A 'single toxin-double lesion' rat model of striatonigral degeneration by intrastriatal 1-methyl-4-phenylpyridinium ion injection: a motor behavioural analysis.

abstract：:In order to determine which neurotransmitters and neuropeptides are utilized by the neurons of the mesencephalic trigeminal nucleus and by the fibres making synaptic contact with these primary sensory cells, we have set up an immunohistochemical study using antibodies against 17 major neurotransmitters and neuropeptid...

journal_title：Neuroscience

authors： Copray JC,Ter Horst GJ,Liem RS,van Willigen JD

更新日期：1990-01-01 00:00:00

abstract：:Our previous studies have shown that selective inhibition of nitric oxide in the brain reduces pressor responses to activation of cardiac sympathetic afferents, thus suggesting that nitric oxide is involved in central regulation of cardiac-cardiovascular sympathoexcitatory reflexes. Central neural regions in which nit...

journal_title：Neuroscience

authors： Guo ZL,Longhurst JC

更新日期：2003-01-01 00:00:00

abstract：:The Fmr1 gene knockout mouse is a model for the human Fragile X mental retardation syndrome. Fmr1 knockout mice with a C57BL/6-129/OlaHsd hybrid background have been reported to have only a very mild deficiency in learning the Morris water maze task. We compared the effect of this knockout mutation on learning in mice...

journal_title：Neuroscience

authors： Dobkin C,Rabe A,Dumas R,El Idrissi A,Haubenstock H,Brown WT

更新日期：2000-01-01 00:00:00

abstract：:Ablation of capsaicin-sensitive afferent neurons enhances experimentally induced ulceration in the rat gastric mucosa, which suggests that these neurons are involved in gastric mucosal protection. To provide direct evidence for such a function it was investigated whether stimulation of afferent nerve endings by the in...

journal_title：Neuroscience

authors： Holzer P,Lippe IT

更新日期：1988-12-01 00:00:00

abstract：:Differences in the uptake of tracers from radioactive 2-deoxyglucose ([1,2-3H] and [2,6-3H]), and glucose ([1-3H], [3-3H]) into hippocampal regions were investigated by freeze-mount microautoradiography after 45 min for 2-deoxyglucose, and after 15 and 45 min for glucose. Silver grains were assessed quantitatively by ...

journal_title：Neuroscience

authors： Shimada M,Shimono R,Ozaki HS

更新日期：1989-01-01 00:00:00

abstract：:Intrathecally-administered endomorphin-1 and endomorphin-2 produce antinociceptive effects which are different from each other. In order to elucidate a cellular basis for this result, we examined the effects of endomorphin-1 and endomorphin-2 on holding currents and spontaneous glutamatergic excitatory transmission in...

journal_title：Neuroscience

authors： Fujita T,Kumamoto E

更新日期：2006-01-01 00:00:00

abstract：:Stressful life events, especially those that induce fear, can produce a state of anxiety that is useful for avoiding similar fearful and potentially dangerous situations in the future. However, they can also lead to exaggerated states, which over time can produce mental illness. These changing states of readiness vers...

journal_title：Neuroscience

authors： Leuner B,Shors TJ

更新日期：2013-10-22 00:00:00

abstract：:The serotonin and circadian systems are principal regulatory networks of the brain. Each consists of a unique set of neurons that make widespread neural connections and a defined gene network of transcriptional regulators and signaling genes that subserve serotonergic and circadian function at the genetic level. These...

journal_title：Neuroscience

authors： Ciarleglio CM,Resuehr HE,McMahon DG

更新日期：2011-12-01 00:00:00

abstract：:Invertebrate microvillar photoreceptors utilize the phosphoinositide cascade to transduce light stimuli and inositol 1,4,5-trisphosphate is thought to be one of the messengers that triggers the electrical response by mobilizing intracellular stored calcium. To further characterize the role of the phosphoinositide sign...

journal_title：Neuroscience

authors： Ukhanov K,Ukhanova M,Taylor CW,Payne R

更新日期：1998-09-01 00:00:00

abstract：:We investigated the effects of the cholinergic agonist carbachol (25 microM) on the synaptic potentials recorded extracellularly and intracellularly from the CA3 area of immature hippocampal slices of the rat (postnatal days 10-20). In control conditions, carbachol reduced the amplitude of evoked synaptic responses (n...

journal_title：Neuroscience

authors： Psarropoulou C,Dallaire F

更新日期：1998-02-01 00:00:00

abstract：:The influence of transient increases in adrenal steroid hormones on the number of Fos-positive neurons after nociceptor activation was assessed in adrenalectomized rats. Fos protein, the product of the immediate early gene, c-fos, was detected immunocytochemically within the spinal trigeminal nucleus 2 h after noxious...

