Reduced chaos of interspike interval of midbrain dopaminergic neurons in aged rats.

abstract：:After loading cultured rat hippocampal neurons with teh acetoxymethyl ester of the Ca2+ buffer BAPTA, or its dimethyl analogue DMB, the magnitudes of transient (20-25 s) depolarization- or excitatory amino acid-induced Ca2+ responses were reduced, as were the rates of increase and recovery of [Ca2+]i. In contrast, dur...

journal_title：Neuroscience

authors： Abdel-Hamid KM,Baimbridge KG

更新日期：1997-12-01 00:00:00

abstract：:The effect of capsaicin on voltage-activated calcium currents was investigated in voltage-clamped somata of cultured adult rat dorsal root ganglion neurons. About half the neurons studied were sensitive to capsaicin, which induced an inward current at negative membrane potentials accompanied by an increase in membrane...

journal_title：Neuroscience

authors： Docherty RJ,Robertson B,Bevan S

更新日期：1991-01-01 00:00:00

abstract：:In order to study structural alterations which occur after a defined unilateral cortical infarct, the hindlimb region of the rat cortex was photochemically lesioned. The infarcts caused edema restricted to the perilesional cortex which affected allocortical and isocortical areas differently. Postlesional changes in cy...

journal_title：Neuroscience

authors： Bidmon HJ,Jancsik V,Schleicher A,Hagemann G,Witte OW,Woodhams P,Zilles K

更新日期：1998-01-01 00:00:00

abstract：:The purpose of the present study was to examine whether the rostroventral portion of the medulla oblongata (RVM) exerts descending modulation on the cardiosomatic motor reflex (CMR) in rats. Capsaicin (1 μg/ml, 0.2 ml) was injected into the pericardial sac as an algesic substance to induce the CMR, which was monitored...

journal_title：Neuroscience

authors： Sun N,Liu XH,Du JQ,Zhu JX,Tang JS,Li Q

更新日期：2011-06-30 00:00:00

abstract：:Administration of kainic acid induces acute seizures that result in the loss of neurons, gliosis and reorganization of mossy fiber pathways in the hippocampus resembling those observed in human temporal lobe epilepsy. Although these structural changes have been well characterized, the mechanisms underlying the degener...

journal_title：Neuroscience

authors： Banerjee M,Sasse VA,Wang Y,Maulik M,Kar S

更新日期：2015-01-22 00:00:00

abstract：:The present experiments examined the role of excitatory amino acid receptors in the orofacial stereotypy induced by direct amphetamine microinjection into the ventrolateral striatum. In these experiments, the influence of prior intra-ventrolateral striatum treatment with various excitatory amino acid antagonists on th...

journal_title：Neuroscience

authors： Kelley AE,Delfs JM

更新日期：1994-05-01 00:00:00

abstract：:Activation of cardiac sympathetic afferents elicits pain and excitatory cardiovascular reflexes including acute hypertension and tachyarrhythmias. Our previous studies have shown that specific regions in the medulla, such as the nucleus of solitary tract and ventrolateral medulla, are involved in central regulation of...

journal_title：Neuroscience

authors： Guo Z-,Li P,Longhurst JC

更新日期：2002-01-01 00:00:00

abstract：:Induction of heat shock/stress proteins is a key feature of a universal mechanism of cellular defence to injury known as the "stress response". The present study investigated whether heat shock protein expression correlates with the extent of neuronal injury inflicted by increasingly intense seizure activity. Limbic e...

journal_title：Neuroscience

authors： Gass P,Prior P,Kiessling M

更新日期：1995-03-01 00:00:00

abstract：:Changes in the amplitude of the calcium inward current caused by intracellular administration of tolbutamide (an inhibitor of the cyclic AMP-dependent protein kinase activity) or catalytic subunits of cAMP-dependent protein kinases from rabbit myocardium were studied on internally perfused nerve cells of the snail, He...

journal_title：Neuroscience

authors： Doroshenko PA,Kostyuk PG,Martynyuk AE,Kursky MD,Vorobetz ZD

更新日期：1984-01-01 00:00:00

abstract：:Sixty-three cortically projecting basal forebrain neurons were identified in chloral hydrate anesthetized rats by antidromic activation from the cerebral cortex. Two subpopulations were noted: type I neurons exhibited two antidromic action potentials of constant latency and identical waveform in response to double pul...

