Long noncoding RNA Malat1 is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2 expression.

abstract：:The glycine transporter GLYT2 is present in axonal boutons throughout the spinal cord, and its laminar distribution matches that of glycine-enriched axons, which are presumed to be glycinergic. In order to determine whether boutons which possess GLYT2 are glycine-enriched, we have carried out pre-embedding immunocytoc...

journal_title：Neuroscience

authors： Spike RC,Watt C,Zafra F,Todd AJ

更新日期：1997-03-01 00:00:00

abstract：:Our previous results obtained by lesioning or stimulating the ventrolateral part of the lateral septum and the bed nuclei of the stria terminalis suggested that this area is involved in the control of milk ejection pattern in rats. The present study was undertaken with the aim of testing ventrolateral part of the late...

journal_title：Neuroscience

authors： Lambert RC,Moos FC,Ingram CD,Wakerley JB,Kremarik P,Guerné Y,Richard P

更新日期：1993-05-01 00:00:00

abstract：:Activation of neural stem/progenitor cells (NSPCs) is a potential therapeutic strategy of neurological disorders. In this study, NSPCs of subventricular zone were isolated and cultured from platelet-derived growth factor-β-receptor-knockout (PDGFR-β(-/-)) mice of postnatal day 1 (P1) and P28, and the roles of PDGFR-β ...

journal_title：Neuroscience

authors： Xu G,Shen J,Ishii Y,Fukuchi M,Dang TC,Zheng Y,Hamashima T,Fujimori T,Tsuda M,Funa K,Sasahara M

更新日期：2013-05-15 00:00:00

abstract：:Angiogenesis after intracerebral hemorrhage (ICH) injury can effectively alleviate brain damage and improve neurological function. Hypoxia-inducible factor 2α (HIF-2α) is an important angiogenic regulator and exhibits protective effects in several neurological diseases; however, its role in ICH has not yet been report...

journal_title：Neuroscience

authors： Chen H,Xiao H,Gan H,Zhang L,Wang L,Li S,Wang D,Li T,Zhai X,Zhao J

更新日期：2020-11-10 00:00:00

abstract：:Calcineurin (PP2B) is a Ca(2+)-dependent protein phosphatase enriched in the brain that takes part in intracellular signaling pathways regulating synaptic plasticity and neuronal functions. Calcineurin-dependent pathways are important for complex brain functions such as learning and memory. More recently, they have be...

journal_title：Neuroscience

authors： Crozatier C,Farley S,Mansuy IM,Dumas S,Giros B,Tzavara ET

更新日期：2007-02-23 00:00:00

abstract：:Dexamethasone (Dex) provides neuroprotection against subsequent hypoxia ischemia (HI) in newborn rats, but the mechanism of this neuroprotection is not well understood. It is known that vascular endothelial growth factor A (VEGF) has neuroprotective effects. The objective of this study was to evaluate the role of the ...

journal_title：Neuroscience

authors： Feng Y,Rhodes PG,Bhatt AJ

更新日期：2011-04-14 00:00:00

abstract：:Rats were systemically pre-treated with capsaicin either on the first day of life or at an age of 1 month. Both treatments were found to deplete substance P levels in the trigeminal nucleus caudalis (55.6% and 57.9% depletions, respectively). Extracellular single neurone recordings in the trigeminal nucleus caudalis r...

journal_title：Neuroscience

authors： Salt TE,Crozier CS,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:Oxidative stress is believed to be a major factor for the onset of Parkinson's disease (PD). In this study, we have investigated oxidative status in transgenic Drosophila model of PD. Our results revealed elevated levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in A30P and A53T α-synuclein PD mode...

journal_title：Neuroscience

authors： Jahromi SR,Haddadi M,Shivanandappa T,Ramesh SR

更新日期：2015-05-07 00:00:00

abstract：:The findings reported in this work show that pretreatment with polyunsaturated fatty acids, particularly linolenic acid, present in vegetable oils, can provide a potent tolerance against neurodegeneration in two models of neuronal death-generating treatments such as kainic acid injection and global ischemia. Rats were...

journal_title：Neuroscience

authors： Blondeau N,Widmann C,Lazdunski M,Heurteaux C

更新日期：2002-01-01 00:00:00

abstract：:The existence of a sex difference in several chronic pain syndromes and the fluctuation of symptoms during the menstrual cycle strongly suggest sex hormones are involved in pain processing. The mechanisms underlying these changes are not well understood. Using the colorectal distention model in the rat, we previously ...

