当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Two types of neurotransmitter release patterns in isolectin B4-positive and negative trigeminal ganglion neurons.

Two types of neurotransmitter release patterns in isolectin B4-positive and negative trigeminal ganglion neurons.

Abstract：

:Mammalian nociceptors have been classified into subclasses based on differential neurotrophin sensitivity and binding of the plant isolectin B4 (IB4). Most of the nerve growth factor-responsive IB4-negative (IB4 (-)) nociceptors contain neuropeptides such as substance P and calcitonin gene-related peptide, whereas the glial-derived neurotrophic factor-responsive IB4-positive (IB4 (+)) neurons predominantly lack such neuropeptides. We hypothesized that the differences in neuropeptide content between IB4 (+) and (-) neurons might be reflected in differences in stimulated exocytosis and/or endocytosis. To address this, we monitored the secretory activity of acutely dissociated neurons from adult rat trigeminal ganglia (TRG) using cell membrane capacitance (Cm) measurements and the fluorescent membrane-uptake marker N-(3-triethylammoniumpropyl)-4-(6-(4-(diethylamino)phenyl)hexatrienyl)pyridinium dibromide (FM4-64). Cm measurements were performed under whole-cell voltage clamp and neurons were depolarized from -75 mV to +10 mV to elicit exocytosis. Both types of TRG neurons showed similarly-sized, calcium-dependent increases in Cm, demonstrating that both IB4 (+) and (-) TRG neurons are capable of stimulated exocytosis. However, the peak Cm of IB4 (+) neurons decayed faster toward baseline than that of IB4 (-) neurons. Also, IB4 (+) neurons had stable Cm responses to repeated stimuli whereas IB4 (-) neurons loss their secretory response during repeated stimulation. These data suggested that the IB4 (+) neurons possess a faster rate of endocytosis and vesicle replenishment than IB4 (-) neurons. To test this, we measured vesicle trafficking with the fluorescent membrane dye FM4-64. FM4-64 staining showed that IB4 (-) neurons exhibit a larger pool of endocytosed vesicles than IB4 (+) neurons because the peak fluorescence increases in IB4 (-) neurons were larger but slower than in IB4 (+) neurons. However, the recycled vesicles were released faster in IB4 (+) compared with IB4 (-) neurons. Taken together these data suggest that the IB4 (+) TRG neurons have faster exocytosis and endocytosis than the IB4 (-) neurons.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Matsuka Y,Edmonds B,Mitrirattanakul S,Schweizer FE,Spigelman I

doi

10.1016/j.neuroscience.2006.09.053

subject

Has Abstract

pub_date

2007-01-19 00:00:00

pages

665-74

issue

2

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(06)01313-3

journal_volume

144

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Transganglionic degeneration of capsaicin-sensitive C-fiber primary afferent terminals.

    abstract：:Local treatment of rat peripheral nerves with capsaicin induces permanent impairment of afferent C-fiber functions and changes in the response properties of spinal dorsal horn neurons. In this study a new experimental approach, the "capsaicin gap" technique, has been utilized in an attempt to unravel pathomorphologica...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90286-d

    authors： Jancsó G,Lawson SN

    更新日期：1990-01-01 00:00:00

  • Neurotransmitters and neuropeptides within the mesencephalic trigeminal nucleus of the rat: an immunohistochemical analysis.

    abstract：:In order to determine which neurotransmitters and neuropeptides are utilized by the neurons of the mesencephalic trigeminal nucleus and by the fibres making synaptic contact with these primary sensory cells, we have set up an immunohistochemical study using antibodies against 17 major neurotransmitters and neuropeptid...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90410-6

    authors： Copray JC,Ter Horst GJ,Liem RS,van Willigen JD

    更新日期：1990-01-01 00:00:00

  • Probucol inhibits neural cell apoptosis via inhibition of mTOR signaling pathway after spinal cord injury.

    abstract：:Autophagy plays an essential role in neurodevelopment, axonal guidance, neuropathic pain remission, and neuronal survival. Inhibiting the mammalian target of rapamycin (mTOR) signaling pathway can induce the occurrence of autophagy. In this study, we initially detected the effect of probucol on autophagy after spinal ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.05.019

    authors： Zhou Z,Chen S,Zhao H,Wang C,Gao K,Guo Y,Shen Z,Wang Y,Wang H,Mei X

    更新日期：2016-08-04 00:00:00

  • Neural xenotransplantation: reconstruction of neuronal circuitry across species barriers.

    abstract：:Selective replacement of degenerated neurons in the adult brain with allogeneic fetal neuroblasts is a promising therapeutic modality for human neurodegenerative diseases, but is confounded with practical and potential ethical problems. To evaluate the potential of xenogeneic donors as a cell source for neural transpl...

