Distinguishing characteristics of serotonin and non-serotonin-containing cells in the dorsal raphe nucleus: electrophysiological and immunohistochemical studies.

abstract：:Most patients with temporal lobe epilepsy (TLE), the most common type of epilepsy, show pronounced loss of neurons in limbic brain regions, including the hippocampus. The massive neurodegeneration in the hippocampus is known as hippocampal sclerosis, and is considered one of the hallmarks of this type of difficult-to-...

journal_title：Neuroscience

authors： Brandt C,Potschka H,Löscher W,Ebert U

更新日期：2003-01-01 00:00:00

abstract：:The neuromodulator adenosine maintains brain homeostasis and regulates complex behaviour via activation of inhibitory and excitatory adenosine receptors (ARs) in a brain region-specific manner. AR antagonists such as caffeine have been shown to ameliorate cognitive impairments in animal disease models but their effect...

journal_title：Neuroscience

authors： Singer P,McGarrity S,Shen HY,Boison D,Yee BK

更新日期：2012-06-28 00:00:00

abstract：:The ventromedial spinal cord of mammals contains a neural network known as the locomotor central pattern generator (CPG) which underlies the basic generation and coordination of muscle activity during walking. To understand how this neural network operates, it is necessary to identify, characterize, and map connectivi...

journal_title：Neuroscience

authors： Griener A,Dyck J,Gosgnach S

更新日期：2013-10-10 00:00:00

abstract：:Visually evoked behaviors mediated by the frog optic tectum require cholinergic activity, but the receptor subtypes through which acetylcholine acts are not yet identified. Using quantitative autoradiography and scintillation spectrometry, we examined the binding of [3H]pirenzepine and [3H]AF-DX 384 in the laminated o...

journal_title：Neuroscience

authors： Butt CM,Pauly JR,Wilkins LH,Dwoskin LP,Debski EA

更新日期：2001-01-01 00:00:00

abstract：:The effect of a transient increase in extracellular calcium concentration on the Schaffer collateral-commissural evoked excitatory postsynaptic potential and population spike responses of CAI pyramidal neurons was investigated using the rat in vitro hippocampal slice preparation. Brief exposure of slices (5-10 min) to...

journal_title：Neuroscience

authors： Turner RW,Baimbridge KG,Miller JJ

更新日期：1982-06-01 00:00:00

abstract：:Opiate addiction is a chronic medical disorder characterized by drug tolerance and dependence, behavioral sensitization, vulnerability to compulsive relapse, and high mortality. In laboratory animals, the potential effect of opiate drugs to induce cell death by apoptosis is a controversial topic. This postmortem human...

journal_title：Neuroscience

authors： García-Fuster MJ,Ramos-Miguel A,Rivero G,La Harpe R,Meana JJ,García-Sevilla JA

更新日期：2008-11-11 00:00:00

abstract：:Mast cells are known for their participation in immediate and, more recently, delayed hypersensitivity reactions. They have been found in the meninges and certain brain areas where they are strictly perivascular, in close apposition to neurons, and they are activated by direct nerve stimulation or by neuropeptides. In...

journal_title：Neuroscience

authors： Theoharides TC,Dimitriadou V,Letourneau R,Rozniecki JJ,Vliagoftis H,Boucher W

更新日期：1993-12-01 00:00:00

abstract：:Retinal ganglion cell axons of the DBA/2J mouse model of glaucoma, a model characterized by extensive neuroinflammation, preserve synaptic contacts with their subcortical targets for a time after onset of anterograde axonal transport deficits, axon terminal hypertrophy, and cytoskeletal alterations. Though retrograde ...

journal_title：Neuroscience

authors： Smith MA,Plyler ES,Dengler-Crish CM,Meier J,Crish SD

更新日期：2018-10-15 00:00:00

abstract：:This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons posit...

journal_title：Neuroscience

authors： Lee Y,Takami K,Kawai Y,Girgis S,Hillyard CJ,MacIntyre I,Emson PC,Tohyama M

更新日期：1985-08-01 00:00:00

abstract：:The mechanisms underlying selective neuronal cell death in kainic acid-mediated neurodegeneration are not fully understood. We have recently demonstrated that in cerebellar granule neurons, kainic acid induces the expression of proteins associated with cell-cycle progression. In the present study we show that 3-amino ...

journal_title：Neuroscience

authors： Verdaguer E,Jordà EG,Canudas AM,Jiménez A,Sureda FX,Rimbau V,Pubill D,Escubedo E,Camarasa J,Pallàs M,Camins A

