The neural basis of regret and relief during a sequential risk-taking task.

Abstract:

:Regret and relief are associated with counterfactual thinking and are sensitive to various social contexts. In the present fMRI study, we investigated the neural basis for regret and relief and how social context (following vs. not following advice) modulates them by employing a sequential risk-taking task. Participants were asked to open a series of boxes consecutively until they decided to stop. Each box contained a reward (gold), except for one that contained an adverse stimulus (devil), which caused the participant to lose all the gold collected in that trial. Before each trial, participants received advice about when to stop, which they then chose to follow or not. Behaviorally, subjective regret and relief were primarily dependent on the number of missed chances and the trade-off between obtained gains and missed chances, respectively. Participants felt less regret when they chose not to follow the advice than when they did. At the neural level, striatum, vmPFC/mOFC, and vACC activations were associated with greater relief. Meanwhile, dmPFC and left superior temporal gyrus were associated with greater regret. Additionally, dACC showed stronger activation in the Not-Follow context than the Follow context.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Liu Z,Li L,Zheng L,Hu Z,Roberts ID,Guo X,Yang G

doi

10.1016/j.neuroscience.2016.04.018

subject

Has Abstract

pub_date

2016-07-07 00:00:00

pages

136-45

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(16)30083-5

journal_volume

327

pub_type

杂志文章
  • Differential involvement of dopamine in the shell and core of the nucleus accumbens in the expression of latent inhibition to an aversively conditioned stimulus.

    abstract::Latent inhibition, the process whereby pre-exposure to a conditioned stimulus without consequence impairs subsequent learning of an association between the conditioned stimulus and an unconditioned stimulus, is reportedly disrupted in both amphetamine-treated rats and in acute schizophrenics. This has led to the sugge...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(00)00043-9

    authors: Murphy CA,Pezze M,Feldon J,Heidbreder C

    更新日期:2000-01-01 00:00:00

  • Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat.

    abstract::The genetically epilepsy-prone rat is an animal model of inherited generalised tonic-clonic epilepsy that shows abnormal susceptibility to audiogenic seizures and a lowered threshold to a variety of seizure-inducing stimuli. Recent studies suggest a crucial role for glutamate and GABA transporters in epileptogenesis a...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00684-2

    authors: Akbar MT,Rattray M,Williams RJ,Chong NW,Meldrum BS

    更新日期:1998-08-01 00:00:00

  • Plasma extravasation in the skin and pelvic organs evoked by antidromic stimulation of the lumbosacral dorsal roots of the rat.

    abstract::Electrical stimulation of the distal stump of cut peripheral nerves is a commonly accepted way to evoke neurogenic inflammation. Nevertheless, the modulatory effect of biogenic amines and vasoactive peptides released from efferent fibres can be excluded only if the dorsal roots are stimulated. The present study was fo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00104-q

    authors: Pintér E,Szolcsányi J

    更新日期:1995-09-01 00:00:00

  • Deep prepiriform cortex modulates kainate-induced hippocampal injury.

    abstract::As seizure propagation within limbic structures is mediated in part by a small area of deep prepiriform cortex (area tempestas), we investigated the role of area tempestas in modulating hippocampal injury induced by systemic kainate administration. Injury was quantitated by counting the numbers of neurons that stained...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90404-9

    authors: Shimosaka S,So YT,Simon RP

    更新日期:1994-08-01 00:00:00

  • Raloxifene acutely reduces glutamate-induced intracellular calcium increase in cultured rat cortical neurons via inhibition of high-voltage-activated calcium current.

    abstract::There is increasing evidence indicating that estrogen replacement therapy produces neuroprotective actions but has undesirable side effects on the reproductive system. Raloxifene is a selective estrogen receptor modulator that exerts estrogen agonist action in the brain while acting as an estrogen antagonist in the re...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.04.037

    authors: Huang Y,Huang YL,Lai B,Zheng P,Zhu YC,Yao T

    更新日期:2007-06-29 00:00:00

  • Significance of slow synaptic potentials for transmission of excitation in guinea-pig myenteric plexus.

    abstract::Intracellular recordings were made from neurones in myenteric ganglia of the guinea-pig ileum in vitro. Synaptic potentials were evoked by electrically stimulating presynaptic fibres as they entered the ganglion, using a small focal electrode. Slow synaptic depolarizations (excitatory postsynaptic potentials) were evo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(85)90317-3

    authors: Morita K,North RA

    更新日期:1985-02-01 00:00:00

  • Fetal sulcation and gyrification in common marmosets (Callithrix jacchus) obtained by ex vivo magnetic resonance imaging.

