upper Limbs in Humans.

    abstract：:Inter-limb reflexes play an important role in coordinating behaviors involving different limbs. Previous studies have demonstrated that human elbow muscles express an inter-limb stretch reflex at long-latency (50-100 ms), a timing consistent with a trans-cortical linkage. Here we probe for inter-limb stretch reflexes ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.02.007

    authors： Muraoka T,Kurtzer I

    更新日期：2020-04-01 00:00:00

  • Signaling pathways that mediate nerve growth factor-induced increase in expression and release of calcitonin gene-related peptide from sensory neurons.

    abstract：:Nerve growth factor (NGF) can augment transmitter release in sensory neurons by acutely sensitizing sensory neurons and by increasing the expression of calcitonin gene-related peptide (CGRP) over time. The current study examined the intracellular signaling pathways that mediate these two temporally distinct effects of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.09.027

    authors： Park KA,Fehrenbacher JC,Thompson EL,Duarte DB,Hingtgen CM,Vasko MR

    更新日期：2010-12-15 00:00:00

  • Importance of D1 and D2 receptors in the dorsal caudate-putamen for the locomotor activity and stereotyped behaviors of preweanling rats.

    abstract：:Dopaminergic compounds often affect the unlearned behaviors of preweanling and adult rats differently, although the brain regions underlying these age-dependent behavioral effects have not been specified. A candidate brain region is the dorsal caudate-putamen (CPu); thus, a goal of the present study was to determine w...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.03.037

    authors： Charntikov S,Der-Ghazarian T,Herbert MS,Horn LR,Widarma CB,Gutierrez A,Varela FA,McDougall SA

    更新日期：2011-06-02 00:00:00

  • Involvement of cannabinoid receptors in peripheral and spinal morphine analgesia.

    abstract：:The interactions between the cannabinoid and opioid systems for pain modulation are reciprocal. However, the role and the importance of the cannabinoid system in the antinociceptive effects of opioids remain uncertain. We studied these interactions with the goal of highlighting the involvement of the cannabinoid syste...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.12.030

    authors： Desroches J,Bouchard JF,Gendron L,Beaulieu P

    更新日期：2014-03-07 00:00:00

  • Respiratory rhythms generated in the lamprey rhombencephalon.

    abstract：:Brainstem networks generating the respiratory rhythm in lampreys are still not fully characterized. In this study, we described the patterns of respiratory activities and we identified the general location of underlying neural networks. In a semi-intact preparation including the brain and gills, rhythmic discharges we...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.05.023

    authors： Martel B,Guimond JC,Gariépy JF,Gravel J,Auclair F,Kolta A,Lund JP,Dubuc R

    更新日期：2007-08-10 00:00:00

  • Tonically Active Neurons in the Monkey Dorsal Striatum Signal Outcome Feedback during Trial-and-error Search Behavior.

    abstract：:An animal's choice behavior is shaped by the outcome feedback from selected actions in a trial-and-error approach. Tonically active neurons (TANs), presumed cholinergic interneurons in the striatum, are thought to be involved in the learning and performance of reward-directed behaviors, but it remains unclear how TANs...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.08.007

    authors： Inokawa H,Matsumoto N,Kimura M,Yamada H

    更新日期：2020-10-15 00:00:00

  • The role of ventral tegmental dopamine neurons in locomotor sensitization following quinpirole or (+)-amphetamine: ex vivo voltammetric evidence.

    abstract：:Behavioural sensitization to the locomotor stimulating effects of (+)-amphetamine or quinpirole was induced in rats by intermittent drug administration. Following expression of sensitization, locomotor activity scores on day 9 were: vehicle 87 +/- 9, (+)-amphetamine 1441 +/- 227 and quinpirole 2078 +/- 214. Electrical...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00389-2

    authors： Muscat R,Iravani MM,Kruk ZL

    更新日期：1996-12-01 00:00:00

  • Stress, anxiety, and dendritic spines: what are the connections?

    abstract：:Stressful life events, especially those that induce fear, can produce a state of anxiety that is useful for avoiding similar fearful and potentially dangerous situations in the future. However, they can also lead to exaggerated states, which over time can produce mental illness. These changing states of readiness vers...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2012.04.021

    authors： Leuner B,Shors TJ

    更新日期：2013-10-22 00:00:00

  • Modulation of hippocampal synapse maturation by activity-regulated E3 ligase via non-canonical pathway.

