Nitric oxide alters proenkephalin and prodynorphin gene expression in hippocampal granule cells.

abstract：:An inflammatory response in the CNS mediated by activation of microglia is a key event in the early stages of the development of neurodegenerative diseases. Using mouse cortical mixed glia cultures, we have previously demonstrated that the bacterial endotoxin lipopolysaccharide induces the activation of microglia and ...

journal_title：Neuroscience

authors： Liu B,Du L,Kong LY,Hudson PM,Wilson BC,Chang RC,Abel HH,Hong JS

更新日期：2000-01-01 00:00:00

abstract：:The hypothalamic paraventricular nucleus (PVN), a site for the integration of both the neuroendocrine and autonomic systems, has heterogeneous cell composition. These neurons are classified into type I and type II neurons based on their electrophysiological properties. In the present study, we investigated the molecul...

journal_title：Neuroscience

authors： Lee SK,Lee S,Shin SY,Ryu PD,Lee SY

更新日期：2012-03-15 00:00:00

abstract：:Cognitive impairment is one of the common non-motor symptoms in Parkinson's disease (PD). The hippocampus is a critical structure for learning and memory processes. The abnormal synaptic plasticity in the hippocampus is suggested to be associated with cognitive dysfunction in PD. Voltage gated sodium channels (VGSCs) ...

journal_title：Neuroscience

authors： Wang Z,Lin Y,Liu W,Kuang P,Lao W,Ji Y,Zhu H

更新日期：2019-10-15 00:00:00

abstract：:Our study examined how different housing conditions modulated the acquisition of a spatial reference memory task and also, a reversal task in the 4-radial arm water maze (4-RAWM). The animals were randomly assigned to standard or enriched cages, and, as a type of complementary stimulation along with the environmental ...

journal_title：Neuroscience

authors： Sampedro-Piquero P,Zancada-Menendez C,Begega A

更新日期：2015-10-29 00:00:00

abstract：:Significant alterations in glutamatergic neurotransmission have been reported in major depressive disorder (MDD) that could underlie psychiatric traits. Studies were mainly interested in synaptic dysfunction in the prefrontal cortex, a key structure involved in depressive-like behavior, however hippocampus has been sh...

journal_title：Neuroscience

authors： Dutar P,Tolle V,Kervern M,Carcenac C,Carola V,Gross C,Savasta M,Darmon M,Masson J

更新日期：2019-01-01 00:00:00

abstract：:Non-invasive criteria determining the progress of brain healing are especially important in aging, providing a case-specific therapeutic strategy in populations with dysregulated neurorepair mechanisms. We hypothesized that temporal evolution of magnetic resonance imaging (MRI) of T2 tissue relaxation values correlate...

journal_title：Neuroscience

authors： Titova EM,Ghosh N,Valadez ZG,Zhang JH,Bellinger DL,Obenaus A

更新日期：2014-12-26 00:00:00

abstract：:Excitatory amino acid carrier 1 (EAAC1) is one important subtype of the excitatory amino acid transporters (EAATs), and its absence can increase the vulnerability to oxidative stress in neural tissue. Enhanced expression of EAAC1 can provide neuroprotection in multiple disorders, including ischemia and multiple sclero...

journal_title：Neuroscience

authors： Huang C,Yuan P,Wu J,Huang J

更新日期：2016-04-05 00:00:00

abstract：:Complementary RNA probes derived from complementary DNA specifically subcloned from monkey tissue were used to localize, by in situ hybridization histochemistry, the relatively rare alpha3, beta3 and gamma1 subunit transcripts of the GABA(A) receptor in visual cortex and lateral geniculate nucleus of normal monkeys an...

journal_title：Neuroscience

authors： Huntsman MM,Jones EG

更新日期：1998-11-01 00:00:00

abstract：:Here we investigated effects of intramuscular (i.m.) heating-needle stimulation on persistent muscle nociception evoked by i.m. injection of different doses (50-200 µl) of complete Freund's adjuvant (CFA) in rats. Paw withdrawal reflexes evoked by noxious mechanical and heat stimulation as well as hind limb swelling w...

journal_title：Neuroscience

authors： Lei J,Ye G,Pertovaara A,You HJ

更新日期：2020-05-01 00:00:00

abstract：:In the vestibular nuclei, GABAergic and glycinergic neurons play important roles in signal processing for normal function, during development, and after peripheral vestibular lesions. The chicken tangential nucleus is a major avian vestibular nucleus, whose principal cells are projection neurons with axons transmittin...