journal_title：Neuroscience

authors： Lu J,Bereiter DA

更新日期：1995-06-01 00:00:00

abstract：:This study examines the proposal that striatonigral pathways support circling mediated by dopamine D1 receptors, but not D2 receptors, in unilaterally 6-hydroxydopamine-treated rats. In this model the D1/D2 agonist apomorphine, the D1 agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrochloride and...

journal_title：Neuroscience

authors： Fletcher GH,Starr MS

更新日期：1987-12-01 00:00:00

abstract：:Cultured neurons offer many advantages over a slice preparation for whole-cell patch-clamp studies, such as better control over the environment and space clamp control. However, heterogeneous cultures of neurons present problems in distinguishing the cell type from which recordings are made. The present study uses cor...

journal_title：Neuroscience

authors： Mynlieff M

更新日期：1999-01-01 00:00:00

abstract：:Nerve cells have been found in hydra, which react with antisera to oxytocin, vasopressin and mesotocin. These nerve cells have a high density in the ectoderm of basal disk and tentacles and lower density in the ectoderm of peduncle, gastric region and hypostome. A very small number of nerve cells occur also in the end...

journal_title：Neuroscience

authors： Grimmelikhuijzen CJ,Dierickx K,Boer GJ

更新日期：1982-01-01 00:00:00

abstract：:Cognitive flexibility, the ability to adjust behavior in response to new and unexpected conditions in the environment, is essential for adaptation to new challenges and survival. The cholinergic system is an important modulator of this complex behavior however, the exact cholinergic circuits involved in this modulatio...

journal_title：Neuroscience

authors： Prado VF,Janickova H,Al-Onaizi MA,Prado MA

更新日期：2017-03-14 00:00:00

abstract：:Incubation of the rat sensory neuron-derived cell line ND7 in serum-free medium results in the arrest of mitosis and the appearance of numerous neuronal processes. During this differentiation event, secretory granule components such as chromogranins, neuropeptide Y and the C-flanking peptide of pro-neuropeptide Y move...

journal_title：Neuroscience

authors： Wheatley SC,Suburo AM,Horn DA,Vucicevic V,Terenghi G,Polak JM,Latchman DS

更新日期：1992-12-01 00:00:00

abstract：:Repeated exposure to the psychostimulant drug, amphetamine, results in a persistent increase in the ability of the drug to elicit behavioral activation.(14,19) The development of sensitized responses to amphetamine involves long-lasting neuroadaptations within defined circuitry.(3,6,12,15,23) The behavioral expression...

journal_title：Neuroscience

authors： Arvanitogiannis A,Sullivan J,Amir S

更新日期：2000-01-01 00:00:00

abstract：:Transthyretin is the major thyroxine-binding protein in the plasma of rodents, and the main thyroxine-binding protein in the cerebrospinal fluid of both rodents and humans. The choroid plexus synthesizes transthyretin and secretes it to the cerebrospinal fluid. Although it was suggested that transthyretin might play a...

journal_title：Neuroscience

authors： Palha JA,Nissanov J,Fernandes R,Sousa JC,Bertrand L,Dratman MB,Morreale de Escobar G,Gottesman M,Saraiva MJ

更新日期：2002-01-01 00:00:00

abstract：:Intracellular and extracellular recording techniques and in vitro preparation were used to examine the effect of [Met]enkephalin on the rat periaqueductal neurons. In the 20 cells that were recorded intracellularly, [Met]enkephalin caused an increase in the resting membrane conductance, hyperpolarization of the cell m...

journal_title：Neuroscience

authors： Behbehani MM,Jiang M,Chandler SD

更新日期：1990-01-01 00:00:00

abstract：:To examine the effect of glucose on the cerebral metabolism of glutamine, rat brain slices were incubated with 5mM [3-(13)C]glutamine without and with 5mM unlabeled glucose. Tissue plus medium extracts were analyzed by using enzymatic and (13)C NMR techniques and fluxes through the enzymatic steps involved were calcul...

journal_title：Neuroscience

authors： El Hage M,Baverel G,Conjard-Duplany A,Martin G

更新日期：2013-09-17 00:00:00

abstract：:Leptin and somatostatin (SRIF) have opposite effects on food seeking and ingestive behaviors, functions partially regulated by the frontoparietal cortex and hippocampus. Although it is known that the acute suppression of food intake mediated by leptin decreases with time, the counter-regulatory mechanisms remain uncle...

