Bradykinin-induced release of calcitonin gene-related peptide from capsaicin-sensitive nerves in guinea-pig atria: mechanism of action and calcium requirements.

abstract：:This study investigated whether somatostatin (SST) modulates the excitability of nociceptive trigeminal ganglion (TRG) neurons that innervate the nasal mucosa and project to the upper cervical (C(1)) dorsal horn by using perforated-patch clamping, retrograde-labeling, and immunohistochemistry. Fluorogold (FG) retrogra...

journal_title：Neuroscience

authors： Takeda M,Kadoi J,Takahashi M,Nasu M,Matsumoto S

更新日期：2007-09-07 00:00:00

abstract：:We have previously shown that the myristoylated alanine-rich C kinase substrate, a primary protein kinase C substrate in brain that binds and cross-links filamentous actin, is enriched in neuronal growth cones and is developmentally regulated in brain. Here we examined myristoylated alanine-rich C kinase substrate exp...

journal_title：Neuroscience

authors： McNamara RK,Jiang Y,Streit WJ,Lenox RH

更新日期：2000-01-01 00:00:00

abstract：:This study aimed to investigate the effects of regular treadmill exercise on nerve growth factor (NGF) expression, the improvement of cognitive function in the hippocampus of diabetic rats, and to understand the molecular mechanisms through which the relevant signaling factors act. We investigated the effects of regul...

journal_title：Neuroscience

authors： Chae CH,Jung SL,An SH,Park BY,Wang SW,Cho IH,Cho JY,Kim HT

更新日期：2009-12-29 00:00:00

abstract：:Fifteen percent to 35% of the United States population experiences tinnitus, a subjective "ringing in the ears". Up to 10% of those afflicted report severe and disabling symptoms. Tinnitus was induced in rats using unilateral, 1 h, 17 kHz-centered octave-band noise (116 dB SPL) and assessed using a gap-startle method....

journal_title：Neuroscience

authors： Wang H,Brozoski TJ,Turner JG,Ling L,Parrish JL,Hughes LF,Caspary DM

更新日期：2009-12-01 00:00:00

abstract：:The projections of the nucleus of the diagonal band of Broca and of the substantia innominata to the cerebral cortex were studied in the rat, using the anterograde transport of wheat germ agglutinin conjugated with horseradish peroxidase. Following diagonal band injections, fibers were observed ascending in the septum...

journal_title：Neuroscience

authors： Lamour Y,Dutar P,Jobert A

更新日期：1984-06-01 00:00:00

abstract：:Inflammation and hyperalgesia induce a dramatic up-regulation of opioid messenger RNA and peptide levels in nociceptive neurons of the spinal dorsal horn. Descending axons modulate nociceptive transmission at the spinal level during inflammatory pain, and may play a role in the development of persistent pain. The role...

journal_title：Neuroscience

authors： MacArthur L,Ren K,Pfaffenroth E,Franklin E,Ruda MA

更新日期：1999-01-01 00:00:00

abstract：:The present studies were undertaken to determine whether the major electrophysiological characteristics of neostriatal neurons are altered during aging. The passive and active membrane properties of 130 neostriatal neurons obtained from young (three to five months, N = 65) and aged (24-26 months, N = 65) Fischer 344 r...

journal_title：Neuroscience

authors： Cepeda C,Lee N,Buchwald NA,Radisavljevic Z,Levine MS

更新日期：1992-11-01 00:00:00

abstract：:Excessive inflammatory response produced after cardiac arrest and cardiopulmonary resuscitation (CA/CPR) is one of major causes of cerebral injury. High mobility group box 1 (HMGB1) is a pro-inflammatory cytokine and its role in brain injury after CA/CPR is unclear. Herein we investigated whether blocking HMGB1 signal...

journal_title：Neuroscience

authors： Shi X,Li M,Huang K,Zhou S,Hu Y,Pan S,Gu Y

更新日期：2017-09-30 00:00:00

abstract：:When the neural tracer Fluoro-Gold is used to retrogradely label a population of axotomized neurons, cellular labeling can persist in the axotomized nucleus even when Nissl staining indicates that the injured neurons have degenerated. In order to determine the identity of the labeled cells that remain, this study comb...

journal_title：Neuroscience

authors： Rinaman L,Milligan CE,Levitt P

更新日期：1991-01-01 00:00:00

abstract：:Previous work had shown that nicotinic antagonists resulted in a marked up-regulation of alpha-bungarotoxin sites in chromaffin cells in culture. The present experiments were done to determine the intracellular mechanism(s) whereby nicotinic antagonists might mediate their effects on these receptors. Chromaffin cells ...

