Nitric oxide and GABAA receptor function in the rat cerebral cortex and cerebellar granule cells.

abstract：:Ca(v)2.1 channels mediate neurotransmitter release at the neuromuscular junction (NMJ) and at many central synapses. Mutations in the encoding gene, CACNA1A, are thus likely to affect neurotransmitter release. Previously, we generated mice carrying the R192Q mutation, associated with human familial hemiplegic migraine...

journal_title：Neuroscience

authors： Kaja S,van de Ven RC,Broos LA,Veldman H,van Dijk JG,Verschuuren JJ,Frants RR,Ferrari MD,van den Maagdenberg AM,Plomp JJ

更新日期：2005-01-01 00:00:00

abstract：:The metabotropic glutamate receptor 4 is highly expressed presynaptically on thalamocortical neurons that are involved in the pathogenesis of generalized absence seizures. Mutant mice devoid of metabotropic glutamate receptor 4 are completely resistant to absence seizures induced by low doses of GABA type A receptor a...

journal_title：Neuroscience

authors： Wang X,Ai J,Hampson DR,Snead OC 3rd

更新日期：2005-01-01 00:00:00

abstract：:Neurotoxicity of (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV), a potent agonist for metabotropic glutamate receptors negatively coupled to adenylyl cyclase, was investigated in vivo by the intraventricular administration in the rat, compared with that of (2S,1'S,2'S)-2-(carboxycyclopropyl)glycine (L-C...

journal_title：Neuroscience

authors： Kwak S,Miyamoto M,Ishida M,Shinozaki H

更新日期：1996-08-01 00:00:00

abstract：:Aged rats may be behaviorally classified as either cognitively impaired or unimpaired based upon their performance in the Morris water maze task. In aged Long-Evans rats, emergence of functional deficits has been related to the increase in the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor s...

journal_title：Neuroscience

authors： Andrés N,Rodríguez MJ,Andrade C,Rowe W,Quirion R,Mahy N

更新日期：2000-01-01 00:00:00

abstract：:Accumulating evidence indicates that odontoblasts act as sensor cells, capable of triggering action potentials in adjacent pulpal nociceptive axons, suggesting a paracrine signaling via a currently unknown mediator. Since glutamate can mediate signaling by non-neuronal cells, and peripheral axons may express glutamate...

journal_title：Neuroscience

authors： Cho YS,Ryu CH,Won JH,Vang H,Oh SB,Ro JY,Bae YC

更新日期：2016-10-29 00:00:00

abstract：:Repeated exposure to cocaine during adolescence may affect both physical and psychological conditions in the brain, and increase the risk of psychiatric disorders and addiction behaviors in adulthood. Adolescence represents a critical development period for the hippocampus. Moreover, different regions of the hippocamp...

journal_title：Neuroscience

authors： Zhu W,Mao Z,Zhu C,Li M,Cao C,Guan Y,Yuan J,Xie G,Guan X

更新日期：2016-01-28 00:00:00

abstract：:Monoclonal antibodies SMI-31 and 150 recognize phosphorylation epitopes on microtubule-associated protein 1B that have been shown to be developmentally down-regulated in the nervous system. We have used these antibodies to establish changes in the pattern of expression of their epitopes on microtubule-associated prote...

journal_title：Neuroscience

authors： Bush MS,Tonge DA,Woolf C,Gordon-Weeks PR

更新日期：1996-07-01 00:00:00

abstract：:It is well established that transforming growth factor alpha is involved prenatally in development of the nervous system, but its role in the postnatal brain is less well understood. Here, we document the occurrence of late-onset, morphological and behavioral deficits in the naturally occurring murine mutant, Waved-1 ...

journal_title：Neuroscience

authors： Burrows RC,Levitt P,Shors TJ

更新日期：2000-01-01 00:00:00

abstract：:Mapping observed actions into the onlooker's motor system seems to provide the neurofunctional mechanisms for action understanding. Subthalamic nucleus (STN) local field potential (LFP) recordings in patients with movement disorders disclosed that network oscillations in the beta range are involved in conveying motor ...

journal_title：Neuroscience

authors： Marceglia S,Fiorio M,Foffani G,Mrakic-Sposta S,Tiriticco M,Locatelli M,Caputo E,Tinazzi M,Priori A

更新日期：2009-07-21 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) is a neuropeptide that plays neuroprotective roles in cerebral ischemia and reperfusion (I/R) injury in animal models or oxygen and glucose deprivation (OGD) in cultured neurons. Recent data suggest that intranasal CART treatment facilitates neuroregeneration in str...

