Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices.

Abstract:

:Saffron, the dried stigmata of Crocus sativus L., is used in traditional medicine for a wide range of indications including cramps, asthma, and depression. To investigate the influence of hydro-ethanolic saffron extract (CSE) and trans-crocetin on synaptic transmission, postsynaptic potentials (PSPs) were elicited by focal electrical stimulation and recorded using intracellular placed microelectrodes in pyramidal cells from rat cingulate cortex. CSE (10-200 μg/ml) inhibited evoked PSPs as well as the isolated NMDA and non-NMDA component of PSPs. Glutamate (500 μM) added into the organ bath induced membrane depolarization. CSE decreased glutamate-induced membrane depolarization. Additionally, CSE at 100 μg/ml decreased NMDA (20 μM) and kainate (1 μM)-induced depolarization, whereas AMPA (1 μM)-induced depolarization was not affected. Trans-crocetin (1-50 μM) showed inhibition of evoked PSPs and glutamate-induced membrane depolarization comparable to CSE. Trans-crocetin at 10 μM decreased NMDA (20 μM)-induced membrane depolarization, but did not inhibit the isolated non-NMDA component of PSPs. We conclude that trans-crocetin is involved in the antagonistic effect of CSE on NMDA but not on kainate receptors.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Berger F,Hensel A,Nieber K

doi

10.1016/j.neuroscience.2011.02.037

subject

Has Abstract

pub_date

2011-04-28 00:00:00

pages

238-47

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(11)00207-7

journal_volume

180

pub_type

杂志文章
  • Plasmalemmal appositions between cholinergic and non-cholinergic neurons in rat caudate-putamen nuclei.

    abstract::We have observed that in rat caudate-putamen nuclei, neurons immunolabeled for choline acetyltransferase were sometimes in direct apposition to unlabeled perikarya and dendrites [Pickel V. M. and Chan J. (1990) J. Neurosci. Res. 25, 263-280]. Similar juxtapositions between plasmalemmas of nerve cells each receiving in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(91)90341-k

    authors: Pickel VM,Chan J

    更新日期:1991-01-01 00:00:00

  • Can prepared anticipatory postural adjustments be updated by proprioception?

    abstract::Stepping over an obstacle is preceded by a center of pressure (CoP) shift, termed anticipatory postural adjustments (APAs). It provides an acceleration of the center of mass forward and laterally prior to step initiation. The APAs are characterized in the lateral direction by a force exerted by the moving leg onto the...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.06.021

    authors: Ruget H,Blouin J,Teasdale N,Mouchnino L

    更新日期:2008-08-26 00:00:00

  • Muscarinic acetylcholine receptor immunoreactivity in the amygdala--II. Fear-induced plasticity.

    abstract::Changes in the distribution of muscarinic acetylcholine receptor-immunoreactive neurons were examined in the amygdaloid complex at different time-intervals following a single training session of active shock avoidance in a two-way shuttle-box. Muscarinic acetylcholine receptors were visualized using M35, a monoclonal ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)00360-0

    authors: Roozendaal B,van der Zee EA,Hensbroek RA,Maat H,Luiten PG,Koolhaas JM,Bohus B

    更新日期:1997-01-01 00:00:00

  • Additive effect of glial cell line-derived neurotrophic factor and neurotrophin-4/5 on rat fetal nigral explant cultures.

    abstract::Transplantation of embryonic dopaminergic neurons is an experimental therapy for Parkinson's disease, but limited tissue availability and suboptimal survival of grafted dopaminergic neurons impede more widespread clinical application. Glial cell line-derived neurotrophic factor (GDNF) and neurotrophin-4/5 (NT-4/5) exe...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00418-3

    authors: Meyer M,Matarredona ER,Seiler RW,Zimmer J,Widmer HR

    更新日期:2001-01-01 00:00:00

  • The late phase of post-stroke neurorepair in aged rats is reflected by MRI-based measures.

    abstract::Non-invasive criteria determining the progress of brain healing are especially important in aging, providing a case-specific therapeutic strategy in populations with dysregulated neurorepair mechanisms. We hypothesized that temporal evolution of magnetic resonance imaging (MRI) of T2 tissue relaxation values correlate...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.09.028

    authors: Titova EM,Ghosh N,Valadez ZG,Zhang JH,Bellinger DL,Obenaus A

    更新日期:2014-12-26 00:00:00

  • Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein.