    abstract：:Development of functional synapses is crucial for the transmission and storage of information in the brain. Post establishment of the initial synaptic contact, synapses are stabilized through neuronal activity-induced signals. Emerging studies have implicated ubiquitination; a reversible posttranslational modification...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.08.057

    authors： Kumari P,Srinivasan B,Banerjee S

    更新日期：2017-11-19 00:00:00

  • Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study.

    abstract：:Ketamine is a dissociative anesthetic with complex actions on the CNS. We investigated here the effects of ketamine anesthesia on somatosensory processing in the rat spinal cord, thalamus, and cerebral cortex, using the quantitative 2-deoxyglucose mapping technique. Unanesthetized or ketamine-anesthetized male Sprague...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.01.039

    authors： Porro CA,Cavazzuti M,Giuliani D,Vellani V,Lui F,Baraldi P

    更新日期：2004-01-01 00:00:00

  • Respiratory phenotypes are distinctly affected in mice with common Rett syndrome mutations MeCP2 T158A and R168X.

    abstract：:Respiratory disturbances are a primary phenotype of the neurological disorder, Rett syndrome (RTT), caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Mouse models generated with null mutations in Mecp2 mimic respiratory abnormalities in RTT girls. Large deletions, however, are see...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.02.043

    authors： Bissonnette JM,Schaevitz LR,Knopp SJ,Zhou Z

    更新日期：2014-05-16 00:00:00

  • Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.

    abstract：:This study aimed to clarify changes in the spatial expressions of types 1, 2 and 3 ryanodine receptors (RyR1, RyR2 and RyR3) in the cerebellum of a Ca(2+) channel alpha(1A) subunit mutant, rolling mouse Nagoya. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) revealed that the mRNA signal lev...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.12.048

    authors： Sawada K,Hosoi E,Bando M,Sakata-Haga H,Lee NS,Jeong YG,Fukui Y

    更新日期：2008-03-27 00:00:00

  • Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels.

    abstract：:Windup--the gradual increase of the response--of dorsal horn neurons to repeated activation of primary afferents is an elementary form of short-term plasticity that may mediate central sensitization to pain. In deep dorsal horn neurons of the turtle spinal cord in vitro we report windup of the response to repeated dep...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90222-4

    authors： Russo RE,Hounsgaard J

    更新日期：1994-07-01 00:00:00

  • Long-Term Conductive Auditory Deprivation During Early Development Causes Irreversible Hearing Impairment and Cochlear Synaptic Disruption.

    abstract：:Conductive hearing loss is a prevalent condition globally. It remains unclear whether conductive hearing loss that occurs during early development disrupts auditory peripheral systems. In this study, a mouse model of conductive auditory deprivation (CAD) was achieved using external auditory canal closure on postnatal ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.01.065

    authors： Qi Y,Yu S,Du Z,Qu T,He L,Xiong W,Wei W,Liu K,Gong S

    更新日期：2019-05-15 00:00:00

  • Effect of the GABAB antagonist, phaclofen, on baclofen-induced inhibition of micturition reflex in urethane-anesthetized rats.

    abstract：:The effect of intrathecal or intracerebroventricular administration of the GABAB receptor agonist, baclofen, on rhythmic contractions induced by distension of the urinary bladder (micturition reflex) was evaluated in urethane-anesthetized rats. Baclofen inhibited bladder motility acting at central nervous system sites...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90350-b

    authors： Giuliani S,Lecci A,Santicioli P,Del Bianco E,Maggi CA

    更新日期：1992-01-01 00:00:00

  • The stop null mice model for schizophrenia displays [corrected] cognitive and social deficits partly alleviated by neuroleptics.

    abstract：:Recently evidence has accumulated that schizophrenia can arise from primary synaptic defects involving structural proteins particularly, microtubule associated proteins. Previous experiments have demonstrated that a STOP (stable tubule only peptide) gene deletion in mice leads to a phenotype mimicking some aspects of ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.07.080

    authors： Bégou M,Volle J,Bertrand JB,Brun P,Job D,Schweitzer A,Saoud M,D'Amato T,Andrieux A,Suaud-Chagny MF

    更新日期：2008-11-11 00:00:00

  • Unintentional force changes in cyclical tasks performed by an abundant system: Empirical observations and a dynamical model.

