当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Effects of restraint stress on the expression of proteins involved in synaptic vesicle exocytosis in the hippocampus.

Effects of restraint stress on the expression of proteins involved in synaptic vesicle exocytosis in the hippocampus.

Abstract：

:Chronic restraint stress has been associated with induction of morphological changes in the hippocampus. Postsynaptically, these changes include decreased length and branching of apical dendrites from CA3 pyramidal neurons, while presynaptically, depletion and clustering of synaptic vesicles have been observed. However, the molecular correlates of these changes remain poorly defined; while some studies have identified changes in the levels of some presynaptic proteins, none have assessed the coordinate expression of components of the membrane fusion complex, including synaptobrevin, syntaxin, and synaptosomal-associated protein 25 kDa, and their major regulatory molecules synaptotagmin, synaptophysin, and synapsin. Therefore, we undertook to assess the immunoreactivity of these proteins in hippocampal slices obtained from rats subjected to either acute (one 6 h session) or chronic (21 days at 6 h per day) of restraint stress. Specifically, we observed a significant increase in synaptobrevin immunoreactivity in the inner molecular layer of the dentate gyrus (54.2%; P=0.005), the stratum radiatum in the CA1 subfield (55.5%; P=0.007), and a region including the stratum lucidum and the proximal portion of the stratum radiatum in the CA3 subfield (52.7%; P=0.002); we also observed a trend toward increased synaptophysin levels in the stratum lucidum/radiatum of the CA3 subfield (8.0%; P=0.051) following chronic, but not acute, restraint stress. In that synaptobrevin has been associated with replenishment of the "readily-releasable" pool of synaptic vesicles and the efficiency of neurotransmitter release, the present results suggest that stress-induced changes in synaptobrevin may at least in part underlie the previously observed changes in synaptic and neuronal morphology.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Gao Y,Bezchlibnyk YB,Sun X,Wang JF,McEwen BS,Young LT

doi

10.1016/j.neuroscience.2006.04.066

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

1139-48

issue

3

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(06)00614-2

journal_volume

141

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Axonal and transneuronal transport in the transmission of neurological disease: potential role in system degenerations, including Alzheimer's disease.

    abstract：:Neurons depend upon the processes of axonal and transneuronal transport for intra- and intercellular communication and trophic support. Experimental studies in the last decade have elucidated the mechanisms underlying these processes, and provided evidence for their role in the spread of viral and toxic diseases throu...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/0306-4522(87)90063-7

    authors： Saper CB,Wainer BH,German DC

    更新日期：1987-11-01 00:00:00

  • Postweaning Enriched Environment Enhances Cognitive Function and Brain-Derived Neurotrophic Factor Signaling in the Hippocampus in Maternally Separated Rats.

    abstract：:Adverse environments during early life may lead to different neurophysiological and behavioral consequences, including depression and learning and memory deficits that persist into adulthood. Previously, we demonstrated that exposure to an enriched environment during adolescence mitigates the cognitive impairment obse...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.09.058

    authors： Cordier JM,Aguggia JP,Danelon V,Mir FR,Rivarola MA,Mascó D

    更新日期：2021-01-15 00:00:00

  • Nitric oxide and GABAA receptor function in the rat cerebral cortex and cerebellar granule cells.

    abstract：:The aim of the present work was to investigate the mechanism by which the diffusible factor nitric oxide regulates GABAA receptor function in the brain. The effect of nitric oxide on GABAA receptor function has been studied in two different neuronal preparations: rat cerebral cortex microsacs and rat cerebellum granul...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00110-8

    authors： Robello M,Amico C,Bucossi G,Cupello A,Rapallino MV,Thellung S

    更新日期：1996-09-01 00:00:00

  • Analysis of genetics and risk factors of Alzheimer's Disease.

    abstract：:Alzheimer's Disease is the leading neurodegenerative cause of dementia. The pathogenesis is not clearly understood yet, is believed to be the complex interaction between genetic and environmental factors. Consequently vascular risk factors and Apolipoprotein E genotyping are increasingly gaining importance. This study...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.03.051

    authors： Panpalli Ates M,Karaman Y,Guntekin S,Ergun MA

    更新日期：2016-06-14 00:00:00

  • Development and retraction of a crossed retinal projection to the inferior colliculus in neonatal pigmented rats.

    abstract：:A transient aberrant projection from the retina to the contralateral inferior colliculus was demonstrated in pigmented rats in both whole-brains and sections following intra-ocular injection of horseradish peroxidase. The projection was prominent on the day of birth but reached its maximum density and extent after inj...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90087-k

    authors： Cooper AM,Cowey A

    更新日期：1990-01-01 00:00:00

  • Cochlear and trigeminal systems contributing to the startle reflex in rats.

