Haloperidol disrupts lipid rafts and impairs insulin signaling in SH-SY5Y cells.

abstract：:Interleukin-1 is known to exert pleiotropic effects in host defence mechanisms and in inflammation. Chronic pain, inflammation and interleukin-1 beta enhance the production of substance P. Recently, axonal transport of opiate receptors was found to increase in rat sciatic nerves in the model of Freund's adjuvant-induc...

journal_title：Neuroscience

authors： Jeanjean AP,Moussaoui SM,Maloteaux JM,Laduron PM

更新日期：1995-09-01 00:00:00

abstract：:In the ascending auditory pathway, the central nucleus of the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these presy...

journal_title：Neuroscience

authors： Wang H,Shen S,Zheng T,Bi L,Li B,Wang X,Yang Y,Jen PH

更新日期：2018-10-15 00:00:00

abstract：:A role has been suggested for hypothalamic alpha1 adrenoceptors in the acute stress-induced activation of the hypothalamic-pituitary-adrenal axis. Using a polyclonal antiserum against the rat alpha1B adrenergic receptor protein, we have demonstrated alpha1B receptor immunoreactivity in neurons and especially in puncta...

journal_title：Neuroscience

authors： Williams AM,Morilak DA

更新日期：1997-02-01 00:00:00

abstract：:Cortical auditory evoked potential (CAEP) testing, a non-invasive technique, is widely employed to study auditory brain development. The aim of this study was to investigate the development of the auditory electrophysiological signal without addressing specific abilities such as speech or music discrimination. We were...

journal_title：Neuroscience

authors： Lippé S,Martinez-Montes E,Arcand C,Lassonde M

更新日期：2009-12-15 00:00:00

abstract：:Previous studies have demonstrated that human astrocytes express mRNA and receptor protein for group I and II metabotropic glutamate receptors (mGluRs). Whether these receptors can influence the inflammatory and immune response and can modulate the capacity of astrocytes to produce inflammatory cytokines is still uncl...

journal_title：Neuroscience

authors： Aronica E,Gorter JA,Rozemuller AJ,Yankaya B,Troost D

更新日期：2005-01-01 00:00:00

abstract：:Extensive research over the past decades has characterized multiple forms of synaptic plasticity, identifying them as key processes that allow the brain to operate in a dynamic manner. Within the wide variety of synaptic plasticity modulators, kainate receptors are receiving increasing attention, given their diversity...

journal_title：Neuroscience

authors： Valbuena S,Lerma J

更新日期：2019-12-19 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with no effective method for its treatment so far. The pathogenesis of AD has been reported, but the endogenous metabolic profile and disease-related biomarkers are still not clear. To better understand AD, an AD model induced by injecting β-amyloid...

journal_title：Neuroscience

authors： Liu Y,Wei M,Yue K,Hu M,Li S,Men L,Pi Z,Liu Z,Liu Z

更新日期：2018-12-01 00:00:00

abstract：:It appears likely that, in analogy to the synaptic development of sensory and motor cortices, which critically depends on sensory or motor stimulation (Rosenzweig and Bennett, 1996), the synaptic development of limbic cortical regions are modulated by early postnatal cognitive and emotional experiences. The very first...

journal_title：Neuroscience

authors： Helmeke C,Poeggel G,Braun K

更新日期：2001-01-01 00:00:00

abstract：:The distribution of neuropeptide Y immunoreactive cell bodies in relation to various types of catecholamine-containing cell bodies in the rat brain was analyzed immunohistochemically using antisera to tyrosine hydroxylase, dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase. Coexistence of the peptide...

journal_title：Neuroscience

authors： Everitt BJ,Hökfelt T,Terenius L,Tatemoto K,Mutt V,Goldstein M

更新日期：1984-02-01 00:00:00

abstract：:The mesopontine tegmental anesthesia area (MPTA) is a small brainstem nucleus that, when exposed to minute quantities of GABAA receptor agonists, induces a state of general anesthesia. In addition to immobility and analgesia this state is accompanied by widespread suppression of neural activity in the cerebral cortex ...

journal_title：Neuroscience

authors： Lellouche Y,Minert A,Schreiber C,Aroch I,Vaso K,Fishman Y,Devor M

更新日期：2020-04-15 00:00:00

abstract：:This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons posit...

