当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Protein cysteine S-nitrosylation inhibits vesicular uptake of neurotransmitters.

Protein cysteine S-nitrosylation inhibits vesicular uptake of neurotransmitters.

Abstract：

:Previous studies have shown that nitric oxide can induce cysteine S-nitrosylation of total protein in synaptosomes, suggesting that nitric oxide may contribute to the regulation of synaptic protein function. Vesicular neurotransmitter transporters pack neurotransmitters into synaptic vesicles and play an important role in neurotransmission. In the central nervous system, vesicular monoamine transporter 2 (VMAT2) is responsible for the uptake of monoamines, vesicular acetylcholine transporter (VAChT) is responsible for the uptake of acetylcholine, while vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) are responsible for the uptake of glutamate. The purpose of this study was to investigate the role of cysteine S-nitrosylation in the regulation of these vesicular neurotransmitter transporters. Using the biotin switch assay followed by avidin precipitation and immunoblotting we found that the nitric oxide donor nitrosoglutathione (GSNO) not only increased total cysteine S-nitrosylation, but also increased cysteine S-nitrosylation of VMAT2, VAChT, VGLUT1 and VGLUT2 in the mouse brain. Further, GSNO also decreased the vesicular uptake of [(3)H]dopamine, [(3)H]acetylcholine and [(3)H]glutamate. Our studies suggest that the cysteine S-nitrosylation may play an important role in the regulation of vesicular neurotransmitter transport.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Wang Y,Zhou Z,Leylek T,Tan H,Sun Y,Parkinson FE,Wang JF

doi

10.1016/j.neuroscience.2015.10.052

subject

Has Abstract

pub_date

2015-12-17 00:00:00

pages

374-81

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(15)00980-X

journal_volume

311

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Nasal and temporal retinal ganglion cells projecting to the midbrain: implications for "blindsight".

    abstract：:We placed pellets of horseradish peroxidase in the superior colliculus of four macaque monkeys and retrogradely labelled the retinal ganglion cells of both eyes. The ratio of labelled cells in the contralateral nasal retina and the ipsilateral temporal retina was no different from the ratio found after implants in the...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)00489-r

    authors： Williams C,Azzopardi P,Cowey A

    更新日期：1995-03-01 00:00:00

  • Prevention of the Severity of Post-ischemic Inflammation and Brain Damage by Simultaneous Knockdown of Toll-like Receptors 2 and 4.

    abstract：:Toll-like receptor 2 (TLR2) and TLR4 belong to a family of highly conserved pattern recognition receptors and are well-known upstream sensors of signaling pathways of innate immunity. TLR2 and TLR4 upregulation is thought to be associated with poor outcome in stroke patients. We currently show that transient focal isc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.01.014

    authors： Nalamolu KR,Smith NJ,Chelluboina B,Klopfenstein JD,Pinson DM,Wang DZ,Vemuganti R,Veeravalli KK

    更新日期：2018-03-01 00:00:00

  • Regional distribution of putative rhythm-generating and pattern-forming components of the mammalian locomotor CPG.

    abstract：:The ventromedial spinal cord of mammals contains a neural network known as the locomotor central pattern generator (CPG) which underlies the basic generation and coordination of muscle activity during walking. To understand how this neural network operates, it is necessary to identify, characterize, and map connectivi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.07.070

    authors： Griener A,Dyck J,Gosgnach S

    更新日期：2013-10-10 00:00:00

  • Organization of the serotonergic innervation of spinal neurons in rats--III. Differential serotonergic innervation of somatic and parasympathetic preganglionic motoneurons as determined by patterns of co-existing peptides.

    abstract：:The spinal cord is innervated by brainstem serotonergic neurons, some of which contain substance P and/or thyrotropin-releasing hormone in addition to serotonin. These neurons project at least three types of axons to the spinal cord: those containing both substance P and thyrotropin-releasing hormone, those containing...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90468-u

    authors： Wu W,Elde R,Wessendorf MW

    更新日期：1993-07-01 00:00:00

  • Maternal separation and proclivity for ethanol intake: a potential role of the endocannabinoid system in rats.

    abstract：:Maternal separation (MS) during the first postnatal weeks induces alcohol intake and a reduction in the expression of glucocorticoid receptors (GR). Adults' alcohol consumption may depend on changes in the endocannabinoid system (eCBs). Our goal was to evaluate the status of the eCBs before the exposition to alcohol t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.07.071

    authors： Romano-López A,Méndez-Díaz M,Ruiz-Contreras AE,Carrisoza R,Prospéro-García O