更新日期：2003-01-01 00:00:00

abstract：:Neuropeptide Y is the most abundant peptide in the mammalian central nervous system and exhibits a variety of potent neurobiological functions. In the present study, double immunolabelling histochemistry was performed, using previously characterized antibodies against neuropeptide Y and the neuropeptide Y Y1 receptor ...

journal_title：Neuroscience

authors： Caberlotto L,Tinner B,Bunnemann B,Agnati L,Fuxe K

更新日期：1998-10-01 00:00:00

abstract：:Examination of spontaneous miniature endplate potentials (MEPPs) in murine skeletal muscle has revealed that in conditions such as botulinum poisoning, during nerve terminal regeneration or in the presence of the drug 4-aminoquinoline, two types of acetylcholine release are responsible for the MEPPs. In addition to th...

journal_title：Neuroscience

authors： Thesleff S,Molgó J

更新日期：1983-05-01 00:00:00

abstract：:Spinocerebellar tract neurons are inhibited by various sources of input via pathways activated by descending tracts as well as peripheral afferents. Inhibition may be used to modulate transmission of excitatory information forwarded to the cerebellum. However it may also provide information on the degree of inhibition...

journal_title：Neuroscience

authors： Shakya Shrestha S,Bannatyne BA,Jankowska E,Hammar I,Nilsson E,Maxwell DJ

更新日期：2012-12-13 00:00:00

abstract：:Midbrain dopamine neurons are critical in mediating the rewarding effects of opiates in dependent rats, as well as modulating some manifestations of opiate withdrawal. Morphine is known to excite dopamine neurons and thereby facilitate forebrain dopamine transmission through inhibition of GABA neurons. Cholinergic neu...

journal_title：Neuroscience

authors： Miller AD,Forster GL,Yeomans JS,Blaha CD

更新日期：2005-01-01 00:00:00

abstract：:Rats were subjected to 90min of focal ischemia by occluding the left middle cerebral and both common carotid arteries. The dynamic changes in the formation of brain ischemic areas were analyzed by measuring the direct current (DC) potential and reduced nicotinamide adenine dinucleotide (NADH) fluorescence with ultravi...

journal_title：Neuroscience

authors： Naito H,Takeda Y,Danura T,Kass IS,Morita K

更新日期：2013-04-03 00:00:00

abstract：:The neurochemical and behavioural recovery following unilateral and bilateral lesions of the nucleus basalis was investigated in adult male Wistar rats 20 days and 6 months after surgery. The lesions were made by stereotaxic injections of ibotenic acid. Twenty days after surgery there was a statistically significant c...

journal_title：Neuroscience

authors： Casamenti F,Di Patre PL,Bartolini L,Pepeu G

更新日期：1988-01-01 00:00:00

abstract：:Recently evidence has accumulated that schizophrenia can arise from primary synaptic defects involving structural proteins particularly, microtubule associated proteins. Previous experiments have demonstrated that a STOP (stable tubule only peptide) gene deletion in mice leads to a phenotype mimicking some aspects of ...

journal_title：Neuroscience

authors： Bégou M,Volle J,Bertrand JB,Brun P,Job D,Schweitzer A,Saoud M,D'Amato T,Andrieux A,Suaud-Chagny MF

更新日期：2008-11-11 00:00:00

abstract：:Zinc plays an important role in synaptic signaling in the mammalian cerebral cortex. Zinc is sequestered into presynaptic vesicles of subpopulations of glutamatergic neurons and is released by depolarization, in a calcium-dependent manner. As the majority of mechanisms that have been suggested to participate in experi...

journal_title：Neuroscience

authors： Brown CE,Dyck RH

更新日期：2003-01-01 00:00:00

abstract：:Astrocytes have been generally believed to perform mainly homeostatic and supportive functions for neurons in the central nervous system. Recently, a growing body of evidence suggests previously unrecognized and surprising functions for astrocytes, including regulation of synaptic formation, transmission and plasticit...

journal_title：Neuroscience

authors： Adamsky A,Goshen I

更新日期：2018-02-01 00:00:00

abstract：:Astrocytes in the somatosensory ventrobasal (VB) thalamus of rats respond to glutamatergic synaptic input with metabotropic glutamate receptor (mGluR) mediated intracellular calcium ([Ca²⁺](i)) elevations. Astrocytes in the VB thalamus also release the gliotransmitter (GT) glutamate in a Ca²⁺-dependent manner. The tri...

