Blockade of excitatory amino acid receptors protects anoxic hippocampal slices.

abstract：:3-Nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase, induced ATP depletion and both necrosis and apoptosis in human NT2-N neurons. Necrosis occurred predominantly within the first two days, and increased in a dose-dependent fashion with the concentration of 3-NP, whereas apoptosis was ob...

journal_title：Neuroscience

authors： Lee WT,Itoh T,Pleasure D

更新日期：2002-01-01 00:00:00

abstract：:Intersegmental interneurons with relatively short axons perform an important role in the coordination of limb movement but surprisingly little is known about their organization and how they contribute to neuronal networks in the adult rat. We undertook a series of anatomical tract-tracing studies to label cell bodies ...

journal_title：Neuroscience

authors： Liu TT,Bannatyne BA,Maxwell DJ

更新日期：2010-12-01 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP) 1 that together form the CGRP receptor. Antagonist antibodie...

journal_title：Neuroscience

authors： Miller S,Liu H,Warfvinge K,Shi L,Dovlatyan M,Xu C,Edvinsson L

更新日期：2016-07-22 00:00:00

abstract：:MicroRNA (miRNA) is a small non-coding RNA that regulates gene expression by degrading target mRNAs or inhibiting translation. Although many miRNAs play important roles in various conditions, it is unclear whether miRNAs are involved in motor nerve regeneration. In this study, we identified the possible implication of...

journal_title：Neuroscience

authors： Nagata K,Hama I,Kiryu-Seo S,Kiyama H

更新日期：2014-01-03 00:00:00

abstract：:This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons posit...

journal_title：Neuroscience

authors： Lee Y,Takami K,Kawai Y,Girgis S,Hillyard CJ,MacIntyre I,Emson PC,Tohyama M

更新日期：1985-08-01 00:00:00

abstract：:The amyloid beta precursor protein can exist as both a membrane-bound and a secreted protein, with the former having the potential to generate the amyloid beta peptide present in the neuritic plaques which are characteristic of Alzheimer's disease. In this study, we have used a clone of the AtT20 mouse pituitary cell ...

journal_title：Neuroscience

authors： McFarlane I,Georgopoulou N,Coughlan CM,Gillian AM,Breen KC

更新日期：1999-04-01 00:00:00

abstract：:Hypofunction of the N-methyl-D-aspartic acid receptor (NMDAr) has been considered to play a crucial role in the pathophysiology of schizophrenia. In rodent electroencephalogram (EEG) studies, non-competitive NMDAr antagonists have been reported to produce aberrant basal gamma band oscillation (GBO), as observed in sch...

journal_title：Neuroscience

authors： Hiyoshi T,Kambe D,Karasawa J,Chaki S

更新日期：2014-11-07 00:00:00

abstract：:Extracellular adenosine 5'-triphosphate (eATP) acts as a neurotransmitter within the retina and brain, activating a range of ionotropic P2X and metabotropic P2Y receptors. In this study, the specific localization of the P2X4 receptor (P2X4-R) subunit was evaluated in the retina using fluorescence immunohistochemistry ...

journal_title：Neuroscience

authors： Ho T,Vessey KA,Fletcher EL

更新日期：2014-09-26 00:00:00

abstract：:The objective of this study was to explore changes in hyaluronan levels in the cerebrospinal fluid (CSF) in a spinal cord compression model, to investigate whether hyaluronan tetrasaccharide was involved in this process, and to test the effects of hyaluronan tetrasaccharide on neuron and oligodendrocyte repair. We dev...

journal_title：Neuroscience

authors： Wang J,Rong W,Hu X,Liu X,Jiang L,Ma Y,Dang G,Liu Z,Wei F

更新日期：2012-05-17 00:00:00

abstract：BACKGROUND:Recent studies suggest that normobaric hyperoxia (HO) reduces hypoxia-reoxygenation injury in the rat brain. We have attempted to determine the effect of HO on Na(+)-Ca(2+) exchangers (NCX) in the rat stroke model. METHODS:Rats were divided into two experimental groups. The first group was exposed to 95% in...

