当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Redistribution of secretory granule components precedes that of synaptic vesicle proteins during differentiation of a neuronal cell line in serum-free medium.

Redistribution of secretory granule components precedes that of synaptic vesicle proteins during differentiation of a neuronal cell line in serum-free medium.

Abstract：

:Incubation of the rat sensory neuron-derived cell line ND7 in serum-free medium results in the arrest of mitosis and the appearance of numerous neuronal processes. During this differentiation event, secretory granule components such as chromogranins, neuropeptide Y and the C-flanking peptide of pro-neuropeptide Y move to the tips of the majority of the neuronal processes regardless of process length. In contrast, the synaptic vesicle component, synaptophysin, is found only at the tips of the very long processes which appear following prolonged periods of culture in serum-free medium. A similar restriction of synaptophysin to long processes is also observed following differentiation and process formation induced by other treatments such as incubation in reduced serum or treatment with cyclic AMP or phorbol myristate acetate. Hence the regulated secretory pathway associated with the chromogranins and neuropeptides appears to be segregated into the processes at an earlier stage of ND7 differentiation than the synaptophysin-associated synaptic vesicle pathway. ND7 cells therefore provide a model system for studying the processes regulating these pathways and the redistribution of their components during neuronal differentiation.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Wheatley SC,Suburo AM,Horn DA,Vucicevic V,Terenghi G,Polak JM,Latchman DS

doi

10.1016/0306-4522(92)90297-f

keywords:

subject

Has Abstract

pub_date

1992-12-01 00:00:00

pages

575-82

issue

3

eissn

0306-4522

issn

1873-7544

pii

0306-4522(92)90297-F

journal_volume

51

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Differential vulnerability in the hindbrain neurons and local cerebral blood flow during bilateral vertebral occlusion in gerbils.

    abstract：:Differential vulnerability in the hindbrain neurons was examined immunohistochemically during hindbrain ischemia in the gerbil. Hindbrain ischemia was produced by extracranial occlusion of the bilateral vertebral arteries just before their entry into the transverse foramen of the cervical vertebra. Local cerebral bloo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90343-e

    authors： Hata R,Matsumoto M,Hatakeyama T,Ohtsuki T,Handa N,Niinobe M,Mikoshiba K,Sakaki S,Nishimura T,Yanagihara T

    更新日期：1993-09-01 00:00:00

  • Deep prepiriform cortex modulates kainate-induced hippocampal injury.

    abstract：:As seizure propagation within limbic structures is mediated in part by a small area of deep prepiriform cortex (area tempestas), we investigated the role of area tempestas in modulating hippocampal injury induced by systemic kainate administration. Injury was quantitated by counting the numbers of neurons that stained...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90404-9

    authors： Shimosaka S,So YT,Simon RP

    更新日期：1994-08-01 00:00:00

  • Comparison of neurons in rat medulla oblongata with fos immunoreactivity evoked by seizures, chemoreceptor, or baroreceptor stimulation.

    abstract：:Neurons in rat medulla oblongata with Fos immunoreactivity as a marker of synaptic excitation evoked by pentylenetetrazole-induced seizures were compared with cell populations activated by the stimulation of chemoreceptor and baroreceptor afferent pathways. Chemoreceptors were stimulated by placing rats in a hypoxic g...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00051-6

    authors： Kanter RK,Strauss JA,Sauro MD

    更新日期：1996-08-01 00:00:00

  • Anatomical characterization of retinal ganglion cells that project to the nucleus of the basal optic root in the turtle (Pseudemys scripta elegans).

    abstract：:There is little detailed information about retinal ganglion cells which project to specific central targets in the brain. The present study examined retinal ganglion cells projecting to the nucleus of the basal optic root, a major accessory retinal target in the turtle. These ganglion cells were first selectively labe...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90446-4

    authors： Zhang D,Eldred WD

    更新日期：1994-08-01 00:00:00

  • Inositol trisphosphate and cyclic adenosine diphosphate-ribose increase quantal transmitter release at frog motor nerve terminals: possible involvement of smooth endoplasmic reticulum.

    abstract：:The release of chemical transmitter from nerve terminals is critically dependent on a transient increase in intracellular Ca2+. The increase in Ca2+ may be due to influx of Ca2+ from the extracellular fluid or release of Ca2+ from intracellular stores such as mitochondria. Whether Ca2+ utilized in transmitter release ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00509-6

    authors： Brailoiu E,Miyamoto MD

    更新日期：2000-01-01 00:00:00

  • Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system.