journal_title：Neuroscience

authors： Pirttimaki TM,Parri HR

更新日期：2012-03-15 00:00:00

abstract：:Overexpression of vascular endothelial growth factor (VEGF) is considered the most critical factor in radiation-induced brain injury (RBI). To investigate the role of VEGF and the mechanism underlying microvascular damage in RBI, wild type mice, and transgenic mice overexpressing VEGF derived from astrocytes, were sep...

journal_title：Neuroscience

authors： Zhou D,Huang X,Xie Y,Deng Z,Guo J,Huang H

更新日期：2019-06-01 00:00:00

abstract：:Morphine induces profound analgesic tolerance in vivo despite inducing little internalization of the mu opioid receptor (muOR). Previously proposed explanations suggest that this lack of internalization could either lead to prolonged signaling and associated compensatory changes in downstream signaling systems, or tha...

journal_title：Neuroscience

authors： Walwyn WM,Wei W,Xie CW,Chiu K,Kieffer BL,Evans CJ,Maidment NT

更新日期：2006-10-13 00:00:00

abstract：:The heme oxygenase (HO) enzyme system has been shown to participate in nociceptive signaling in a number of different models of pain. In these experiments we investigated the role of the HO type 2 (HO-2) isozyme in tolerance to the analgesic effects of morphine, and the hyperalgesia and allodynia which are measurable ...

journal_title：Neuroscience

authors： Liang D,Li X,Lighthall G,Clark JD

更新日期：2003-01-01 00:00:00

abstract：:In the present study the time-course of DNA fragmentation following insulin-induced hypoglycemia was examined. In situ localization of DNA breaks were studied by the terminal deoxynucleotidyl transferase-mediated biotin-deoxyuridine triphosphate nick-end labelling method, and the temporal profile of DNA-fragmentation ...

journal_title：Neuroscience

authors： Ferrand-Drake M,Friberg H,Wieloch T

更新日期：1999-01-01 00:00:00

abstract：:The dual effect of capsaicin on primary afferent neurons, excitation and stimulation of transmitter release, its dependence on extracellular calcium and its modulation by Ruthenium Red have been investigated in the rabbit ear. Injection of capsaicin into the central artery of the isolated perfused ear with intact neur...

journal_title：Neuroscience

authors： Amann R,Donnerer J,Lembeck F

更新日期：1989-01-01 00:00:00

abstract：:How does our mind produce physical, goal-directed action of our body? For about 200years, philosophers and psychologists hypothesized the transformation from mind to body to rely on the anticipation of an action's sensory consequences. Whereas this hypothesis received tremendous support from behavioral experiments, th...

journal_title：Neuroscience

authors： Pfister R,Melcher T,Kiesel A,Dechent P,Gruber O

更新日期：2014-02-14 00:00:00

abstract：:Most mammals rely on semiochemicals, such as pheromones, to mediate their social interactions. Recent studies found that semiochemicals are perceived by at least two distinct chemosensory systems: the main and accessory olfactory systems, which share many molecular, cellular, and anatomical features. Nevertheless, the...

journal_title：Neuroscience

authors： Zibman S,Shpak G,Wagner S

更新日期：2011-08-25 00:00:00

abstract：:Thiamine deficiency during embryonic or early postnatal development causes deficits in cerebellum-dependent activities including motor control and procedural memory. Here, we give a detailed description of the changes to A-type current in cultured cerebellar granule neurons exposed to thiamine deficiency in vitro. A-t...

journal_title：Neuroscience

authors： Cruz JS,Kushmerick C,Moreira-Lobo DC,Oliveira FA

更新日期：2012-09-27 00:00:00

abstract：:Previous studies from our laboratory and others have shown that there are major age-related differences in brainstem neuronal function. Since GABAA receptors are major targets for GABA-mediated inhibitory modulation and play a key role in regulating cardiorespiratory function, especially during O2 deprivation, we exam...

journal_title：Neuroscience

authors： Xia Y,Haddad GG

更新日期：1992-08-01 00:00:00

abstract：:Botulinum toxin is an agent that is typically encountered in two settings: as an agent that can cause disease (e.g. botulism), and as an agent that can be used to treat disease (i.e., a variety of neurologic disorders). In both cases it would be advantageous to develop a sound understanding of the mechanisms by which ...

journal_title：Neuroscience

authors： Joshi SG,Elias M,Singh A,Al-Saleem FH,Ancharski D,Nasser Z,Takahashi T,Simpson LL

更新日期：2011-04-14 00:00:00