journal_title：Neuroscience

authors： Reiner PB,Semba K,Fibiger HC,McGeer EG

更新日期：1987-02-01 00:00:00

abstract：:Localized distension of the intestine evokes an ascending excitatory reflex and a descending inhibitory reflex in the circular muscle layer. The sequential activation of these two reflexes is believed to underlie the motor pattern of peristalsis, which is responsible for the co-ordinated propulsion of intestinal conte...

journal_title：Neuroscience

authors： Tonini M,Costa M,Brookes SJ,Humphreys CM

更新日期：1996-07-01 00:00:00

abstract：:In vivo voltammetry was used to study the effects of basolateral amygdala dopamine depletion on stress-induced dopamine release in the nucleus accumbens and medial prefrontal cortex. Male Long-Evans rats received bilateral microinjections of 6-hydroxydopamine or vehicle into the basolateral amygdala. Changes in dopami...

journal_title：Neuroscience

authors： Stevenson CW,Sullivan RM,Gratton A

更新日期：2003-01-01 00:00:00

abstract：:The aim of the present study was to investigate whether the activation of muscarinic receptors is a preliminary step to the endogenous release of nitric oxide modulating nicotinic transmission within the prevertebral ganglia. This work has been performed in vitro in isolated rabbit coeliac ganglion. The electrical act...

journal_title：Neuroscience

authors： Quinson N,Miolan JP,Niel JP

更新日期：2000-01-01 00:00:00

abstract：:Stepping over an obstacle is preceded by a center of pressure (CoP) shift, termed anticipatory postural adjustments (APAs). It provides an acceleration of the center of mass forward and laterally prior to step initiation. The APAs are characterized in the lateral direction by a force exerted by the moving leg onto the...

journal_title：Neuroscience

authors： Ruget H,Blouin J,Teasdale N,Mouchnino L

更新日期：2008-08-26 00:00:00

abstract：:The roles of the central noradrenergic and serotonergic system in the activity-dependent regulation of ocular dominance plasticity have been a contentious issue. Using c-Fos activity mapping, we have developed a new, straightforward method to measure the strength of ocular dominance plasticity: the number of c-Fos-imm...

journal_title：Neuroscience

authors： Nakadate K,Imamura K,Watanabe Y

更新日期：2013-04-03 00:00:00

abstract：:Modeling Parkinson's disease remains a major challenge for preclinical researchers, as existing models fail to reliably recapitulate all of the classic features of the disease, namely, the progressive emergence of a bradykinetic motor syndrome with underlying nigrostriatal α-synuclein protein accumulation and nigrostr...

journal_title：Neuroscience

authors： Mulcahy P,O'Doherty A,Paucard A,O'Brien T,Kirik D,Dowd E

更新日期：2012-02-17 00:00:00

abstract：:Investigating the localization of gastric sensation within the brain is important for understanding the neural correlates of satiety. Previous rodent studies have identified the brain-stem and hypothalamus as key mediators of gastric distention-induced satiation. Although, recent blood oxygen level-dependent functiona...

journal_title：Neuroscience

authors： Min DK,Tuor UI,Chelikani PK

更新日期：2011-04-14 00:00:00

abstract：:Small (SK) and intermediate (IK) conductance calcium-activated potassium channels are candidate ion channels for the regulation of excitability in nociceptive neurones. We have used unique peptide-directed antisera to describe the immunocytochemical distribution of the known isoforms of these ion channels in dorsal ro...

journal_title：Neuroscience

authors： Mongan LC,Hill MJ,Chen MX,Tate SN,Collins SD,Buckby L,Grubb BD

更新日期：2005-01-01 00:00:00

abstract：:The main action of organophosphorous insecticides is generally believed to be the inhibition of acetylcholinesterase (AChE). However, these compounds also inhibit many other enzymes, any of which may play a role in their toxicity. We tested the neurotoxic mechanism of two organophosphorous insecticides, chlorpyrifos a...

journal_title：Neuroscience

authors： Rush T,Liu XQ,Hjelmhaug J,Lobner D

更新日期：2010-03-31 00:00:00

abstract：:We have recently reported on the efficacy of an NK1 tachykinin receptor antagonist in improving outcome following stroke, including reduced blood-brain barrier (BBB) disruption, reduced cerebral edema and improved functional outcome. The clinically approved stroke treatment, tissue plasminogen activator (tPA), has bee...

journal_title：Neuroscience

authors： Turner RJ,Vink R

更新日期：2012-09-18 00:00:00

abstract：:In the cerebral cortex, the voltage-gated potassium channel, Kv3.1b, a splicing variant of Kv3.1, has been associated with fast-firing interneurons. Here, we report strong expression of Kv3.1b-protein and mRNA in both Betz and Meynert pyramidal cells of the monkey, as shown by immunohistochemistry and in situ hybridiz...

