Study on Urine Metabolic Profile of Aβ25-35-Induced Alzheimer's Disease Using UHPLC-Q-TOF-MS.

abstract：:Differences in the uptake of tracers from radioactive 2-deoxyglucose ([1,2-3H] and [2,6-3H]), and glucose ([1-3H], [3-3H]) into hippocampal regions were investigated by freeze-mount microautoradiography after 45 min for 2-deoxyglucose, and after 15 and 45 min for glucose. Silver grains were assessed quantitatively by ...

journal_title：Neuroscience

authors： Shimada M,Shimono R,Ozaki HS

更新日期：1989-01-01 00:00:00

abstract：:Activation of neural stem/progenitor cells (NSPCs) is a potential therapeutic strategy of neurological disorders. In this study, NSPCs of subventricular zone were isolated and cultured from platelet-derived growth factor-β-receptor-knockout (PDGFR-β(-/-)) mice of postnatal day 1 (P1) and P28, and the roles of PDGFR-β ...

journal_title：Neuroscience

authors： Xu G,Shen J,Ishii Y,Fukuchi M,Dang TC,Zheng Y,Hamashima T,Fujimori T,Tsuda M,Funa K,Sasahara M

更新日期：2013-05-15 00:00:00

abstract：:Increasing evidence indicates that endothelin-1 has a role for peripheral nociceptive signaling in animals and humans. However, the mechanisms of the nociceptive effects of endothelin-1 have not been fully understood. The current study investigated the effects of endothelin-1 on the capsaicin-evoked intracellular Ca2+...

journal_title：Neuroscience

authors： Yamamoto H,Kawamata T,Ninomiya T,Omote K,Namiki A

更新日期：2006-02-01 00:00:00

abstract：:Past studies have implicated calcium influx through the N-methyl-D-aspartate class of ionotropic glutamate receptors as a key factor in excitotoxicity. Here, primary cultures of hippocampal neurons were exposed to N-methyl-D-aspartate with or without the L-type calcium channel agonist BayK8644(+/-). Calcium influxes w...

journal_title：Neuroscience

authors： Barger SW

更新日期：1999-03-01 00:00:00

abstract：:The effects of steady iontophoretic applications of serotonin on the spontaneous discharge and on the excitatory responses induced in deep cerebellar nuclei neurons by iontophoretic pulse applications of L-glutamate, L-aspartate, N-methyl-D,L-aspartate and quisqualate were studied in rat cerebellar slices maintained i...

journal_title：Neuroscience

authors： Gardette R,Krupa M,Crepel F

更新日期：1987-11-01 00:00:00

abstract：:The mechanisms involved in morphine tolerance are poorly understood. It was reported by our group that calcitonin gene-related peptide (CGRP)-like immunoreactivity (IR) was increased in the spinal dorsal horn during morphine tolerance [Ménard et al. (1996) J. Neurosci. 16, 2342-2351]. More recently, we observed that i...

journal_title：Neuroscience

authors： Belanger S,Ma W,Chabot JG,Quirion R

更新日期：2002-01-01 00:00:00

abstract：:Leptin and somatostatin (SRIF) have opposite effects on food seeking and ingestive behaviors, functions partially regulated by the frontoparietal cortex and hippocampus. Although it is known that the acute suppression of food intake mediated by leptin decreases with time, the counter-regulatory mechanisms remain uncle...

journal_title：Neuroscience

authors： Perianes-Cachero A,Burgos-Ramos E,Puebla-Jiménez L,Canelles S,Frago LM,Hervás-Aguilar A,de Frutos S,Toledo-Lobo MV,Mela V,Viveros MP,Argente J,Chowen JA,Arilla-Ferreiro E,Barrios V

更新日期：2013-11-12 00:00:00

abstract：:We have previously demonstrated that progesterone significantly increases the rate of myelination in organotypic slice cultures of 7-day-old rat and mouse cerebellum. Here, we show that progesterone (20microM) stimulates the proliferation of oligodendrocyte precursors in cultured cerebellar slices of 7-day-old rats. T...

journal_title：Neuroscience

authors： Ghoumari AM,Baulieu EE,Schumacher M

更新日期：2005-01-01 00:00:00

abstract：:Some glutamatergic synapses in the mammalian central nervous system exhibit high levels of free ionic zinc in their synaptic vesicles. The precise role of this vesicular zinc remains obscure, despite suggestive evidence for zinc as a neuromodulator. As a step towards elucidating the role of free zinc in the brain we h...

journal_title：Neuroscience

authors： Budde T,Minta A,White JA,Kay AR

更新日期：1997-07-01 00:00:00

abstract：:Previous findings, mainly in in vitro systems, have shown that the density of vesicles and the synaptic efficacy at excitatory synapses are reduced in the absence of synapsins, despite the fact that transgenic mice lacking synapsins develop an epileptic phenotype. Here we study glutamate receptors by quantitative immu...

