The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons.

abstract：:Responses to nerve stimulation were recorded with intracellular microelectrodes from neurons in the inferior mesenteric ganglion of the guinea-pig. An event was recorded which was subthreshold for a somatic action potential but which had a short rise time and a rapid initial repolarization that gave the event a small ...

journal_title：Neuroscience

authors： Coleman HA

更新日期：1987-02-01 00:00:00

abstract：:Experiments in a variety of preparations have indicated that excessive activation of receptors for the excitatory amino acids glutamate and aspartate may mediate irreversible anoxic neuronal injury. We investigated this hypothesis in the in vitro hippocampal slice. Rat hippocampal slices perfused for 40 min with buffe...

journal_title：Neuroscience

authors： Clark GD,Rothman SM

更新日期：1987-06-01 00:00:00

abstract：:The present experiments examined the role of excitatory amino acid receptors in the orofacial stereotypy induced by direct amphetamine microinjection into the ventrolateral striatum. In these experiments, the influence of prior intra-ventrolateral striatum treatment with various excitatory amino acid antagonists on th...

journal_title：Neuroscience

authors： Kelley AE,Delfs JM

更新日期：1994-05-01 00:00:00

abstract：:Microinjections of the neuroexcitatory substance L-glutamate, were made directly into various laminae of trigeminal nucleus caudalis to examine the influence of medullary dorsal horn neurons on the adrenal secretion of catecholamines in the anesthetized cat. Microinjections into the marginal layers (lamina I-II) or in...

journal_title：Neuroscience

authors： Bereiter DA,Gann DS

更新日期：1988-05-01 00:00:00

abstract：:Ascending projections from the several nuclei of the medullary reticular formation were examined using the autoradiographic method. The majority of fibers labeled after injections of [3H]leucine into nucleus gigantocellularis ascended within Forel's tractus fasciculorum tegmenti which is located ventrolateral to the m...

journal_title：Neuroscience

authors： Vertes RP,Martin GF,Waltzer R

更新日期：1986-11-01 00:00:00

abstract：:alpha-Calcitonin gene-related peptide expression in alpha-motoneurons is regulated by spinal cord transection, axotomy and testosterone, but to date there are no studies which examine the regulation of cholecystokinin expression in motoneurons. In the present study, we compared the regulation of preprocholecystokinin ...

journal_title：Neuroscience

authors： Popper P,Abelson L,Micevych PE

更新日期：1992-11-01 00:00:00

abstract：:The present study examines the spatial distribution within rat locus coeruleus of neurons projecting to particular brain regions. In order to accurately recreate, in digital and pictorial formats, the spatial distribution of neurons for the entire nucleus locus coeruleus, three-dimensional reconstructions were created...

journal_title：Neuroscience

authors： Loughlin SE,Foote SL,Bloom FE

更新日期：1986-06-01 00:00:00

abstract：:In the present autoradiographic study, we took advantage of 5-hydroxytryptamine(7) (5-HT(7)) receptor knockout mice to analyze the brain distribution of 5-HT(7) receptor binding sites using [(3)H]5-carboxamidotryptamine (5-CT; a 5-HT(1A/1B/1D/5/7) receptor ligand) and [(3)H]8-hydroxy-2-(di-n-propylamino)tetralin (8-OH...

journal_title：Neuroscience

authors： Bonaventure P,Nepomuceno D,Hein L,Sutcliffe JG,Lovenberg T,Hedlund PB

更新日期：2004-01-01 00:00:00

abstract：:Phenylethylidenehydrazine (PEH), an analog of the monoamine oxidase inhibitor, beta-phenylethylhydrazine (phenelzine), inhibits the gamma-aminobutyric acid (GABA) catabolic enzyme GABA-transaminase and increases brain levels of GABA. GABA is the predominant fast inhibitory transmitter counteracting glutamatergic excit...

journal_title：Neuroscience

authors： Duffy S,Nguyen PV,Baker GB

更新日期：2004-01-01 00:00:00

abstract：:Superior olivary complex (SOC) neurons receive excitatory and inhibitory inputs from both ears. We determined the nature of such inputs to the main SOC nuclei with an optical imaging system. To do so, brainstem slices of postnatal (P) rats (P3-13) were treated with the fast voltage-sensitive dye RH795, and ipsilateral...

journal_title：Neuroscience

authors： Srinivasan G,Friauf E,Löhrke S

更新日期：2004-01-01 00:00:00

abstract：:Chronic restraint stress produces morphological changes in medial prefrontal cortex and disrupts a prefrontally mediated behavior, retrieval of extinction. To assess potential physiological correlates of these alterations, we compared neural activity in infralimbic and prelimbic cortex of unstressed versus stressed ra...

