Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats.

abstract：:The encoding of reward-predictive stimuli by neurons in the nucleus accumbens (NAcc) depends on integrated synaptic activity from the basolateral amygdala (BLA) and medial prefrontal cortex (mPFC) afferent inputs. In a previous study, we found that single electrical stimulation pulses applied to the BLA facilitate mPF...

journal_title：Neuroscience

authors： McGinty VB,Grace AA

更新日期：2009-09-15 00:00:00

abstract：:The distribution of CA3 hippocampal axonal terminal fields undergo a period of widespread connectivity-based changes in the early postnatal stages of life. The purpose of the current study was to examine the effect of acute phthalate exposure during this period of hippocampal development (postnatal days 16-22 (p16-p22...

journal_title：Neuroscience

authors： Smith CA,Macdonald A,Holahan MR

更新日期：2011-10-13 00:00:00

abstract：:To investigate the degree of plasticity of hippocampal neural stem cells from adult mice (mHNSC), we have analyzed their differentiation in co-culture with quail neural crest cells. In mixed culture, mHNSC give rise to several non-neuronal neural crest derivatives, including melanocytes, chondrocytes and smooth muscle...

journal_title：Neuroscience

authors： Alexanian AR,Sieber-Blum M

更新日期：2003-01-01 00:00:00

abstract：:Activation of poly (ADP-ribose) polymerases (PARP) contributes to ischemic damage by causing neuronal nicotinamide adenine dinucleotide (NAD(+)) depletion, release of apoptosis-inducing factor and consequent caspase-independent cell death. PARP-mediated cell death is sexually dimorphic, participating in ischemic damag...

journal_title：Neuroscience

authors： Vagnerova K,Liu K,Ardeshiri A,Cheng J,Murphy SJ,Hurn PD,Herson PS

更新日期：2010-03-17 00:00:00

abstract：:Excitotoxic mechanisms involving alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionate (AMPA)/kainate receptors play an important role in mediating cellular damage in spinal cord injury. However, the precise cellular mechanisms of glutamate release from non-synaptic white matter are not well understood. We examined ho...

journal_title：Neuroscience

authors： Li S,Stys PK

更新日期：2001-01-01 00:00:00

abstract：:We examined the immunohistochemical regional distribution of calcineurin (Ca2+/calmodulin-dependent protein phosphatase) in the adult rat hippocampus, following various regional destruction. In the normal adult rat hippocampus, the calcineurin immunoreactivity showed a characteristic pattern. This protein phosphatase ...

journal_title：Neuroscience

authors： Morioka M,Nagahiro S,Fukunaga K,Miyamoto E,Ushio Y

更新日期：1997-06-01 00:00:00

abstract：:P2X receptor-mediated responses to the ATP analogue, alpha,beta-methylene ATP, in rat brain cannot be accounted for by the receptor proteins known to be present. Such experiments are often performed on cells from neonates and, since differential developmental regulation of P2X1 and P2X2 receptor messenger RNAs has alr...

journal_title：Neuroscience

authors： Kidd EJ,Miller KJ,Sansum AJ,Humphrey PP

更新日期：1998-12-01 00:00:00

abstract：:Complementary RNA probes derived from complementary DNA specifically subcloned from monkey tissue were used to localize, by in situ hybridization histochemistry, the relatively rare alpha3, beta3 and gamma1 subunit transcripts of the GABA(A) receptor in visual cortex and lateral geniculate nucleus of normal monkeys an...

journal_title：Neuroscience

authors： Huntsman MM,Jones EG

更新日期：1998-11-01 00:00:00

abstract：:In this study, we investigated effects of intra-central amygdala (intra-CeA) administrations of a cannabinoid agonist, WIN55,212-2 by itself and its interaction with β1-adrenoceptor agents on memory consolidation. We used a step-through inhibitory avoidance (IA) task to assess memory in male Wistar rats. The results s...

journal_title：Neuroscience

authors： Zarrindast MR,Ghiasvand M,Rezayof A,Ahmadi S

更新日期：2012-06-14 00:00:00

abstract：:The effects of hypertonic solutions on the spontaneous and evoked catecholamine release from isolated, perfused cat adrenal glands were studied. Hypertonic solutions enhanced three times the spontaneous release of the amines, but markedly inhibited the release evoked by nicotine (5 microM for 2 min) or high K+ (17.7 m...

journal_title：Neuroscience

authors： Ladona MG,Sanchez-García P,García AG

更新日期：1984-05-01 00:00:00

abstract：:Apart from therapeutic discovery, the study of mild traumatic brain injury (mTBI) has been focused on two challenges: why do a majority of individuals recover with little concern, while a considerable proportion suffer with persistent and often debilitating symptomology; and, how do mild injuries significantly increas...