    journal_title：Neuroscience

    pub_type： 杂志文章,meta分析

    doi：10.1016/0306-4522(94)90338-7

    authors： Pakzaban P,Isacson O

    更新日期：1994-10-01 00:00:00

  • Calpastatin overexpression attenuates amyloid-beta-peptide toxicity in differentiated PC12 cells.

    abstract：:Amyloid beta peptide (Abeta) plays a major role in the pathogenesis of Alzheimer's disease (AD). Abeta is toxic to neurons, possibly through causing initial synaptic dysfunction and neuronal membrane dystrophy, promoted by increased cellular Ca(2+). Calpain (Ca(2+)-dependent protease) and caspase have been implicated ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.07.072

    authors： Vaisid T,Barnoy S,Kosower NS

    更新日期：2008-10-28 00:00:00

  • Differential increase in Fos immunoreactivity in hypothalamic and septal nuclei by arginine8-vasopressin and desglycinamide9-arginine8-vasopressin.

    abstract：:Subcutaneous or intracerebroventricular injection of either arginine8-vasopressin or desglycinamide9-arginine8-vasopressin has been shown to facilitate memory, reduce or reverse the effects of amnesic drugs, and maintain tolerance to some effects of ethanol. These actions of vasopressin (and, by inference, of desglyci...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00709-x

    authors： Lança AJ,Wu PH,Jung B,Liu JF,Ng V,Kalant H

    更新日期：1999-01-01 00:00:00

  • Dendritic arborization and axon trajectory of neurons in the hypothalamic arcuate nucleus of the rat--updated.

    abstract：:Neurons in the hypothalamic arcuate nucleus (arcuate neurons) were traced on Golgi-impregnated sections. Dendrites of arcuate neurons showed characteristic orientation patterns. Dendrites along the lateral side follow the convex border of the nucleus by running parallel to the tanycyte processes. Neurons located in th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(85)90005-3

    authors： Réthelyi M

    更新日期：1985-10-01 00:00:00

  • Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis.

    abstract：:Pathological changes occur in areas of CNS tissue remote from inflammatory lesions in multiple sclerosis (MS) and its animal model experimental allergic encephalomyelitis (EAE). To determine if oxidative stress is a significant contributor to this non-inflammatory pathology, cortex tissues from mice with clinical sign...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.04.041

    authors： Castegna A,Palmieri L,Spera I,Porcelli V,Palmieri F,Fabis-Pedrini MJ,Kean RB,Barkhouse DA,Curtis MT,Hooper DC

    更新日期：2011-06-30 00:00:00

  • Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway.

    abstract：:Colivelin is a neuroprotective humanin family peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. We seek to investigate whether this effect of Colivelin also govern ischemic brain injury, and potential mechanism underlying th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.07.020

    authors： Zhao H,Feng Y,Wei C,Li Y,Ma H,Wang X,Cui Z,Jin WN,Shi FD

    更新日期：2019-09-15 00:00:00

  • The intraspinal release of prostaglandin E2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord.

    abstract：:In anaesthetized rats, the intraspinal release of immunoreactive prostaglandin E2 was measured using antibody microprobes. We addressed the question of whether the release of immunoreactive prostaglandin E2 is altered during development of acute inflammation in the knee evoked by intra-articular injections of kaolin a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00164-5

    authors： Ebersberger A,Grubb BD,Willingale HL,Gardiner NJ,Nebe J,Schaible HG

    更新日期：1999-01-01 00:00:00

  • Regional distribution of putative rhythm-generating and pattern-forming components of the mammalian locomotor CPG.

    abstract：:The ventromedial spinal cord of mammals contains a neural network known as the locomotor central pattern generator (CPG) which underlies the basic generation and coordination of muscle activity during walking. To understand how this neural network operates, it is necessary to identify, characterize, and map connectivi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.07.070

    authors： Griener A,Dyck J,Gosgnach S

    更新日期：2013-10-10 00:00:00

  • GABA and glycine immunolabeling in the chicken tangential nucleus.

    abstract：:In the vestibular nuclei, GABAergic and glycinergic neurons play important roles in signal processing for normal function, during development, and after peripheral vestibular lesions. The chicken tangential nucleus is a major avian vestibular nucleus, whose principal cells are projection neurons with axons transmittin...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.11.050

    authors： Popratiloff A,Peusner KD

    更新日期：2011-02-23 00:00:00

  • Thiamine deficiency in vitro accelerates A-type potassium current inactivation in cerebellar granule neurons.

    abstract：:Thiamine deficiency during embryonic or early postnatal development causes deficits in cerebellum-dependent activities including motor control and procedural memory. Here, we give a detailed description of the changes to A-type current in cultured cerebellar granule neurons exposed to thiamine deficiency in vitro. A-t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.06.053

    authors： Cruz JS,Kushmerick C,Moreira-Lobo DC,Oliveira FA

    更新日期：2012-09-27 00:00:00

  • Tonic and stimulus-evoked nitric oxide production in the mouse olfactory bulb.

