当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > A voltage-gated potassium channel, Kv3.1b, is expressed by a subpopulation of large pyramidal neurons in layer 5 of the macaque monkey cortex.

A voltage-gated potassium channel, Kv3.1b, is expressed by a subpopulation of large pyramidal neurons in layer 5 of the macaque monkey cortex.

Abstract：

:In the cerebral cortex, the voltage-gated potassium channel, Kv3.1b, a splicing variant of Kv3.1, has been associated with fast-firing interneurons. Here, we report strong expression of Kv3.1b-protein and mRNA in both Betz and Meynert pyramidal cells of the monkey, as shown by immunohistochemistry and in situ hybridization. Strong expression also occurs in large pyramidal neurons in layer 5 of several cortical areas. In addition, most of these Betz and layer 5 pyramids, and about 10% of the labeled Meynert cells weakly co-expressed the calcium binding protein parvalbumin. Electron microscopy shows that the expression of Kv3.1b is localized to the somal and proximal dendritic cytoplasmic membrane, as expected for a channel protein. These results suggest that some large pyramidal neurons may constitute a functional subpopulation, with a distinctive distribution of voltage-gated potassium channels capable of influencing their repetitive firing properties.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Ichinohe N,Watakabe A,Miyashita T,Yamamori T,Hashikawa T,Rockland KS

doi

10.1016/j.neuroscience.2004.08.005

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

179-85

issue

1

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(04)00697-9

journal_volume

129

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Dopaminergic activation excites rat lateral habenular neurons in vivo.

    abstract：:The lateral habenular complex (LHb) of the epithalamus is part of a dorsal diencephalic conduction system connecting basal forebrain with regulatory midbrain nuclei. The LHb has been implicated in the regulation of ascending monoaminergic transmission, particularly midbrain dopaminergic neuronal activity. Here, we hav...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.04.026

    authors： Kowski AB,Veh RW,Weiss T

    更新日期：2009-07-21 00:00:00

  • Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress.

    abstract：:Neurotrophic factors, including basic fibroblast growth factor (FGF-2) and brain-derived neurotrophic factor (BDNF) are known to be affected by exposure to stressful experiences. Here, we examine the effects of behaviorally controllable (escapable tailshock, ES) or uncontrollable (inescapable tailshock, IS) stress on ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.11.026

    authors： Bland ST,Tamlyn JP,Barrientos RM,Greenwood BN,Watkins LR,Campeau S,Day HE,Maier SF

    更新日期：2007-02-23 00:00:00

  • Anti-mouse CX3CR1 Antibody Alleviates Cognitive Impairment, Neuronal Loss and Myelin Deficits in an Animal Model of Brain Ischemia.

    abstract：:White matter lesions are common when global cerebral ischemia (GCI) occurs in the elderly, and cause damage to neurological and psychological functions. Remyelination often fails because of the limited recruitment of oligodendrocyte progenitor cells (OPCs) to the demyelinated site or the inefficient differentiation of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.05.011

    authors： Du B,Liang M,Zheng H,Fan C,Zhang H,Lu X,Du Z,Lian Y,Zhang Y,Bi X

    更新日期：2020-07-01 00:00:00

  • The protective effect of astrocyte-derived 14,15-epoxyeicosatrienoic acid on hydrogen peroxide-induced cell injury in astrocyte-dopaminergic neuronal cell line co-culture.

    abstract：:Astrocytes perform several functions that are essential for normal neuronal activity. They play a critical role in neuronal survival during ischemia and other degenerative injuries and also modulate neuronal recovery by influencing neurite outgrowth. In this study, we investigated the neuroprotective effects of astroc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.07.045

    authors： Terashvili M,Sarkar P,Nostrand MV,Falck JR,Harder DR

    更新日期：2012-10-25 00:00:00

  • The Impact of Perineuronal Net Digestion Using Chondroitinase ABC on the Intrinsic Physiology of Cortical Neurons.

    abstract：:Perineuronal nets (PNNs) are a form of aggregate Extracellular Matrix (ECM) in the brain. Recent evidence suggests that the postnatal deposition of PNNs may play an active role in regulating neuroplasticity and, potentially, neurological disorders. Observations of high levels of PNN expression around somas, proximal d...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.07.004

    authors： Chu P,Abraham R,Budhu K,Khan U,De Marco Garcia N,Brumberg JC

    更新日期：2018-09-15 00:00:00

  • GABAergic and glutamatergic terminals differentially influence the organization of GABAergic synapses in rat cerebellar granule cells in vitro.