    abstract：:The startle reflex is evoked by strong acoustic or tactile stimuli, or by electrical stimulation of acoustic or tactile pathways. To dissociate the contributions of acoustic and tactile pathways, stimulating electrodes were placed in adjacent cochlear and trigeminal nuclei. The currents needed to evoke startle-like re...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00708-8

    authors： Scott BW,Frankland PW,Li L,Yeomans JS

    更新日期：1999-01-01 00:00:00

  • Disproportionate regulation of nuclear- and mitochondrial-encoded cytochrome oxidase subunit proteins by functional activity in neurons.

    abstract：:Cytochrome oxidase is the terminal enzyme in the mitochondrial respiratory chain engaged in oxidative metabolism and energy production. In mammals, the holoenzyme is composed of 13 subunits encoded by both nuclear and mitochondrial genomes. The goal of the present study was to compare the effect of afferent impulse bl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00043-i

    authors： Liu S,Wong-Riley M

    更新日期：1995-07-01 00:00:00

  • GABA mechanisms and sleep.

    abstract：:GABA is the main inhibitory neurotransmitter of the CNS. It is well established that activation of GABA(A) receptors favors sleep. Three generations of hypnotics are based on these GABA(A) receptor-mediated inhibitory processes. The first and second generation of hypnotics (barbiturates and benzodiazepines respectivel...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/s0306-4522(02)00034-9

    authors： Gottesmann C

    更新日期：2002-01-01 00:00:00

  • Protein cysteine S-nitrosylation inhibits vesicular uptake of neurotransmitters.

    abstract：:Previous studies have shown that nitric oxide can induce cysteine S-nitrosylation of total protein in synaptosomes, suggesting that nitric oxide may contribute to the regulation of synaptic protein function. Vesicular neurotransmitter transporters pack neurotransmitters into synaptic vesicles and play an important rol...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.10.052

    authors： Wang Y,Zhou Z,Leylek T,Tan H,Sun Y,Parkinson FE,Wang JF

    更新日期：2015-12-17 00:00:00

  • Two electrophysiologically distinct types of granule cells in epileptic human hippocampus.

    abstract：:We investigated the electrophysiology of morphologically identified human granule cells with conventional current-clamp recordings. Slices were prepared from 14 human epileptic sclerotic hippocampi. Granule cells appeared to have a diverse electrophysiology. Each cell was distinguished by the shape of the afterhyperpo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00574-0

    authors： Dietrich D,Clusmann H,Kral T,Steinhäuser C,Blümcke I,Heinemann U,Schramm J

    更新日期：1999-01-01 00:00:00

  • Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system.

    abstract：:The anatomical distributions and affinity states of dopamine D1 and D2 receptors were compared in the rat central nervous system using quantitative autoradiography. [3H]SCH23390 and [3H]spiperone (in the presence of 100 nM mianserin) were used to label the D1 and D2 receptors, respectively. The densities of D1 and D2 ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90168-1

    authors： Richfield EK,Penney JB,Young AB

    更新日期：1989-01-01 00:00:00

  • Intraventricular capsaicin: alterations in analgesic responsivity without depletion of substance P.

    abstract：:Both systemic and intrathecal capsaicin release and deplete substance P from primary sensory afferents and induce prolonged chemical and thermal analgesia. Given the existence of efferents containing substance P together with a pain-inhibitory serotoninergic pathway, the present study investigated the effects of intra...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(82)90068-9

    authors： Bodnar RJ,Kirchgessner A,Nilaver G,Mulhern J,Zimmerman EA

    更新日期：1982-03-01 00:00:00

  • GABA and glycine immunolabeling in the chicken tangential nucleus.

    abstract：:In the vestibular nuclei, GABAergic and glycinergic neurons play important roles in signal processing for normal function, during development, and after peripheral vestibular lesions. The chicken tangential nucleus is a major avian vestibular nucleus, whose principal cells are projection neurons with axons transmittin...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.11.050

    authors： Popratiloff A,Peusner KD

    更新日期：2011-02-23 00:00:00

  • Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor.

    abstract：:This study investigated whether somatostatin (SST) modulates the excitability of nociceptive trigeminal ganglion (TRG) neurons that innervate the nasal mucosa and project to the upper cervical (C(1)) dorsal horn by using perforated-patch clamping, retrograde-labeling, and immunohistochemistry. Fluorogold (FG) retrogra...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.06.048

    authors： Takeda M,Kadoi J,Takahashi M,Nasu M,Matsumoto S

    更新日期：2007-09-07 00:00:00

  • Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat.