    abstract::Amyloid deposits in Alzheimer's disease, Down's syndrome and aged brain are composed largely of A beta protein, which is generated by proteolytic processing of beta-amyloid precursor protein. Proteases responsible for liberating the A beta protein from the precursor have not yet been identified. Here, we examined the ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90490-1

    authors: Savage MJ,Iqbal M,Loh T,Trusko SP,Scott R,Siman R

    更新日期:1994-06-01 00:00:00

  • Heme oxygenase type 2 modulates behavioral and molecular changes during chronic exposure to morphine.

    abstract::The heme oxygenase (HO) enzyme system has been shown to participate in nociceptive signaling in a number of different models of pain. In these experiments we investigated the role of the HO type 2 (HO-2) isozyme in tolerance to the analgesic effects of morphine, and the hyperalgesia and allodynia which are measurable ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(03)00483-4

    authors: Liang D,Li X,Lighthall G,Clark JD

    更新日期:2003-01-01 00:00:00

  • Nerve growth factor reduces apoptosis of axotomized retinal ganglion cells in the neonatal rat.

    abstract::It has recently been reported that the degeneration of retinal ganglion cells induced by transection of the optic nerve in the neonatal rat is due to an active process of apoptosis, as opposed to passive necrosis. Here we tested whether the administration of the trophic factor nerve growth factor could prevent the apo...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90565-7

    authors: Rabacchi SA,Ensini M,Bonfanti L,Gravina A,Maffei L

    更新日期:1994-12-01 00:00:00

  • Mechanisms of Neurological Dysfunction in GOSR2 Progressive Myoclonus Epilepsy, a Golgi SNAREopathy.

    abstract::Successive fusion events between transport vesicles and their target membranes mediate trafficking of secreted, membrane- and organelle-localised proteins. During the initial steps of this process, termed the secretory pathway, COPII vesicles bud from the endoplasmic reticulum (ER) and fuse with the cis-Golgi membrane...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2019.03.057

    authors: Jepson JEC,Praschberger R,Krishnakumar SS

    更新日期:2019-11-10 00:00:00

  • Targeting the motor end plates in the mouse hindlimb gives access to a greater number of spinal cord motor neurons: an approach to maximize retrograde transport.

    abstract::Lower motor neuron dysfunction is one of the most debilitating neurological conditions and, as such, significantly impacts on the quality of life of affected individuals. Within the last decade, the engineering of mouse models of lower motor neuron diseases has facilitated the development of new therapeutic scenarios ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.05.045

    authors: Mohan R,Tosolini AP,Morris R

    更新日期:2014-08-22 00:00:00

  • Older Adults Differentially Modulate Transcranial Magnetic Stimulation-Electroencephalography Measures of Cortical Inhibition during Maximal Single-joint Exercise.

    abstract::The effects of muscle fatigue are known to be altered in older adults, and age-related changes in the brain are likely to be a contributing factor. However, the neural mechanisms underlying these changes are not known. The aim of the current study was to use transcranial magnetic stimulation combined with electroencep...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.11.022

    authors: Opie GM,Otieno LA,Pourmajidian M,Semmler JG,Sidhu SK

    更新日期:2020-01-15 00:00:00

  • Types of synapses contacting the soma of corticotectal cells in the visual cortex of the cat.

    abstract::Retrograde transport of horseradish peroxidase has been used to single out a distinct functional cortical cell type for ultrastructural study. Following injection of horseradish peroxidase into the superior colliculus, labelled pyramidal cells were found in layer V of the visual cortex. Examination of the labelled cor...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(82)90127-0

    authors: Kennedy H

    更新日期:1982-01-01 00:00:00

  • Sex-specific 24-h acetylcholine release profile in the medial prefrontal cortex: simultaneous measurement of spontaneous locomotor activity in behaving rats.

    abstract::The difference in visual object recognition by males and females suggests a sex-specific function in the medial prefrontal cortex (mPFC). In the present study, we performed an in vivo microdialysis study in three groups of rats (males, diestrous females, and proestrous females) to examine the potential sex difference ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.12.039

    authors: Takase K,Kimura F,Yagami T,Mitsushima D

    更新日期:2009-03-03 00:00:00

  • Role of astrocytic S100beta in behavioral hypersensitivity in rodent models of neuropathic pain.

    abstract::S100beta is a calcium-binding peptide produced mainly by astrocytes that exerts paracrine and autocrine effects on neurons and glia. We have previously shown that S100beta is markedly elevated at the mRNA level in the spinal cord following peripheral inflammation, intraplantar administration of complete Freund's adjuv...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.02.070

    authors: Tanga FY,Raghavendra V,Nutile-McMenemy N,Marks A,Deleo JA

    更新日期:2006-07-07 00:00:00

  • An ultrastructural study of the glycine transporter GLYT2 and its association with glycine in the superficial laminae of the rat spinal dorsal horn.