journal_title：Neuroscience

authors： Perianes-Cachero A,Burgos-Ramos E,Puebla-Jiménez L,Canelles S,Frago LM,Hervás-Aguilar A,de Frutos S,Toledo-Lobo MV,Mela V,Viveros MP,Argente J,Chowen JA,Arilla-Ferreiro E,Barrios V

更新日期：2013-11-12 00:00:00

abstract：:Accumulation of mutant ubiquitin-B (UBB(+1)) in neurons is considered the hallmark of proteasomal dysfunction in neurodegenerative disorders, however no such evidence in ischemic brain has been reported. We investigated the contribution of UBB(+1) in delayed neuronal death after transient global ischemia. Transient gl...

journal_title：Neuroscience

authors： Yamashiro K,Liu R,Maeda M,Hattori N,Urabe T

更新日期：2007-06-15 00:00:00

abstract：:Efr3a has been found to be involved in the functional maintenance and structural degeneration of sensory and motor nervous tissues. Our previous data have suggested that Efr3a may be associated with the initiation of the degeneration of spiral ganglion neurons (SGNs). In this study, we used Efr3a knockdown (Efr3a KD) ...

journal_title：Neuroscience

authors： Hu H,Ma Y,Ye B,Wang Q,Yang T,Lv J,Shi J,Wu H,Xiang M

更新日期：2017-01-26 00:00:00

abstract：:GABA(A) receptor/Cl- channels and voltage-gated Ca2+ channels are believed to be important sites of ethanol action in the CNS. Acute exposure of ethanol potentiates GABA(A) receptor/Cl- channel activity and inhibits voltage-gated Ca2+ channels in a number of preparations, mostly post-mitotic neurons. The effects of et...

journal_title：Neuroscience

authors： Ma W,Pancrazio JJ,Andreadis JD,Shaffer KM,Stenger DA,Li BS,Zhang L,Barker JL,Maric D

更新日期：2001-01-01 00:00:00

abstract：:Neurons containing melanin-concentrating hormone (MCH) in the lateral hypothalamic area (LH) have been shown to promote rapid eye movement sleep (REMs) in mice. However, the downstream neural pathways through which MCH neurons influence REMs remained unclear. Because MCH neurons are considered to be primarily inhibito...

journal_title：Neuroscience

authors： Kroeger D,Bandaru SS,Madara JC,Vetrivelan R

更新日期：2019-05-15 00:00:00

abstract：:Estradiol-induced plasticity involves changes in dendritic spine density and in the relative proportions of the different dendritic spine types that influence neurons and neural circuits. Such events affect brain structures that control the timing of neuroendocrine and behavioral processes, influencing both reproducti...

journal_title：Neuroscience

authors： González-Burgos I,Velázquez-Zamora DA,González-Tapia D,Cervantes M

更新日期：2015-07-09 00:00:00

abstract：:The functional changes of astrocytes are deeply involved in neurodegenerating processes of various CNS diseases. ATP is released during various neuronal damages such as brain ischemia and may control astrocyte functions. We examined the effect of ATP on the production of nitric oxide in the cultured astrocytes from ra...

journal_title：Neuroscience

authors： Murakami K,Nakamura Y,Yoneda Y

更新日期：2003-01-01 00:00:00

abstract：:Deafferentation of the adult rat dentate gyrus induces reactive axonal growth by surviving afferent systems. In middle aged and aged rats, axonal sprouting is delayed and reduced relative to young adults. The cause for this age-related decline is not known, but it may reflect a decrement in trophic signals which initi...

journal_title：Neuroscience

authors： Woods AG,Guthrie KM,Kurlawalla MA,Gall CM

更新日期：1998-04-01 00:00:00

abstract：:A double transgenic mouse expressing the amyloid precursor protein, bearing the Swedish mutations, and expressing tau protein containing three of the mutations present in frontotemporal dementia linked to chromosome 17 (FTDP-17), has been characterized. In the double transgenic mouse an increase in tau phosphorylation...

journal_title：Neuroscience

authors： Pérez M,Ribe E,Rubio A,Lim F,Morán MA,Ramos PG,Ferrer I,Isla MT,Avila J

更新日期：2005-01-01 00:00:00

abstract：:The pharmacological features of putative nicotinic acetylcholine receptor sites involved in the release of [3H]noradrenaline were assessed in rat hippocampus. The effect of nicotinic agonists to induce [3H]noradrenaline release was examined in superfused slices. The nicotinic agonists (-)-epibatidine, (+)-anatoxin-a, ...

journal_title：Neuroscience

authors： Sershen H,Balla A,Lajtha A,Vizi ES

更新日期：1997-03-01 00:00:00