Migration and fate of therapeutic stem cells in different brain disease models.

abstract：:The effects of acute application of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNFalpha) on levels of intracellular Ca(2+) ([Ca(2+)]i) and on whole-cell outward and inward K(+) currents were studied in cultured human microglia. TNFalpha elicited a linear increase in [Ca(2+)]i to a plateau level in micr...

journal_title：Neuroscience

authors： McLarnon JG,Franciosi S,Wang X,Bae JH,Choi HB,Kim SU

更新日期：2001-01-01 00:00:00

abstract：:In rats under continuous stress (CS) there is decreased hypothalamic dopaminergic innervation to the intermediate lobe (IL) of the pituitary gland, which causes hyperactivation and subsequent degeneration of melanotrophs in the IL. In this study, we investigated the molecular basis for the changes that occur in melano...

journal_title：Neuroscience

authors： Konishi H,Ogawa T,Nakagomi S,Inoue K,Tohyama M,Kiyama H

更新日期：2010-09-15 00:00:00

abstract：:Recent studies investigating neural correlates of human thirst have identified various subcortical and telencephalic brain areas. The experience of thirst represents a homeostatic emotion and a state that slowly evolves over time. Therefore, the present study aims at systematically examining cerebral perfusion during ...

journal_title：Neuroscience

authors： Meier L,Federspiel A,Jann K,Wiest R,Strik W,Dierks T

更新日期：2018-07-15 00:00:00

abstract：:Microglial cells exhibit Notch-1 signaling expression which is enhanced upon activation. We reported previously that enhanced Notch-1 expression in activated microglia modulates production of proinflammatory cytokines and nitric oxide (NO). Furthermore, Notch-1 modulates transcription factor nuclear factor-kappa B (NF...

journal_title：Neuroscience

authors： Cao Q,Kaur C,Wu CY,Lu J,Ling EA

更新日期：2011-09-29 00:00:00

abstract：:GABA(B) receptors are G-protein-coupled receptors mediating the slow onset and prolonged synaptic actions of GABA in the CNS. The recent cloning of two genes, GABA(B1) and GABA(B2), has revealed a novel requirement for GABA(B) receptor signalling. Studies have demonstrated that the two receptor subunits associate as a...

journal_title：Neuroscience

authors： Charles KJ,Evans ML,Robbins MJ,Calver AR,Leslie RA,Pangalos MN

更新日期：2001-01-01 00:00:00

abstract：:Interactions of acoustic and somatosensory evoked potentials were studied in the anterior suprasylvian gyrus of the cat. Two kinds of interaction could be observed: occlusion or facilitation. In most cases occlusion was observed. The interactions showed dynamic changes and were susceptible to different kinds of influe...

journal_title：Neuroscience

authors： Toldi J,Fehér O,Feuer L

更新日期：1984-11-01 00:00:00

abstract：:The present study characterized fetal sulcation patterns and gyrification in the cerebrum of the New World monkey group, common marmosets, using a 3D T2-weighted high-resolution anatomical magnetic resonance imaging (MRI) sequence from the fixed brain at 7-tesla ex vivo. Fetal sulcation in the marmoset cerebrum began ...

journal_title：Neuroscience

authors： Sawada K,Hikishima K,Murayama AY,Okano HJ,Sasaki E,Okano H

更新日期：2014-01-17 00:00:00

abstract：:Electrical stimulation of the distal stump of cut peripheral nerves is a commonly accepted way to evoke neurogenic inflammation. Nevertheless, the modulatory effect of biogenic amines and vasoactive peptides released from efferent fibres can be excluded only if the dorsal roots are stimulated. The present study was fo...

journal_title：Neuroscience

authors： Pintér E,Szolcsányi J

更新日期：1995-09-01 00:00:00

abstract：:Inflammation and hyperalgesia induce a dramatic up-regulation of opioid messenger RNA and peptide levels in nociceptive neurons of the spinal dorsal horn. Descending axons modulate nociceptive transmission at the spinal level during inflammatory pain, and may play a role in the development of persistent pain. The role...

journal_title：Neuroscience

authors： MacArthur L,Ren K,Pfaffenroth E,Franklin E,Ruda MA

更新日期：1999-01-01 00:00:00

abstract：:Several lines of research have implicated glutathione (GSH) in schizophrenia. For instance, GSH deficiency has been reported in the prefrontal cortex of schizophrenics in vivo. Further, in rats postnatal GSH-deficiency combined with hyperdopaminergia led to cognitive impairments in the adult. In the present report we ...

