Patterns of activation and de-activation associated with cue-guided spatial navigation: A whole-brain, voxel-based study.

abstract：:Modeling Parkinson's disease remains a major challenge for preclinical researchers, as existing models fail to reliably recapitulate all of the classic features of the disease, namely, the progressive emergence of a bradykinetic motor syndrome with underlying nigrostriatal α-synuclein protein accumulation and nigrostr...

journal_title：Neuroscience

authors： Mulcahy P,O'Doherty A,Paucard A,O'Brien T,Kirik D,Dowd E

更新日期：2012-02-17 00:00:00

abstract：:Social play is a motivated and rewarding behavior that is displayed by nearly all mammals and peaks in the juvenile period. Moreover, social play is essential for the development of social skills and is impaired in social disorders like autism. We recently showed that the lateral septum (LS) is involved in the regulat...

journal_title：Neuroscience

authors： Bredewold R,Schiavo JK,van der Hart M,Verreij M,Veenema AH

更新日期：2015-10-29 00:00:00

abstract：:Age-dependent, neuronal apoptosis following N-methyl-D-aspartate receptor blockade has been linked to loss of calcium. To further explore this relationship, we examined expression of activated caspase-3, as well as the calcium binding proteins, calbindin-D 28K, calretinin and parvalbumin, following injection of vehicl...

journal_title：Neuroscience

authors： Lema Tomé CM,Bauer C,Nottingham C,Smith C,Blackstone K,Brown L,Hlavaty C,Nelson C,Daker R,Sola R,Miller R,Bryan R,Turner CP

更新日期：2006-09-01 00:00:00

abstract：:Recent studies have demonstrated that total cellular levels of voltage-gated potassium channel subunits can change on a time scale of minutes in acute slices and cultured neurons, raising the possibility that rapid changes in the abundance of channel proteins contribute to experience-dependent plasticity in vivo. In o...

journal_title：Neuroscience

authors： Strumbos JG,Polley DB,Kaczmarek LK

更新日期：2010-05-19 00:00:00

abstract：BACKGROUND:depression is characterized by a stable negative bias toward emotional stimuli. This bias is associated with abnormal activities in emotion-processing regions (such as the amygdala) and cognitive-control regions (such as the dorsolateral prefrontal cortex [DLPFC]). However, it remains unclear whether the emo...

journal_title：Neuroscience

authors： Liao C,Feng Z,Zhou D,Dai Q,Xie B,Ji B,Wang X,Wang X

更新日期：2012-01-10 00:00:00

abstract：:The effect of a transient increase in extracellular calcium concentration on the Schaffer collateral-commissural evoked excitatory postsynaptic potential and population spike responses of CAI pyramidal neurons was investigated using the rat in vitro hippocampal slice preparation. Brief exposure of slices (5-10 min) to...

journal_title：Neuroscience

authors： Turner RW,Baimbridge KG,Miller JJ

更新日期：1982-06-01 00:00:00

abstract：:Cholecystokinin binding sites were labeled with [3H]cholecystokinin-8, [125I]cholecystokinin-33, and [125I]cholecystokinin-8 in major structures of macaque basal ganglia by in vitro receptor autoradiography. Analysis of autoradiograms revealed areas of heavy cholecystokinin binding in the neostriatum and substantia ni...

journal_title：Neuroscience

authors： Kritzer MF,Innis RB,Goldman-Rakic PS

更新日期：1990-01-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons and leads to death a few years after symptom onset. Despite its high morbidity and mortality, its underlying pathogenic mechanisms still remain poorly understood. Although there is increasing evidence for sign...

journal_title：Neuroscience

authors： Konsolaki E,Koropouli E,Tsape E,Pothakos K,Zagoraiou L

更新日期：2020-12-01 00:00:00

abstract：:It was investigated whether grafts of the suprachiasmatic nucleus could re-instate circadian rhythmicity in the absence of its endogenous vasopressin production and whether the restored rhythm would have the long period length of the donor. Grafts of 17-days-old vasopressin-deficient homozygous Brattleboro rat fetuses...

journal_title：Neuroscience

authors： Boer GJ,van Esseveldt KE,van der Geest BA,Duindam H,Rietveld WJ

更新日期：1999-03-01 00:00:00

abstract：:Compelling lines of evidence indicate that overexpression of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) in subjects with trisomy 21 (Down syndrome[DS]) contributes to the abnormal structure and function of the DS brain. In the present study, we used a novel, phospho-dependent antibody r...