journal_title：Neuroscience

authors： Gylterud Owe S,Bogen IL,Walaas SI,Storm-Mathisen J,Bergersen LH

更新日期：2005-01-01 00:00:00

abstract：:It is well established that task complexity can affect both performance and brain processing. Event-related potentials (ERPs) studies have shown modulation of the well-known N2 and P3 components. However, limited information is available on the recently described frontal components associated with processing within th...

journal_title：Neuroscience

authors： Mussini E,Berchicci M,Bianco V,Perri RL,Quinzi F,Di Russo F

更新日期：2020-11-21 00:00:00

abstract：:Reg-2 is a secreted protein that is expressed de novo in motoneurons, sympathetic neurons, and dorsal root ganglion (DRG) neurons after nerve injury and which can act as a Schwann cell mitogen. We now show that Reg-2 is also upregulated by DRG neurons in inflammation with a very unusual expression pattern. In a rat mo...

journal_title：Neuroscience

authors： Averill S,Inglis JJ,King VR,Thompson SW,Cafferty WB,Shortland PJ,Hunt SP,Kidd BL,Priestley JV

更新日期：2008-09-09 00:00:00

abstract：:Olvanil ((N-vanillyl)-9-oleamide), a non-pungent transient receptor potential vanilloid type 1 agonist, desensitizes nociceptors and alleviates pain. But its molecular targets and signaling mechanisms are little known. Calcium influx through voltage-activated Ca(2+) channels plays an important role in neurotransmitter...

journal_title：Neuroscience

authors： Wu ZZ,Chen SR,Pan HL

更新日期：2006-08-11 00:00:00

abstract：:To examine changes in corticostriatal synaptic transmission in rats with ethanol withdrawal syndrome, intracellular and extracellular responses to subcortical white matter stimulation were recorded in neostriatal slice preparations. The resting membrane potential, input resistance and depolarizing postsynaptic potenti...

journal_title：Neuroscience

authors： Yamamoto Y,Nakanishi H,Takai N,Shimazoe T,Watanabe S,Kita H

更新日期：1999-01-01 00:00:00

abstract：:It has recently become clear that the neurotrophic factor, nerve growth factor, interacts specifically with nociceptive sensory neurons during development and maturity. Indeed, it may serve as a critical link between inflammation and the hyperalgesia that ensues in adult animals. Nerve growth factor is normally expres...

journal_title：Neuroscience

authors： Davis BM,Lewin GR,Mendell LM,Jones ME,Albers KM

更新日期：1993-10-01 00:00:00

abstract：:It is commonly believed that the cell bodies of mammalian sensory neurons are contained within spinal and cranial sensory ganglia associated with the central nervous system or within the central nervous system itself. However, strong circumstantial evidence implies that some sensory neurons are contained entirely with...

journal_title：Neuroscience

authors： Kunze WA,Bornstein JC,Furness JB

更新日期：1995-05-01 00:00:00

abstract：:By its projections to the primary visual and the prefrontal cortices, the basal forebrain cholinergic system is involved in cognitive processing of sensory stimuli. It has been suggested that visual stimulus-induced cholinergic activation of the visual cortex may exert a permissive role on thalamocortical inputs. Howe...

journal_title：Neuroscience

authors： Laplante F,Morin Y,Quirion R,Vaucher E

更新日期：2005-01-01 00:00:00

abstract：:Neurosteroids such as dehydroepiandrosterone (DHEA), pregnenolone and 17beta-estradiol are synthesized by cytochrome P450s from endogenous cholesterol. We previously reported a new cytochrome P450 enzyme, CYP7B, highly expressed in rat and mouse brain that metabolizes DHEA and related steroids by hydroxylation at the ...

journal_title：Neuroscience

authors： Yau JL,Rasmuson S,Andrew R,Graham M,Noble J,Olsson T,Fuchs E,Lathe R,Seckl JR

更新日期：2003-01-01 00:00:00

abstract：:Huntington's disease is a genetic disease, autosomal and dominant, that induces motor disorders, an inexorable deterioration of higher brain functions and psychiatric disturbances. At present, there are no known therapeutics against Huntington's disease. The Network of European CNS Transplantation and Restoration (NEC...

journal_title：Neuroscience

authors： Peschanski M,Cesaro P,Hantraye P

更新日期：1995-09-01 00:00:00

abstract：:The neuropeptide oxytocin (OT) has been implicated in a range of mammalian reproductive and social behaviors including parent-offspring bonding and partner preference formation between socially monogamous mates. Its role in mediating non-reproductive social relationships in rodents, however, remains largely unexplored...

