Towards Cell and Subtype Resolved Functional Organization: Mouse as a Model for the Cortical Control of Movement.

abstract：:The Tg2576 mouse model of Alzheimer's disease (AD) exhibits age-dependent amyloid beta (Abeta) deposition in the brain. We studied electroencephalographically defined sleep and the circadian regulation of waking activities in Tg2576 mice to determine whether these animals exhibit sleep abnormalities akin to those in A...

journal_title：Neuroscience

authors： Wisor JP,Edgar DM,Yesavage J,Ryan HS,McCormick CM,Lapustea N,Murphy GM Jr

更新日期：2005-01-01 00:00:00

abstract：:Ochratoxin A (OTA), a mycotoxin and widespread food contaminant, is known for its patent nephrotoxicity and potential neurotoxicity. Previous observations in vitro showed that in the CNS, glial cells were particularly sensitive to OTA. In the search for the molecular mechanisms underlying OTA neurotoxicity, we investi...

journal_title：Neuroscience

authors： Zurich MG,Lengacher S,Braissant O,Monnet-Tschudi F,Pellerin L,Honegger P

更新日期：2005-01-01 00:00:00

abstract：:Neuronal loss is the most common and critical feature of a spectrum of brain traumas and neurodegenerative disorders such as Alzheimer's disease (AD). The capacity to generate new neurons in the central nervous system diminishes early during brain development and is restricted mainly to two brain areas in the mature b...

journal_title：Neuroscience

authors： Yeung ST,Myczek K,Kang AP,Chabrier MA,Baglietto-Vargas D,Laferla FM

更新日期：2014-02-14 00:00:00

abstract：:Classic neurotransmitter phenotypes are generally predetermined and develop as a consequence of target-independent lineage decisions. A unique mode of target-dependent phenotype instruction is the acquisition of the cholinergic phenotype in the peripheral sympathetic nervous system. A body of work suggests that the sw...

journal_title：Neuroscience

authors： Schütz B,von Engelhardt J,Gördes M,Schäfer MK,Eiden LE,Monyer H,Weihe E

更新日期：2008-10-02 00:00:00

abstract：:Previous studies found that prostaglandins in skeletal muscle play a role in evoking the exercise pressor reflex; however the role played by prostaglandins in the spinal transmission of the reflex is not known. We determined, therefore, whether or not spinal blockade of cyclooxygenase (COX) activity and/or spinal bloc...

journal_title：Neuroscience

authors： Stone AJ,Copp SW,Kaufman MP

更新日期：2014-09-26 00:00:00

abstract：:Lysophosphatidic acid receptor (LPA(1)) signaling initiates neuropathic pain and several pathological events in a partial sciatic nerve injury model. Recently, we reported that lysophosphatidic acid (LPA) induces neuropathic pain as well as demyelination and pain-related protein expression changes via LPA(1) receptor ...

journal_title：Neuroscience

authors： Inoue M,Xie W,Matsushita Y,Chun J,Aoki J,Ueda H

更新日期：2008-03-18 00:00:00

abstract：:Development and differentiation of basal forebrain-derived cholinergic neurons were studied using a new technique that combines dissociated cell cultures with organotypic slice cultures. Slices of cerebral cortex or entire forebrain hemispheres were taken from early postnatal rat pups and maintained as organotypic cul...

journal_title：Neuroscience

authors： Robertson RT,Baratta J,Kageyama GH,Ha DH,Yu J

更新日期：1997-10-01 00:00:00

abstract：:The study of the neural basis of predatory behavior has been largely neglected over the recent years. Using an ethologically based approach, we presently delineate the prosencephalic systems mobilized during predation by examining Fos immunoreactivity in rats performing insect hunting. These results were further compa...

journal_title：Neuroscience

authors： Comoli E,Ribeiro-Barbosa ER,Negrão N,Goto M,Canteras NS

更新日期：2005-01-01 00:00:00

abstract：:Certain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that re...

journal_title：Neuroscience

authors： Zhu YY,Jing L,Duan TT,Yuan Q,Cao J,Zhou QX,Xu L

更新日期：2013-10-10 00:00:00

abstract：:Histamine H(3) autoreceptors induce a negative feedback on histamine synthesis and release. While it is known that cAMP/cAMP dependent protein kinase (PKA) and Ca(2+)/CaMKII transduction pathways mediate H(3) effects on histamine synthesis, the pathways regulating neuronal histamine release are poorly known. Given the...

journal_title：Neuroscience

authors： Moreno-Delgado D,Gómez-Ramírez J,Torrent-Moreno A,González-Sepúlveda M,Blanco I,Ortiz J

