Adenosine triphosphate-evoked currents in cultured dorsal root ganglion neurons obtained from rat embryos: desensitization kinetics and modulation of glutamate release.

abstract：:In vitro cell cultures are an important tool for obtaining insights into cellular processes in an isolated system and a supplement to in vivo animal experiments. While primary dissociated cultures permit a single homogeneous cell population to be studied, there is a clear need to explore the function of brain cells in...

journal_title：Neuroscience

authors： Humpel C

更新日期：2015-10-01 00:00:00

abstract：:The effects of steady iontophoretic applications of serotonin on the spontaneous discharge and on the excitatory responses induced in deep cerebellar nuclei neurons by iontophoretic pulse applications of L-glutamate, L-aspartate, N-methyl-D,L-aspartate and quisqualate were studied in rat cerebellar slices maintained i...

journal_title：Neuroscience

authors： Gardette R,Krupa M,Crepel F

更新日期：1987-11-01 00:00:00

abstract：:This study was performed using intracellular and multiunit extracellular recording techniques in order to characterize the role of nitric oxide in the afferent synaptic transmission of the vestibular system of the axolotl (Ambystoma tigrinum). Bath application of nitric oxide synthase inhibitors N(G)-nitro-L-arginine ...

journal_title：Neuroscience

authors： Flores A,Soto E,Vega R

更新日期：2001-01-01 00:00:00

abstract：:The inhibitory neurotransmitter GABA plays an important role in regulating the activity of magnocellular oxytocin and vasopressin neurons located in the supraoptic and paraventricular nuclei through occupancy of GABAA receptors. However, the GABAA receptor is a hetero-oligomeric protein comprised of different subunits...

journal_title：Neuroscience

authors： Fenelon VS,Sieghart W,Herbison AE

更新日期：1995-02-01 00:00:00

abstract：:The present study examined the antihyperalgesic effect of a specific inhibitor of Glycogen Synthase Kinase 3 (GSK3), AR-A014418, on the partial ligation of the sciatic nerve (PSNL), a neuropathic pain model in mice and investigated some mechanisms of action. AR-A014418 (0.01-1 mg/kg) administered by intraperitoneal ro...

journal_title：Neuroscience

authors： Mazzardo-Martins L,Martins DF,Stramosk J,Cidral-Filho FJ,Santos AR

更新日期：2012-12-13 00:00:00

abstract：:In the present study, we investigated whether endoplasmic reticulum (ER) stress is associated with neuronal- and astroglial-death in the hippocampus using LiCl-pilocarpine-induced status epilepticus (SE) rat model. Glucose-related protein (GRP) 78 and protein disulfide isomerase (PDI) expressions were transiently incr...

journal_title：Neuroscience

authors： Ko AR,Kim JY,Hyun HW,Kim JE

更新日期：2015-10-29 00:00:00

abstract：:Parkinson's disease (PD) is a progressive aging disorder that affects millions worldwide, thus, disease-modifying-therapies are urgently needed. PD pathology includes α-synuclein (aSyn) accumulation as synucleinopathy. Loss of GM1 gangliosides occurs in PD brain, which is modeled in GM2 synthase transgenic mice. GM2+/...

journal_title：Neuroscience

authors： Vidal-Martinez G,Najera K,Miranda JD,Gil-Tommee C,Yang B,Vargas-Medrano J,Diaz-Pacheco V,Perez RG

更新日期：2019-07-15 00:00:00

abstract：:Electroconvulsive therapy has been commonly applied in the treatment of refractory depression, but its cognitive side effects are noticed and restrict its application. The molecular mechanisms underlying the side effects remain elusive, and there is no efficient prevention. By employing a recognized electroconvulsive ...

journal_title：Neuroscience

authors： Yao Z,Guo Z,Yang C,Tian Q,Gong CX,Liu G,Wang JZ

更新日期：2010-06-30 00:00:00

abstract：:Hippocampal cell firing in awake, behaving rats is often spatially selective, and such cells have been called place cells. Similar spatial correlates have also been described for neurons in the medial entorhinal and perirhinal cortices. All three regions receive sensory associational input from postrhinal cortex, whic...

journal_title：Neuroscience

authors： Burwell RD,Hafeman DM

更新日期：2003-01-01 00:00:00

abstract：:For over two decades it has been increasingly appreciated that synaptic plasticity mechanisms are subject to activity-dependent metaplastic regulation. In recent years it has also become apparent that astrocytes are active partners with neurons at synapses, and have the capability to powerfully regulate synaptic plast...

