An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction.

abstract：:Current theories of neuropathic hypersensitivity include an imbalance of supraspinal inhibition and facilitation. Our overall hypothesis is that the locus coeruleus (LC), classically interpreted as a source of pain inhibition, may paradoxically result in facilitation after tibial and common peroneal nerve transection ...

journal_title：Neuroscience

authors： Brightwell JJ,Taylor BK

更新日期：2009-04-21 00:00:00

abstract：:Prenatal exposure to the antiepileptic valproic acid (VPA) is associated with an increased risk of autism spectrum disorder (ASD) in humans and is used as an animal model of ASD. The majority of individuals with ASD exhibit adverse reactions to sensory stimuli and auditory dysfunction. Previous studies of animals expo...

journal_title：Neuroscience

authors： Mansour Y,Mangold S,Chosky D,Kulesza RJ Jr

更新日期：2019-01-01 00:00:00

abstract：:Here we investigate the temporal properties of recurrent seizure-like events (SLEs) in a low-[Mg(2+)] model of experimental epilepsy. Simultaneous intra- and extracellular electric signals were recorded in the CA3 region of rat hippocampal slices whereby cytosolic [Ca(2+)] transients were imaged by fluorescence detect...

journal_title：Neuroscience

authors： Nyikos L,Lasztóczi B,Antal K,Kovács R,Kardos J

更新日期：2003-01-01 00:00:00

abstract：:The role of agrin in synaptogenesis has been extensively studied. On the other hand, little is known about the function of this extracellular matrix protein during developmental processes that precede the formation of synapses. Recently, agrin was shown to regulate the rate of neurite elongation and the behavior of gr...

journal_title：Neuroscience

authors： Bergstrom RA,Sinjoanu RC,Ferreira A

更新日期：2007-11-09 00:00:00

abstract：:The pharmacological features of putative nicotinic acetylcholine receptor sites involved in the release of [3H]noradrenaline were assessed in rat hippocampus. The effect of nicotinic agonists to induce [3H]noradrenaline release was examined in superfused slices. The nicotinic agonists (-)-epibatidine, (+)-anatoxin-a, ...

journal_title：Neuroscience

authors： Sershen H,Balla A,Lajtha A,Vizi ES

更新日期：1997-03-01 00:00:00

abstract：:It has previously been demonstrated, in dual probe microdialysis studies, that stimulation of the neostriatum with kainic acid causes the release of GABA both locally within the neostriatum and distally in the substantia nigra, observations that are consistent with the known anatomy of the basal ganglia. The object of...

journal_title：Neuroscience

authors： Bianchi L,Colivicchi MA,Bolam JP,Della Corte L

更新日期：1998-11-01 00:00:00

abstract：:Antagonists acting at the 5-hydroxytryptamine3 receptor are potent anti-emetic agents in cases of cytotoxic- and radiation-induced vomiting, and binding sites for these compounds have been described in brainstem areas known to be involved in mediation of nausea and vomiting. We have used autoradiography to examine the...

journal_title：Neuroscience

authors： Leslie RA,Reynolds DJ,Andrews PL,Grahame-Smith DG,Davis CJ,Harvey JM

更新日期：1990-01-01 00:00:00

abstract：:Fluctuations in the endogenous levels of kynurenic acid (KYNA), a potent alpha7 nicotinic and NMDA receptor antagonist, affect extracellular dopamine (DA) concentrations in the rat brain. Moreover, reductions in KYNA levels increase the vulnerability of striatal neurons to NMDA receptor-mediated excitotoxic insults. W...

journal_title：Neuroscience

authors： Amori L,Wu HQ,Marinozzi M,Pellicciari R,Guidetti P,Schwarcz R

更新日期：2009-03-03 00:00:00

abstract：:The neurosensory cells of the primary olfactory and vomeronasal projections are in a state of continuous replacement throughout adult life. Since their axons form synaptic terminals with neurons in the olfactory and accessory olfactory bulbs, this system is an apparent exception to the rule that peripheral axons canno...

journal_title：Neuroscience

authors： Raisman G

更新日期：1985-01-01 00:00:00

abstract：:The sphenopalatine ganglion (SPG) is a gathering of the cell bodies of parasympathetic fibers that dominate the nasal gland, lacrimal gland and cerebral blood vessels. The SPG controls nasal secretions, tears, and the dilation of cerebral blood vessels. However, it is unclear how serotonin regulates SPG functions. In ...

journal_title：Neuroscience

authors： Ishida Y,Sugiura Y,Magome T,Kamakura T,Takimoto Y,Hanada Y,Kitayama K,Nakamura Y,Shimada S,Ohta N,Naono-Nakayama R,Kamijo K

