Abstract：
:Saffron, the dried stigmata of Crocus sativus L., is used in traditional medicine for a wide range of indications including cramps, asthma, and depression. To investigate the influence of hydro-ethanolic saffron extract (CSE) and trans-crocetin on synaptic transmission, postsynaptic potentials (PSPs) were elicited by focal electrical stimulation and recorded using intracellular placed microelectrodes in pyramidal cells from rat cingulate cortex. CSE (10-200 μg/ml) inhibited evoked PSPs as well as the isolated NMDA and non-NMDA component of PSPs. Glutamate (500 μM) added into the organ bath induced membrane depolarization. CSE decreased glutamate-induced membrane depolarization. Additionally, CSE at 100 μg/ml decreased NMDA (20 μM) and kainate (1 μM)-induced depolarization, whereas AMPA (1 μM)-induced depolarization was not affected. Trans-crocetin (1-50 μM) showed inhibition of evoked PSPs and glutamate-induced membrane depolarization comparable to CSE. Trans-crocetin at 10 μM decreased NMDA (20 μM)-induced membrane depolarization, but did not inhibit the isolated non-NMDA component of PSPs. We conclude that trans-crocetin is involved in the antagonistic effect of CSE on NMDA but not on kainate receptors.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Berger F,Hensel A,Nieber Kdoi
10.1016/j.neuroscience.2011.02.037subject
Has Abstractpub_date
2011-04-28 00:00:00pages
238-47eissn
0306-4522issn
1873-7544pii
S0306-4522(11)00207-7journal_volume
180pub_type
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