Abstract：
:Numerous studies have shown that human endogenous retrovirus W family (HERV-W) envelope gene (env) is related to various diseases but the underlying mechanism has remained poorly understood. Our previous study showed that there was abnormal expression of HERV-W env in sera of patients with schizophrenia. In this paper, we reported that overexpression of the HERV-W env elevated the levels of small conductance Ca(2+)-activated K(+) channel protein 3 (SK3) in human neuroblastoma cells. Using a luciferase reporter system and RNA interference method, we found that functional cAMP response element site was required for the expression of SK3 triggered by HERV-W env. In addition, it was also found that the SK3 channel was activated by HERV-W env. Further study indicated that cAMP response element-binding protein (CREB) was required for the activation of the SK3 channel. Thus, a novel signaling mechanism of how HERV-W env influences neuronal activity and contributes to mental illnesses such as schizophrenia was proposed.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Li S,Liu ZC,Yin SJ,Chen YT,Yu HL,Zeng J,Zhang Q,Zhu Fdoi
10.1016/j.neuroscience.2013.05.033subject
Has Abstractpub_date
2013-09-05 00:00:00pages
164-74eissn
0306-4522issn
1873-7544pii
S0306-4522(13)00453-3journal_volume
247pub_type
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