journal_title：Neuroscience

authors： Lee Y,Takami K,Kawai Y,Girgis S,Hillyard CJ,MacIntyre I,Emson PC,Tohyama M

更新日期：1985-08-01 00:00:00

abstract：:The excitation of densely packed mammalian central neurons is followed by a substantial transitory elevation of external K+ concentration. This phenomenon may have a different functional significance depending on how the resting membrane conductance mechanisms react to the changes in the gradient of these ions. We hav...

journal_title：Neuroscience

authors： Filippov V,Krishtal O

更新日期：1999-01-01 00:00:00

abstract：:Repeated administration of amphetamine-like psychostimulants produce a progressive and long-lasting hypersensitivity to their behavioural effects known as behavioural sensitization. Previous studies have shown that administration of the purinergic P2 receptor agonist 2-methylthio ATP into the nucleus accumbens of rats...

journal_title：Neuroscience

authors： Kittner H,Krügel U,Illes P

更新日期：2001-01-01 00:00:00

abstract：:Neurosteroids are synthesized de novo in the brain and the cerebellar Purkinje cell is a major site for neurosteroid formation. We have demonstrated that the rat Purkinje cell actively produces progesterone de novo from cholesterol only during neonatal life and progesterone promotes dendritic growth, spinogenesis and ...

journal_title：Neuroscience

authors： Sakamoto H,Ukena K,Takemori H,Okamoto M,Kawata M,Tsutsui K

更新日期：2004-01-01 00:00:00

abstract：:alpha-Calcitonin gene-related peptide expression in alpha-motoneurons is regulated by spinal cord transection, axotomy and testosterone, but to date there are no studies which examine the regulation of cholecystokinin expression in motoneurons. In the present study, we compared the regulation of preprocholecystokinin ...

journal_title：Neuroscience

authors： Popper P,Abelson L,Micevych PE

更新日期：1992-11-01 00:00:00

abstract：:The aim of this study was to assess the effect of blocking the axonal transport of sensory neuropeptides, by local injection of colchicine at pelvic ganglia level, on the sensory and efferent functions mediated by capsaicin-sensitive primary afferent neurons innervating the rat urinary bladder. Bilateral injection of ...

journal_title：Neuroscience

authors： Lecci A,Patacchini R,De Giorgio R,Corinaldesi R,Theodorsson E,Giuliani S,Santicioli P,Maggi CA

更新日期：1996-03-01 00:00:00

abstract：:S100beta is a calcium-binding peptide produced mainly by astrocytes that exerts paracrine and autocrine effects on neurons and glia. We have previously shown that S100beta is markedly elevated at the mRNA level in the spinal cord following peripheral inflammation, intraplantar administration of complete Freund's adjuv...

journal_title：Neuroscience

authors： Tanga FY,Raghavendra V,Nutile-McMenemy N,Marks A,Deleo JA

更新日期：2006-07-07 00:00:00

abstract：:Iron-overload can cause cognitive impairment due to blood-brain barrier (BBB) breakdown and brain mitochondrial dysfunction. Although deferiprone (DFP) has been shown to exert neuroprotection, the head-to-head comparison among iron chelators used clinically on brain iron-overload has not been investigated. Moreover, s...

journal_title：Neuroscience

authors： Sripetchwandee J,Wongjaikam S,Krintratun W,Chattipakorn N,Chattipakorn SC

更新日期：2016-09-22 00:00:00

abstract：:Mast cells are known for their participation in immediate and, more recently, delayed hypersensitivity reactions. They have been found in the meninges and certain brain areas where they are strictly perivascular, in close apposition to neurons, and they are activated by direct nerve stimulation or by neuropeptides. In...

journal_title：Neuroscience

authors： Theoharides TC,Dimitriadou V,Letourneau R,Rozniecki JJ,Vliagoftis H,Boucher W

更新日期：1993-12-01 00:00:00

abstract：:Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure. We have shown that a certain amount of (3)H₂O from the bloodstream enters osmotically loaded cerebrospinal fluid significantly fas...

journal_title：Neuroscience

authors： Klarica M,Miše B,Vladić A,Radoš M,Orešković D

更新日期：2013-09-17 00:00:00

abstract：:Mast cells and their location in the cat lateral geniculate complex of the thalamus were examined by means of histamine immunohistochemistry and the mast cell stain pinacyanol erythrosinate. Brain sections from seven normal adult pigmented cats were processed for light or electron microscopy. Histamine-containing and ...