journal_title：Neuroscience

authors： Jacobsen JP,Rodriguiz RM,Mørk A,Wetsel WC

更新日期：2005-01-01 00:00:00

abstract：:Migraine attacks are typically described as unilateral, throbbing pain that is usually accompanied by nausea, vomiting, and exaggerated sensitivities to light, noise and smell. The headache phase of a migraine attack is mediated by activation of the trigeminovascular pathway; a nociceptive pathway that originates in t...

journal_title：Neuroscience

authors： Kagan R,Kainz V,Burstein R,Noseda R

更新日期：2013-09-17 00:00:00

abstract：:Local treatment of rat peripheral nerves with capsaicin induces permanent impairment of afferent C-fiber functions and changes in the response properties of spinal dorsal horn neurons. In this study a new experimental approach, the "capsaicin gap" technique, has been utilized in an attempt to unravel pathomorphologica...

journal_title：Neuroscience

authors： Jancsó G,Lawson SN

更新日期：1990-01-01 00:00:00

abstract：:The effects of steady iontophoretic applications of serotonin on the spontaneous discharge and on the excitatory responses induced in deep cerebellar nuclei neurons by iontophoretic pulse applications of L-glutamate, L-aspartate, N-methyl-D,L-aspartate and quisqualate were studied in rat cerebellar slices maintained i...

journal_title：Neuroscience

authors： Gardette R,Krupa M,Crepel F

更新日期：1987-11-01 00:00:00

abstract：:Exercise induces neuroplasticity in descending motor pathways facilitating motor learning, and as such it could be utilized as an intervention in neurorehabilitation, for example when re-learning motor skills after stroke. To date, however, the neurophysiological and molecular mechanisms underlying exercise-induced ne...

journal_title：Neuroscience

authors： Nicolini C,Michalski B,Toepp SL,Turco CV,D'Hoine T,Harasym D,Gibala MJ,Fahnestock M,Nelson AJ

更新日期：2020-06-15 00:00:00

abstract：:After transection of the sciatic nerve there is a dramatic increase in both galanin/galanin message-associated peptide-like immunoreactivities and preprogalanin messenger RNA levels in rat and mouse lumbar 4 and 5 dorsal root ganglion neurons. There is strong evidence that after nerve injury leukemia inhibitor factor ...

journal_title：Neuroscience

authors： Kerekes N,Landry M,Hökfelt T

更新日期：1999-01-01 00:00:00

abstract：:The possible involvement of fibroblast growth factor receptor (FGFR) activation in the dorsal root ganglion (DRG) was examined following peripheral nerve injury in the rat. Ligation of the sciatic nerve down-regulated FGFR2, -3 and -4 mRNA; however, the expression of FGFR1 mRNA showed no change. Activation of FGFR was...

journal_title：Neuroscience

authors： Yamanaka H,Obata K,Kobayashi K,Dai Y,Fukuoka T,Noguchi K

更新日期：2007-11-30 00:00:00

abstract：:It is well known that the electroencephalogram of the cat in the early stages of slow wave sleep is mainly characterized by rhythmic wave activity at 7-14 Hz, termed spindles, which recur periodically with a slow rhythm of 0.1-0.2 Hz. From early stimulation, decortication and transection studies (see Ref. 14), spindle...

journal_title：Neuroscience

authors： Marini G,Macchi G,Mancia M

更新日期：1992-12-01 00:00:00

abstract：:The possible neuroprotective effect of physical exercise was investigated in rats after middle cerebral artery occlusion (MCAO), a focal stroke model. It was found that physical exercise in the form of a 12-week treadmill running programme reduced the volume of infarction caused by MCAO. At the molecular level, revers...

journal_title：Neuroscience

authors： Ang ET,Wong PT,Moochhala S,Ng YK

更新日期：2003-01-01 00:00:00

abstract：:Subiculum receives output of hippocampal CA1 neurons and projects glutamatergic synapses onto nucleus accumbens (NAc), the subicular-NAc pathway linking memory and reward system. It is unknown whether morphine withdrawal influences synaptic plasticity in the subicular-NAc pathway. Here, we recorded the field excitator...

journal_title：Neuroscience

authors： Dong Z,Cao J,Xu L

更新日期：2007-02-09 00:00:00

abstract：:The hemispheric content of dopamine and its metabolites in the frontal cortex, caudatus putamen and nucleus accumbens septi was evaluated in relation to behavioral lateralization assessed by paw preference. Three groups of C3H/He mice were selected on the basis of their performance in the paw preference test (left-han...

