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Entorhinal cortex lesioning promotes neurogenesis in the hippocampus of adult mice.

Abstract：

:Hippocampal neurogenesis in adult mammals is influenced by many factors. Lesioning of the entorhinal cortex is a standard model used to study injury and repair in the hippocampus. Here we use bromodeoxyuridine (BrdU) labeling combined with immunohistochemical identification using cell type specific markers to follow the fate of neural progenitors in the hippocampus following entorhinal cortex lesioning in mice. We show that unilateral entorhinal cortex lesioning does not alter the rate of neural progenitor proliferation in the ipsilateral dentate gyrus during the first 3 days after lesioning. However it enhances cell survival at 42 days post-lesioning leading to an increased number of beta-III tubulin and calbindin-immunoreactive neurons being produced. By contrast, when BrdU was administered 21 days post-lesioning, the number of surviving cells 21 days later was similar on the lesioned and non-lesioned sides. Thus, acutely entorhinal cortex lesioning promotes neurogenesis by enhancing survival of either neural progenitors or their progeny. However, this stimulus to neurogenesis is not sustained into the recovery period.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Gama Sosa MA,Wen PH,De Gasperi R,Perez GM,Senturk E,Friedrich VL Jr,Elder GA

doi

10.1016/j.neuroscience.2004.05.058

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

881-91

issue

4

eissn

0306-4522

issn

1873-7544

pii

S0306452204004713

journal_volume

127

pub_type

杂志文章

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