Neuroprotection and mechanisms of atractylenolide III in preventing learning and memory impairment induced by chronic high-dose homocysteine administration in rats.

abstract：:Substance P is an important neuropeptide neurotransmitter in the central, autonomic and enteric nervous systems. In sympathetic ganglia, substance P is thought to play a role in modulating synaptic transmission. Release of substance P by neuronal stimulation or direct application of substance P to ganglionic neurons i...

journal_title：Neuroscience

authors： Simmons MA,Brodbeck RM,Karpitskiy VV,Schneider CR,Neff DP,Krause JE

更新日期：1997-08-01 00:00:00

abstract：:Neural insult during development results in recovery outcomes that vary dependent upon the system under investigation. Nerve regeneration does not occur if the rat gustatory chorda tympani nerve is sectioned (CTX) during neonatal (≤P10) development. It is unclear how chorda tympani soma and terminal fields are affecte...

journal_title：Neuroscience

authors： Martin LJ,Lane AH,Samson KK,Sollars SI

更新日期：2019-03-15 00:00:00

abstract：:Interactions between dopamine and glutamate receptors are essential for the prefrontal cortical (PFC) and hippocampal cognitive functions. In order to understand the molecular basis of dopamine/glutamate interactions in rat PFC and hippocampus, we investigated (a) the effect of in vitro dopamine D1 receptor stimulatio...

journal_title：Neuroscience

authors： Sarantis K,Matsokis N,Angelatou F

更新日期：2009-11-10 00:00:00

abstract：:Compensatory counter-rotations of the eyes provoked by head turns are commonly attributed to the vestibulo-ocular reflex (VOR). A recent study in guinea pigs demonstrates, however, that this assumption is not always valid. During voluntary head turns, guinea pigs make highly accurate compensatory eye movements that oc...

journal_title：Neuroscience

authors： King WM

更新日期：2013-04-16 00:00:00

abstract：:Pituitary adenylate-cyclase activating polypeptide (PACAP) has been implicated in the (patho)physiology of stress-adaptation. PACAP deficient (PACAP(-/-)) mice show altered anxiety levels and depression-like behavior, but little is known about the underlying mechanisms in stress-related brain areas. Therefore, we aime...

journal_title：Neuroscience

authors： Gaszner B,Kormos V,Kozicz T,Hashimoto H,Reglodi D,Helyes Z

更新日期：2012-01-27 00:00:00

abstract：:Nerve injury often leads to chronic, sometimes excruciating, pain. The mechanisms contributing to this syndrome include neurochemical plasticity in neurons involved in the earliest stages of pain transmission. Endomorphin-2 (Tyr-Pro-Phe-Phe-NH(2)) is an endogenous morphine-like substance that binds to the mu-opioid re...

journal_title：Neuroscience

authors： Smith RR,Martin-Schild S,Kastin AJ,Zadina JE

更新日期：2001-01-01 00:00:00

abstract：:We have previously shown that voluntary exercise produces enhanced neurogenesis and long-term potentiation (LTP) in the dentate gyrus (DG) of mice in vitro. In the present experiments we show that rats given access to a running wheel (Runners) exhibit significantly more short-term potentiation and LTP with theta-patte...

journal_title：Neuroscience

authors： Farmer J,Zhao X,van Praag H,Wodtke K,Gage FH,Christie BR

更新日期：2004-01-01 00:00:00

abstract：:Glutamate, the main excitatory amino acid transmitter in the vertebrate brain is involved in the dynamic changes in protein repertoire that underlie synaptic plasticity. Activity-dependent differential expression patterns occur not only in neurons but also in glial cells. In fact, a membrane to nuclei signaling has be...

journal_title：Neuroscience

authors： González-Mejia ME,Morales M,Hernández-Kelly LC,Zepeda RC,Bernabé A,Ortega A

更新日期：2006-09-01 00:00:00

abstract：:Turning in circles is among the behaviors elicited by unilateral cholinergic stimulation of the substantia nigra. Recent studies have shown that microinjection of cholinergic agonists into the substantia nigra pars compacta increases dopamine release and turnover in the striatum of anesthetized rats [Hernández-López e...

journal_title：Neuroscience

authors： Hernández-López S,Góngora-Alfaro JL,Martínez-Fong D,Rosales MG,Aceves J

更新日期：1994-09-01 00:00:00

abstract：:To elucidate the role and the mechanism of action of nerve growth factor in the adult central nervous system, we investigated the localization of nerve growth factor-like immunoreactivity in adult rat brain, both quantitatively and immunohistochemically, using polyclonal anti-nerve growth factor immunoglobulin G. We r...