更新日期：2009-12-15 00:00:00

abstract：:Clinical reports show that oxytocin (OT) is related to stress-related disorders such as depression, anxiety disorder, and post-traumatic stress disorder. Two key structures in the brain should be paid special attention with regard to stress regulation, namely, the hypothalamus and the hippocampus. The former is the re...

journal_title：Neuroscience

authors： Matsushita H,Latt HM,Koga Y,Nishiki T,Matsui H

更新日期：2019-10-01 00:00:00

abstract：:In partially denervated skeletal muscle, spared motor fibres sprout, enlarging motor unit size. Neuritogenesis and sprouting are known to depend on the synaptic input to the neurons. This suggests that spared motoneuron reaction to partial muscle denervation might be controlled by primary sensory neurons which directl...

journal_title：Neuroscience

authors： Cuppini R,Ambrogini P,Sartini S

更新日期：1998-05-01 00:00:00

abstract：:Using arsenazo III as an intracellular indicator to monitor the calcium transients elicited by voltage-clamp depolarizing pulse, the effect of prolonged in vitro lithium treatment on excitation--contraction coupling in frog twitch muscle fibres was investigated. Incubation in 10 mM Li+ Ringer's solution for 2 days cau...

journal_title：Neuroscience

authors： Zhu PH,Fu DX

更新日期：1990-01-01 00:00:00

abstract：:Our series of rat experiments have shown that locomotor activity, arousal level, body and brown adipose tissue temperatures, heart rate and arterial pressure increase episodically in an integrated manner approximately every 100min (ultradian manner). Although it has been proposed that the integrated ultradian pattern ...

journal_title：Neuroscience

authors： Miyata K,Kuwaki T,Ootsuka Y

更新日期：2016-10-15 00:00:00

abstract：:Cortical pyramidal neurons are considered to be less excitable in the immature cortex than in adults. Our previous report revealed that a negative feedback regulation of membrane excitability is highly correlated with a novel form of calcium release from inositol-1,4,5-trisphosphate (IP(3))-sensitive calcium stores (I...

journal_title：Neuroscience

authors： Yamamoto K,Nakano M,Hashimoto K,Shimohama S,Kato N

更新日期：2002-01-01 00:00:00

abstract：:Laminins are the major glycoproteins present in basement membrane, a type of extracellular matrix. We showed that the LAMB1 gene, which encodes the laminin beta1 subunit, is transcriptionally activated by retinoic acid in embryonic stem cells. However, little information is available concerning LAMB1 developmental reg...

journal_title：Neuroscience

authors： Sharif KA,Baker H,Gudas LJ

更新日期：2004-01-01 00:00:00

abstract：:In the past 15 years the classical view that astrocytes play a relatively passive role in brain function has been overturned and it has become increasingly clear that signaling between neurons and astrocytes may play a crucial role in the information processing that the brain carries out. This new view stems from two ...

journal_title：Neuroscience

authors： Santello M,Volterra A

更新日期：2009-01-12 00:00:00

abstract：:In a natural acoustic environment, sound stimuli often occur in a contextual acoustic stream. The aim of the present study was to determine how the frequency tuning of auditory cortical neurons is affected by an acoustic context. A forward masking paradigm was used to determine the frequency receptive fields of rat au...

journal_title：Neuroscience

authors： Peng Y,Sun X,Zhang J

更新日期：2010-09-01 00:00:00

abstract：:In this study, we describe a model of opiate sensitization characterized by a brief schedule of treatment with repeated morphine administrations. In this model, we investigated the changes produced by repeated morphine treatment on dopamine transmission at the level of the two major terminal dopaminergic areas, the do...

journal_title：Neuroscience

authors： Cadoni C,Di Chiara G

更新日期：1999-05-01 00:00:00

abstract：:Manganese-enhanced MRI (MEMRI) is a newly developed noninvasive imaging technique of brain activities. The signal intensity of MEMRI reflects cumulative activities of the neurons. To validate the use of MEMRI technique to investigate the neural mechanisms of learning and memory, we tried to map brain areas involved in...

journal_title：Neuroscience

authors： Inui-Yamamoto C,Yoshioka Y,Inui T,Sasaki KS,Ooi Y,Ueda K,Seiyama A,Ohzawa I

更新日期：2010-05-05 00:00:00

abstract：:Zinc plays an important role in synaptic signaling in the mammalian cerebral cortex. Zinc is sequestered into presynaptic vesicles of subpopulations of glutamatergic neurons and is released by depolarization, in a calcium-dependent manner. As the majority of mechanisms that have been suggested to participate in experi...