journal_title：Neuroscience

authors： Ji Y,Tang B,Traub RJ

更新日期：2008-07-17 00:00:00

abstract：:Hotfoot is a mutant mouse with an ataxic phenotype which has been shown to be due to a mutation in the Grid2 gene. In this paper, we compare molecular, morphological, electrophysiological and behavioral features of two Grid2 alleles: Grid2(ho-4J) and Grid2(ho-Nancy). We first show that these two mutations are deletion...

journal_title：Neuroscience

authors： Lalouette A,Lohof A,Sotelo C,Guénet J,Mariani J

更新日期：2001-01-01 00:00:00

abstract：:Acidic fibroblast growth factor (aFGF) is a neurotrophic factor which is a powerful neuroprotective and neuroregenerative factor of the nervous system. Prior study had shown that levels of FGFs significantly increase following ischemic injury, reflecting a physiological protection mechanism. However, few reports demon...

journal_title：Neuroscience

authors： Tsai MJ,Tsai SK,Huang MC,Liou DY,Huang SL,Hsieh WH,Huang WC,Huang SS,Cheng H

更新日期：2015-10-01 00:00:00

abstract：:Biases in facial expression recognition can be reduced successfully using feedback-based training tasks. Here we investigate with event-related potentials (ERPs) at which stages of stimulus processing emotion-related modulations are influenced by training. Categorization of subtle facial expressions (morphed from neut...

journal_title：Neuroscience

authors： Pollux PM

更新日期：2016-05-13 00:00:00

abstract：:Several genetic mutations affecting the development and function of mammalian hair cells have been shown to cause deafness but not vestibular defects, most likely because vestibular deficits are sometimes centrally compensated. The study of hair cell physiology is thus a powerful direct approach to ascertain the funct...

journal_title：Neuroscience

authors： Tavazzani E,Spaiardi P,Zampini V,Contini D,Manca M,Russo G,Prigioni I,Marcotti W,Masetto S

更新日期：2016-07-22 00:00:00

abstract：:A delayed-matching spatial working memory protocol in a 5-arm maze was used to test the hypothesis of differential roles for central nicotinic and muscarinic cholinergic receptors in mediating task performance. In experiment 1, using a within subjects-repeated design, groups of C57Bl/6 mice, previously trained to crit...

journal_title：Neuroscience

authors： Maviel T,Durkin TP

更新日期：2003-01-01 00:00:00

abstract：:Since mild thermal stress seems to exert neuroprotection via induction of heat-shock protein 70 kDa (hsp70), we tested whether hsp70 would preserve striatal bioelectrical activity under conditions of mitochondrial impairment. Corticostriatal slices from rats that had undergone mild thermal stress were exposed to eithe...

journal_title：Neuroscience

authors： Tantucci M,Mariucci G,Taha E,Spaccatini C,Tozzi A,Luchetti E,Calabresi P,Ambrosini MV

更新日期：2009-10-20 00:00:00

abstract：:Nociceptin/orphanin FQ (N/OFQ) is an opioid-related peptide that stimulates corticosterone release after i.c.v. administration in non-stressed rats. We employed in situ hybridization histochemistry to investigate N/OFQ-stimulated activation of the HPA axis at the hypothalamic and pituitary level. We have demonstrated ...

journal_title：Neuroscience

authors： Leggett JD,Harbuz MS,Jessop DS,Fulford AJ

更新日期：2006-09-15 00:00:00

abstract：:Ghrelin is a stomach-derived hormone that regulates rewarding behaviors and reinforcement by acting on the ventral tegmental area (VTA). The VTA is a complex midbrain structure mainly comprised of dopamine (DA) and gamma-aminobutiric acid (GABA) neurons that are distributed in several VTA sub-nuclei. Here, we investig...

journal_title：Neuroscience

authors： Cornejo MP,Barrile F,De Francesco PN,Portiansky EL,Reynaldo M,Perello M

更新日期：2018-11-10 00:00:00

abstract：:The Ca(2+)-dependent release of the neurotransmitter glutamate from purified nerve terminals (synaptosomes) of the rat hippocampus was studied in a rapid perfusion apparatus. The response of the terminals was investigated with respect to the kinetics and duration of the release of endogenous glutamate upon brief and s...

journal_title：Neuroscience

authors： Verhage M,Lopes da Silva FH,Ghijsen WE

更新日期：1991-01-01 00:00:00

abstract：:Mutation of the α-thalassemia/mental retardation syndrome X-linked protein, ATRX, causes intellectual disability and is associated with pleiotropic defects including ophthalmological abnormalities. We have previously demonstrated that Atrx deficiency in the mouse retina leads to the selective loss of inhibitory intern...