journal_title：Neuroscience

authors： Beery AK,Zucker I

更新日期：2010-08-25 00:00:00

abstract：:Despite a long history of interrogation, the functional organization of motor cortex remains obscure. A major barrier has been the inability to measure and perturb activity with sufficient resolution to reveal clear functional elements within motor cortex and its associated circuits. Increasingly, the mouse has been e...

journal_title：Neuroscience

authors： Warriner CL,Fageiry SK,Carmona LM,Miri A

更新日期：2020-12-01 00:00:00

abstract：:A double transgenic mouse expressing the amyloid precursor protein, bearing the Swedish mutations, and expressing tau protein containing three of the mutations present in frontotemporal dementia linked to chromosome 17 (FTDP-17), has been characterized. In the double transgenic mouse an increase in tau phosphorylation...

journal_title：Neuroscience

authors： Pérez M,Ribe E,Rubio A,Lim F,Morán MA,Ramos PG,Ferrer I,Isla MT,Avila J

更新日期：2005-01-01 00:00:00

abstract：:The membrane properties and receptor-mediated responses of rat dorsal raphe nucleus neurons were measured using intracellular recording techniques in a slice preparation. After each experiment, the recorded neuron was filled with neurobiotin and immunohistochemically identified as 5-hydroxytryptamine (5-HT)-immunoposi...

journal_title：Neuroscience

authors： Kirby LG,Pernar L,Valentino RJ,Beck SG

更新日期：2003-01-01 00:00:00

abstract：:Fifteen percent to 35% of the United States population experiences tinnitus, a subjective "ringing in the ears". Up to 10% of those afflicted report severe and disabling symptoms. Tinnitus was induced in rats using unilateral, 1 h, 17 kHz-centered octave-band noise (116 dB SPL) and assessed using a gap-startle method....

journal_title：Neuroscience

authors： Wang H,Brozoski TJ,Turner JG,Ling L,Parrish JL,Hughes LF,Caspary DM

更新日期：2009-12-01 00:00:00

abstract：:Phospholipids and cholesterol were found to be the main lipids in mature and immature neuroblastoma cells. The ratios for the total cholesterol/phospholipids in these undifferentiated and differentiated cells were 0.33 and 0.52, respectively. The ratios of 0.45 and 0.62 were obtained with corresponding plasma membrane...

journal_title：Neuroscience

authors： Gulaya NM,Volkov GL,Klimashevsky VM,Govseeva NN,Melnik AA

更新日期：1989-01-01 00:00:00

abstract：:Our previous studies indicate that endogenous opioids (primarily beta-endorphin) released during stressful stimuli can interact with peripheral opioid receptors to inhibit nociception in inflamed tissue of rats. This study sought to localize opioid precursor mRNAs and opioid peptides deriving therefrom in inflamed tis...

journal_title：Neuroscience

authors： Przewłocki R,Hassan AH,Lason W,Epplen C,Herz A,Stein C

更新日期：1992-01-01 00:00:00

abstract：:Mesopontine cholinergic neurons have been implicated in the initiation and maintenance of rapid eye movement sleep via their efferent connections to the thalamus and the medial pontine reticular formation. As a first step toward understanding how these modulatory neurons integrate synaptic input, we have investigated ...

journal_title：Neuroscience

authors： Surkis A,Taylor B,Peskin CS,Leonard CS

更新日期：1996-09-01 00:00:00

abstract：:Rat cerebrocortical minislices were incubated with physiological saline in the absence or presence of 5 mM ammonium acetate ("ammonia") and/or inhibitors of osmosensitive amino acid transport: 50 microM niflumic acid and 100 microM N-ethyl-maleimide for 60 min, with medium changes after 20 min and 40 min. The efflux o...

journal_title：Neuroscience

authors： Zielińska M,Hilgier W,Law RO,Goryński P,Albrecht J

更新日期：1999-01-01 00:00:00

abstract：:Enteric viscerofugal neurons are mechanosensory interneurons that form the afferent limb of intestino-intestinal reflexes involving prevertebral sympathetic neurons. Fast synaptic inputs to viscerofugal neurons arise from other enteric neurons, but their sources are unknown. We aimed to describe the origins of synapti...

journal_title：Neuroscience

authors： Hibberd TJ,Spencer NJ,Zagorodnyuk VP,Chen BN,Brookes SJ

更新日期：2014-09-05 00:00:00

abstract：:Perceiving the sensory consequences of our actions with a delay alters the interpretation of these afferent signals and impacts motor learning. For reaching movements, delayed visual feedback of hand position reduces the rate and extent of visuomotor adaptation, but substantial adaptation still occurs. Moreover, the d...

journal_title：Neuroscience

authors： Shiller DM,Mitsuya T,Max L

更新日期：2020-10-15 00:00:00