journal_title：Neuroscience

authors： Wang Y,Qiu B,Liu J,Zhu WG,Zhu S

更新日期：2014-09-26 00:00:00

abstract：:The cholinergic cells of the tegmental pedunculopontine nucleus monosynaptically excite dopaminergic neurons of the substantia nigra. In vivo electrochemical methods were used to monitor dorsal striatal dopamine efflux in awake rats following intraperitoneal scopolamine injections and following the direct application ...

journal_title：Neuroscience

authors： Chapman CA,Yeomans JS,Blaha CD,Blackburn JR

更新日期：1997-01-01 00:00:00

abstract：:During rapid cell growth the availability of phospholipid precursors like cytidine triphosphate and diacylglycerol can become limiting in the formation of key membrane constituents like phosphatidylcholine. Uridine, a normal plasma constituent, can be converted to cytidine triphosphate in PC12 [corrected] cells and in...

journal_title：Neuroscience

authors： Pooler AM,Guez DH,Benedictus R,Wurtman RJ

更新日期：2005-01-01 00:00:00

abstract：:Adult synapsin triple-knockout mice exhibit epilepsy that manifests as generalized tonic-clonic seizures. Because in vitro recordings have shown a reduction in quantal release from inhibitory neurons, an inherent excitation-inhibition imbalance has been hypothesized as the direct culprit for epilepsy in these mice. We...

journal_title：Neuroscience

authors： Ketzef M,Kahn J,Weissberg I,Becker AJ,Friedman A,Gitler D

更新日期：2011-08-25 00:00:00

abstract：:Tenascin-C is an extracellular matrix glycoprotein involved in cell adhesion and migration, and neurite outgrowth. Since these processes have been found to be under thyroid control in the developing rat brain, we have investigated the effect of congenital hypothyroidism on tenascin-C expression. At birth, in situ hybr...

journal_title：Neuroscience

authors： Alvarez-Dolado M,González-Sancho JM,Bernal J,Muñoz A

更新日期：1998-05-01 00:00:00

abstract：:It has been hypothesized [Colpaert, F.C., 1994. In: Briley, M., Marien, M. (Eds.), Noradrenergic Mechanisms in Parkinson's Disease. CRC Press, Boca Raton, FL, pp. 225-254] that a deficiency in the noradrenergic system originating from the locus coeruleus is a decisive factor in the progression of central neurodegenera...

journal_title：Neuroscience

authors： Debeir T,Marien M,Chopin P,Martel JC,Colpaert F,Raisman-Vozari R

更新日期：2002-01-01 00:00:00

abstract：:Sensory neurons mediate diabetic peripheral neuropathy. Using a mouse model of diabetic peripheral neuropathy (BKS.Cg-m+/+Lepr(db)/J (db/db) mice) and cultured dorsal root ganglion (DRG) neurons, the present study showed that hyperglycemia downregulated miR-146a expression and elevated interleukin-1 receptor-activated...

journal_title：Neuroscience

authors： Wang L,Chopp M,Szalad A,Zhang Y,Wang X,Zhang RL,Liu XS,Jia L,Zhang ZG

更新日期：2014-02-14 00:00:00

abstract：:The purpose of the present study was to examine whether the rostroventral portion of the medulla oblongata (RVM) exerts descending modulation on the cardiosomatic motor reflex (CMR) in rats. Capsaicin (1 μg/ml, 0.2 ml) was injected into the pericardial sac as an algesic substance to induce the CMR, which was monitored...

journal_title：Neuroscience

authors： Sun N,Liu XH,Du JQ,Zhu JX,Tang JS,Li Q

更新日期：2011-06-30 00:00:00

abstract：:The interaction between the dopaminergic and glutamatergic systems governs normal behavior and is perturbed in many psychiatric disorders including schizophrenia. Hypofunction of the D1 family of receptors, to which the D(1) and D(5) subtypes belong, is a typical feature of schizophrenia. Here we have used confocal li...

journal_title：Neuroscience

authors： Kruusmägi M,Kumar S,Zelenin S,Brismar H,Aperia A,Scott L

更新日期：2009-12-01 00:00:00

abstract：:It is commonly believed that the cell bodies of mammalian sensory neurons are contained within spinal and cranial sensory ganglia associated with the central nervous system or within the central nervous system itself. However, strong circumstantial evidence implies that some sensory neurons are contained entirely with...

journal_title：Neuroscience

authors： Kunze WA,Bornstein JC,Furness JB

更新日期：1995-05-01 00:00:00

abstract：:Recombinant human erythropoietin (EPO) has been successfully tested as neuroprotectant in brain injury models. The first large clinical trial with stroke patients, however, revealed negative results. Reasons are manifold and may include side-effects such as thrombotic complications or interactions with other medicatio...