journal_title：Neuroscience

authors： Nishio T,Furukawa S,Akiguchi I,Oka N,Ohnishi K,Tomimoto H,Nakamura S,Kimura J

更新日期：1994-05-01 00:00:00

abstract：:Synaptic vesicle recycling is a critical feature of neuronal communication as it ensures a constant supply of releasable transmitter at the nerve terminal. Physiological studies predict that vesicle recycling is rapid and recent studies with fluorescent dyes have confirmed that the entire process may occur in less tha...

journal_title：Neuroscience

authors： Palfrey HC,Artalejo CR

更新日期：1998-04-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) produced in the medial preoptic region (MPO) in response to immune signals is generally accepted to play a major role in triggering the illness response, a complex of physiological and behavioral changes induced by infection or injury. Hyperalgesia is now thought to be an important component of...

journal_title：Neuroscience

authors： Heinricher MM,Neubert MJ,Martenson ME,Gonçalves L

更新日期：2004-01-01 00:00:00

abstract：:Intracellular recording and staining was applied to study non-pyramidal neurons in the guinea-pig hippocampus. To avoid accidental impalement of pyramidal or granule cells, two hippocampal regions known to be devoid of pyramidal or granule cells were chosen. In transverse and longitudinal slices, neurons of the deep h...

journal_title：Neuroscience

authors： Misgeld U,Frotscher M

更新日期：1986-09-01 00:00:00

abstract：:The excitation of densely packed mammalian central neurons is followed by a substantial transitory elevation of external K+ concentration. This phenomenon may have a different functional significance depending on how the resting membrane conductance mechanisms react to the changes in the gradient of these ions. We hav...

journal_title：Neuroscience

authors： Filippov V,Krishtal O

更新日期：1999-01-01 00:00:00

abstract：:Ghrelin induces orexigenic behavior by activation of growth hormone secretagogue 1 receptors (GHSRs) in the ventral tegmental area (VTA) as well as hypothalamus, suggesting the involvement of mesolimbic dopamine system in the action of ghrelin. The present study aimed to identify neuronal mechanisms by which periphera...

journal_title：Neuroscience

authors： Kawahara Y,Kawahara H,Kaneko F,Yamada M,Nishi Y,Tanaka E,Nishi A

更新日期：2009-07-07 00:00:00

abstract：:The cholinergic agonist nicotine facilitates detection of invalidly cued trials in location-cueing paradigms and reduces the associated neural activity in human inferior parietal cortex. By using functional magnetic resonance imaging we test the hypothesis that the nicotinic modulation of attentional reorienting may r...

journal_title：Neuroscience

authors： Thiel CM,Fink GR

更新日期：2008-03-18 00:00:00

abstract：:The alpha- and beta-stereoisomers of kainate correspond sterically to the L- and D-isomers of glutamate. Alpha-Kainate is a potent excitant at a specific membrane receptor site (kainate receptor). Beta-Kainate has been proposed as a functional N-methyl-D-aspartate antagonist in vivo. Because of the structural similari...

journal_title：Neuroscience

authors： Turski L,Klockgether T,Schwarz M,Sontag KH,Meldrum BS

更新日期：1987-01-01 00:00:00

abstract：:The distribution of peptide histidine-isoleucine (PHI) and vasoactive intestinal polypeptide (VIP), two peptides derived from the same precursor molecule, was analysed with immunohistochemistry in the central nervous system of the rat, and to a limited extent in some other species including sheep, monkey and man. Spec...

journal_title：Neuroscience

authors： Hökfelt T,Fahrenkrug J,Ju G,Ceccatelli S,Tsuruo Y,Meister B,Mutt V,Rundgren M,Brodin E,Terenius L

更新日期：1987-12-01 00:00:00

abstract：:A quantitative electron-microscopic analysis has been conducted on the neurons within the gustatory zone of the nucleus of the solitary tract of the hamster. The most common group of neurons within the gustatory zone contains both large (X1) and small (X3) members that possess deeply invaginated nuclear profiles. Thes...

journal_title：Neuroscience

authors： Davis BJ,Jang T

更新日期：1988-12-01 00:00:00

abstract：:Leptin microinjections into the nucleus of the solitary tract (NTS) have been shown to elicit sympathoexcitatory responses, and potentiate the cardiovascular responses to activation of the chemoreflex. In this study, experiments were done in Sprague-Dawley rats initially to provide a detailed mapping within the NTS co...

