Abstract：
:Explants of anterior, intermediate and posterior pituitary lobes of rats at various ages evoked an intense nerve fibre outgrowth when co-cultured with neonatal sympathetic superior cervical ganglia in a collagen gel medium. Freezing and thawing of pituitary lobes, prior to culture, did not abolish their growth-promoting effect. Since the addition of antiserum to nerve growth factor in the culture medium inhibited totally the stimulative action of both fresh and frozen pituitary explants it is suggested that the stimulation is mediated by nerve growth factor or an immunologically related molecule. Based on the present results it is concluded that nerve growth factor is synthesized by both the anterior, intermediate and posterior lobes throughout the postnatal period, as well as in adult rats. The function of nerve growth factor in the pituitary gland is discussed.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Lahtinen T,Soinila S,Lakshmanan Jdoi
10.1016/0306-4522(89)90362-xsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
165-70issue
1eissn
0306-4522issn
1873-7544pii
0306-4522(89)90362-Xjournal_volume
30pub_type
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