journal_title：Neuroscience

authors： Lagali PS,Zhao BYH,Yan K,Baker AN,Coupland SG,Tsilfidis C,Picketts DJ

更新日期：2021-01-01 00:00:00

abstract：:The beta-amyloid precursor protein is the precursor of the main component of senile plaques (the beta-amyloid peptide or beta/A4) found in the brain of aged humans and, in higher amounts, in the brain of Alzheimer's disease and Down's syndrome subjects. Four different forms of beta-amyloid precursor protein messenger ...

journal_title：Neuroscience

authors： Solà C,Mengod G,Probst A,Palacios JM

更新日期：1993-03-01 00:00:00

abstract：:The aim of this study was to examine the development of the basalocortical pathway by using choline acetyltransferase and nerve growth factor receptor immunocytochemistry, acetylcholinesterase histochemistry and retrograde axonal transport. The observations were made in the ferret because in this species brain develop...

journal_title：Neuroscience

authors： Henderson Z

更新日期：1991-01-01 00:00:00

abstract：:Ivane Beritashvili ("Beritoff" in Russian, and often in Western languages) was a major figure in 20th-century neuroscience. Mastering the string galvanometer, he founded the electrophysiology of spinal cord reflexes, showing that inhibition is a distinctly different process from excitation, contrary to the concepts of...

journal_title：Neuroscience

authors： Tsagareli MG,Doty RW

更新日期：2009-10-20 00:00:00

abstract：:The distribution of neurotensin-immunoreactive structures in the rat striatum was evaluated after blockade of dopamine neurotransmission by drugs that act presynaptically (6-hydroxydopamine, reserpine) and postsynaptically, preferentially at the D2 (eticlopride, haloperidol) and D1 [(R)-(+)-8-chloro-2,3,4,5-tetrahydro...

journal_title：Neuroscience

authors： Zahm DS

更新日期：1992-01-01 00:00:00

abstract：:Sigma receptor (sigmaR), known as a unique nonopiate, nonphencyclidine brain receptor, can bind diverse classes of psychotropic drugs, neurosteroids and other synthetic compounds, such as (+)pentazocine, etc. Two types of sigmaRs have been identified: sigmaR1 and sigmaR2. In this work, we examined the expression of si...

journal_title：Neuroscience

authors： Liu LL,Wang L,Zhong YM,Yang XL

更新日期：2010-06-02 00:00:00

abstract：:The present paper is the first immunocytochemical demonstration of kappa-opioid receptors in neurons isolated from seven-day-old chick embryonic forebrains and cultivated for one to seven days. The monoclonal antibody KA8 (IgG1-k) [Maderspach et al. (1991) J. Neurochem. 56, 1897-1904] was raised against the frog brain...

journal_title：Neuroscience

authors： Maderspach K,Németh K

更新日期：1993-11-01 00:00:00

abstract：:The forced swim test (FST) has been considered as a pharmacologically valid test of the depressive syndrome in rodents. However, few studies have focused on neurochemical and behavioral responses during FST in both male and female rats. Thus, we investigated certain behavioral and neuroendocrine responses as well as t...

journal_title：Neuroscience

authors： Drossopoulou G,Antoniou K,Kitraki E,Papathanasiou G,Papalexi E,Dalla C,Papadopoulou-Daifoti Z

更新日期：2004-01-01 00:00:00

abstract：:Properties of excitatory synaptic responses in fast-spiking interneurons (FSIs) and pyramidal neurons (PNs) are different; however, the mechanisms and determinants of this diversity have not been fully investigated. In the present study, voltage-clamp recording of miniature excitatory post-synaptic currents (mEPSCs) w...

journal_title：Neuroscience

authors： Malkin SL,Kim KK,Tikhonov DB,Magazanik LG,Zaitsev AV

更新日期：2015-08-20 00:00:00

abstract：:The ventral tegmental area of the rat brain has been shown to possess high densities of neurotensin- and dopamine-containing neuronal perikarya. We recently demonstrated that microinjection of neurotensin into the ventral tegmental area produces behavioral hyperactivity similar to amphetamine-induced increase in explo...

journal_title：Neuroscience

authors： Kalivas PW,Burgess SK,Nemeroff CB,Prange AJ Jr

更新日期：1983-03-01 00:00:00

abstract：:Extinction of drug-seeking is an integral part of addiction treatment, and can profoundly reverse or ameliorate the harmful consequences of drug use. These consequences may be the most deleterious during adolescence. The studies presented here build from recent evidence that adolescent rats are more resistant to extin...

journal_title：Neuroscience

authors： Brenhouse HC,Dumais K,Andersen SL

更新日期：2010-08-25 00:00:00