journal_title：Neuroscience

authors： Jones OD

更新日期：2015-11-19 00:00:00

abstract：OBJECT:The aim of this study is to explore the changes of inter-hemispheric functional connectivity in patients with unilateral brachial plexus injury. METHODS:Nine patients with five roots of unilateral brachial plexus avulsion injury and 11 healthy controls were recruited in this study. Resting-state functional conn...

journal_title：Neuroscience

authors： Liu B,Li T,Tang WJ,Zhang JH,Sun HP,Xu WD,Liu HQ,Feng XY

更新日期：2013-07-23 00:00:00

abstract：:The rostral ventromedial medulla contains three physiologically defined classes of pain-modulating neuron that project to the spinal and trigeminal dorsal horns. OFF cells contribute to anti-nociceptive processes, ON cells contribute to pro-nociceptive processes (i.e. hyperalgesia) and neutral cells tonically modulate...

journal_title：Neuroscience

authors： Hirakawa N,Tershner SA,Fields HL,Manning BH

更新日期：2000-01-01 00:00:00

abstract：:We have investigated effects of letrozole, an aromatase inhibitor, on spatial learning and memory, expression of neural cell adhesion molecules (NCAM) and catecholaminergic neurotransmitters in the hippocampus and cortex of female rats. In the intact model, adult Sprague-Dawley rats were divided into four groups (n=8)...

journal_title：Neuroscience

authors： Aydin M,Yilmaz B,Alcin E,Nedzvetsky VS,Sahin Z,Tuzcu M

更新日期：2008-01-02 00:00:00

abstract：:Seizures and status epilepticus induce an excessive production of reactive oxygen species leading to oxidative stress. Vitamin E, a classic antioxidant, has a neuroprotective effect on rats with seizures by regulating reactive oxygen species production. The activity of chaperone-mediated autophagy, a selective pathway...

journal_title：Neuroscience

authors： Cao L,Chen R,Xu J,Lin Y,Wang R,Chi Z

更新日期：2009-06-16 00:00:00

abstract：:The uptake and release of catecholamines was investigated in the isolated perfused adrenal gland of the rat after preloading the preparation with [3H]norepinephrine, and the effects of various agents were examined on the stimulation-evoked secretion of catecholamines and total tritium. Large quantities of tritium were...

journal_title：Neuroscience

authors： Wakade AR,Malhotra RK,Wakade TD,Dixon WR

更新日期：1986-08-01 00:00:00

abstract：:In the rat spinal cord in vitro, block of synaptic inhibition evokes persistent, regular disinhibited bursting which is a manifestation of the intrinsic network rhythmicity and is readily recorded from ventral roots. This model is advantageous to explore the network mechanisms controlling burst periodicity, and durati...

journal_title：Neuroscience

authors： Taccola G,Nistri A

更新日期：2007-06-08 00:00:00

abstract：:Somatosensory information from the limbs reaches the contralateral Primary Sensory Cortex (S1) with a delay of 23ms for finger, and 40ms for leg (somatosensory N20/N40). Upon arrival of this input in the cortex, motor evoked potentials (MEPs) elicited by Transcranial Magnetic Stimulation (TMS) are momentarily inhibite...

journal_title：Neuroscience

authors： Ruddy KL,Jaspers E,Keller M,Wenderoth N

更新日期：2016-10-01 00:00:00

abstract：:P2X receptor-mediated responses to the ATP analogue, alpha,beta-methylene ATP, in rat brain cannot be accounted for by the receptor proteins known to be present. Such experiments are often performed on cells from neonates and, since differential developmental regulation of P2X1 and P2X2 receptor messenger RNAs has alr...

journal_title：Neuroscience

authors： Kidd EJ,Miller KJ,Sansum AJ,Humphrey PP

更新日期：1998-12-01 00:00:00

abstract：:We tested a hypothesis that the classical relation between movement time and index of difficulty (ID) in quick pointing action (Fitts' Law) reflects processes at the level of motor planning. Healthy subjects stood on a force platform and performed quick and accurate hand movements into targets of different size locate...

journal_title：Neuroscience

authors： Bertucco M,Cesari P,Latash ML

更新日期：2013-02-12 00:00:00

abstract：:Colivelin is a neuroprotective humanin family peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. We seek to investigate whether this effect of Colivelin also govern ischemic brain injury, and potential mechanism underlying th...