journal_title：Neuroscience

authors： Popratiloff A,Peusner KD

更新日期：2011-02-23 00:00:00

abstract：:Recent studies have revealed that the ventral premotor cortex (PMv) of nonhuman primates plays a pivotal role in various behaviors that require the transformation of sensory cues to appropriate actions. Examples include decision-making based on various sensory cues, preparation for upcoming motor behavior, adaptive se...

journal_title：Neuroscience

authors： Kurata K

更新日期：2018-07-01 00:00:00

abstract：:The orexinergic neurons of the lateral hypothalamus (LH) are critical for wakefulness [McCarley RW (2007) Neurobiology of REM and NREM sleep. Sleep Med 8:302-330]. Recent evidence suggests that adenosine (AD), a homeostatic sleep factor, may act via A1 receptor (A1R) to control orexinergic activity and regulate sleep-...

journal_title：Neuroscience

authors： Thakkar MM,Engemann SC,Walsh KM,Sahota PK

更新日期：2008-06-02 00:00:00

abstract：:Although there is little overlap in core diagnostic criteria for ADHD and Autism Spectrum Disorder (ASD), ASD symptoms are estimated to co-occur in children with ADHD in 20-50% of cases. As motor control deficits are common to both disorders, we investigated the impact of ASD symptoms on ocular motor control in childr...

journal_title：Neuroscience

authors： Connolly AJ,Rinehart NJ,Johnson B,Papadopoulos N,Fielding J

更新日期：2016-10-15 00:00:00

abstract：:Wnt proteins have been implicated in regulating a variety of developmental processes in the CNS. Secreted Frizzled-related protein 3 (sFRP3) is a member of the sFRP family that can inhibit the Wnt signaling by binding directly to Wnts via their regions of homology to the Wnt-binding domain of Frizzleds. Recent studies...

journal_title：Neuroscience

authors： Zhao X,Huang H,Chen Y,Liu Y,Zhang Z,Ma Q,Qiu M

更新日期：2013-09-17 00:00:00

abstract：:After experimentally inducing long term changes in transmitter release, a series of frog neuromuscular junctions were studied with intracellular recording and then semi-serially sectioned and examined in the electron microscope. Transmitter release per unit length of motor nerve terminal was well correlated with sever...

journal_title：Neuroscience

authors： Herrera AA,Grinnell AD,Wolowske B

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:depression is characterized by a stable negative bias toward emotional stimuli. This bias is associated with abnormal activities in emotion-processing regions (such as the amygdala) and cognitive-control regions (such as the dorsolateral prefrontal cortex [DLPFC]). However, it remains unclear whether the emo...

journal_title：Neuroscience

authors： Liao C,Feng Z,Zhou D,Dai Q,Xie B,Ji B,Wang X,Wang X

更新日期：2012-01-10 00:00:00

abstract：:Diabetic peripheral neuropathy is a common complication of diabetes mellitus, and a significant proportion of individuals suffer debilitating pain that significantly affects their quality of life. Unfortunately, symptomatic treatment options have limited efficacy, and often carry significant risk of systemic adverse e...

journal_title：Neuroscience

authors： Katz NK,Ryals JM,Wright DE

更新日期：2015-01-29 00:00:00

abstract：:Serotonin induces 'spontaneous' (non-electrically evoked) excitatory postsynaptic currents in layer V pyramidal neurons in the prefrontal cortex. This is likely due to a serotonin2A receptor-mediated focal release of glutamate onto apical dendrites. In addition, activation of the serotonin2A receptor selectively enhan...

journal_title：Neuroscience

authors： Stutzmann GE,Marek GJ,Aghajanian GK

更新日期：2001-01-01 00:00:00

abstract：:Cell surface glycoconjugates are thought to mediate cell-cell recognition and play roles in neuronal development and functions. We demonstrated here that exposure of neuronal cells to nanomolar levels of gangliosides Neu5Acalpha 8Neu5Acalpha 3Galbeta 4GlcCer, Galbeta 3GalNAcbeta 4(Neu5Acalpha 8Neu5Acalpha 3)Galbeta 4G...

journal_title：Neuroscience

authors： Chen N,Furuya S,Doi H,Hashimoto Y,Kudo Y,Higashi H

更新日期：2003-01-01 00:00:00

abstract：:Activity-regulated, cytoskeletal-associated protein (Arc) is an immediate early gene induced in excitatory circuits following behavioral episodes. Arc mRNA is targeted to activated regions of the dendrite after long-term potentiation (LTP) of the dentate gyrus, a process dependent on NMDA receptor activation. We used ...