journal_title：Neuroscience

authors： Mohammadi E,Bigdeli MR

更新日期：2013-05-01 00:00:00

abstract：:Early life experiences, particularly the experience with parents, are crucial to phenotypic outcomes in both humans and animals. Although the effects of maternal deprivation on offspring well-being have been studied, paternal deprivation (PD) has received little attention despite documented associations between father...

journal_title：Neuroscience

authors： Tabbaa M,Lei K,Liu Y,Wang Z

更新日期：2017-02-20 00:00:00

abstract：:It has been half a century since brain volume enlargement was first reported in animals reared in an enriched environment (EE). As EE animals show improved memory task performance, exposure to EE has been a useful model system for studying the effects of experience on brain plasticity. We review EE-induced neural chan...

journal_title：Neuroscience

authors： Hirase H,Shinohara Y

更新日期：2014-11-07 00:00:00

abstract：:The cellular mechanisms underlying the genesis of thalamic ponto-geniculo-occipital waves were studied in reserpinized cats under urethane anaesthesia. Simultaneous field potential and intracellular recordings were performed in the lateral geniculate nucleus after acute lesions of retinal and visual cortical inputs. I...

journal_title：Neuroscience

authors： Hu B,Steriade M,Deschênes M

更新日期：1989-01-01 00:00:00

abstract：:We tested a hypothesis that the classical relation between movement time and index of difficulty (ID) in quick pointing action (Fitts' Law) reflects processes at the level of motor planning. Healthy subjects stood on a force platform and performed quick and accurate hand movements into targets of different size locate...

journal_title：Neuroscience

authors： Bertucco M,Cesari P,Latash ML

更新日期：2013-02-12 00:00:00

abstract：:Brain microvascular endothelial cell (BMEC) injury induced by ischemia-reperfusion (I/R) is the initial stage of blood-brain barrier (BBB) disruption, which results in a poor prognosis in ischemic stroke patients. Autophagy has been shown to have protective effects on BMECs against cerebral ischemic insults. However, ...

journal_title：Neuroscience

authors： Li Z,Li J,Tang N

更新日期：2017-06-23 00:00:00

abstract：:Our light and electron microscopic studies (Seress L., Nitsch R. and Leranth C. (1993) Neuroscience 55, 775-796.) indicated that in the hippocampus of the African Green monkey, calretinin is exclusively present in non-pyramidal cells. Calretinin-positive axons formed a prominent band at the border of the dentate molec...

journal_title：Neuroscience

authors： Nitsch R,Leranth C

更新日期：1993-08-01 00:00:00

abstract：:We employed simultaneous field potential recordings from CA3, subiculum and entorhinal cortex in an in vitro brain slice preparation to understand the involvement of these limbic areas in the generation of the field potential oscillations that are induced by bath application of the muscarinic receptor agonist carbacho...

journal_title：Neuroscience

authors： Lévesque M,Cataldi M,Chen LY,Hamidi S,Avoli M

更新日期：2017-04-21 00:00:00

abstract：:Increasing evidence indicates that endothelin-1 has a role for peripheral nociceptive signaling in animals and humans. However, the mechanisms of the nociceptive effects of endothelin-1 have not been fully understood. The current study investigated the effects of endothelin-1 on the capsaicin-evoked intracellular Ca2+...

journal_title：Neuroscience

authors： Yamamoto H,Kawamata T,Ninomiya T,Omote K,Namiki A

更新日期：2006-02-01 00:00:00

abstract：:Characteristics of atrial natriuretic peptide receptors were determined in cultured mouse spinal cord cells. Saturation and competition experiments demonstrated the presence of a single class of atrial natriuretic peptide binding sites with high affinity (KD = 0.054 nM) and a density of 1.92 fmoles/10(6) cells. A simi...

journal_title：Neuroscience

authors： Simonnet G,Allard M,Legendre P,Gabrion J,Vincent JD

更新日期：1989-01-01 00:00:00

abstract：:The nucleus accumbens septi is the major target of mesolimbic dopamine neurons originating in the ventral tegmental area of the mesencephalon. Studies involving experimental manipulation of dopamine transmission by drugs and by lesions, as well as in vivo monitoring of extracellular dopamine concentrations, have provi...