    abstract：:Synapse formation in CNS neurons requires appropriate sorting and clustering of neurotransmitter receptors and associated proteins at postsynaptic sites. In GABAergic synapses, clustering of GABA(A) receptors requires gephyrin, but it is not known whether presynaptic signals are also involved in this process. To inves...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00206-3

    authors： Studler B,Fritschy JM,Brünig I

    更新日期：2002-01-01 00:00:00

  • Biological demonstration of nerve growth factor in the rat pituitary gland.

    abstract：:Explants of anterior, intermediate and posterior pituitary lobes of rats at various ages evoked an intense nerve fibre outgrowth when co-cultured with neonatal sympathetic superior cervical ganglia in a collagen gel medium. Freezing and thawing of pituitary lobes, prior to culture, did not abolish their growth-promoti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90362-x

    authors： Lahtinen T,Soinila S,Lakshmanan J

    更新日期：1989-01-01 00:00:00

  • Transformation of cortical and hippocampal neural circuit by environmental enrichment.

    abstract：:It has been half a century since brain volume enlargement was first reported in animals reared in an enriched environment (EE). As EE animals show improved memory task performance, exposure to EE has been a useful model system for studying the effects of experience on brain plasticity. We review EE-induced neural chan...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2014.09.031

    authors： Hirase H,Shinohara Y

    更新日期：2014-11-07 00:00:00

  • Immunohistochemical evidence for a spinothalamic pathway co-containing cholecystokinin- and galanin-like immunoreactivities in the rat.

    abstract：:Using indirect immunofluorescence technique combined with retrograde tracing as well as surgical lesions, a system of spinothalamic neurons containing both galanin- and cholecystokinin-like immunoreactivity has been defined. The cell bodies are located in the lumbar segments L1-L5 with a preferential localization dors...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90103-5

    authors： Ju G,Melander T,Ceccatelli S,Hökfelt T,Frey P

    更新日期：1987-02-01 00:00:00

  • Treadmill exercise improves cognitive function and facilitates nerve growth factor signaling by activating mitogen-activated protein kinase/extracellular signal-regulated kinase1/2 in the streptozotocin-induced diabetic rat hippocampus.

    abstract：:This study aimed to investigate the effects of regular treadmill exercise on nerve growth factor (NGF) expression, the improvement of cognitive function in the hippocampus of diabetic rats, and to understand the molecular mechanisms through which the relevant signaling factors act. We investigated the effects of regul...

    journal_title：Neuroscience

    pub_type： 杂志文章,收录出版

    doi：10.1016/j.neuroscience.2009.09.075

    authors： Chae CH,Jung SL,An SH,Park BY,Wang SW,Cho IH,Cho JY,Kim HT

    更新日期：2009-12-29 00:00:00

  • Moderate drinking? Alcohol consumption significantly decreases neurogenesis in the adult hippocampus.

    abstract：:Drinking alcohol in moderation is often considered a health-conscious behavior, associated with improved cardiovascular and brain health. However, "moderate" amounts of alcohol include drinking 3-4 alcohol beverages in a day, which is closer to binge drinking and may do more harm than good. Here we examined how daily ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.08.018

    authors： Anderson ML,Nokia MS,Govindaraju KP,Shors TJ

    更新日期：2012-11-08 00:00:00

  • The n-terminal 5-MER peptide analogue P165 of amyloid precursor protein exerts protective effects on SH-SY5Y cells and rat hippocampus neuronal synapses.

    abstract：:The disturbance of the insulin-signaling pathway plays an important role in Alzheimer's disease. Resistance to insulin signaling renders neurons energy-deficient and vulnerable to oxidization or other metabolic insults and impairs synaptic plasticity. In search of neuroprotective drugs, we synthesized a peptide analog...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.10.069

    authors： Wang P,Jiang S,Cui Y,Yue Z,Su C,Sun J,Sheng S,Tian J

    更新日期：2011-01-26 00:00:00

  • Central corticotropin-releasing hormone receptors modulate hypothalamic-pituitary-adrenocortical and sympathoadrenal activity during stress.

    abstract：:The role of brain corticotropin-releasing hormone receptors in modulating hypothalamic-pituitary-adrenal and sympathoadrenal responses to acute immobilization stress was studied in conscious rats under central corticotropin-releasing hormone receptor blockade by intracerebroventricular injection of a peptide corticotr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00333-4

    authors： Jezova D,Ochedalski T,Glickman M,Kiss A,Aguilera G

    更新日期：1999-01-01 00:00:00

  • Ascorbate modulates pentylenetetrazol-induced convulsions biphasically.