journal_title：Neuroscience

authors： Rahimi Nedjat M,Wähmann M,Bächli H,Güresir E,Vatter H,Raabe A,Heimann A,Kempski O,Alessandri B

更新日期：2013-05-15 00:00:00

abstract：:The bladder and distal colon are innervated by lumbar splanchnic (LSN) and pelvic nerves (PN) whose axons arise from dorsal root ganglia (DRG) neurons at thoracolumbar (TL) and lumbosacral (LS) spinal levels, respectively. In an attempt to understand the molecular basis of differences between LSN and PN mechanosensiti...

journal_title：Neuroscience

authors： La JH,Schwartz ES,Gebhart GF

更新日期：2011-07-14 00:00:00

abstract：:Investigation of the integrity of the ryanodine receptor in Alzheimer's disease is important because it plays a critical role in the regulation of calcium release from the endoplasmic reticulum in brain, impairment of which is believed to contribute to the pathogenesis of Alzheimer's disease. The present study compare...

journal_title：Neuroscience

authors： Kelliher M,Fastbom J,Cowburn RF,Bonkale W,Ohm TG,Ravid R,Sorrentino V,O'Neill C

更新日期：1999-01-01 00:00:00

abstract：:Pathological narcissism is often characterized by arrogant behavior, a lack of empathy, and willingness to exploit other individuals. Generally, individuals with high levels of narcissism are more likely to suffer mental disorders. However, the brain structural basis of individual pathological narcissism trait among h...

journal_title：Neuroscience

authors： Mao Y,Sang N,Wang Y,Hou X,Huang H,Wei D,Zhang J,Qiu J

更新日期：2016-07-22 00:00:00

abstract：:Working memory has often been modeled and conceptualized as a kind of binary (bistable) memory switch, where stimuli turn on plateau-like persistent activity in subsets of cells, in line with many in vivo electrophysiological reports. A potentially related form of bistability, termed up- and down-states, has been stud...

journal_title：Neuroscience

authors： Durstewitz D,Seamans JK

更新日期：2006-04-28 00:00:00

abstract：:Systemically administered cholinomimetics or cholinesterase inhibitors can depress behavior in humans and animals, whereas antimuscarinic agents reverse this effect or even produce euphoria. Although these effects have been well documented, the specific brain regions that mediate them remain largely unknown. In the pr...

journal_title：Neuroscience

authors： Chau DT,Rada P,Kosloff RA,Taylor JL,Hoebel BG

更新日期：2001-01-01 00:00:00

abstract：:A new double-label autoradiographic glucose analog method for the sequential measurement of altered regional cerebral metabolic rates for glucose in the same animal is presented. This method is based on the sequential injection of two boluses of glucose tracer labeled with two different isotopes (short-lived 18F and l...

journal_title：Neuroscience

authors： Redies C,Diksic M,Evans AC,Gjedde A,Yamamoto YL

更新日期：1987-08-01 00:00:00

abstract：:The effects of centrifugal afferents on membrane potentials of identified granule cell layer using evoked field potential profiles, and trans-synaptic activation via antidromic stimulation of output cell axon collaterals. Intracellular recordings maintained for 4-30 min showed complex spontaneous spike discharges and ...

journal_title：Neuroscience

authors： Kunze WA,Shafton AD,Kem RE,McKenzie JS

更新日期：1992-01-01 00:00:00

abstract：:GABA(B) receptors are G-protein-coupled receptors mediating the slow onset and prolonged synaptic actions of GABA in the CNS. The recent cloning of two genes, GABA(B1) and GABA(B2), has revealed a novel requirement for GABA(B) receptor signalling. Studies have demonstrated that the two receptor subunits associate as a...

journal_title：Neuroscience

authors： Charles KJ,Evans ML,Robbins MJ,Calver AR,Leslie RA,Pangalos MN

更新日期：2001-01-01 00:00:00

abstract：:We have recently shown that the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate enhances the depolarization induced, calcium dependent release of [3H]dopamine from cultured brain neurons in the rat. In the present study the effects of 12-O-tetradecanoyl-phorbol-13-acetate on the kinetic parameters of depolarizatio...

journal_title：Neuroscience

authors： Zurgil N,Yarom M,Zisapel N

更新日期：1986-12-01 00:00:00

abstract：:Six human fetuses of gestational ages 16-28 weeks were employed. The immunocytochemical avidin-biotin-peroxidase complex method combined with the silver Bodian technique was used to evaluate the presence of tyrosine hydroxylase and dopamine-beta-hydroxylase neurons and afferent and efferent fibres in the cerebellum du...

journal_title：Neuroscience

authors： Yew DT,Luo CB,Shen WZ,Chow PH,Zheng DR,Yu MC

更新日期：1995-03-01 00:00:00