journal_title：Neuroscience

authors： Moga DE,Calhoun ME,Chowdhury A,Worley P,Morrison JH,Shapiro ML

更新日期：2004-01-01 00:00:00

abstract：:The purpose of the present study was to test the respective roles of the intrinsic neurons and of the catecholaminergic fibers in two behaviors elicited by electrical stimulation of the lateral hypothalamus, intracranial self-stimulation and the increase in locomotor activity produced by noncontingent stimulation. One...

journal_title：Neuroscience

authors： Velley L,Verney C,Kempf E,Berger B

更新日期：1988-05-01 00:00:00

abstract：:The axonal development of serotonin (5-HT)-, noradrenaline (NA)-, or tyrosine hydroxylase (TH)-containing monoaminergic neurons is affected by rearing conditions during the juvenile period. Impaired monoaminergic axonal development is implicated in the pathophysiology of emotional and cognitive dysfunction. On the oth...

journal_title：Neuroscience

authors： Ishikawa J,Ishikawa A

更新日期：2013-01-29 00:00:00

abstract：:In anaesthetized albino rabbits, the cerebellar flocculus was systematically mapped with a glass microelectrode to identify the location of Purkinje cells that inhibit specific vestibulo-ocular reflex pathways. The effects of microstimulation of the flocculus Purkinje cell layer on vestibular nerve-evoked reflexes to ...

journal_title：Neuroscience

authors： Ito M,Orlov I,Yamamoto M

更新日期：1982-07-01 00:00:00

abstract：:The viral transneuronal labeling method was used to examine whether the suprachiasmatic nucleus (SCN) is linked by multisynaptic connections to the medial prefrontal cortex of the rat. In separate experiments, pseudorabies virus (PRV) was injected into one of the three different cytoarchitectonic regions that comprise...

journal_title：Neuroscience

authors： Sylvester CM,Krout KE,Loewy AD

更新日期：2002-01-01 00:00:00

abstract：:The hypothesis that electrotonic spread among oxytocinergic neurons contributes to synchronized bursting in the lactating rat leads to the prediction that coupling among oxytocinergic neurons would be stronger and more abundant in lactating than in non-lactating animals. We tested this prediction using, as an index of...

journal_title：Neuroscience

authors： Hatton GI,Yang QZ,Cobbett P

更新日期：1987-06-01 00:00:00

abstract：:To date, the neurochemical basis underlying the motor and cognitive deficits described in patients with multiple sclerosis (MS) is unclear. Since the neuropeptide somatostatin (SRIF) and the striatum have been implicated in movement control and implicit memory, the aim of this study was to analyze the striatal somatos...

journal_title：Neuroscience

authors： Aguado-Llera D,Puebla-Jiménez L,Yébenes-Gregorio L,Arilla-Ferreiro E

更新日期：2007-08-10 00:00:00

abstract：:Handedness in humans and paw preference (PP) in rodents have been associated with neural and physiological correlates, which frequently appear to be sex-specific. The present study examines sex differences in the effects of differential PP on post mortem measures of regional monoamine activity in adult Long-Evans rats...

journal_title：Neuroscience

authors： Sullivan RM,Chehab SL,Dufresne MM,Laplante F

更新日期：2012-01-27 00:00:00

abstract：:Accumulating evidences indicate that ceramide is closely involved in apoptotic cell death in neurodegenerative disorders and aging. We examined ceramide levels in the cerebrospinal fluid (CSF) or brain tissues from patients with neurodegenerative disorders and the mechanism of how intra- and extracellular ceramide was...

journal_title：Neuroscience

authors： Satoi H,Tomimoto H,Ohtani R,Kitano T,Kondo T,Watanabe M,Oka N,Akiguchi I,Furuya S,Hirabayashi Y,Okazaki T

更新日期：2005-01-01 00:00:00

abstract：:The effects of intense noise exposure on the classical auditory pathway have been extensively investigated; however, little is known about the effects of noise-induced hearing loss on non-classical auditory areas in the brain such as the lateral amygdala (LA) and striatum (Str). To address this issue, we compared the ...

journal_title：Neuroscience

authors： Chen GD,Sheppard A,Salvi R

更新日期：2016-02-19 00:00:00

abstract：:Dopaminergic compounds often affect the unlearned behaviors of preweanling and adult rats differently, although the brain regions underlying these age-dependent behavioral effects have not been specified. A candidate brain region is the dorsal caudate-putamen (CPu); thus, a goal of the present study was to determine w...

journal_title：Neuroscience

authors： Charntikov S,Der-Ghazarian T,Herbert MS,Horn LR,Widarma CB,Gutierrez A,Varela FA,McDougall SA

更新日期：2011-06-02 00:00:00