    abstract：:Ascorbate is an antioxidant vitamin that is found in high concentrations in the brain which seems to have neuroprotective properties in some experimental models of excitotoxic neurological disorders, including convulsive behavior and reactive species-related damage. In this study we tested whether ascorbate (30, 100 o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.07.012

    authors： Schneider Oliveira M,Flávia Furian A,Freire Royes LF,Rechia Fighera M,de Carvalho Myskiw J,Gindri Fiorenza N,Mello CF

    更新日期：2004-01-01 00:00:00

  • Mechanisms of etomidate potentiation of GABAA receptor-gated currents in cultured postnatal hippocampal neurons.

    abstract：:The effect of etomidate, an imidazole general anesthetic, on GABAA receptor function was studied in cultured hippocampal neurons. At a clinically relevant concentration of 4.1 microM, etomidate shifts the GABA dose response to the left (ED50 shift from 10.2 to 5.2 microM), with no change in the maximum current evoked ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00018-8

    authors： Yang J,Uchida I

    更新日期：1996-07-01 00:00:00

  • Phosphorylation of transcription factor cyclic-AMP response element binding protein mediates c-fos induction elicited by sustained hypertension in rat nucleus tractus solitarii.

    abstract：:We investigated the role of cyclic-AMP response element binding protein signaling in the induction of the immediate-early gene c-fos by baroreceptor activation in neurons of the nucleus tractus solitarii of anesthetized rats. Activation of the arterial baroreceptors with sustained hypertension significantly increased ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00273-5

    authors： Chan JY,Chen WC,Lee HY,Chang TJ,Chan SH

    更新日期：1999-01-01 00:00:00

  • Dissociation of function within the hippocampus: effects of dorsal, ventral and complete excitotoxic hippocampal lesions on spatial navigation.

    abstract：:The present study was designed to assess the possibility that sub-total ventral hippocampal lesions might leave intact a mechanism for only highly accurate navigation, whereas sub-total dorsal hippocampal lesions might leave intact a mechanism only for less precise navigation. Animals with selective dorsal, ventral or...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.05.007

    authors： Zhang WN,Pothuizen HH,Feldon J,Rawlins JN

    更新日期：2004-01-01 00:00:00

  • Somatostatin and neuropeptide Y in organotypic slice cultures of the rat hippocampus: an immunocytochemical and in situ hybridization study.

    abstract：:The neuronal distributions of somatostatin and neuropeptide Y and their respective mRNAs in hippocampal slice cultures were examined by immunohistochemical staining and in situ hybridization. For the in situ hybridization we used an alkaline phosphatase-labelled oligodeoxynucleotide probe for somatostatin mRNA and an ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90125-l

    authors： Finsen BR,Tønder N,Augood S,Zimmer J

    更新日期：1992-01-01 00:00:00

  • Pregabalin enhances myelin repair and attenuates glial activation in lysolecithin-induced demyelination model of rat optic chiasm.

    abstract：:Multiple sclerosis (MS) is an autoimmune disease in which more than 70% of patients experience visual disturbance as the earliest symptoms. Lysolecithin (LPC)-induced focal demyelination model has been developed to evaluate the effects of different therapies on myelin repair improvement. In this study, the effects of ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.12.037

    authors： Daneshdoust D,Khalili-Fomeshi M,Ghasemi-Kasman M,Ghorbanian D,Hashemian M,Gholami M,Moghadamnia A,Shojaei A

    更新日期：2017-03-06 00:00:00

  • Neurofilament and glial fibrillary acid protein-related immunoreactivity in rodent enteric nervous system.

    abstract：:Using antisera raised against neurofilaments and the glial fibrillary acidic protein (GFAP) we have examined the appearance and distribution of neurofilament- and GFAP-like immunoreactivity in the enteric nervous system of rat, mouse and guinea-pig. In whole mounts of the external circular and longitudinal muscle laye...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90153-2

    authors： Björklund H,Dahl D,Seiger A

    更新日期：1984-05-01 00:00:00

  • Anterograde horseradish peroxidase tracing and immunohistochemistry of trigeminal ganglion tooth pulp neurons after dental nerve lesions in the rat.

    abstract：:The peripheral reorganization of pulpal nerves after tooth injury was studied, in the rat, with anterograde horseradish peroxidase tracing techniques, and combined retrograde Fluorogold tracing and immunohistochemistry was employed to examine the effects of inferior alveolar nerve lesions or tooth injury on some cytoc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90434-p

    authors： Fried K,Arvidsson J,Robertson B,Pfaller K

    更新日期：1991-01-01 00:00:00

  • Fine structural alteration in target-deprived axonal terminals in the rat thalamus.