journal_title：Neuroscience

authors： Ichinohe N,Watakabe A,Miyashita T,Yamamori T,Hashikawa T,Rockland KS

更新日期：2004-01-01 00:00:00

abstract：:Serotonin and gamma-aminobutyric acid (GABA) neurons in the nucleus raphe dorsalis were identified by immunocytochemistry using antibodies to 5-hydroxytryptamine or GABA. The pattern of the 5-hydroxytryptamine and GABA immunostaining presented similar features: 5-hydroxytryptamine or GABA immunoreactive somata were fu...

journal_title：Neuroscience

authors： Harandi M,Aguera M,Gamrani H,Didier M,Maitre M,Calas A,Belin MF

更新日期：1987-04-01 00:00:00

abstract：:In the present study, we found that amyloid-beta peptide enhanced glutamate release from primary cultured rat microglia via the Na+-dependent glutamate transporter, which was activated by extracellular K+. Glutamate transport current was measured by a conventional whole-cell patch recording mode under voltage-clamp co...

journal_title：Neuroscience

authors： Noda M,Nakanishi H,Akaike N

更新日期：1999-01-01 00:00:00

abstract：:Motor effects of bilateral lesions of the globus pallidus induced by quinolinic acid (30 and 60 nmol in 0.5 microl) were investigated in rats. Globus pallidus lesions with 60 nmol quinolinic acid produced a significant reduction of spontaneous motor activity measured by a reduced locomotor activity in an open field an...

journal_title：Neuroscience

authors： Hauber W,Lutz S,Münkle M

更新日期：1998-09-01 00:00:00

abstract：:Electroconvulsive therapy has been commonly applied in the treatment of refractory depression, but its cognitive side effects are noticed and restrict its application. The molecular mechanisms underlying the side effects remain elusive, and there is no efficient prevention. By employing a recognized electroconvulsive ...

journal_title：Neuroscience

authors： Yao Z,Guo Z,Yang C,Tian Q,Gong CX,Liu G,Wang JZ

更新日期：2010-06-30 00:00:00

abstract：:The hippocampus is a multifaceted, complex brain structure considered to be the learning center. The use of primary hippocampal cell cultures has uncovered important cellular mechanisms involved in overall physiological function. Yet, the use of primary culture is inherently difficult, and the lack of immortalized cel...

journal_title：Neuroscience

authors： Gingerich S,Kim GL,Chalmers JA,Koletar MM,Wang X,Wang Y,Belsham DD

更新日期：2010-09-29 00:00:00

abstract：:Rat brain synaptosomes were isolated to study the effects of protein kinase inhibitors (sphingosine, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, N-(6-aminohexyl)-5-chloro-1-naphtalenesulfonamide, staurosporine) on Ca2+-dependent and Ca2+-independent [14C]GABA release. The Ca2+-dependent [14C]GABA re...

journal_title：Neuroscience

authors： Storchak LG,Pozdnyakova NG,Himmelreich NH

更新日期：1998-08-01 00:00:00

abstract：:The cellular mechanisms underlying the genesis of thalamic ponto-geniculo-occipital waves were studied in reserpinized cats under urethane anaesthesia. Simultaneous field potential and intracellular recordings were performed in the lateral geniculate nucleus after acute lesions of retinal and visual cortical inputs. I...

journal_title：Neuroscience

authors： Hu B,Steriade M,Deschênes M

更新日期：1989-01-01 00:00:00

abstract：:The medial thalamus contains abundant mu-opioid receptors and is activated by acute morphine administration. However, the role of the medial thalamus in the rewarding effects of morphine is unclear. The present study examined whether mu-opioid receptors of the medial thalamus influenced the acquisition and expression ...

journal_title：Neuroscience

authors： Guo N,Garcia MM,Taylor BK,Zadina JE,Harlan RE

更新日期：2008-02-19 00:00:00

abstract：:Systemically administered cholinomimetics or cholinesterase inhibitors can depress behavior in humans and animals, whereas antimuscarinic agents reverse this effect or even produce euphoria. Although these effects have been well documented, the specific brain regions that mediate them remain largely unknown. In the pr...

journal_title：Neuroscience

authors： Chau DT,Rada P,Kosloff RA,Taylor JL,Hoebel BG

更新日期：2001-01-01 00:00:00