    更新日期：2012-10-25 00:00:00

  • Bradykinin-induced release of calcitonin gene-related peptide from capsaicin-sensitive nerves in guinea-pig atria: mechanism of action and calcium requirements.

    abstract：:The mechanism of neuropeptide secretion induced by bradykinin from capsaicin-sensitive afferents was studied in guinea-pig atria. Both the inotropic response induced by bradykinin (0.1 microM) in the electrically driven isolated guinea-pig left atria and the bradykinin (10 microM)-induced release of calcitonin gene-re...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90062-9

    authors： Geppetti P,Tramontana M,Santicioli P,Del Bianco E,Giuliani S,Maggi CA

    更新日期：1990-01-01 00:00:00

  • Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.

    abstract：:Alzheimer's disease (AD), the most prominent form of dementia in elderly, is a yet incurable degenerative neurological illness characterized by memory loss. Here, we used an AD rat model to investigate the in vivo efficacy of caprospinol, a disease-modifying steroid developed on the concept that reduced synthesis of 2...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.10.033

    authors： Lecanu L,Rammouz G,McCourty A,Sidahmed EK,Greeson J,Papadopoulos V

    更新日期：2010-01-20 00:00:00

  • Distribution of intracerebrally injected dopamine as studied by a punch-scintillation modeling technique.

    abstract：:Three-dimensional distribution gradients of intracerebrally injected tritiated dopamine were calculated on the basis of concentrations in multiple punch-samples from sequential sections of Macaca fascicularis brain tissue. The monkey was pretreated systemically with a monoamine oxidase inhibitor to retard elimination....

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90107-y

    authors： Dubach M

    更新日期：1991-01-01 00:00:00

  • Red wine antioxidants protect hippocampal neurons against ethanol-induced damage: a biochemical, morphological and behavioral study.

    abstract：:Chronic ethanol consumption increases oxidative stress, which accounts for the striking neurological changes seen in this condition. Notwithstanding, there is well-documented evidence that polyphenols, present in grape skin and seeds, exhibit a strong antioxidant activity. As red wine is rich in polyphenols, the aim o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.03.040

    authors： Assunção M,Santos-Marques MJ,de Freitas V,Carvalho F,Andrade JP,Lukoyanov NV,Paula-Barbosa MM

    更新日期：2007-06-08 00:00:00

  • Amyloid-like inclusions in Huntington's disease.

    abstract：:Huntington's disease is a progressive, autosomal dominantly inherited, neurodegenerative disease that is characterized by involuntary movements (chorea), cognitive decline and psychiatric manifestations. This is one of a number of late-onset neurodegenerative disorders caused by expanded glutamine repeats, with a like...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00391-2

    authors： McGowan DP,van Roon-Mom W,Holloway H,Bates GP,Mangiarini L,Cooper GJ,Faull RL,Snell RG

    更新日期：2000-01-01 00:00:00

  • Selective neocortical and thalamic cell death in the gerbil after transient ischemia.

    abstract：:In animal models of transients ischemia, selective vulnerability and delayed neuronal death in the hippocampus have been extensively described. However, little is known about selective damage in the neocortex and the thalamus, even though deficits in sensorimotor function are common in humans surviving hypoxic/ischemi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90083-g

    authors： Lin CS,Polsky K,Nadler JV,Crain BJ

    更新日期：1990-01-01 00:00:00

  • Haloperidol disrupts lipid rafts and impairs insulin signaling in SH-SY5Y cells.

    abstract：:Haloperidol exerts its therapeutic effects basically by acting on dopamine receptors. We previously reported that haloperidol inhibits cholesterol biosynthesis in cultured cells. In the present work we investigated its effects on lipid-raft composition and functionality. In both neuroblastoma SH-SY5Y and promyelocytic...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.01.051

    authors： Sánchez-Wandelmer J,Dávalos A,de la Peña G,Cano S,Giera M,Canfrán-Duque A,Bracher F,Martín-Hidalgo A,Fernández-Hernando C,Lasunción MA,Busto R

    更新日期：2010-04-28 00:00:00

  • Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease.

    abstract：:Besides formation of neurofibrillary tangles and neuron loss, the Alzheimer's disease brain is characterized by neuritic plaques consisting of beta-amyloid peptide deposits and impaired neurotransmission. The proteins Munc18a, Munc18-interacting protein 1 and Munc18-interacting protein 2 mediate exocytosis and decreas...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.11.017

    authors： Jacobs EH,Williams RJ,Francis PT

    更新日期：2006-01-01 00:00:00

  • The impact of Abeta-plaques on cortical cholinergic and non-cholinergic presynaptic boutons in alzheimer's disease-like transgenic mice.