journal_title：Neuroscience

authors： Manning KA,Pienkowski TP,Uhlrich DJ

更新日期：1994-11-01 00:00:00

abstract：:Within the D2-class of dopamine receptors, the D2 and D3 subtypes share the highest degree of similarity in their primary structure. However, the extent to which these two receptor subtypes have similar or different functional properties is unclear. The present study used gene targeting to generate mice deficient for ...

journal_title：Neuroscience

authors： Jung MY,Skryabin BV,Arai M,Abbondanzo S,Fu D,Brosius J,Robakis NK,Polites HG,Pintar JE,Schmauss C

更新日期：1999-01-01 00:00:00

abstract：:Limb somatosensory signals modify the discharge of vestibular neurons and elicit postural reflexes, which stabilize the body position. The aim of this study was to investigate the contribution of the γ-amino-butyric-acid (GABA) to the responsiveness of vestibular neurons to somatosensory inputs. The activity of 128 ve...

journal_title：Neuroscience

authors： Grasso C,Li Volsi G,Cataldo E,Manzoni D,Barresi M

更新日期：2016-10-29 00:00:00

abstract：:Intracellular stimulation of single propriospinal axons evoked excitatory postsynaptic potentials (EPSPs) in lumbar motoneurons. Mean EPSP amplitudes differed by two orders of magnitude when measured in different connections. After analyzing the distribution of mean amplitudes of 47 single-fiber EPSPs, two populations...

journal_title：Neuroscience

authors： Dityatev A,Birinyi A,Puskár Z,Antal M,Clamann HP

更新日期：2001-01-01 00:00:00

abstract：:Extensive studies have shown that a sports expert is superior to a sports novice in visually perceptual-cognitive processes of sports scene information, however the attentional and neural basis of it has not been thoroughly explored. The present study examined whether a sport expert has the attentional superiority on ...

journal_title：Neuroscience

authors： He M,Qi C,Lu Y,Song A,Hayat SZ,Xu X

更新日期：2018-05-21 00:00:00

abstract：:Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show increased plasma, spinal cord and brain corticosterone levels and focal adrenocortical hyperplasia, su...

journal_title：Neuroscience

authors： Meyer M,Lara A,Hunt H,Belanoff J,de Kloet ER,Gonzalez Deniselle MC,De Nicola AF

更新日期：2018-08-01 00:00:00

abstract：:It is not known why expression of a protein with an expanded polyglutamine region is pathogenic in spinocerebellar ataxia, Huntington's disease and several other neurodegenerative diseases. Dietary supplementation with creatine improves survival and motor performance and delays neuronal atrophy in the R6/2 transgenic ...

journal_title：Neuroscience

authors： Kaemmerer WF,Rodrigues CM,Steer CJ,Low WC

更新日期：2001-01-01 00:00:00

abstract：:The blockade of the central nucleus of the amygdala (CeA) with the GABAA receptor agonist muscimol significantly reduces hypertonic NaCl and water intake by sodium-depleted rats. In the present study we investigated the effects of previous injection of losartan, an angiotensin II type-1 (AT1) receptor antagonist, into...

journal_title：Neuroscience

authors： Hu B,Qiao H,Sun B,Jia R,Fan Y,Wang N,Lu B,Yan JQ

更新日期：2015-10-29 00:00:00

abstract：:We evaluate a novel set-up for scanning functional connectivity in brain slices from the somatosensory cortex of the rat. Upright infrared video microscopy for targeted placement of electrodes is combined with rapid photolysis of bath-applied caged neurotransmitter induced by a xenon flash lamp. Flash photolysis of ca...

journal_title：Neuroscience

authors： Kötter R,Staiger JF,Zilles K,Luhmann HJ

更新日期：1998-09-01 00:00:00

abstract：:Activities of daily living require simultaneous and coordinated activation of trunk and upper-limb segments, which involves complex interlimb interaction within the central nervous system. Although many studies have reported associations between activity of trunk and limb muscles during functional tasks, evidence on c...

journal_title：Neuroscience

authors： Sasaki A,Milosevic M,Nakazawa K

更新日期：2020-12-15 00:00:00