    abstract：:Glial cell line-derived neurotrophic factor (GDNF) signals through multisubunit receptor complex consisting of RET tyrosine kinase and a glycosylphosphatidylinositol-anchored coreceptor called GDNF family receptor alpha1 (GFRalpha1). In the current study, we cloned a human SEP1 gene as a GDNF-inducible gene using huma...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00487-1

    authors： Shimoyama Y,Morikawa Y,Ichihara M,Kodama Y,Fukuda N,Hayashi H,Morinaga T,Iwashita T,Murakumo Y,Takahashi M

    更新日期：2003-01-01 00:00:00

  • Neurochemical changes following occlusion of the middle cerebral artery in rats.

    abstract：:We have developed a stroke model involving middle cerebral artery occlusion in the rat which elicits changes in cardiac and autonomic variables that are similar to those observed clinically. It is likely that these neurogenic autonomic responses are mediated by changes in neurotransmitter systems subsequent to the str...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00198-r

    authors： Allen GV,Cheung RT,Cechetto DF

    更新日期：1995-10-01 00:00:00

  • The organization and hypothalamic projections of the tuberomammillary nucleus in the rat: an immunohistochemical study of adenosine deaminase-positive neurons and fibers.

    abstract：:The intense immunohistochemical reaction for the enzyme adenosine deaminase displayed by neurons in the tuberomammillary nucleus in the rat was used to study the distribution and morphology of cells comprising this nucleus, their fiber fields within the posterior hypothalamus and their projection pathways from the hyp...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90077-7

    authors： Staines WA,Daddona PE,Nagy JI

    更新日期：1987-11-01 00:00:00

  • Long-term potentiation and memory processes in the psychological works of Sigmund Freud and in the formation of neuropsychiatric symptoms.

    abstract：:Far from disproving the model of mind functioning proposed by psychoanalysis, the recent advances in neuropsychiatrical research confirmed the crucial ideas of Sigmund Freud. The hypothesis that the origin of mental illnesses lies in the impossibility for a subject to erase the long-term effects of a remote adverse ev...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2004.09.032

    authors： Centonze D,Siracusano A,Calabresi P,Bernardi G

    更新日期：2005-01-01 00:00:00

  • Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro.

    abstract：:Presenilin-1 (PS1) is the gene responsible for the development of early-onset familial Alzheimer's disease. To probe the functions of PS1 on neuronal resistance to oxidative stress, we pharmacologically examined the death signals in PS1-deficient neurons induced by oxidative stress. Because the death of primarily cult...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.01.016

    authors： Nakajima M,Shirasawa T

    更新日期：2004-01-01 00:00:00

  • Working memory and the homeostatic control of brain adenosine by adenosine kinase.

    abstract：:The neuromodulator adenosine maintains brain homeostasis and regulates complex behaviour via activation of inhibitory and excitatory adenosine receptors (ARs) in a brain region-specific manner. AR antagonists such as caffeine have been shown to ameliorate cognitive impairments in animal disease models but their effect...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.03.051

    authors： Singer P,McGarrity S,Shen HY,Boison D,Yee BK

    更新日期：2012-06-28 00:00:00

  • Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatum.

    abstract：:Recent studies using DNA fragmentation assays suggest a role for apoptosis in cell death in Huntington's disease. In this study, we investigated the relationship between the degree of DNA fragmentation and the number of trinucleotide (CAG) repeats of the Huntington's disease gene in striatal tissue from Huntington's d...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00129-8

    authors： Butterworth NJ,Williams L,Bullock JY,Love DR,Faull RL,Dragunow M

    更新日期：1998-11-01 00:00:00

  • The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia.

    abstract：:Apoptosis, or programmed cell death, resulting from cerebral ischemia may be related to decreased levels of anti-apoptotic factors, such as serine/threonine kinase (Akt), phosphorylated Akt (pAkt), pBAD, and Bcl-2, and increased levels of pro-apoptotic factors, such as BAD, caspase 9, and caspase 3 activities. In this...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.06.022

    authors： Yip KK,Lo SC,Leung MC,So KF,Tang CY,Poon DM

    更新日期：2011-09-08 00:00:00

  • Distribution of opiate receptors in the monkey brain: an autoradiographic study.