    abstract：:Nitric oxide (NO) has been long assumed to play a key role in mammalian olfaction. This was based largely on circumstantial evidence, i.e. prominent staining for nitric oxide synthase (NOS) and cyclic guanosine 3',5'-cyclic monophosphate (cGMP) or soluble guanylyl cyclase, an effector enzyme activated by NO, in local ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.03.003

    authors： Lowe G,Buerk DG,Ma J,Gelperin A

    更新日期：2008-05-15 00:00:00

  • Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat.

    abstract：:Gut microbiota colonization is a key event for host physiology that occurs early in life. Disruption of this process leads to altered brain development which ultimately manifests as changes in brain function and behaviour in adulthood. Studies using germ-free (GF) mice highlight the extreme impact on brain health that...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.10.003

    authors： Hoban AE,Moloney RD,Golubeva AV,McVey Neufeld KA,O'Sullivan O,Patterson E,Stanton C,Dinan TG,Clarke G,Cryan JF

    更新日期：2016-12-17 00:00:00

  • Relationship between serotonin transporter occupancies and analgesic effects of AS1069562, the (+)-isomer of indeloxazine, and duloxetine in reserpine-induced myalgia rats.

    abstract：:Serotonin (5-HT) and norepinephrine (NE) have been implicated in the mediation of endogenous analgesic mechanisms via the descending inhibitory pain pathway in the brain, and dysfunction in both the 5-HT and NE systems has been suggested as an etiology of fibromyalgia (FM). Given that 5-HT reuptake inhibition in the b...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.12.065

    authors： Murai N,Fushiki H,Honda S,Murakami Y,Iwashita A,Irie M,Tamura S,Nagakura Y,Aoki T

    更新日期：2015-03-19 00:00:00

  • Hindbrain structures involved in pain processing as revealed by the expression of c-Fos and other immediate early gene proteins.

    abstract：:We have used the evoked expression of the immediate early gene-encoded proteins (c-Fos, Fos B, Jun B, Jun D, c-Jun and Krox-24) to monitor sensory processing in the hindbrain structures of rats undergoing somatic inflammation. Experiments were performed on freely moving animals that did not experience constraints othe...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90035-3

    authors： Lantéri-Minet M,Weil-Fugazza J,de Pommery J,Menétrey D

    更新日期：1994-01-01 00:00:00

  • Non-Invasive Assays of Cochlear Synaptopathy - Candidates and Considerations.

    abstract：:Studies in multiple species, including in post-mortem human tissue, have shown that normal aging and/or acoustic overexposure can lead to a significant loss of afferent synapses innervating the cochlea. Hypothetically, this cochlear synaptopathy can lead to perceptual deficits in challenging environments and can contr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.02.031

    authors： Bharadwaj HM,Mai AR,Simpson JM,Choi I,Heinz MG,Shinn-Cunningham BG

    更新日期：2019-05-21 00:00:00

  • Functional role of Barrington's nucleus in the micturition reflex: relevance in the surgical treatment of Parkinson's disease.

    abstract：:The pontine micturition center or Barrington's nucleus (BN) - besides regulating micturition - co-regulates the activity of other pelvic viscera such as the colon and genitals. At present, this issue is gaining particular importance due to: (i) recent findings of α-synuclein in BN, (ii) known urinary dysfunction in pa...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2014.02.002

    authors： Blanco L,Ros CM,Tarragón E,Fernández-Villalba E,Herrero MT

    更新日期：2014-04-25 00:00:00

  • Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) enhances neurogenesis via phosphatidylinositol 3-kinase/Akt and extracellular signal regulated kinase activation in the hippocampal subgranular zone after mouse focal cerebral ischemia.

    abstract：:Although neurogenesis in the hippocampus is critical for improvement of depressive behaviors and cognitive functions in neurodegeneration disorders, there is no therapeutic agent available to promote neurogenesis in adult brain following brain ischemic injury. Here we found that i.p. administration of bis(1-oxy-2-pyri...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.05.056

    authors： Shioda N,Han F,Morioka M,Fukunaga K

    更新日期：2008-08-26 00:00:00

  • Activin induces long-lasting N-methyl-D-aspartate receptor activation via scaffolding PDZ protein activin receptor interacting protein 1.

    abstract：:Calcium entry into the postsynaptic neuron through N-methyl-D-aspartate-type glutamate receptors (NMDARs) triggers the induction of long-term potentiation (LTP), which is considered to contribute to synaptic plasticity and plays a critical role in behavioral learning. We report here that activin, a member of the trans...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.12.012

    authors： Kurisaki A,Inoue I,Kurisaki K,Yamakawa N,Tsuchida K,Sugino H

    更新日期：2008-02-19 00:00:00

  • α6 and β1 Integrin Heterodimer Mediates Schwann Cell Interactions with Axons and Facilitates Axonal Regeneration after Peripheral Nerve Injury.