    abstract::The present study characterized fetal sulcation patterns and gyrification in the cerebrum of the New World monkey group, common marmosets, using a 3D T2-weighted high-resolution anatomical magnetic resonance imaging (MRI) sequence from the fixed brain at 7-tesla ex vivo. Fetal sulcation in the marmoset cerebrum began ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.10.067

    authors: Sawada K,Hikishima K,Murayama AY,Okano HJ,Sasaki E,Okano H

    更新日期:2014-01-17 00:00:00

  • Exocytotic release from neuronal cell bodies, dendrites and nerve terminals in sympathetic ganglia of the rat, and its differential regulation.

    abstract::Stimulant-induced exocytosis has been demonstrated in sympathetic ganglia of the rat by in vitro incubation of excised ganglia in the presence of tannic acid, which stabilizes vesicle cores after their exocytotic release. Sites of exocytosis were observed along non-synaptic regions of the surfaces of neuron somata and...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)00664-1

    authors: Zaidi ZF,Matthews MR

    更新日期:1997-10-01 00:00:00

  • Functional Dissociations of the Left Anterior and Posterior Occipitotemporal Cortex for Semantic and Non-semantic Phonological Access.

    abstract::Previous studies have identified the ventral and dorsal brain regions that respectively support semantic and non-semantic phonological access. Nevertheless, the specific role of the left occipitotemporal cortex (lOTC) in the two pathways of phonological access is ambiguous. To address that question, the present study ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.01.024

    authors: Dong J,Lu C,Chen C,Li H,Liu X,Mei L

    更新日期:2020-03-15 00:00:00

  • Neuronal Loss in the Developing Cerebral Cortex of Normal and Bax-Deficient Mice: Effects of Ethanol Exposure.

    abstract::Fetal alcohol spectrum disorder is associated with defects in neuronal generation, migration, and differentiation. The present study tested the hypothesis that ethanol exposure during the period of naturally occurring neuronal death causes a time- and Bax-dependent neuronal loss. Wild-type and Bax knockout mice were g...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.11.013

    authors: Britton SM,Miller MW

    更新日期:2018-01-15 00:00:00

  • Decreases in endomorphin-2-like immunoreactivity concomitant with chronic pain after nerve injury.

    abstract::Nerve injury often leads to chronic, sometimes excruciating, pain. The mechanisms contributing to this syndrome include neurochemical plasticity in neurons involved in the earliest stages of pain transmission. Endomorphin-2 (Tyr-Pro-Phe-Phe-NH(2)) is an endogenous morphine-like substance that binds to the mu-opioid re...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00228-7

    authors: Smith RR,Martin-Schild S,Kastin AJ,Zadina JE

    更新日期:2001-01-01 00:00:00

  • Imaging genetics and the power of combined technologies: a perspective from neuroethics.

    abstract::Imaging genetics has emerged as a powerful and sensitive approach to the study of functional genetic variations and brain responses in psychiatric and neurologic disorders. Ethics issues in contemporary neuroscience as they apply separately to genetics and neuroimaging have been a growing focus for research but, to da...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2009.01.052

    authors: Tairyan K,Illes J

    更新日期:2009-11-24 00:00:00

  • Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices.

    abstract::Saffron, the dried stigmata of Crocus sativus L., is used in traditional medicine for a wide range of indications including cramps, asthma, and depression. To investigate the influence of hydro-ethanolic saffron extract (CSE) and trans-crocetin on synaptic transmission, postsynaptic potentials (PSPs) were elicited by ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2011.02.037

    authors: Berger F,Hensel A,Nieber K

    更新日期:2011-04-28 00:00:00

  • Reversal of dopamine neurons and locomotor ability degeneration in aged rats with smilagenin.

    abstract::The purpose of this paper is to study the effect of smilagenin (SMI) (PYM50028), a sapogenin compound originally identified from Chinese medicinal herb, on dopamine neurons and locomotor ability in aged rats. Experiments were carried out on young and aged Sprague-Dawley rats, which were daily administered with either ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.04.028

    authors: Li J,Xia Z,Sun X,Zhang R,Huang G,Hickling R,Xia Z,Hu Y,Zhang Y

    更新日期:2013-08-15 00:00:00

  • Effect of neurotoxic lesion of pedunculopontine nucleus in nigral and striatal redox balance and motor performance in rats.