    abstract：:Astrocyte hypertrophy and swelling occur in a variety of pathophysiological conditions, including diseases associated with hyperammonemia. Ammonia is rapidly incorporated into glutamine by glutamine synthetase localized in astrocytes. We tested the hypotheses that (1) 6 h of hyperammonemia (500-600 microM) is adequate...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00462-9

    authors： Willard-Mack CL,Koehler RC,Hirata T,Cork LC,Takahashi H,Traystman RJ,Brusilow SW

    更新日期：1996-03-01 00:00:00

  • Cochlear protection from acoustic injury by inhibitors of p38 mitogen-activated protein kinase and sequestosome 1 stress protein.

    abstract：:This study evaluated the protective role of p38 mitogen-activated protein kinase (p38 MAPK) inhibitors and sequestosome 1 (Sqstm1/A170/p62), a stress-induced signal modulator, in acoustic injury of the cochlea in mice. Two weeks after the exposure of mice to acoustic stress, threshold shifts of the auditory brainstem ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.12.038

    authors： Tabuchi K,Oikawa K,Hoshino T,Nishimura B,Hayashi K,Yanagawa T,Warabi E,Ishii T,Tanaka S,Hara A

    更新日期：2010-03-17 00:00:00

  • Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator.

    abstract：:Vitamin D is a neuroactive steroid. Its genomic actions are mediated via the active form of vitamin D, 1,25(OH)2D3, binding to the vitamin D receptor (VDR). The VDR emerges in the rat mesencephalon at embryonic day 12, representing the peak period of dopaminergic cell birth. Our prior studies reveal that developmental...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.07.048

    authors： Cui X,Pertile R,Liu P,Eyles DW

    更新日期：2015-09-24 00:00:00

  • Fitts' Law in early postural adjustments.

    abstract：:We tested a hypothesis that the classical relation between movement time and index of difficulty (ID) in quick pointing action (Fitts' Law) reflects processes at the level of motor planning. Healthy subjects stood on a force platform and performed quick and accurate hand movements into targets of different size locate...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.11.043

    authors： Bertucco M,Cesari P,Latash ML

    更新日期：2013-02-12 00:00:00

  • Expression of angiotensin II and its receptors in the normal and hypoxic amoeboid microglial cells and murine BV-2 cells.

    abstract：:Involvement of the local angiotensin receptor system in the central nervous system is well documented, yet its cellular localization and role in the glial cells have remained elusive. This study reports expression of angiotensin II and its receptors namely, angiotensin II receptor type 1 (AT(1)) and angiotensin II rec...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.11.046

    authors： Li JJ,Lu J,Kaur C,Sivakumar V,Wu CY,Ling EA

    更新日期：2009-02-18 00:00:00

  • Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus.

    abstract：:Pannexins (Panx) constitute a new family of gap junction type proteins. Functional expression in paired Xenopus oocytes indicated that pannexins are capable of forming communicating junctions but also proved to be active in forming of unopposed hemichannels. In the vertebrate brain pannexins have been found in neurons...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.01.061

    authors： Zoidl G,Petrasch-Parwez E,Ray A,Meier C,Bunse S,Habbes HW,Dahl G,Dermietzel R

    更新日期：2007-04-25 00:00:00

  • Development of the suprachiasmatic nucleus in rats during ontogenesis: serotonin-immunopositive fibers.

    abstract：:The innervation of the suprachiasmatic nucleus by serotoninergic fibers has been studied in rats from the 22nd embryonic until the 21st postnatal day. The serotoninergic fibers were detected with the pre-embedding immunocytochemical technique at the electron-microscopic level using antibodies to serotonin. Serotonin-i...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90163-5

    authors： Ugrumov MV,Popov AP,Vladimirov SV,Kasmambetova S,Novodjilova AP,Tramu G

    更新日期：1994-01-01 00:00:00

  • Training on Abacus-based Mental Calculation Enhances Resting State Functional Connectivity of Bilateral Superior Parietal Lobules.

    abstract：:Accumulating evidence indicates a positive effect of abacus-based mental calculation (AMC) training on various cognitive functions including short-term memory (STM). Our previous work has shown AMC training-induced activation changes in the frontal-parietal network (FPN) using task fMRI. However, whether AMC training-...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.02.033

    authors： Zhou H,Geng F,Wang T,Wang C,Xie Y,Hu Y,Chen F

    更新日期：2020-04-15 00:00:00

  • FTY720 Improves Behavior, Increases Brain Derived Neurotrophic Factor Levels and Reduces α-Synuclein Pathology in Parkinsonian GM2+/- Mice.