journal_title：Neuroscience

authors： Brown CE,Dyck RH

更新日期：2003-01-01 00:00:00

abstract：:In this study, the nonlinear prediction method combined with Gaussian-scaled surrogate data was used to quantify, as a first goal, the chaotic behavior of the interspike interval of ventral tegmental area dopaminergic neurons, extracellularly recorded in vivo, in anesthetized rats. The second goal was to determine the...

journal_title：Neuroscience

authors： Di Mascio M,Di Giovanni G,Di Matteo V,Esposito E

更新日期：1999-01-01 00:00:00

abstract：:In this study, using an in vitro superfusion technique for the first time, we provide direct neurochemical evidence of the transmitter role of dopamine at the level of lateral olivocochlear efferent fibres of the guinea-pig cochlea. Our results revealed that nerve terminals are able to take up and release dopamine upo...

journal_title：Neuroscience

authors： Gáborján A,Lendvai B,Vizi ES

更新日期：1999-04-01 00:00:00

abstract：:Serotonin (5-HT) and norepinephrine (NE) have been implicated in the mediation of endogenous analgesic mechanisms via the descending inhibitory pain pathway in the brain, and dysfunction in both the 5-HT and NE systems has been suggested as an etiology of fibromyalgia (FM). Given that 5-HT reuptake inhibition in the b...

journal_title：Neuroscience

authors： Murai N,Fushiki H,Honda S,Murakami Y,Iwashita A,Irie M,Tamura S,Nagakura Y,Aoki T

更新日期：2015-03-19 00:00:00

abstract：:The rodent whisker-barrel system is characterized by its patterned somatotopic mapping between the sensory periphery and multiple regions of the brain. While somatotopy in the whisker system is established, we know far less about how preferences for stimulus orientation or other features are organized. Mouse somatosen...

journal_title：Neuroscience

authors： Kwon SE,Tsytsarev V,Erzurumlu RS,O'Connor DH

更新日期：2018-01-01 00:00:00

abstract：:Glutamate excitotoxicity has been suggested to play a role in amyotrophic lateral sclerosis, since overstimulation of post-synaptic glutamate receptors by accumulated extracellular glutamate leads to motoneuron cell death. It is however unclear as to why some groups of motoneurons degenerate in this disease while othe...

journal_title：Neuroscience

authors： Ma L,Ostrovsky H,Miles G,Lipski J,Funk GD,Nicholson LF

更新日期：2006-11-17 00:00:00

abstract：:Rats receiving a complete spinal cord transection (ST) at a neonatal stage spontaneously can recover significant stepping ability, whereas minimal recovery is attained in rats transected as adults. In addition, neonatally spinal cord transected rats trained to step more readily improve their locomotor ability. We hypo...

journal_title：Neuroscience

authors： Tillakaratne NJ,Guu JJ,de Leon RD,Bigbee AJ,London NJ,Zhong H,Ziegler MD,Joynes RL,Roy RR,Edgerton VR

更新日期：2010-03-10 00:00:00

abstract：:Sucrose gap techniques recorded dorsal root potentials evoked by supramaximal dorsal root stimulation in in vitro, hemisected frog spinal cords. In 0 mM Mg2+ large (mean 13.0 mV), long lasting (mean 8.1 s) dorsal root potentials were recorded which consisted of two components: (1) an early component sensitive to picro...

journal_title：Neuroscience

authors： Hackman JC,Davidoff RA

更新日期：1991-01-01 00:00:00

abstract：:Functional imaging studies have implicated the hippocampus and parahippocampal gyrus in cue-guided spatial navigation, but also many other regions. Furthermore, little is known about de-activations that take place during performance of navigation tasks, something that is of interest given that the hippocampus is a com...

journal_title：Neuroscience

authors： Salgado-Pineda P,Landin-Romero R,Pomes A,Spanlang B,Sarró S,Salvador R,Slater M,McKenna PJ,Pomarol-Clotet E

更新日期：2017-09-01 00:00:00

abstract：:The neuropeptide substance P is an excitatory neurotransmitter produced by various cells including neurons and microglia that is involved in regulating inflammation and cerebral blood flow--functions that affect sleep and slow-wave activity (SWA). Substance P is the major ligand for the neurokinin-1 receptor (NK-1R), ...

journal_title：Neuroscience

authors： Zielinski MR,Karpova SA,Yang X,Gerashchenko D

更新日期：2015-01-22 00:00:00