journal_title：Neuroscience

authors： Kida E,Walus M,Jarząbek K,Palminiello S,Albertini G,Rabe A,Hwang YW,Golabek AA

更新日期：2011-11-10 00:00:00

abstract：:Clinical and experimental evidence indicates that exposure to alcohol in utero is associated with altered immune capacity. The mechanisms underlying such abnormalities are not clear. However, the suggestion that reciprocal interactions between the immune and the nervous systems are necessary for a competent immune res...

journal_title：Neuroscience

authors： Gottesfeld Z,Christie R,Felten DL,LeGrue SJ

更新日期：1990-01-01 00:00:00

abstract：:We addressed the issue of the possible degradation of the aiming precision of a whole-body pointing task, when movement coordination is deranged by selective fatigue of the postural task component. The protocol involved continuous repetition (0.1 Hz frequency) of rapid whole-body pointing trials toward a target locate...

journal_title：Neuroscience

authors： Schmid M,Schieppati M,Pozzo T

更新日期：2006-01-01 00:00:00

abstract：:The post-stroke angiogenic response is accompanied by changes of tight junctions (TJs) of the blood-brain barrier (BBB). However, the precise dynamic change of TJ proteins (TJPs) in the different stages of stroke-induced vascular remodeling and the molecules mediating these processes have yet to be fully defined. To i...

journal_title：Neuroscience

authors： Sun J,Yu L,Huang S,Lai X,Milner R,Li L

更新日期：2017-10-24 00:00:00

abstract：:Rats were given bilateral lesions of the motor cortex on the tenth day of life, and then received a daily subcutaneously injection of either basic fibroblast growth factor (FGF-2) or vehicle for 7 consecutive days. In adulthood, they were trained and assessed on a skilled forelimb reaching task. Although all lesion gr...

journal_title：Neuroscience

authors： Monfils MH,Driscoll I,Vandenberg PM,Thomas NJ,Danka D,Kleim JA,Kolb B

更新日期：2005-01-01 00:00:00

abstract：:Recent studies have revealed that the ventral premotor cortex (PMv) of nonhuman primates plays a pivotal role in various behaviors that require the transformation of sensory cues to appropriate actions. Examples include decision-making based on various sensory cues, preparation for upcoming motor behavior, adaptive se...

journal_title：Neuroscience

authors： Kurata K

更新日期：2018-07-01 00:00:00

abstract：:Recently evidence has accumulated that schizophrenia can arise from primary synaptic defects involving structural proteins particularly, microtubule associated proteins. Previous experiments have demonstrated that a STOP (stable tubule only peptide) gene deletion in mice leads to a phenotype mimicking some aspects of ...

journal_title：Neuroscience

authors： Bégou M,Volle J,Bertrand JB,Brun P,Job D,Schweitzer A,Saoud M,D'Amato T,Andrieux A,Suaud-Chagny MF

更新日期：2008-11-11 00:00:00

abstract：:The cortical representation of the body surface is not fixed, but rather, is continuously modified by ongoing changes in sensory experience. Although the cellular and molecular mechanisms that subserve these changes are uncertain, increasing evidence suggests that synaptically-released zinc may play a role. Zinc is re...

journal_title：Neuroscience

authors： Brown CE,Dyck RH

更新日期：2005-01-01 00:00:00

abstract：:Neurotrophin gene expression in adult brain varies according to physiological activity and following brain injury, suggesting a role in neuronal maintenance and plasticity. However, the exact roles and mechanisms of action of neurotrophins in the adult brain are still poorly understood. We have recently demonstrated t...

journal_title：Neuroscience

authors： Guilhem D,Dreyfus PA,Makiura Y,Suzuki F,Onteniente B

更新日期：1996-06-01 00:00:00

abstract：:Investigations of local field potentials of the subthalamic nucleus of patients with Parkinson's disease have provided evidence for pathologically exaggerated oscillatory beta-band activity (13-30 Hz) which is amenable to physiological modulation by, e.g., voluntary movement. Previous functional magnetic resonance ima...

journal_title：Neuroscience

authors： Florin E,Dafsari HS,Reck C,Barbe MT,Pauls KA,Maarouf M,Sturm V,Fink GR,Timmermann L

更新日期：2013-06-14 00:00:00

abstract：:Drug addiction behavior that is established and maintained by psychostimulants has been shown to be associated with the expression of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine (DA) system. Cocaine has been used for most prior studies testing this effect of psychostimulants and therefore relat...