journal_title：Neuroscience

authors： Wilber AA,Walker AG,Southwood CJ,Farrell MR,Lin GL,Rebec GV,Wellman CL

更新日期：2011-02-03 00:00:00

abstract：:Mesial temporal lobe epilepsy (MTLE) is often characterized pathologically by severe neuronal loss in the hippocampus. In this study we investigated concomitant appearance of the pro-apoptotic and anti-apoptotic mechanisms in injured neurons in epileptic human hippocampi. Postsurgical hippocampal specimens of randomly...

journal_title：Neuroscience

authors： Dericioglu N,Soylemezoglu F,Gursoy-Ozdemir Y,Akalan N,Saygi S,Dalkara T

更新日期：2013-05-01 00:00:00

abstract：:In order to examine differential strain susceptibility to neurotoxic effects of amphetamine and to assess the potential role of superoxide radicals in amphetamine-induced dopaminergic damage, the drug was injected to mice with different levels of copper/zinc superoxide dismutase (Cu/Zn SOD) enzyme. Administration of a...

journal_title：Neuroscience

authors： Krasnova IN,Ladenheim B,Jayanthi S,Oyler J,Moran TH,Huestis MA,Cadet JL

更新日期：2001-01-01 00:00:00

abstract：:Perineuronal nets (PNNs) are a form of aggregate Extracellular Matrix (ECM) in the brain. Recent evidence suggests that the postnatal deposition of PNNs may play an active role in regulating neuroplasticity and, potentially, neurological disorders. Observations of high levels of PNN expression around somas, proximal d...

journal_title：Neuroscience

authors： Chu P,Abraham R,Budhu K,Khan U,De Marco Garcia N,Brumberg JC

更新日期：2018-09-15 00:00:00

abstract：:Physiological studies suggest visceral spinal afferents are generally small diameter, unmyelinated C-fibers or myelinated Adelta-fibers, but little is known about the size and chemical phenotypes of visceral sensory neurons supplying the small intestine. This study examines the size and expression patterns of transien...

journal_title：Neuroscience

authors： Tan LL,Bornstein JC,Anderson CR

更新日期：2008-10-02 00:00:00

abstract：:The mesopontine tegmentum, which contains both cholinergic and non-cholinergic neurons, plays a crucial role in behavioral state control. Using microiontophoresis in unanesthetized cats, we have examined the effect of cholinergic and monoaminergic drugs on two putative cholinergic neurons located mostly in the laterod...

journal_title：Neuroscience

authors： Koyama Y,Sakai K

更新日期：2000-01-01 00:00:00

abstract：:The pontine projection of the flocculus and adjacent ventral paraflocculus was investigated with antegrade and retrograde axonal tracer techniques. Injections of horseradish peroxidase into the floccular complex revealed subsets of labeled neurons in the nucleus reticularis tegmenti pontis, the nucleus raphe pontis an...

journal_title：Neuroscience

authors： Gerrits NM,Epema AH,Voogd J

更新日期：1984-03-01 00:00:00

abstract：:The viral transneuronal labeling method was used to examine whether the suprachiasmatic nucleus (SCN) is linked by multisynaptic connections to the medial prefrontal cortex of the rat. In separate experiments, pseudorabies virus (PRV) was injected into one of the three different cytoarchitectonic regions that comprise...

journal_title：Neuroscience

authors： Sylvester CM,Krout KE,Loewy AD

更新日期：2002-01-01 00:00:00

abstract：:The ontogeny of the cholecystokinin-8 neuron system in the lower brain stem of the rat was investigated by means of indirect immunofluorescence. Cholecystokinin-8-like immunoreactive structures first appeared in the primordium of the ventral tegmental area, ventral tegmental nucleus of Gudden and the area lateral to t...

journal_title：Neuroscience

authors： Kiyama H,Shiosaka S,Kubota Y,Cho HJ,Takagi H,Tateishi K,Hashimura E,Hamaoka T,Tohyama M

更新日期：1983-12-01 00:00:00

abstract：:The capacity of neural stem cells (NSC) to generate different types of neurons and glia depends on the action of intrinsic determinants and extracellular signals. Here, we isolated adult olfactory bulb stem cells (aOBSC) that express nestin, RC2 and Sox2, and that have the capacity to generate neurons possessing matur...

journal_title：Neuroscience

authors： Vergaño-Vera E,Méndez-Gómez HR,Hurtado-Chong A,Cigudosa JC,Vicario-Abejón C

更新日期：2009-08-04 00:00:00

abstract：:Hepatic encephalopathy is characterized by disturbances of motor and cognitive functions involving the basal ganglia. So far no standards for assessment of neuropsychiatric abnormalities (disorders of sleep, mood, anxiety and personality) in subclinical hepatic encephalopathy have been defined. Using an animal model o...