journal_title：Neuroscience

authors： Geertsen S,Afar R,Trifaró JM,Quik M

更新日期：1990-01-01 00:00:00

abstract：:Cholinergic neurons of the basal forebrain are implicated in startle reflex inhibition by a prior weak stimulus often referred to as prepulse inhibition (PPI) and used as an index of sensorimotor gating deficits in schizophrenia. Gating deficits can be produced in rodent models by acute systemic administration of apom...

journal_title：Neuroscience

authors： Mengual E,Chan J,Lane D,San Luciano Palenzuela M,Hara Y,Lessard A,Pickel VM

更新日期：2008-02-06 00:00:00

abstract：:Stressful life events, especially those that induce fear, can produce a state of anxiety that is useful for avoiding similar fearful and potentially dangerous situations in the future. However, they can also lead to exaggerated states, which over time can produce mental illness. These changing states of readiness vers...

journal_title：Neuroscience

authors： Leuner B,Shors TJ

更新日期：2013-10-22 00:00:00

abstract：:A double transgenic mouse expressing the amyloid precursor protein, bearing the Swedish mutations, and expressing tau protein containing three of the mutations present in frontotemporal dementia linked to chromosome 17 (FTDP-17), has been characterized. In the double transgenic mouse an increase in tau phosphorylation...

journal_title：Neuroscience

authors： Pérez M,Ribe E,Rubio A,Lim F,Morán MA,Ramos PG,Ferrer I,Isla MT,Avila J

更新日期：2005-01-01 00:00:00

abstract：:Our sensory receptors are faced with an onslaught of different environmental inputs. Each sensory event or encounter with an object involves a distinct combination of physical energy sources impinging upon receptors. In the rodent whisker system, each primary afferent neuron located in the trigeminal ganglion innervat...

journal_title：Neuroscience

authors： Bale MR,Maravall M

更新日期：2018-01-01 00:00:00

abstract：:The effects of hypertonic solutions on the spontaneous and evoked catecholamine release from isolated, perfused cat adrenal glands were studied. Hypertonic solutions enhanced three times the spontaneous release of the amines, but markedly inhibited the release evoked by nicotine (5 microM for 2 min) or high K+ (17.7 m...

journal_title：Neuroscience

authors： Ladona MG,Sanchez-García P,García AG

更新日期：1984-05-01 00:00:00

abstract：:Perceiving the sensory consequences of our actions with a delay alters the interpretation of these afferent signals and impacts motor learning. For reaching movements, delayed visual feedback of hand position reduces the rate and extent of visuomotor adaptation, but substantial adaptation still occurs. Moreover, the d...

journal_title：Neuroscience

authors： Shiller DM,Mitsuya T,Max L

更新日期：2020-10-15 00:00:00

abstract：:The superior temporal gyrus (STG) is involved in speech recognition against informational masking under cocktail-party-listening conditions. Compared to healthy listeners, people with schizophrenia perform worse in speech recognition under informational speech-on-speech masking conditions. It is not clear whether the ...

journal_title：Neuroscience

authors： Li J,Wu C,Zheng Y,Li R,Li X,She S,Wu H,Peng H,Ning Y,Li L

更新日期：2017-09-17 00:00:00

abstract：:An odorant's code is represented by activity in a dispersed ensemble of olfactory sensory neurons in the nose, activation of a specific combination of groups of mitral cells in the olfactory bulb and is considered to be mapped at divergent locations in the olfactory cortex. We present here an in vitro model of the mam...

journal_title：Neuroscience

authors： Markopoulos F,Neubauer FB,Berger T,Scotti AL

更新日期：2008-10-28 00:00:00

abstract：:The concentration of intracellular Ca(2+) ([Ca(2+)](i)) influences neuronal properties ranging from excitability to neurotransmitter release. Persistent inflammation is associated with changes in the properties of primary afferent neurons ranging from excitability to transmitter release. The purpose of the present stu...

journal_title：Neuroscience

authors： Lu SG,Gold MS

更新日期：2008-04-22 00:00:00

abstract：:Mammalian nociceptors have been classified into subclasses based on differential neurotrophin sensitivity and binding of the plant isolectin B4 (IB4). Most of the nerve growth factor-responsive IB4-negative (IB4 (-)) nociceptors contain neuropeptides such as substance P and calcitonin gene-related peptide, whereas the...

journal_title：Neuroscience

authors： Matsuka Y,Edmonds B,Mitrirattanakul S,Schweizer FE,Spigelman I

更新日期：2007-01-19 00:00:00

abstract：:Treatment of P19 embryonal carcinoma cells with retinoic acid induces their differentiation into a population of cells consisting of neurons and other cell types normally derived from neuroectoderm. We used immunohistological and histochemical techniques to identify some of the neurotransmitters in the P19-derived neu...