journal_title：Neuroscience

authors： Ciriello J,Moreau JM

更新日期：2013-01-15 00:00:00

abstract：:The visual word form area (VWFA) has been consistently identified as a crucial structure in visual word processing. Nevertheless, it is controversial whether the VWFA represents external visual information (e.g., case information) of visual words. To address that question, we functionally localized VWFA at the group l...

journal_title：Neuroscience

authors： Lu C,Li H,Fu R,Qu J,Yue Q,Mei L

更新日期：2021-01-01 00:00:00

abstract：:Inside-out patch recordings from rat acutely dissociated cerebral cortical neurons revealed time and voltage-dependent activity of a large-conductance calcium-activated potassium channel. Channel activity inactivated within minutes following a depolarizing voltage step, and was recovered from inactivation by membrane ...

journal_title：Neuroscience

authors： Smith MA,Ashford ML

更新日期：2000-01-01 00:00:00

abstract：:Fetal striatal neurons were transplanted into the ibotenic acid lesioned rat striatum. Three months after transplantation the grafted tissue was Golgi-impregnated and examined at the light microscopic level to determine the morphological characteristics of the transplanted neurons. Golgi-impregnated neurons were then ...

journal_title：Neuroscience

authors： Helm GA,Palmer PE,Bennett JP Jr

更新日期：1990-01-01 00:00:00

abstract：:Spinules found in brain consist of small invaginations of plasma membranes which enclose membrane evaginations from adjacent cells. Here, we focus on the dynamic properties of the most common type, synaptic spinules, which reside in synaptic terminals. In order to test whether depolarization triggers synaptic spinule ...

journal_title：Neuroscience

authors： Tao-Cheng JH,Dosemeci A,Gallant PE,Miller S,Galbraith JA,Winters CA,Azzam R,Reese TS

更新日期：2009-04-21 00:00:00

abstract：:Using the indirect immunofluorescence method, the distribution of substance P-like-immunoreactivity was studied in spinal cord and dorsal root ganglia of 25 human foetuses ranging from 12 to 29 weeks of gestational age. The spinal cord and dorsal root ganglia of three infants (1 day-, 2 and 4 month-old) were also inve...

journal_title：Neuroscience

authors： Charnay Y,Paulin C,Chayvialle JA,Dubois PM

更新日期：1983-09-01 00:00:00

abstract：:Past studies have implicated calcium influx through the N-methyl-D-aspartate class of ionotropic glutamate receptors as a key factor in excitotoxicity. Here, primary cultures of hippocampal neurons were exposed to N-methyl-D-aspartate with or without the L-type calcium channel agonist BayK8644(+/-). Calcium influxes w...

journal_title：Neuroscience

authors： Barger SW

更新日期：1999-03-01 00:00:00

abstract：:This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons posit...

journal_title：Neuroscience

authors： Lee Y,Takami K,Kawai Y,Girgis S,Hillyard CJ,MacIntyre I,Emson PC,Tohyama M

更新日期：1985-08-01 00:00:00

abstract：:Several genetic mutations affecting the development and function of mammalian hair cells have been shown to cause deafness but not vestibular defects, most likely because vestibular deficits are sometimes centrally compensated. The study of hair cell physiology is thus a powerful direct approach to ascertain the funct...

journal_title：Neuroscience

authors： Tavazzani E,Spaiardi P,Zampini V,Contini D,Manca M,Russo G,Prigioni I,Marcotti W,Masetto S

更新日期：2016-07-22 00:00:00

abstract：:Nerve injuries cause pain, paralysis and numbness that can lead to major disability, and newborns often sustain nerve injuries during delivery that result in lifelong impairment. Without a pharmacologic agent to enhance functional recovery from these injuries, clinicians rely solely on surgery and rehabilitation to tr...

journal_title：Neuroscience

authors： Kemp SWP,Szynkaruk M,Stanoulis KN,Wood MD,Liu EH,Willand MP,Morlock L,Naidoo J,Williams NS,Ready JM,Mangano TJ,Beggs S,Salter MW,Gordon T,Pieper AA,Borschel GH

更新日期：2015-01-22 00:00:00

abstract：:The role of nitric oxide (NO) in post-ischemic cerebral infarction has been extensively examined, but few studies have investigated its role on the neurological deficit. In the present study, we investigated the effect of spermine on the temporal evolution of infarct volume, NO production and neurological deficit usin...

journal_title：Neuroscience

authors： Shirhan MD,Moochhala SM,Ng PY,Lu J,Ng KC,Teo AL,Yap E,Ng I,Hwang P,Lim T,Sitoh YY,Rumpel H,Jose R,Ling E

更新日期：2004-01-01 00:00:00