    abstract：:Several isoforms of integrin subunits are expressed in Schwann cells and mediate Schwann cell interactions with axons. Here, we identify α6 and β1 integrins as heterodimeric proteins expressed in Schwann cells and define their functions in axonal regeneration. α6 and β1 integrins are induced in Schwann cells in the sc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.11.046

    authors： Chang IA,Kim KJ,Namgung U

    更新日期：2018-02-10 00:00:00

  • Uptake and axonal transport of horseradish peroxidase isoenzymes by different neuronal types.

    abstract：:The uptake and transport of basic and acidic horseradish peroxidase isoenzymes was compared in the neuromuscular, visual and olfactory systems of Xenopus larvae and postmetamorphic frogs. The concentration (w/v) of the two preparations was corrected to compensate for their difference in enzymatic activity (unit/w), wh...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)92988-5

    authors： Key B,Giorgi PP

    更新日期：1987-09-01 00:00:00

  • Time-course of hippocampal granule cell degeneration and changes in adult neurogenesis after adrenalectomy in rats.

    abstract：:The hippocampus maintains the remarkable ability to generate new neurons throughout the lifespan. Progenitor cells in the subgranular zone give rise mainly to granule cells that migrate to the granule cell layer and become mature, functionally integrated neurons. Numerous factors are capable of regulating the prolifer...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.06.023

    authors： Spanswick SC,Epp JR,Sutherland RJ

    更新日期：2011-09-08 00:00:00

  • A stain for ischaemic or excessively stimulated neurons.

    abstract：:Loyez' myelin stain sometimes impregnates the perikarya and processes of neurons. This is rare in normal adult mice, but can be provoked by various means including electrical stimulation and mild ischaemia shortly before fixation. Passing a direct current or a train of pulses across the dura of the cerebral cortex pro...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90172-2

    authors： Clarke PG,Nussbaumer JC

    更新日期：1987-12-01 00:00:00

  • Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes.

    abstract：:An increased frequency of apolipoprotein E E4 allele has been reported in patients with late onset Alzheimer's disease. Apolipoprotein E participates in the transport of cholesterol and other lipids and interferes with the growth and regeneration of both peripheral and central nervous system tissues during development...

    journal_title：Neuroscience

    pub_type： 临床试验,杂志文章

    doi：10.1016/0306-4522(95)00014-a

    authors： Lehtovirta M,Laakso MP,Soininen H,Helisalmi S,Mannermaa A,Helkala EL,Partanen K,Ryynänen M,Vainio P,Hartikainen P

    更新日期：1995-07-01 00:00:00

  • A cholinoceptive desynchronized sleep induction zone in the anterodorsal pontine tegmentum: locus of the sensitive region.

    abstract：:Carbachol, a long-acting cholinergic agonist, was microinjected (4 micrograms/250 nl per 90 s) into 90 sites within the anterodorsal pontine tegmentum of four cats and the time to onset and percentage of time spent in a desynchronized sleep-like state during 40 min postinjection were calculated. Compared with more pos...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90267-8

    authors： Yamamoto K,Mamelak AN,Quattrochi JJ,Hobson JA

    更新日期：1990-01-01 00:00:00

  • The overrepresentation of the fovea and adjacent retina in the striate cortex and dorsal lateral geniculate nucleus of the macaque monkey.

    abstract：:The central part of the retina, which includes the fovea, is substantially overrepresented in the topographic map of the retina in the striate cortex. We tested whether this simply reflects the uneven distribution of ganglion cells in the retina in accordance with the "principle" of peripheral scaling, or whether ther...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00589-7

    authors： Azzopardi P,Cowey A

    更新日期：1996-06-01 00:00:00

  • Age-related audiovisual interactions in the superior colliculus of the rat.

    abstract：:It is well established that multisensory integration is a functional characteristic of the superior colliculus that disambiguates external stimuli and therefore reduces the reaction times toward simple audiovisual targets in space. However, in a condition where a complex audiovisual stimulus is used, such as the optic...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.01.058

    authors： Costa M,Piché M,Lepore F,Guillemot JP

    更新日期：2016-04-21 00:00:00

  • The auditory-evoked arousal modulates motor cortex excitability.

    abstract：:Arousal enhances the readiness to process sensory information and respond to it. Rapid increment of arousal, referred to as arousal reaction or startle, increases the level of attention and the chance of survival. Arousal reaction is known to originate from the brainstem ascending reticular activating system and to mo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.05.060

    authors： Löfberg O,Julkunen P,Pääkkönen A,Karhu J

    更新日期：2014-08-22 00:00:00