journal_title：Neuroscience

authors： Staines WA,Morassutti DJ,Reuhl KR,Ally AI,McBurney MW

更新日期：1994-02-01 00:00:00

abstract：:The development of the catecholaminergic system in the hypothalamus and in the septal region was studied in rats from the 12th fetal day until the 9th postnatal day. Catecholaminergic structures were visualized with pre-embedding immunocytochemistry using antiserum to tyrosine hydroxylase. An intensification of diamin...

journal_title：Neuroscience

authors： Ugrumov MV,Taxi J,Tixier-Vidal A,Thibault J,Mitskevich MS

更新日期：1989-01-01 00:00:00

abstract：:Autophagy plays an essential role in neurodevelopment, axonal guidance, neuropathic pain remission, and neuronal survival. Inhibiting the mammalian target of rapamycin (mTOR) signaling pathway can induce the occurrence of autophagy. In this study, we initially detected the effect of probucol on autophagy after spinal ...

journal_title：Neuroscience

authors： Zhou Z,Chen S,Zhao H,Wang C,Gao K,Guo Y,Shen Z,Wang Y,Wang H,Mei X

更新日期：2016-08-04 00:00:00

abstract：:Ochratoxin A (OTA), a mycotoxin and widespread food contaminant, is known for its patent nephrotoxicity and potential neurotoxicity. Previous observations in vitro showed that in the CNS, glial cells were particularly sensitive to OTA. In the search for the molecular mechanisms underlying OTA neurotoxicity, we investi...

journal_title：Neuroscience

authors： Zurich MG,Lengacher S,Braissant O,Monnet-Tschudi F,Pellerin L,Honegger P

更新日期：2005-01-01 00:00:00

abstract：:We have re-examined in the rat the nuclear localization of the medullary catecholamine-containing cell groups (A1 and A2) and their relation to the vagal motor nuclei using a double labeling method. The vagal nuclei were defined by the retrograde transport of horseradish peroxidase applied to the cervical vagus, and n...

journal_title：Neuroscience

authors： Ritchie TC,Westlund KN,Bowker RM,Coulter JD,Leonard RB

更新日期：1982-06-01 00:00:00

abstract：:Studies in rats and mice have shown several sex-dependent functional and structural differences in the hippocampal region, a brain structure playing a key role in learning and memory. The aim of the present study was to establish whether sex differences exist prior to puberty in the stereological parameters of the den...

journal_title：Neuroscience

authors： Severi S,Guidi S,Ciani E,Bartesaghi R

更新日期：2005-01-01 00:00:00

abstract：:Semi-quantitative immunocytochemistry was used to investigate the levels of cyclase response element-binding protein, phosphorylated cyclase response element-binding protein, Fos and Fos-related antigen immunoreactivity in the striatum of rats after acute or repeated amphetamine administration. Rats were perfused 20 m...

journal_title：Neuroscience

authors： Simpson JN,Wang JQ,McGinty JF

更新日期：1995-11-01 00:00:00

abstract：:The startle reflex is evoked by strong acoustic or tactile stimuli, or by electrical stimulation of acoustic or tactile pathways. To dissociate the contributions of acoustic and tactile pathways, stimulating electrodes were placed in adjacent cochlear and trigeminal nuclei. The currents needed to evoke startle-like re...

journal_title：Neuroscience

authors： Scott BW,Frankland PW,Li L,Yeomans JS

更新日期：1999-01-01 00:00:00

abstract：:Cholecystokinin binding sites were labeled with [3H]cholecystokinin-8, [125I]cholecystokinin-33, and [125I]cholecystokinin-8 in major structures of macaque basal ganglia by in vitro receptor autoradiography. Analysis of autoradiograms revealed areas of heavy cholecystokinin binding in the neostriatum and substantia ni...

journal_title：Neuroscience

authors： Kritzer MF,Innis RB,Goldman-Rakic PS

更新日期：1990-01-01 00:00:00

abstract：:Extracellular recordings were made from serotonergic neurons of the rat dorsal raphe nucleus in a slice preparation. In the presence of phenylephrine (3 microM) to restore the pacemaker activity of otherwise silent serotonergic neurons, superfusion with the 5-hydroxytryptamine1A agonist ipsapirone depressed the firing...

journal_title：Neuroscience

authors： Haj-Dahmane S,Hamon M,Lanfumey L

更新日期：1991-01-01 00:00:00