    abstract：:A previous study in our laboratory, involving early stage, amyloid pathology in 8-month-old transgenic mice, demonstrated a selective loss of cholinergic terminals in the cerebral and hippocampal cortices of doubly transgenic (APP(K670N,M671L)+PSl(M146L)) mice, an up-regulation in the single mutant APP(K670N,M671L) mi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00394-4

    authors： Hu L,Wong TP,Côté SL,Bell KF,Cuello AC

    更新日期：2003-01-01 00:00:00

  • Fast, synchronous neurotransmitter release: Past, present and future.

    abstract：:This mini-review starts with a summary of the crucial contributions Ricardo Miledi made to our understanding of how the action potential triggers fast, synchronous transmitter release. It then transitions to the discovery of synaptotagmin and its role as the exocytotic Ca2+ sensor at nerve terminals. The final section...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2019.04.030

    authors： Gundersen CB

    更新日期：2020-07-15 00:00:00

  • Topography of dopamine behaviours mediated by D1 and D2 receptors revealed by intrastriatal injection of SKF 38393, lisuride and apomorphine in rats with a unilateral 6-hydroxydopamine-induced lesion.

    abstract：:Stereotaxic injections of a dopamine D1 receptor agonist (SKF 38393) into different regions of the supersensitive striatum of rats with a unilateral 6-hydroxydopamine-induced lesion duplicated the systemic effects of the drug in a topographical manner. Although there was considerable overlap, it was possible to recogn...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90112-6

    authors： Fletcher GH,Starr MS

    更新日期：1987-02-01 00:00:00

  • Effects of paired-pulse and repetitive stimulation on neurons in the rat medial geniculate body.

    abstract：:Many behaviorally relevant sounds, including language, are composed of brief, rapid, repetitive acoustic features. Recent studies suggest that abnormalities in producing and understanding spoken language are correlated with abnormal neural responsiveness to such auditory stimuli at higher auditory levels [Tallal et al...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00240-3

    authors： Bartlett EL,Smith PH

    更新日期：2002-01-01 00:00:00

  • Examination of the role of the pedunculopontine tegmental nucleus in radial maze tasks with or without a delay.

    abstract：:Two radial maze tasks, random foraging and delayed spatial win-shift, have been used to investigate, in rats, the functions and inter-relationships of structures connected through the corticostriatal loops, such as the prelimbic cortex, nucleus accumbens, ventral pallidum and mediodorsal thalamus. The random foraging ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00108-2

    authors： Keating GL,Winn P

    更新日期：2002-01-01 00:00:00

  • Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone.

    abstract：:Modeling Parkinson's disease remains a major challenge for preclinical researchers, as existing models fail to reliably recapitulate all of the classic features of the disease, namely, the progressive emergence of a bradykinetic motor syndrome with underlying nigrostriatal α-synuclein protein accumulation and nigrostr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.12.011

    authors： Mulcahy P,O'Doherty A,Paucard A,O'Brien T,Kirik D,Dowd E

    更新日期：2012-02-17 00:00:00

  • Plasticity of glomeruli and olfactory-mediated behavior in zebrafish following detergent lesioning of the olfactory epithelium.

    abstract：:The zebrafish olfactory system is a valuable model for examining neural regeneration after damage due to the remarkable plasticity of this sensory system and of fish species. We applied detergent to the olfactory organ and examined the effects on both morphology and function of the olfactory system in adult zebrafish....

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.10.036

    authors： White EJ,Kounelis SK,Byrd-Jacobs CA

    更新日期：2015-01-22 00:00:00

  • Involvement of electrical coupling in the in vivo ictal epileptiform activity induced by 4-aminopyridine in the neocortex.

    abstract：:In the present study we have investigated the possible role of gap junctions in the induction and manifestation of 4-aminopyridine-induced acute seizure activity both at the primary focus and at the mirror focus in anaesthetized rats by combining electrophysiological, pharmacological and molecular biological technique...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00533-x

    authors： Szente M,Gajda Z,Said Ali K,Hermesz E

    更新日期：2002-01-01 00:00:00

  • Central corticotropin-releasing hormone receptors modulate hypothalamic-pituitary-adrenocortical and sympathoadrenal activity during stress.