    abstract：:Lesioning of thalamic target neurons in the adult rat provokes a resorption of terminal axonal branches of afferent neurons from the dorsal column nuclei. There is, however, no massive neuronal loss in the dorsal column nuclei. In the adult, therefore, the thalamic post synaptic target cells influence primarily the ex...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90348-4

    authors： Marty S,Peschanski M

    更新日期：1994-10-01 00:00:00

  • Ectopic uterine tissue as a chronic pain generator.

    abstract：:While chronic pain is a main symptom in endometriosis, the underlying mechanisms and effective therapy remain elusive. We developed an animal model enabling the exploration of ectopic endometrium as a source of endometriosis pain. Rats were surgically implanted with autologous uterus in the gastrocnemius muscle. Withi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.08.033

    authors： Alvarez P,Chen X,Hendrich J,Irwin JC,Green PG,Giudice LC,Levine JD

    更新日期：2012-12-06 00:00:00

  • Mouse strains that lack spinal dynorphin upregulation after peripheral nerve injury do not develop neuropathic pain.

    abstract：:Several experimental models of peripheral neuropathy show that a significant upregulation of spinal dynorphin A and its precursor peptide, prodynorphin, is a common consequence of nerve injury. A genetically modified mouse strain lacking prodynorphin does not exhibit sustained neuropathic pain after nerve injury, supp...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2003.08.021

    authors： Gardell LR,Ibrahim M,Wang R,Wang Z,Ossipov MH,Malan TP Jr,Porreca F,Lai J

    更新日期：2004-01-01 00:00:00

  • Stimulatory role of calcium in rapid eye movement sleep deprivation-induced noradrenaline-mediated increase in Na-K-ATPase activity in rat brain.

    abstract：:Rapid eye movement (REM) sleep deprivation elevates noradrenaline level, which upon acting on alpha1-adrenoceptors increases Na-K-ATPase activity; however, the detailed intracellular mechanism of action was unknown. Since membrane integrity is crucial for maintaining Na-K-ATPase activity as well as ionic exchange and ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.04.069

    authors： Das G,Gopalakrishnan A,Faisal M,Mallick BN

    更新日期：2008-07-31 00:00:00

  • Investigation of the modulation of glutamate release by sodium channels using neurotoxins.

    abstract：:The modulation of neurotransmitter release by calcium channels is well established, yet, sodium channels were regarded mainly as charge carriers. Many lines of evidence suggest a more fine-tuning role played by sodium channels. Using rat cerebrocortical isolated nerve endings (synaptosomes) and two toxins that have se...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00139-2

    authors： Bicalho AF,Guatimosim C,Prado MA,Gomez MV,Romano-Silva MA

    更新日期：2002-01-01 00:00:00

  • Hypothermia prevents hearing loss and progressive hair cell loss after transient cochlear ischemia in gerbils.

    abstract：:The effects of hypothermia on ischemia-reperfusion injury of the cochlea were studied in gerbils. Hearing was assessed by sequentially recording compound action potentials before, during and after the ischemia. The degree of hair cell loss in the organ of Corti was evaluated in specimens stained with rhodamine-phalloi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00510-8

    authors： Watanabe F,Koga K,Hakuba N,Gyo K

    更新日期：2001-01-01 00:00:00

  • Myelin-induced inhibition in a spiral ganglion organ culture - Approaching a natural environment in vitro.

    abstract：:The performance of a cochlear implant depends on the defined interaction between afferent neurons of the spiral ganglion and the inserted electrode. Neurite outgrowth can be induced by neurotrophins such as brain-derived neurotrophic factor (BDNF) via tropomyosin kinase receptor B (TrkB). However, neurotrophin signali...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.05.053

    authors： Kramer B,Tropitzsch A,Müller M,Löwenheim H

    更新日期：2017-08-15 00:00:00

  • Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn.

    abstract：:Although there is evidence that reduced inhibition in the spinal dorsal horn contributes to neuropathic pain, the mechanisms that underlie this are poorly understood. We have previously demonstrated that there is no loss of neurons from laminae I-III in the spared nerve injury (SNI) model [Polgár E, Hughes DI, Arham A...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.07.009

    authors： Polgár E,Todd AJ

    更新日期：2008-09-22 00:00:00

  • Nerve-induced release of nitric oxide from the rabbit corpus cavernosum is modulated by cyclic guanosine 3',5'-monophosphate.

    abstract：:Nitric oxide (NO) is a neurotransmitter of the autonomic nerves in the urogenital tract, in particular the release of NO in the cavernous tissue is of importance for maintaining erection. However, the regulation of NO formation in neurons of the corpus cavernosum is poorly understood. Here, we report, that upon electr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.02.015

    authors： Hallén K,Gustafsson LE,Wiklund NP

    更新日期：2005-01-01 00:00:00