    abstract：:By employing both in vivo and in vitro labeling techniques, opiate receptors were labeled with tritiated diprenorphine in the monkey brain and localized by light microscopic autoradiography. Both methods of labeling gave similar results, allowing a description of discrete areas having opiate binding sites. High concen...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(82)90066-5

    authors： Wamsley JK,Zarbin MA,Young WS 3rd,Kuhar MJ

    更新日期：1982-03-01 00:00:00

  • Voxel-based morphometry study of the insular cortex in female patients with current and remitted depression.

    abstract：OBJECTIVE:Women are more prone to major depressive disorders (MDDs) and the incidence of MDD in women is almost twice that of men. Insular cortex abnormalities are a common finding in neuroanatomical studies of patients with MDD. However, it remains largely unclear whether female MDD patients at different clinical stag...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.12.058

    authors： Liu CH,Jing B,Ma X,Xu PF,Zhang Y,Li F,Wang YP,Tang LR,Wang YJ,Li HY,Wang CY

    更新日期：2014-03-14 00:00:00

  • Persistence of fluoro-gold following degeneration of labeled motoneurons is due to phagocytosis by microglia and macrophages.

    abstract：:When the neural tracer Fluoro-Gold is used to retrogradely label a population of axotomized neurons, cellular labeling can persist in the axotomized nucleus even when Nissl staining indicates that the injured neurons have degenerated. In order to determine the identity of the labeled cells that remain, this study comb...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90096-7

    authors： Rinaman L,Milligan CE,Levitt P

    更新日期：1991-01-01 00:00:00

  • In vivo induction of striatal long-term potentiation by low-frequency stimulation of the cerebral cortex.

    abstract：:Both long-term depression and long-term potentiation have been described at corticostriatal synapses. These long-lasting changes in synaptic strength were classically induced by high-frequency (100 Hz) electrical stimulations of cortical afferents. The purpose of the present study was to test the ability of corticostr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00719-2

    authors： Charpier S,Mahon S,Deniau JM

    更新日期：1999-01-01 00:00:00

  • Immunolocalization of the P2X4 receptor on neurons and glia in the mammalian retina.

    abstract：:Extracellular adenosine 5'-triphosphate (eATP) acts as a neurotransmitter within the retina and brain, activating a range of ionotropic P2X and metabotropic P2Y receptors. In this study, the specific localization of the P2X4 receptor (P2X4-R) subunit was evaluated in the retina using fluorescence immunohistochemistry ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.06.055

    authors： Ho T,Vessey KA,Fletcher EL

    更新日期：2014-09-26 00:00:00

  • Efferent projections of nucleus locus coeruleus: topographic organization of cells of origin demonstrated by three-dimensional reconstruction.

    abstract：:The present study examines the spatial distribution within rat locus coeruleus of neurons projecting to particular brain regions. In order to accurately recreate, in digital and pictorial formats, the spatial distribution of neurons for the entire nucleus locus coeruleus, three-dimensional reconstructions were created...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(86)90155-7

    authors： Loughlin SE,Foote SL,Bloom FE

    更新日期：1986-06-01 00:00:00

  • Human endogenous retrovirus W family envelope gene activates the small conductance Ca2+-activated K+ channel in human neuroblastoma cells through CREB.

    abstract：:Numerous studies have shown that human endogenous retrovirus W family (HERV-W) envelope gene (env) is related to various diseases but the underlying mechanism has remained poorly understood. Our previous study showed that there was abnormal expression of HERV-W env in sera of patients with schizophrenia. In this paper...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.05.033

    authors： Li S,Liu ZC,Yin SJ,Chen YT,Yu HL,Zeng J,Zhang Q,Zhu F

    更新日期：2013-09-05 00:00:00

  • Deficits in cortico-striatal synaptic plasticity and behavioral habituation in rats with portacaval anastomosis.

    abstract：:Hepatic encephalopathy is characterized by disturbances of motor and cognitive functions involving the basal ganglia. So far no standards for assessment of neuropsychiatric abnormalities (disorders of sleep, mood, anxiety and personality) in subclinical hepatic encephalopathy have been defined. Using an animal model o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.05.031

    authors： Sergeeva OA,Schulz D,Doreulee N,Ponomarenko AA,Selbach O,Borsch E,Kircheis G,Huston JP,Häussinger D,Haas HL

    更新日期：2005-01-01 00:00:00

  • Contextual modulation of frequency tuning of neurons in the rat auditory cortex.

    abstract：:In a natural acoustic environment, sound stimuli often occur in a contextual acoustic stream. The aim of the present study was to determine how the frequency tuning of auditory cortical neurons is affected by an acoustic context. A forward masking paradigm was used to determine the frequency receptive fields of rat au...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.05.047

    authors： Peng Y,Sun X,Zhang J

    更新日期：2010-09-01 00:00:00

  • Encoding of temporal features of auditory stimuli in the medial nucleus of the trapezoid body and superior paraolivary nucleus of the rat.