    abstract::Early degeneration of pedunculopontine nucleus (PPN) is considered part of changes that characterize premotor stages of Parkinson's disease (PD). In this paper, the effects of unilateral neurotoxic lesion of the PPN in motor execution and in the development of oxidative stress events in striatal and nigral tissues in ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.12.056

    authors: Jimenez-Martin J,Blanco-Lezcano L,González-Fraguela ME,Díaz-Hung ML,Serrano-Sánchez T,Almenares JL,Francis-Turner L

    更新日期:2015-03-19 00:00:00

  • Cytochemical localization of 5'-nucleotidase activity in retinal photoreceptor cells.

    abstract::Further cytochemical studies on the ultrastructural localization of 5'-nucleotidase in the rat retina have revealed activity to be associated with the complex synapses formed by the rod spherules of the receptors and the bipolar and horizontal cell processes. Activity was also seen on the axolemma of receptor fibers. ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(84)90196-9

    authors: Kreutzberg GW,Hussain ST

    更新日期:1984-04-01 00:00:00

  • Changes in interneuronal phenotypes regulated by estradiol in the adult rat hippocampus: a potential role for neuropeptide Y.

    abstract::Ovarian hormones regulate pyramidal cell synapse formation and excitability and interneuronal GABAergic tone in the CA1 region of the adult female rat hippocampus. The role of 17beta-estradiol in these effects is complex and appears to involve a subset of hippocampal interneurons, which express different calcium-bindi...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.07.056

    authors: Nakamura NH,McEwen BS

    更新日期:2005-01-01 00:00:00

  • Effects of basolateral amygdala dopamine depletion on the nucleus accumbens and medial prefrontal cortical dopamine responses to stress.

    abstract::In vivo voltammetry was used to study the effects of basolateral amygdala dopamine depletion on stress-induced dopamine release in the nucleus accumbens and medial prefrontal cortex. Male Long-Evans rats received bilateral microinjections of 6-hydroxydopamine or vehicle into the basolateral amygdala. Changes in dopami...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00553-5

    authors: Stevenson CW,Sullivan RM,Gratton A

    更新日期:2003-01-01 00:00:00

  • The light chain of tetanus toxin inhibits calcium-dependent vasopressin release from permeabilized nerve endings.

    abstract::The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland. Exocytosis was induced by challenging the permeabilized nerve endings with micromolar calcium ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90068-d

    authors: Dayanithi G,Weller U,Ahnert-Hilger G,Link H,Nordmann JJ,Gratzl M

    更新日期:1992-01-01 00:00:00

  • Microglia in the neurohypophysis associate with and endocytose terminal portions of neurosecretory neurons.

    abstract::The rat neurohypophysis contains a population of microglial cells, the majority of which occupy a pericapillary position in the resting gland. The microglia are immunocytochemically identifiable by the presence of macrophage-associated antigens and resemble microglia of the CNS. Morphometry at light and electron micro...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90409-0

    authors: Pow DV,Perry VH,Morris JF,Gordon S

    更新日期:1989-01-01 00:00:00

  • Cortical and Subcortical Neural Interactions Between Trunk and Upper-limb Muscles in Humans.

    abstract::Activities of daily living require simultaneous and coordinated activation of trunk and upper-limb segments, which involves complex interlimb interaction within the central nervous system. Although many studies have reported associations between activity of trunk and limb muscles during functional tasks, evidence on c...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.10.011

    authors: Sasaki A,Milosevic M,Nakazawa K

    更新日期:2020-12-15 00:00:00

  • Speech Disfluency-dependent Amygdala Activity in Adults Who Stutter: Neuroimaging of Interpersonal Communication in MRI Scanner Environment.

    abstract::Affective states, such as anticipatory anxiety, critically influence speech communication behavior in adults who stutter. However, there is currently little evidence regarding the involvement of the limbic system in speech disfluency during interpersonal communication. We designed this neuroimaging study and experimen...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2018.01.037

    authors: Toyomura A,Fujii T,Yokosawa K,Kuriki S

    更新日期:2018-03-15 00:00:00

  • Evidence for an intrinsic mechanism of antinociceptive tolerance within the ventrolateral periaqueductal gray of rats.