journal_title：Neuroscience

authors： Shen YL,Chang TY,Chang YC,Tien HH,Yang FC,Wang PY,Liao RM

更新日期：2014-03-28 00:00:00

abstract：:We have developed a specific radioimmunoassay for "cerebellin", a 16-amino acid peptide recently isolated from rat cerebellum. In both rat and guinea-pig, cerebellin-like immunoreactivity was highest in the cerebellum but was also present in high concentrations elsewhere in the central nervous system, especially in th...

journal_title：Neuroscience

authors： Burnet PW,Bretherton-Watt D,Ghatei MA,Bloom SR

更新日期：1988-05-01 00:00:00

abstract：:On guinea-pig neocortical slices the spatial organization of dendrites sensitive to excitatory amino acids was studied. Extracellular recording were obtained from the the soma of layer V neurons. Responses of 135 neurons to iontophoretically applied glutamate or aspartate have been analysed. An increased firing rate t...

journal_title：Neuroscience

authors： Mednikova YS,Karnup SV

更新日期：1995-11-01 00:00:00

abstract：:In an earlier study we have shown that local application of capsaicin directly to one sciatic nerve induces a decrease of substance P and cholecystokinin octapeptide (CCK8)-like peptide from the dorsal spinal cord using immunocytochemical analysis. Here the effect of locally applied capsaicin on seven peptides known t...

journal_title：Neuroscience

authors： Gibson SJ,McGregor G,Bloom SR,Polak JM,Wall PD

更新日期：1982-01-01 00:00:00

abstract：:Identification of novel molecules that can induce neuronal differentiation of embryonic stem (ES) cells is essential for deciphering the molecular mechanisms of early development and for exploring cell therapy approaches. Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide ...

journal_title：Neuroscience

authors： Chafai M,Basille M,Galas L,Rostene W,Gressens P,Vaudry H,Gonzalez BJ,Louiset E

更新日期：2011-12-29 00:00:00

abstract：:NADPH-diaphorase histochemical staining demonstrated a distinct neural group that might synthesize nitric oxide in the lower brainstem of rats. The NADPH-diaphorase stain revealed a Golgi-like network in the dorsomedial spinal trigeminal nucleus oralis and rostrolateral solitary tract nucleus, whereas this network was...

journal_title：Neuroscience

authors： Takemura M,Wakisaka S,Yoshida A,Nagase Y,Bae YC,Shigenaga Y

更新日期：1994-08-01 00:00:00

abstract：:Administration of kainic acid induces acute seizures that result in the loss of neurons, gliosis and reorganization of mossy fiber pathways in the hippocampus resembling those observed in human temporal lobe epilepsy. Although these structural changes have been well characterized, the mechanisms underlying the degener...

journal_title：Neuroscience

authors： Banerjee M,Sasse VA,Wang Y,Maulik M,Kar S

更新日期：2015-01-22 00:00:00

abstract：:It has recently been reported that the degeneration of retinal ganglion cells induced by transection of the optic nerve in the neonatal rat is due to an active process of apoptosis, as opposed to passive necrosis. Here we tested whether the administration of the trophic factor nerve growth factor could prevent the apo...

journal_title：Neuroscience

authors： Rabacchi SA,Ensini M,Bonfanti L,Gravina A,Maffei L

更新日期：1994-12-01 00:00:00

abstract：:The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The metabotropic glutamate receptors first d...

journal_title：Neuroscience

authors： Birse EF,Eaton SA,Jane DE,Jones PL,Porter RH,Pook PC,Sunter DC,Udvarhelyi PM,Wharton B,Roberts PJ

更新日期：1993-02-01 00:00:00

abstract：:To examine the effect of glucose on the cerebral metabolism of glutamine, rat brain slices were incubated with 5mM [3-(13)C]glutamine without and with 5mM unlabeled glucose. Tissue plus medium extracts were analyzed by using enzymatic and (13)C NMR techniques and fluxes through the enzymatic steps involved were calcul...

journal_title：Neuroscience

authors： El Hage M,Baverel G,Conjard-Duplany A,Martin G

更新日期：2013-09-17 00:00:00

abstract：:Stimulant-induced exocytosis has been demonstrated in sympathetic ganglia of the rat by in vitro incubation of excised ganglia in the presence of tannic acid, which stabilizes vesicle cores after their exocytotic release. Sites of exocytosis were observed along non-synaptic regions of the surfaces of neuron somata and...

journal_title：Neuroscience

authors： Zaidi ZF,Matthews MR

更新日期：1997-10-01 00:00:00