journal_title：Neuroscience

authors： Bassareo V,Di Chiara G

更新日期：1999-03-01 00:00:00

abstract：:Using a semihorizontal section plane tangential to the ventral surface of the cerebral peduncle, the authors re-examined cyto-, myelo- and dendroarchitecture, acetylcholinesterase activity, afferent fibers, and efferent projection neurons of the substantia nigra pars reticulata. In the semihorizontal section plane, th...

journal_title：Neuroscience

authors： Tokuno H,Nakamura Y,Kudo M,Kitao Y

更新日期：1990-01-01 00:00:00

abstract：:GABA is the main inhibitory neurotransmitter of the CNS. It is well established that activation of GABA(A) receptors favors sleep. Three generations of hypnotics are based on these GABA(A) receptor-mediated inhibitory processes. The first and second generation of hypnotics (barbiturates and benzodiazepines respectivel...

journal_title：Neuroscience

authors： Gottesmann C

更新日期：2002-01-01 00:00:00

abstract：:The presence of subgroups in vomeronasal sensory neurons has been known in various animals. To elucidate possible functional subdivisions in the guinea-pig accessory olfactory bulb, the combined studies with GTP-binding protein immunohistochemistry, electrophysiological and optical recordings were carried out. Gi2 alp...

journal_title：Neuroscience

authors： Sugai T,Sugitani M,Onoda N

更新日期：1997-08-01 00:00:00

abstract：:Regret and relief are associated with counterfactual thinking and are sensitive to various social contexts. In the present fMRI study, we investigated the neural basis for regret and relief and how social context (following vs. not following advice) modulates them by employing a sequential risk-taking task. Participan...

journal_title：Neuroscience

authors： Liu Z,Li L,Zheng L,Hu Z,Roberts ID,Guo X,Yang G

更新日期：2016-07-07 00:00:00

abstract：:An odorant's code is represented by activity in a dispersed ensemble of olfactory sensory neurons in the nose, activation of a specific combination of groups of mitral cells in the olfactory bulb and is considered to be mapped at divergent locations in the olfactory cortex. We present here an in vitro model of the mam...

journal_title：Neuroscience

authors： Markopoulos F,Neubauer FB,Berger T,Scotti AL

更新日期：2008-10-28 00:00:00

abstract：:To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine and GABAARs to the cytoskeleton, thus ensuring the accurate accumulatio...

journal_title：Neuroscience

authors： Pizzarelli R,Griguoli M,Zacchi P,Petrini EM,Barberis A,Cattaneo A,Cherubini E

更新日期：2020-07-15 00:00:00

abstract：:Microglia, the primary immune cells in the brain, have been implicated as the predominant cells governing inflammation-mediated neuronal damage. In response to immunological challenges such as lipopolysaccharide (LPS), microglia are activated and subsequently inflammatory process is initiated as evidenced by the relea...

journal_title：Neuroscience

authors： Liu F,Zhou R,Yan H,Yin H,Wu X,Tan Y,Li L

更新日期：2014-12-05 00:00:00

abstract：:Respiratory disturbances are a primary phenotype of the neurological disorder, Rett syndrome (RTT), caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Mouse models generated with null mutations in Mecp2 mimic respiratory abnormalities in RTT girls. Large deletions, however, are see...

journal_title：Neuroscience

authors： Bissonnette JM,Schaevitz LR,Knopp SJ,Zhou Z

更新日期：2014-05-16 00:00:00

abstract：:l-glutamate, an umami taste substance, is a key molecule coupled to a food intake signaling pathway. Furthermore, recent studies have unveiled new roles for dietary glutamate on gut-brain axis communication via activation of gut glutamate receptors and subsequent vagus nerve. In the present study, we mapped activation...

journal_title：Neuroscience

authors： Otsubo H,Kondoh T,Shibata M,Torii K,Ueta Y

更新日期：2011-11-24 00:00:00

abstract：:The globus pallidus, one of the basal ganglia nuclei, plays a major role in both basal ganglia physiology and pathophysiology. The globus pallidus is innervated mainly by striatal spiny neurons and globus pallidus collaterals. These GABAergic synapses constitute 90% of the input to globus pallidus cells. Despite the d...

journal_title：Neuroscience

authors： Rav-Acha M,Sagiv N,Segev I,Bergman H,Yarom Y

更新日期：2005-01-01 00:00:00