更新日期：2019-07-15 00:00:00

abstract：:The present study was undertaken to investigate the possible effects of Spantide [D-Arg1, D-Trp7,9 Leu11]-substance P, a substance P antagonist, and of somatostatin on spinal cord blood flow. The experiments were performed with the laser-doppler technique on the L1 spinal cord segment exposed by laminectomy. The effec...

journal_title：Neuroscience

authors： Freedman J,Post C,Kåhrström J,Ohlen A,Mollenholt P,Owman C,Alari L,Hökfelt T

更新日期：1988-10-01 00:00:00

abstract：:Treatment of P19 embryonal carcinoma cells with retinoic acid induces their differentiation into a population of cells consisting of neurons and other cell types normally derived from neuroectoderm. We used immunohistological and histochemical techniques to identify some of the neurotransmitters in the P19-derived neu...

journal_title：Neuroscience

authors： Staines WA,Morassutti DJ,Reuhl KR,Ally AI,McBurney MW

更新日期：1994-02-01 00:00:00

abstract：:Huntington's disease is a progressive, inherited neurodegenerative disorder characterized by the loss of subsets of neurons primarily in the striatum. In this study, we assessed the neuroprotective effect of lithium against striatal lesion formation in a rat model of Huntington's disease in which quinolinic acid was u...

journal_title：Neuroscience

authors： Wei H,Qin ZH,Senatorov VV,Wei W,Wang Y,Qian Y,Chuang DM

更新日期：2001-01-01 00:00:00

abstract：:Physiological studies suggest visceral spinal afferents are generally small diameter, unmyelinated C-fibers or myelinated Adelta-fibers, but little is known about the size and chemical phenotypes of visceral sensory neurons supplying the small intestine. This study examines the size and expression patterns of transien...

journal_title：Neuroscience

authors： Tan LL,Bornstein JC,Anderson CR

更新日期：2008-10-02 00:00:00

abstract：:Three-dimensional distribution gradients of intracerebrally injected tritiated dopamine were calculated on the basis of concentrations in multiple punch-samples from sequential sections of Macaca fascicularis brain tissue. The monkey was pretreated systemically with a monoamine oxidase inhibitor to retard elimination....

journal_title：Neuroscience

authors： Dubach M

更新日期：1991-01-01 00:00:00

abstract：:The N170 is a large deflection of the human electroencephalogram (EEG), peaking at about 170 milliseconds over the occipito-temporal cortex after the sudden onset of a face stimulus. The N170 reflects perceptual awareness of a face and its onset corresponds to the emergence of reliable face-selectivity in the human br...

journal_title：Neuroscience

authors： Caharel S,Rossion B

更新日期：2021-01-16 00:00:00

abstract：:The vertebrate blood-brain barrier (BBB) creates an obstacle for central nervous system-related drug delivery. Claudin-5 (Cldn5), expressed in large quantities in BBB, plays a vital role in restricting BBB permeability. The C-terminal domain of Clostridium perfringens enterotoxin (cCPE) has been verified as binding to...

journal_title：Neuroscience

authors： Liao Z,Yang Z,Piontek A,Eichner M,Krause G,Li L,Piontek J,Zhang J

更新日期：2016-07-07 00:00:00

abstract：:Hippocampal cell firing in awake, behaving rats is often spatially selective, and such cells have been called place cells. Similar spatial correlates have also been described for neurons in the medial entorhinal and perirhinal cortices. All three regions receive sensory associational input from postrhinal cortex, whic...

journal_title：Neuroscience

authors： Burwell RD,Hafeman DM

更新日期：2003-01-01 00:00:00

abstract：:Laminar organization is a fundamental cytoarchitecture in mammalian CNS and a striking feature of the neocortex. ER81, a transcription factor, has recently been utilized as a marker of cells in the layer 5 of the neocortex. We further pursued the distribution of ER81 to investigate the identity of the ER81-expressing ...

journal_title：Neuroscience

authors： Yoneshima H,Yamasaki S,Voelker CC,Molnár Z,Christophe E,Audinat E,Takemoto M,Nishiwaki M,Tsuji S,Fujita I,Yamamoto N

更新日期：2006-01-01 00:00:00

abstract：:The 5-HT mixed agonist/antagonist 1-(2-methoxyphenyl)4-[4-(phthalimido)butyl]-piperazine hydrobromide (NAN-190) has been shown to greatly potentiate photic phase shifts in hamsters. The mechanism of this potentiation has yet to be determined. NAN-190 is believed to act primarily through the 5-HT(1A) receptor, but also...