    abstract::The glycine transporter GLYT2 is present in axonal boutons throughout the spinal cord, and its laminar distribution matches that of glycine-enriched axons, which are presumed to be glycinergic. In order to determine whether boutons which possess GLYT2 are glycine-enriched, we have carried out pre-embedding immunocytoc...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)00501-5

    authors: Spike RC,Watt C,Zafra F,Todd AJ

    更新日期:1997-03-01 00:00:00

  • Neonatal lesions of the entorhinal cortex induce long-term changes of limbic brain regions and maze learning deficits in adult rats.

    abstract::We here investigated the effects of neonatal lesions of the entorhinal cortex (EC) in rats on maze learning and on structural alterations of its main projection region, the hippocampus, as well as other regions with anatomical connections to the EC that are involved in maze learning. Since early brain damage is consid...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.03.017

    authors: Harich S,Kinfe T,Koch M,Schwabe K

    更新日期:2008-06-02 00:00:00

  • Strategies for Gaze Stabilization Critically Depend on Locomotor Speed.

    abstract::Locomotion involves complex combinations of translational and rotational head movements. For gaze stability, this necessitates the interplay of angular and linear vestibulo-ocular reflexes (VOR) as well as the integration of visual feedback about the desired viewing distance. Furthermore, gaze stabilizing systems must...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.01.025

    authors: Dietrich H,Wuehr M

    更新日期:2019-06-01 00:00:00

  • 1H-MRS can monitor metabolites changes of lateral intraventricular BDNF infusion into a mouse model of Alzheimer's disease in vivo.

    abstract::Proton magnetic resonance spectroscopy (1H-MRS) can provide noninvasive detection of brain metabolite changes in vivo in Alzheimer's disease (AD). AD is a prevalent neurodegenerative disorder characterized by deposition of β-amyloid peptides (Aβ) in multiple brain regions. Brain-derived neurotrophic factor (BDNF) is a...

    journal_title:Neuroscience

    pub_type: 杂志文章,收录出版

    doi:10.1016/j.neuroscience.2013.04.015

    authors: Zhang W,Wang PJ,Li MH,Gao XL,Gu GJ,Shao ZH

    更新日期:2013-08-15 00:00:00

  • A novel role for receptor-associated protein in somatostatin modulation: implications for Alzheimer's disease.

    abstract::Receptor-associated protein appears to play an important role in low-density lipoprotein receptor-related protein trafficking. Since ligands for the low-density lipoprotein receptor-related protein have been implicated in Alzheimer's disease and normal functioning of this protein is indispensable for central nervous s...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00272-3

    authors: Van Uden E,Veinbergs I,Mallory M,Orlando R,Masliah E

    更新日期:1999-01-01 00:00:00

  • Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization.

    abstract::Mental function has as its cerebral basis a specific dynamic structure. In particular, cortical and limbic areas involved in "higher brain functions" such as learning, memory, perception, self-awareness and consciousness continuously need to be self-adjusted even after development is completed. By this lifelong self-o...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/s0306-4522(00)00516-9

    authors: Arendt T

    更新日期:2001-01-01 00:00:00

  • Leu27 insulin-like growth factor-II, an insulin-like growth factor-II analog, attenuates depolarization-evoked GABA release from adult rat hippocampal and cortical slices.

    abstract::Accumulated evidence suggests that the single transmembrane domain insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/M6P or IGF-II receptor) plays an important role in the intracellular trafficking of lysosomal enzymes and endocytosis-mediated degradation of insulin like growth factor (IGF-II). Howeve...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2010.07.026

    authors: Amritraj A,Rauw G,Baker GB,Kar S

    更新日期:2010-10-27 00:00:00

  • Estrogen-dependent MicroRNA-504 Expression and Related Baroreflex Afferent Neuroexcitation via Negative Regulation on KCNMB4 and KCa1.1 β4-subunit Expression.

    abstract::Large conductance of Ca2+-activated K+ channel (KCa1.1) plays an inhibitory role in neuroexcitation. However, the expression of KCNMB4/β4-subunit in the nodose ganglia (NG) and nucleus tractus solitarius (NTS), and its effect and regulation on baroreflex afferent function at post-transcriptional level of female rats r...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.07.003

    authors: Feng Y,Liu Y,Cao PX,Sun X,Li KX,Li XY,Liu L,Wang HD,Cui CP,Xiong X,Zhang HC,Qiao GF,Li BY