    abstract：:Neurons in the superior paraolivary nucleus (SPON) of the rat respond to the offset of pure tones with a brief burst of spikes. Medial nucleus of the trapezoid body (MNTB) neurons, which inhibit the SPON, produce a sustained pure tone response followed by an offset response characterized by a period of suppressed spon...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.11.008

    authors： Kadner A,Berrebi AS

    更新日期：2008-02-06 00:00:00

  • Rare Diseases of Neurodevelopment: Maintain the Mystery or Use a Dazzling Tool for Investigation? The Case of Rett Syndrome.

    abstract：:The investigation on neurotransmission function during normal and pathologic development is a pivotal component needed to understand the basic mechanisms underlying neurodevelopmental pathologies. To study these diseases, many animal models have been generated which allowed to face the limited availability of human ti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.06.015

    authors： Ruffolo G,Cifelli P,Miranda-Lourenço C,De Felice E,Limatola C,Sebastião AM,Diógenes MJ,Aronica E,Palma E

    更新日期：2020-07-15 00:00:00

  • Porcine neural xenografts in the immunocompetent rat: immune response following grafting of expanded neural precursor cells.

    abstract：:Intracerebral neural xenografts elicit a host immune response that results in their rapid rejection. This forms a key barrier to the therapeutic use of xenogeneic tissue transplantation for conditions such as Parkinson's disease. The current study sought to provide insight into the cellular components of donor cell su...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00273-1

    authors： Armstrong RJ,Harrower TP,Hurelbrink CB,McLaughin M,Ratcliffe EL,Tyers P,Richards A,Dunnett SB,Rosser AE,Barker RA

    更新日期：2001-01-01 00:00:00

  • Behavioral analysis of opiate-mediated inhibition in the early chick embryo.

    abstract：:Morphine (opiate agonist) produced a dose-dependent decrease in the spontaneous motility of 5- and 9-day chick embryos. Naloxone (opiate antagonist) appeared to reverse competitively the inhibition of motility caused by morphine. The effects of morphine on spontaneous motility in 5-day embryos were also reversed stere...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(85)90012-0

    authors： Maderdrut JL,Reitzel JL,Okado N,Oppenheim RW

    更新日期：1985-10-01 00:00:00

  • Decreased expression of N-methyl-D-aspartate receptor 1 messenger RNA in select regions of Alzheimer brain.

    abstract：:An antisense oligonucleotide probe was used to examine the expression of gene encoding the obligatory NMDAR1 subunit of the N-methyl-D-aspartate receptor in the hippocampus and adjacent cortical areas (entorhinal and perirhinal cortices) of seven Alzheimer patients and in the same brain regions of seven control indivi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00023-7

    authors： Ulas J,Cotman CW

    更新日期：1997-08-01 00:00:00

  • Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition.

    abstract：:Adenosine tonically inhibits synaptic transmission through actions at A(1) receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre- and/or postsynaptic A(2A) receptor activation or from indirect control of inhibitory GABAergic transmission. The A(2A) receptor agoni...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00080-5

    authors： Lopes LV,Cunha RA,Kull B,Fredholm BB,Ribeiro JA

    更新日期：2002-01-01 00:00:00

  • Multiple sites for the initiation of action potentials in neurons of the inferior mesenteric ganglion of the guinea-pig.

    abstract：:Responses to nerve stimulation were recorded with intracellular microelectrodes from neurons in the inferior mesenteric ganglion of the guinea-pig. An event was recorded which was subthreshold for a somatic action potential but which had a short rise time and a rapid initial repolarization that gave the event a small ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90097-2

    authors： Coleman HA

    更新日期：1987-02-01 00:00:00

  • Cellular localization of nerve growth factor-like immunoreactivity in adult rat brain: quantitative and immunohistochemical study.

    abstract：:To elucidate the role and the mechanism of action of nerve growth factor in the adult central nervous system, we investigated the localization of nerve growth factor-like immunoreactivity in adult rat brain, both quantitatively and immunohistochemically, using polyclonal anti-nerve growth factor immunoglobulin G. We r...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90204-6

    authors： Nishio T,Furukawa S,Akiguchi I,Oka N,Ohnishi K,Tomimoto H,Nakamura S,Kimura J

    更新日期：1994-05-01 00:00:00