journal_title：Neuroscience

authors： Sergeeva OA,Schulz D,Doreulee N,Ponomarenko AA,Selbach O,Borsch E,Kircheis G,Huston JP,Häussinger D,Haas HL

更新日期：2005-01-01 00:00:00

abstract：:Morphine induces profound analgesic tolerance in vivo despite inducing little internalization of the mu opioid receptor (muOR). Previously proposed explanations suggest that this lack of internalization could either lead to prolonged signaling and associated compensatory changes in downstream signaling systems, or tha...

journal_title：Neuroscience

authors： Walwyn WM,Wei W,Xie CW,Chiu K,Kieffer BL,Evans CJ,Maidment NT

更新日期：2006-10-13 00:00:00

abstract：:Nerve growth factor (NGF) can augment transmitter release in sensory neurons by acutely sensitizing sensory neurons and by increasing the expression of calcitonin gene-related peptide (CGRP) over time. The current study examined the intracellular signaling pathways that mediate these two temporally distinct effects of...

journal_title：Neuroscience

authors： Park KA,Fehrenbacher JC,Thompson EL,Duarte DB,Hingtgen CM,Vasko MR

更新日期：2010-12-15 00:00:00

abstract：:We describe two distinct mechanisms for the enhancement of plasma extravasation in the knee joint of the rat. One is activated by bradykinin and is neurogenic; the other is activated by platelet-activating factor and is non-neurogenic. Bradykinin-induced synovial plasma extravasation is known to be dependent on the sy...

journal_title：Neuroscience

authors： Green PG,Luo J,Heller PH,Levine JD

更新日期：1993-02-01 00:00:00

abstract：:Dopamine and endocannabinoids are neurotransmitters known to play a role in the activity of the basal ganglia motor circuit. While a number of studies have demonstrated functional interactions between type 1 cannabinoid (CB1) receptors and dopaminergic systems, we still lack detailed neuroanatomical evidence to explai...

journal_title：Neuroscience

authors： Julian MD,Martin AB,Cuellar B,Rodriguez De Fonseca F,Navarro M,Moratalla R,Garcia-Segura LM

更新日期：2003-01-01 00:00:00

abstract：:The glomeruli are the first synaptic relay on the olfactory pathway and play a basic role in smell perception. Glomerular degeneration occurs in humans with age and in Alzheimer's disease (AD). The glomeruli heavily express β-amyloid precursor protein (APP), β-secretase (BACE1) and γ-secretase complex. However, extrac...

journal_title：Neuroscience

authors： Cai Y,Xue ZQ,Zhang XM,Li MB,Wang H,Luo XG,Cai H,Yan XX

更新日期：2012-07-26 00:00:00

abstract：:The acute behavioural and metabolic consequences of functional changes following unilateral intracaudate kainic acid at the level of the feline caudate nucleus, the substantia nigra pars reticulata and the deeper layers of the colliculus superior were investigated. The present study became possible since it was previo...

journal_title：Neuroscience

authors： Jaspers RM,Berkelbach van der Sprenkel JW,Cools AR

更新日期：1989-01-01 00:00:00

abstract：:A double transgenic mouse expressing the amyloid precursor protein, bearing the Swedish mutations, and expressing tau protein containing three of the mutations present in frontotemporal dementia linked to chromosome 17 (FTDP-17), has been characterized. In the double transgenic mouse an increase in tau phosphorylation...

journal_title：Neuroscience

authors： Pérez M,Ribe E,Rubio A,Lim F,Morán MA,Ramos PG,Ferrer I,Isla MT,Avila J

更新日期：2005-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) have been implicated in the modulation of synaptic plasticity, glial activation, and long-term potentiation in the CNS. Here we demonstrate for the first time a mechanism for the regulation of nociceptive processing by spinal MMP-3 during peripheral inflammation. We first determined by...

journal_title：Neuroscience

authors： Christianson CA,Fitzsimmons BL,Shim JH,Agrawal A,Cohen SM,Hua XY,Yaksh TL

更新日期：2012-01-03 00:00:00

abstract：:Involvement of both the serotonergic and the endogenous opioid systems in the onset of depressive behavior has been suggested. Previously we showed that serotonin (5-hydroxytryptamine) facilitates beta-endorphin release in the nucleus accumbens (NAcc). Herein, the microdialysis method was used to assess in vivo the ef...

journal_title：Neuroscience

authors： Zangen A,Nakash R,Roth-Deri I,Overstreet DH,Yadid G

更新日期：2002-01-01 00:00:00