journal_title：Neuroscience

authors： Smith VM,Hagel K,Antle MC

更新日期：2010-01-13 00:00:00

abstract：:Using arsenazo III as an intracellular indicator to monitor the calcium transients elicited by voltage-clamp depolarizing pulse, the effect of prolonged in vitro lithium treatment on excitation--contraction coupling in frog twitch muscle fibres was investigated. Incubation in 10 mM Li+ Ringer's solution for 2 days cau...

journal_title：Neuroscience

authors： Zhu PH,Fu DX

更新日期：1990-01-01 00:00:00

abstract：:While the effects of progesterone in the CNS, like those of estrogen, have generally been considered within the context of reproductive function, growing evidence supports its importance in regulating non-reproductive functions including cognition and affect. In addition, progesterone has well-described protective eff...

journal_title：Neuroscience

authors： Singh M,Su C

更新日期：2013-06-03 00:00:00

abstract：:Chronic restraint stress has been associated with induction of morphological changes in the hippocampus. Postsynaptically, these changes include decreased length and branching of apical dendrites from CA3 pyramidal neurons, while presynaptically, depletion and clustering of synaptic vesicles have been observed. Howeve...

journal_title：Neuroscience

authors： Gao Y,Bezchlibnyk YB,Sun X,Wang JF,McEwen BS,Young LT

更新日期：2006-09-01 00:00:00

abstract：:We describe two distinct mechanisms for the enhancement of plasma extravasation in the knee joint of the rat. One is activated by bradykinin and is neurogenic; the other is activated by platelet-activating factor and is non-neurogenic. Bradykinin-induced synovial plasma extravasation is known to be dependent on the sy...

journal_title：Neuroscience

authors： Green PG,Luo J,Heller PH,Levine JD

更新日期：1993-02-01 00:00:00

abstract：:Freezing of gait (FOG) is a common, disabling symptom of Parkinson's disease (PD) that is associated with deficits in motor initiation and inhibition. Understanding of underlying neurobiological mechanisms has been limited by difficulties in eliciting and objectively characterizing such gait phenomena in the clinical ...

journal_title：Neuroscience

authors： Georgiades MJ,Gilat M,Ehgoetz Martens KA,Walton CC,Bissett PG,Shine JM,Lewis SJ

更新日期：2016-11-19 00:00:00

abstract：:The uptake and release of catecholamines was investigated in the isolated perfused adrenal gland of the rat after preloading the preparation with [3H]norepinephrine, and the effects of various agents were examined on the stimulation-evoked secretion of catecholamines and total tritium. Large quantities of tritium were...

journal_title：Neuroscience

authors： Wakade AR,Malhotra RK,Wakade TD,Dixon WR

更新日期：1986-08-01 00:00:00

abstract：:Seizures and status epilepticus induce an excessive production of reactive oxygen species leading to oxidative stress. Vitamin E, a classic antioxidant, has a neuroprotective effect on rats with seizures by regulating reactive oxygen species production. The activity of chaperone-mediated autophagy, a selective pathway...

journal_title：Neuroscience

authors： Cao L,Chen R,Xu J,Lin Y,Wang R,Chi Z

更新日期：2009-06-16 00:00:00

abstract：:Dopamine and endocannabinoids are neurotransmitters known to play a role in the activity of the basal ganglia motor circuit. While a number of studies have demonstrated functional interactions between type 1 cannabinoid (CB1) receptors and dopaminergic systems, we still lack detailed neuroanatomical evidence to explai...

journal_title：Neuroscience

authors： Julian MD,Martin AB,Cuellar B,Rodriguez De Fonseca F,Navarro M,Moratalla R,Garcia-Segura LM

更新日期：2003-01-01 00:00:00

abstract：:Foetal mouse hippocampal primordia from mice homozygous for the Thy-1.1 allele were transplanted into the hippocampal region of adult histocompatible mice, homozygous for the Thy-1.2 allele. After survival periods of two months to one year the transplants consisted of a discrete tissue mass, well fused with the host, ...

journal_title：Neuroscience

authors： Zhou CF,Raisman G,Morris RJ

更新日期：1985-12-01 00:00:00

abstract：:In the spinal cord, glycine and γ-amino butyric acid (GABA) are inhibitory neurotransmitters. However, the ontogeny of the glycinergic network remains unclear. To address this point, we examined the developmental formation of glycinergic terminals by immunohistochemistry for glycine transporter 2 (GlyT2), a marker of ...

journal_title：Neuroscience

authors： Sunagawa M,Shimizu-Okabe C,Kim J,Kobayashi S,Kosaka Y,Yanagawa Y,Matsushita M,Okabe A,Takayama C

更新日期：2017-02-20 00:00:00