    abstract::Repeated microinjections of morphine into the ventrolateral periaqueductal gray produce antinociceptive tolerance. This tolerance may be a direct effect of morphine on cells within the ventrolateral periaqueductal gray or may require activation of downstream structures such as the rostral ventromedial medulla or spina...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.06.014

    authors: Lane DA,Patel PA,Morgan MM

    更新日期:2005-01-01 00:00:00

  • Modulation by serotonin of the neurons in rat nucleus raphe magnus in vitro.

    abstract::Nucleus raphe magnus contains a large population of raphe-spinal serotonergic neurons that are thought to be involved in descending control of pain transmission and the modulation of opioid analgesia. Intracellular recordings were made from nucleus raphe magnus neurons in the slice preparation. Cells were divided into...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90263-f

    authors: Pan ZZ,Wessendorf MW,Williams JT

    更新日期:1993-05-01 00:00:00

  • Caffeine-induced calcium release from internal stores in cultured rat sensory neurons.

    abstract::Free intracellular calcium concentration ([Ca2+]in) was recorded at 22 degrees C by means of Indo-1 or Fura-2 single-cell microfluorometry in cultured dorsal root ganglion neurons obtained from neonatal rats. The resting [Ca2+]in in dorsal root ganglion neurons was 73 +/- 21 nM (mean +/- S.D., n = 94). Fast applicatio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90029-f

    authors: Usachev Y,Shmigol A,Pronchuk N,Kostyuk P,Verkhratsky A

    更新日期:1993-12-01 00:00:00

  • Comparing the after-effects of continuous theta burst stimulation and conventional 1 Hz rTMS on semantic processing.

    abstract::Our aim was to evaluate continuous theta burst stimulation (cTBS) as a tool to induce temporary impairment (virtual lesion) in semantic processing. Four groups with 20 subjects each were stimulated. In the three experimental groups the stimulation site was the left superior temporal cortex. Stimulation was either 1Hz ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.12.033

    authors: Brückner S,Kiefer M,Kammer T

    更新日期:2013-03-13 00:00:00

  • Central Nervous System-Derived Exosomal Alpha-Synuclein in Serum May Be a Biomarker in Parkinson's Disease.

    abstract::Parkinson's disease (PD) is a common movement disorder. Alpha-synuclein (α-synuclein) plays a critical role in PD. In this study, we evaluated the level of central nervous system (CNS)-derived exosomal α-synuclein in serum, which may be regarded as a specific peripheral biomarker for PD. We recruited patients with PD ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.05.015

    authors: Si X,Tian J,Chen Y,Yan Y,Pu J,Zhang B

    更新日期:2019-08-10 00:00:00

  • Evidence for a periaqueductal gray-nucleus retroambiguus-spinal cord pathway in the rat.

    abstract::The nucleus retroambiguus in the cat has been shown to receive strong projections from the periaqueductal gray and to send fibres to distinct motoneuronal cell groups in brainstem and spinal cord. The nucleus retroambiguus plays a role in the production of vocalization and possibly copulatory (lordosis and mounting) b...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00061-4

    authors: Holstege G,Kerstens L,Moes MC,Vanderhorst VG

    更新日期:1997-09-01 00:00:00

  • High resolution immunogold analysis reveals distinct subcellular compartmentation of protein kinase C gamma and delta in rat Purkinje cells.

    abstract::High resolution immunogold cytochemistry was used to investigate the subcellular distribution of protein kinase C gamma and delta in Purkinje cells of the rat cerebellum. Postembedding incubation with an antibody raised to a peptide sequence near the C-terminus of protein kinase C gamma resulted in strong labelling al...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00305-9

    authors: Cardell M,Landsend AS,Eidet J,Wieloch T,Blackstad TW,Ottersen OP

    更新日期:1998-02-01 00:00:00

  • Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies.

    abstract::The membrane properties and receptor-mediated responses of rat dorsal raphe nucleus neurons were measured using intracellular recording techniques in a slice preparation. After each experiment, the recorded neuron was filled with neurobiotin and immunohistochemically identified as 5-hydroxytryptamine (5-HT)-immunoposi...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00584-5

    authors: Kirby LG,Pernar L,Valentino RJ,Beck SG

    更新日期:2003-01-01 00:00:00