journal_title：Neuroscience

authors： Zhao H,Feng Y,Wei C,Li Y,Ma H,Wang X,Cui Z,Jin WN,Shi FD

更新日期：2019-09-15 00:00:00

abstract：:Morphological features of nerve fibers and synapses containing GABA and [Met]enkephalin were studied at the light and electron microscopic levels in the superior cervical ganglia of rats by pre- and postembedding immunohistochemistry. Both GABA and [Met]enkephalin immunoreactivities were found in varicose nerve fibers...

journal_title：Neuroscience

authors： Párducz A,Dobó E,Joó F,Wolff JR

更新日期：1992-08-01 00:00:00

abstract：:The relationship between discharge rates of locus coeruleus noradrenergic neurons and rates of norepinephrine release was examined in the anesthetized rat. Neuronal discharge rates of locus coeruleus neurons were altered and quantified using a combined recording-infusion probe. Peri-locus coeruleus infusions of either...

journal_title：Neuroscience

authors： Berridge CW,Abercrombie ED

更新日期：1999-01-01 00:00:00

abstract：:Constraints involving the delivery method of glial cell line-derived neurotrophic factor (GDNF) have hampered its efficacy as a neuroprotectant in Parkinson's disease. Ex vivo gene therapy, in which suitable cells, such as bone marrow-derived mesenchymal stem cells (MSCs), are genetically engineered to overexpress GDN...

journal_title：Neuroscience

authors： Hoban DB,Howard L,Dowd E

更新日期：2015-09-10 00:00:00

abstract：:We have recently shown that isolated neuronal growth cones from developing rat forebrain possess an appreciable activity of adenylate cyclase, producing cyclic adenosine monophosphate, which can be stimulated by various neurotransmitter receptor agonists and by forskolin [Lockerbie R. O., Hervé D., Blanc G., Tassin J....

journal_title：Neuroscience

authors： Lockerbie RO,Autillo-Touati A,Araud D,Seite R,Chneiweiss H,Glowinski J,Prochiantz A

更新日期：1989-01-01 00:00:00

abstract：:Hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels contribute to rhythmic spontaneous activity in the heart and CNS. Ectopic spontaneous neuronal activity has been implicated in the development and maintenance of acute and chronic hyperalgesia, allodynia and spontaneous pain. Previously, we docume...

journal_title：Neuroscience

authors： Luo L,Chang L,Brown SM,Ao H,Lee DH,Higuera ES,Dubin AE,Chaplan SR

更新日期：2007-02-23 00:00:00

abstract：:Intracerebral neural xenografts elicit a host immune response that results in their rapid rejection. This forms a key barrier to the therapeutic use of xenogeneic tissue transplantation for conditions such as Parkinson's disease. The current study sought to provide insight into the cellular components of donor cell su...

journal_title：Neuroscience

authors： Armstrong RJ,Harrower TP,Hurelbrink CB,McLaughin M,Ratcliffe EL,Tyers P,Richards A,Dunnett SB,Rosser AE,Barker RA

更新日期：2001-01-01 00:00:00

abstract：:This paper presents results obtained from experiments performed on two behaving monkeys (Macaca mulatta) viewing correlated and uncorrelated dynamic random dot stereograms. Extracellular single unit activity was recorded from areas V1 and V2. We found that cells sensitive to correlated stereograms (38%) were also sens...

journal_title：Neuroscience

authors： Gonzalez F,Krause F,Perez R,Alonso JM,Acuña C

更新日期：1993-02-01 00:00:00

abstract：:The present study examines the role of central beta-endorphin in the generation of stimulation-induced analgesia from the ventral midbrain periaqueductal gray of freely-moving rats. Electrical stimulation of the ventral midbrain periaqueductal gray led to an antinociception against noxious heat which gradually subside...

journal_title：Neuroscience

authors： Millan MH,Millan MJ,Herz A

更新日期：1986-07-01 00:00:00

abstract：:The aim of the present work was to investigate the mechanism by which the diffusible factor nitric oxide regulates GABAA receptor function in the brain. The effect of nitric oxide on GABAA receptor function has been studied in two different neuronal preparations: rat cerebral cortex microsacs and rat cerebellum granul...

journal_title：Neuroscience

authors： Robello M,Amico C,Bucossi G,Cupello A,Rapallino MV,Thellung S

更新日期：1996-09-01 00:00:00

abstract：:Studies were made on the effect of the neuroexcitatory agent kainic acid, microinjected into raphe dorsal nucleus by glass micropipette and an air pressure system in doses ranging from 0.2 to 24.0 nmol (in volumes from 0.05 microliter to 0.47 microliter), on the somatosensory evoked potentials and their cycles of reco...

journal_title：Neuroscience

authors： Moyanova S,Dimov S,Ivanova A

更新日期：1987-07-01 00:00:00