    abstract：:Parkinson's disease (PD) is a progressive aging disorder that affects millions worldwide, thus, disease-modifying-therapies are urgently needed. PD pathology includes α-synuclein (aSyn) accumulation as synucleinopathy. Loss of GM1 gangliosides occurs in PD brain, which is modeled in GM2 synthase transgenic mice. GM2+/...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.05.029

    authors： Vidal-Martinez G,Najera K,Miranda JD,Gil-Tommee C,Yang B,Vargas-Medrano J,Diaz-Pacheco V,Perez RG

    更新日期：2019-07-15 00:00:00

  • Enduring and Sex-specific Changes in Hippocampal Gene Expression after a Subchronic Immune Challenge.

    abstract：:Major illnesses, including heart attack and sepsis, can cause cognitive impairments, depression, and progressive memory decline that persist long after recovery from the original illness. In rodent models of sepsis or subchronic immune challenge, memory deficits also persist for weeks or months, even in the absence of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.12.019

    authors： Tchessalova D,Tronson NC

    更新日期：2020-01-21 00:00:00

  • The ontogeny of NADPH-diaphorase neurons in serum-free striatal cultures parallels in vivo development.

    abstract：:Nitric oxide synthase is co-localized with somatostatin and neuropeptide Y in a subpopulation of striatal interneurons that stain selectively for NADPH-diaphorase. We studied the ontogeny of diaphorase-positive neurons in striatal serum-free cultures derived from 15-16-day-old CD1 mice. NADPH-diaphorase staining was d...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00415-0

    authors： Garside S,Woulfe J,Mazurek MF

    更新日期：1997-02-01 00:00:00

  • HMGB1 binding heptamer peptide improves survival and ameliorates brain injury in rats after cardiac arrest and cardiopulmonary resuscitation.

    abstract：:Excessive inflammatory response produced after cardiac arrest and cardiopulmonary resuscitation (CA/CPR) is one of major causes of cerebral injury. High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine and its role in brain injury after CA/CPR is unclear. Herein we investigated whether blocking HMGB1 signal...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.07.052

    authors： Shi X,Li M,Huang K,Zhou S,Hu Y,Pan S,Gu Y

    更新日期：2017-09-30 00:00:00

  • Effect of prolonged in vitro lithium treatment on calcium transients in frog twitch muscle fibres and its reversal by exogenous myo-inositol.

    abstract：:Using arsenazo III as an intracellular indicator to monitor the calcium transients elicited by voltage-clamp depolarizing pulse, the effect of prolonged in vitro lithium treatment on excitation--contraction coupling in frog twitch muscle fibres was investigated. Incubation in 10 mM Li+ Ringer's solution for 2 days cau...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90240-5

    authors： Zhu PH,Fu DX

    更新日期：1990-01-01 00:00:00

  • Effects of estradiol, sex, and season on estrogen receptor alpha mRNA expression and forebrain morphology in adult green anole lizards.

    abstract：:Steroid hormones, especially estradiol, facilitate reproductive behaviors in male and female rodents and birds. In green anole lizards estradiol facilitates receptivity in females but, unlike in some other species, is not the activating hormone for courtship and copulatory behavior in males. Instead, testicular androg...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.02.060

    authors： Beck LA,Wade J

    更新日期：2009-05-19 00:00:00

  • Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways.

    abstract：:Amyloid-β (Aβ) production and clearance in the brain is a crucial focus of investigations into the pathogenesis of Alzheimer disease. Imbalance between production and clearance leads to accumulation of Aβ. The important Aβ-degrading enzymes in the brain are neprilysin (NEP) and insulin-degrading enzyme (IDE), and defe...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.08.030

    authors： Yamamoto N,Shibata M,Ishikuro R,Tanida M,Taniguchi Y,Ikeda-Matsuo Y,Sobue K

    更新日期：2017-10-24 00:00:00

  • Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments.

    abstract：:The nucleus accumbens septi is the major target of mesolimbic dopamine neurons originating in the ventral tegmental area of the mesencephalon. Studies involving experimental manipulation of dopamine transmission by drugs and by lesions, as well as in vivo monitoring of extracellular dopamine concentrations, have provi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00583-1

    authors： Bassareo V,Di Chiara G

    更新日期：1999-03-01 00:00:00