    abstract：:The role of brain corticotropin-releasing hormone receptors in modulating hypothalamic-pituitary-adrenal and sympathoadrenal responses to acute immobilization stress was studied in conscious rats under central corticotropin-releasing hormone receptor blockade by intracerebroventricular injection of a peptide corticotr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00333-4

    authors： Jezova D,Ochedalski T,Glickman M,Kiss A,Aguilera G

    更新日期：1999-01-01 00:00:00

  • Lateral habenular neurons projecting to reward-processing monoaminergic nuclei express hyperpolarization-activated cyclic nucleotid-gated cation channels.

    abstract：:The lateral habenular complex (LHb) is a key signal integrator between limbic forebrain regions and monoaminergic hindbrain nuclei. Major projections of LHb neurons target the dopaminergic ventral tegmental area (VTA) and the serotonergic dorsal (DR) and median raphe nuclei (MnR). Both monoaminergic neurotransmitter s...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.07.013

    authors： Poller WC,Bernard R,Derst C,Weiss T,Madai VI,Veh RW

    更新日期：2011-10-13 00:00:00

  • A novel SDS-stable dimer of a heterogeneous nuclear ribonucleoprotein at presynaptic terminals of squid neurons.

    abstract：:The presence of mRNAs in synaptic terminals and their regulated translation are important factors in neuronal communication and plasticity. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in the translocation, stability, and subcellular localization of mRNA and the regulation of its translation....

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.05.040

    authors： Lico DT,Lopes GS,Brusco J,Rosa JC,Gould RM,De Giorgis JA,Larson RE

    更新日期：2015-08-06 00:00:00

  • Contingency Training Alters Neurobiological Components of Emotional Resilience in Male and Female Rats.

    abstract：:Prior research with a rat model of behavioral therapy [i.e., effort-based reward (EBR) contingency training] suggests that strengthened associations between physical effort and desired outcomes enhance neurobiological indices of resilience. In the current study, male and female Long-Evans rats were exposed to either s...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.06.010

    authors： Kent M,Scott S,Lambert S,Kirk E,Terhune-Cotter B,Thompson B,Neal S,Dozier B,Bardi M,Lambert K

    更新日期：2018-08-21 00:00:00

  • Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degeneration.

    abstract：:The vulnerability of different dopaminergic cell populations to damage caused by the herbicide paraquat was assessed by stereological counts of tyrosine hydroxylase-positive and calbindin-D28k-immunoreactive neurons in A9 (substantia nigra pars compacta) and A10 (ventral tegmental area and other cell groups). In salin...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.03.069

    authors： McCormack AL,Atienza JG,Langston JW,Di Monte DA

    更新日期：2006-08-25 00:00:00

  • Training-induced cortical plasticity compared between three tongue-training paradigms.

    abstract：:The primary aim of this study was to investigate the effect of different training types and secondary to test gender differences on the training-related cortical plasticity induced by three different tongue-training paradigms: (1) therapeutic tongue exercises (TTE), (2) playing computer games with the tongue using the...

    journal_title：Neuroscience

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neuroscience.2013.04.040

    authors： Kothari M,Svensson P,Jensen J,Kjærsgaard A,Jeonghee K,Nielsen JF,Ghovanloo M,Baad-Hansen L

    更新日期：2013-08-29 00:00:00

  • Short-term plasticity in turtle dorsal horn neurons mediated by L-type Ca2+ channels.

    abstract：:Windup--the gradual increase of the response--of dorsal horn neurons to repeated activation of primary afferents is an elementary form of short-term plasticity that may mediate central sensitization to pain. In deep dorsal horn neurons of the turtle spinal cord in vitro we report windup of the response to repeated dep...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90222-4

    authors： Russo RE,Hounsgaard J

    更新日期：1994-07-01 00:00:00

  • Schwann cells genetically modified to express neurotrophins promote spiral ganglion neuron survival in vitro.

    abstract：:The intracochlear infusion of neurotrophic factors via a mini-osmotic pump has been shown to prevent deafness-induced spiral ganglion neuron (SGN) degeneration; however, the use of pumps may increase the incidence of infection within the cochlea, making this technique unsuitable for neurotrophin administration in a cl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.11.057

    authors： Pettingill LN,Minter RL,Shepherd RK

    更新日期：2008-03-27 00:00:00

  • Time acts as a conditioned stimulus to control behavioral sensitization to amphetamine in rats.

    abstract：:Repeated exposure to the psychostimulant drug, amphetamine, results in a persistent increase in the ability of the drug to elicit behavioral activation.(14,19) The development of sensitized responses to amphetamine involves long-lasting neuroadaptations within defined circuitry.(3,6,12,15,23) The behavioral expression...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/s0306-4522(00)00401-2

    authors： Arvanitogiannis A,Sullivan J,Amir S

    更新日期：2000-01-01 00:00:00