    abstract：:The study explored unintentional force changes elicited by removing visual feedback during cyclical, two-finger isometric force production tasks. Subjects performed two types of tasks at 1Hz, paced by an auditory metronome. One - Force task - required cyclical changes in total force while maintaining the sharing, defi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.03.022

    authors： Reschechtko S,Hasanbarani F,Akulin VM,Latash ML

    更新日期：2017-05-14 00:00:00

  • Localized decrease in serotonin transporter-immunoreactive axons in the prefrontal cortex of depressed subjects committing suicide.

    abstract：:A variety of postmortem brain studies and clinical investigations have provided evidence that reduced serotonin neurotransmission is associated with suicidal behavior and depression, and several serotonergic parameters have been found to be altered in the prefrontal cortex of suicide victims. However, the integrity of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00289-0

    authors： Austin MC,Whitehead RE,Edgar CL,Janosky JE,Lewis DA

    更新日期：2002-01-01 00:00:00

  • Entorhinal cortex lesioning promotes neurogenesis in the hippocampus of adult mice.

    abstract：:Hippocampal neurogenesis in adult mammals is influenced by many factors. Lesioning of the entorhinal cortex is a standard model used to study injury and repair in the hippocampus. Here we use bromodeoxyuridine (BrdU) labeling combined with immunohistochemical identification using cell type specific markers to follow t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.05.058

    authors： Gama Sosa MA,Wen PH,De Gasperi R,Perez GM,Senturk E,Friedrich VL Jr,Elder GA

    更新日期：2004-01-01 00:00:00

  • Free radicals accelerate the decay of long-term potentiation in field CA1 of guinea-pig hippocampus.

    abstract：:Free radicals have been implicated in a number of pathological conditions. To evaluate the neurophysiological consequences of free radical exposure, slices of hippocampus isolated from guinea-pigs were exposed to hydrogen peroxide which reacts with tissue iron to generate hydroxyl free radicals. Long-term potentiation...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90060-2

    authors： Pellmar TC,Hollinden GE,Sarvey JM

    更新日期：1991-01-01 00:00:00

  • Oxytocin-induced stimulation and inhibition of bladder activity in normal, conscious rats--influence of nitric oxide synthase inhibition.

    abstract：:The role of the oxytocin-containing projections to the autonomic nuclei of the spinal cord for lower urinary tract function has not been clarified. The hypothesis was tested that oxytocin acts as a mediator of bladder contraction at the spinal cord level. In conscious female rats undergoing continuous cystometry, intr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00651-9

    authors： Pandita RK,Nylén A,Andersson KE

    更新日期：1998-08-01 00:00:00

  • Muscarinic cholinergic and glutamatergic reciprocal regulation of expression of hippocampal cholinergic neurostimulating peptide precursor protein gene in rat hippocampus.

    abstract：:Hippocampal cholinergic neurostimulating peptide, an undecapeptide originally isolated from the hippocampus of young rats, enhances acetylcholine synthesis in rat medial septal nucleus in vitro. Hippocampal cholinergic neurostimulating peptide is derived from the N-terminal region of its 21-kmol.wt precursor protein. ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00495-4

    authors： Iwase T,Ojika K,Matsukawa N,Nishino H,Yamamoto T,Okada H,Fujimori O,Ueda R

    更新日期：2001-01-01 00:00:00

  • Neuroprotection and mechanisms of atractylenolide III in preventing learning and memory impairment induced by chronic high-dose homocysteine administration in rats.

    abstract：:Studies demonstrated that chronic high-dose homocysteine administration induced learning and memory impairment in animals. Atractylenolide III (Aen-III), a neuroprotective constituent of Atractylodis macrocephalae Koidz, was isolated in our previous study. In this study, we investigated potential benefits of Aen-III i...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.01.060

    authors： Zhao H,Ji ZH,Liu C,Yu XY

    更新日期：2015-04-02 00:00:00

  • Voluntary saccades in attention-deficit/hyperactivity disorder: Looking into the relationship between motor impairment and Autism Spectrum Disorder symptoms.

    abstract：:Although there is little overlap in core diagnostic criteria for ADHD and Autism Spectrum Disorder (ASD), ASD symptoms are estimated to co-occur in children with ADHD in 20-50% of cases. As motor control deficits are common to both disorders, we investigated the impact of ASD symptoms on ocular motor control in childr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.07.013

    authors： Connolly AJ,Rinehart NJ,Johnson B,Papadopoulos N,Fielding J

    更新日期：2016-10-15 00:00:00