    更新日期:2020-08-21 00:00:00

  • Origin and trajectory of the cerebello-olivary projection: an experimental study with radioactive and fluorescent tracers in the cat.

    abstract::It was demonstrated with autoradiographic methods that a tract of thin fibers, which is for the most part distinct from the brachium conjunctivum and its crossed descending limb, can be followed from the cerebellar nuclei to the inferior olive. Neurons from all regions of the interposed and dentate nuclei contribute t...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90044-3

    authors: Legendre A,Courville J

    更新日期:1987-06-01 00:00:00

  • Repeated i.v. cocaine exposure produces long-lasting behavioral sensitization in pregnant adults, but behavioral tolerance in their offspring.

    abstract::Repeated exposure to cocaine during sensitive periods of forebrain development produces specific, long-lasting changes in the structure and function of maturing neural circuits. Similar regimens of drug exposure in adult animals with mature, homeostatically regulated nervous systems produce neuroadaptations that appea...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2003.08.029

    authors: Stanwood GD,Levitt P

    更新日期:2003-01-01 00:00:00

  • Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia.

    abstract::Brain ischemia induces a marked response of resident microglia and hematopoietic cells including monocytes/macrophages. The present study was designed to assess the distribution of microglia/macrophages in cerebral ischemia using bone marrow chimera mice known to express enhanced green fluorescent protein (EGFP). At 2...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00954-5

    authors: Tanaka R,Komine-Kobayashi M,Mochizuki H,Yamada M,Furuya T,Migita M,Shimada T,Mizuno Y,Urabe T

    更新日期:2003-01-01 00:00:00

  • α6 and β1 Integrin Heterodimer Mediates Schwann Cell Interactions with Axons and Facilitates Axonal Regeneration after Peripheral Nerve Injury.

    abstract::Several isoforms of integrin subunits are expressed in Schwann cells and mediate Schwann cell interactions with axons. Here, we identify α6 and β1 integrins as heterodimeric proteins expressed in Schwann cells and define their functions in axonal regeneration. α6 and β1 integrins are induced in Schwann cells in the sc...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.11.046

    authors: Chang IA,Kim KJ,Namgung U

    更新日期:2018-02-10 00:00:00

  • D2 autoreceptor inhibition reveals oxygen-glucose deprivation-induced release of dopamine in guinea-pig cochlea.

    abstract::Dopamine (DA), released from the lateral olivocochlear (LOC) efferent terminals, the efferent arm of the short-loop feedback in the cochlea, is considered as a protective factor in the inner ear since it inhibits auditory nerve dendrite firing in ischemia- or noise-induced excitotoxicity leading to sensorineural heari...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.01.023

    authors: Halmos G,Doleviczényi Z,Répássy G,Kittel A,Vizi ES,Lendvai B,Zelles T

    更新日期:2005-01-01 00:00:00

  • Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein.

    abstract::Synucleinopathies including Parkinson's disease (PD) are characterized by the accumulation of alpha-synuclein (α-syn) within neural cell bodies and their processes. Transgenic mice overexpressing human wild-type or mutant forms of α-syn under the control of different promoters were developed to analyse the underlying ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.07.001

    authors: May VE,Nuber S,Marxreiter F,Riess O,Winner B,Winkler J

    更新日期:2012-10-11 00:00:00

  • Mice expressing constitutively active Gsalpha exhibit stimulus encoding deficits similar to those observed in schizophrenia patients.

    abstract::People with schizophrenia display sensory encoding deficits across a broad range of electrophysiological and behavioral measures, suggesting fundamental impairments in the ability to transduce the external environment into coherent neural representations. This inability to create basic components of complex stimuli in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.04.028

    authors: Maxwell CR,Liang Y,Kelly MP,Kanes SJ,Abel T,Siegel SJ

    更新日期:2006-09-01 00:00:00

  • Origins and pathways of cerebrovascular nerves storing substance P and calcitonin gene-related peptide in rat.

    abstract::Origins and pathways of cerebrovascular substance P- and calcitonin gene-related peptide-positive nerves in rat were studied by immunohistochemistry combined with denervation experiments and retrograde axonal tracer technique. The two peptides have been found to coexist in one and the same neuron. After sectioning of ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90385-0

    authors: Suzuki N,Hardebo JE,Owman C

    更新日期:1989-01-01 00:00:00