journal_title：Neuroscience

authors： Cabib S,D'Amato FR,Neveu PJ,Deleplanque B,Le Moal M,Puglisi-Allegra S

更新日期：1995-01-01 00:00:00

abstract：:The ontogeny of substance P-containing neuron system in the forebrain and upper brain stem of the rat was investigated by means of the indirect immunofluorescence technique. Substance P-positive structures first appeared in the primordium of the epithalamus and the area which surrounded the commissura posterior of the...

journal_title：Neuroscience

authors： Inagaki S,Sakanaka M,Shiosaka S,Senba E,Takatsuki K,Takagi H,Kawai Y,Minagawa H,Tohyama M

更新日期：1982-01-01 00:00:00

abstract：:Chronic psychosocial stress is an important environmental risk factor for the development of psychiatric diseases. However, studying the impact of chronic psychosocial stress in mice is time consuming and thus not optimally suited to 'screen' increasing numbers of genetically manipulated mouse models for psychiatric e...

journal_title：Neuroscience

authors： Brzózka MM,Unterbarnscheidt T,Schwab MH,Rossner MJ

更新日期：2016-02-09 00:00:00

abstract：:Hippocampal sclerosis is the most frequent pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis. These alterations are accompanied by changes in the expression of a variety of molecules in the sur...

journal_title：Neuroscience

authors： Andrioli A,Alonso-Nanclares L,Arellano JI,DeFelipe J

更新日期：2007-10-12 00:00:00

abstract：:Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure. We have shown that a certain amount of (3)H₂O from the bloodstream enters osmotically loaded cerebrospinal fluid significantly fas...

journal_title：Neuroscience

authors： Klarica M,Miše B,Vladić A,Radoš M,Orešković D

更新日期：2013-09-17 00:00:00

abstract：:Our working hypothesis is that brain neurotrophins and brain Na(+),K(+)-ATPase may be strongly associated with the occurrence of depression in animals subjected to chronic unpredictable mild stress (CUMS). Still, we believe that chrysin, a natural and bioactive flavonoid found in honey and some plants, can provide sat...

journal_title：Neuroscience

authors： Filho CB,Jesse CR,Donato F,Giacomeli R,Del Fabbro L,da Silva Antunes M,de Gomes MG,Goes AT,Boeira SP,Prigol M,Souza LC

更新日期：2015-03-19 00:00:00

abstract：:Increase in proton concentration [H+] or decrease in local and global extracellular pH occurs in both physiological and pathological conditions. Acid-sensing ion channels (ASICs), belonging to the ENaC/Deg superfamily, play an important role in signal transduction as proton sensor. ASICs and in particular ASIC-1a (one...

journal_title：Neuroscience

authors： Natalia Gobetto M,González-Inchauspe Osvaldo D Uchitel C

更新日期：2021-01-22 00:00:00

abstract：:The distribution of [125I]omega-conotoxin GVIA binding sites, the putative voltage-sensitive calcium channels, was studied by an autoradiographic method in the rat brain. The toxin binding sites were distributed throughout the brain in a highly heterogeneous manner. The highest density of the binding sites was observe...

journal_title：Neuroscience

authors： Takemura M,Kiyama H,Fukui H,Tohyama M,Wada H

更新日期：1989-01-01 00:00:00

abstract：:The presence of mRNAs in synaptic terminals and their regulated translation are important factors in neuronal communication and plasticity. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in the translocation, stability, and subcellular localization of mRNA and the regulation of its translation....

journal_title：Neuroscience

authors： Lico DT,Lopes GS,Brusco J,Rosa JC,Gould RM,De Giorgis JA,Larson RE

更新日期：2015-08-06 00:00:00

abstract：:alpha-Calcitonin gene-related peptide expression in alpha-motoneurons is regulated by spinal cord transection, axotomy and testosterone, but to date there are no studies which examine the regulation of cholecystokinin expression in motoneurons. In the present study, we compared the regulation of preprocholecystokinin ...

journal_title：Neuroscience

authors： Popper P,Abelson L,Micevych PE

更新日期：1992-11-01 00:00:00

abstract：:Endocannabinoids modulate a diverse array of functions including progenitor cell proliferation in the central nervous system, and odorant detection and food intake in the mammalian central olfactory system and larval Xenopus laevis peripheral olfactory system. However, the presence and role of endocannabinoids in the ...

journal_title：Neuroscience

authors： Hutch CR,Hillard CJ,Jia C,Hegg CC

更新日期：2015-08-06 00:00:00