journal_title：Neuroscience

authors： Mychasiuk R,Hehar H,Ma I,Kolb B,Esser MJ

更新日期：2015-03-12 00:00:00

abstract：:[3H]Bremazocine, in the presence of saturating concentrations of mu and delta receptor blocking agents, was used to label putative kappa opiate binding sites in rat brain. The binding of [3H]bremazocine under these conditions was completely displaced with high affinity by U-50488H and dynorphin1-17, and the potency of...

journal_title：Neuroscience

authors： Morris BJ,Herz A

更新日期：1986-11-01 00:00:00

abstract：:In humans, bromocriptine (BRO) is used as a treatment for many disorders, such as prolactinomas, even during pregnancy and lactation. Previously we demonstrated that maternal BRO treatment at the end of lactation programs offspring for obesity and several endocrine dysfunctions. Here, we studied the long-term effects ...

journal_title：Neuroscience

authors： Carvalho JC,Lisboa PC,de Oliveira E,Peixoto-Silva N,Pinheiro CR,Fraga MC,Claudio-Neto S,Franci CR,Manhães AC,Moura EG

更新日期：2016-06-14 00:00:00

abstract：:A synthetic fragment 31-35 of beta-amyloid peptide was used in cultured cortical neurons to examine whether this smaller sequence could trigger apoptotic degeneration in vitro by using morphological, biochemical and flow-cytometric examinations. The results showed that: (i) neurons treated with fragment 31-35 of beta-...

journal_title：Neuroscience

authors： Yan XZ,Qiao JT,Dou Y,Qiao ZD

更新日期：1999-01-01 00:00:00

abstract：:Dopamine and endocannabinoids are neurotransmitters known to play a role in the activity of the basal ganglia motor circuit. While a number of studies have demonstrated functional interactions between type 1 cannabinoid (CB1) receptors and dopaminergic systems, we still lack detailed neuroanatomical evidence to explai...

journal_title：Neuroscience

authors： Julian MD,Martin AB,Cuellar B,Rodriguez De Fonseca F,Navarro M,Moratalla R,Garcia-Segura LM

更新日期：2003-01-01 00:00:00

abstract：:Chronic stress and spatial training have been proposed to affect hippocampal structure and function in opposite ways. Previous morphological studies that addressed structural changes after chronic restraint stress and spatial training were based on two-dimensional morphometry which does not allow a complete morphometr...

journal_title：Neuroscience

authors： Stewart MG,Davies HA,Sandi C,Kraev IV,Rogachevsky VV,Peddie CJ,Rodriguez JJ,Cordero MI,Donohue HS,Gabbott PL,Popov VI

更新日期：2005-01-01 00:00:00

abstract：:Purkinje cell maturation during thyroxine-induced metamorphosis in premetamorphic bullfrog tadpoles was studied using electron microscopy and Golgi (silver-impregnated) preparations. Cerebella from tadpoles were examined following 1, 2, or 3 weeks of thyroxine treatment. Particular attention was paid to possible diffe...

journal_title：Neuroscience

authors： Hauser KF,Gona AG

更新日期：1984-01-01 00:00:00

abstract：:Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by the presence of extracellular plaques composed of amyloid β (Aβ) peptides and intracellular tau aggregates. The plaques are surrounded by microglia, the brain's resident immune cells, which likely participate in the clearanc...

journal_title：Neuroscience

authors： Gyoneva S,Swanger SA,Zhang J,Weinshenker D,Traynelis SF

更新日期：2016-08-25 00:00:00

abstract：:The sympathetic and sensory innervation of guinea-pig trachea and lung were studied by means of retrograde neuronal tracing using fluorescent dyes, and double-labelling immunofluorescence. Sympathetic neurons supplying the lung were located in stellate ganglia and in thoracic sympathetic chain ganglia T2-T4; those sup...

journal_title：Neuroscience

authors： Kummer W,Fischer A,Kurkowski R,Heym C

更新日期：1992-08-01 00:00:00

abstract：:Spinocerebellar tract neurons are inhibited by various sources of input via pathways activated by descending tracts as well as peripheral afferents. Inhibition may be used to modulate transmission of excitatory information forwarded to the cerebellum. However it may also provide information on the degree of inhibition...

journal_title：Neuroscience

authors： Shakya Shrestha S,Bannatyne BA,Jankowska E,Hammar I,Nilsson E,Maxwell DJ

更新日期：2012-12-13 00:00:00

abstract：:Past studies have implicated calcium influx through the N-methyl-D-aspartate class of ionotropic glutamate receptors as a key factor in excitotoxicity. Here, primary cultures of hippocampal neurons were exposed to N-methyl-D-aspartate with or without the L-type calcium channel agonist BayK8644(+/-). Calcium influxes w...

journal_title：Neuroscience

authors： Barger SW

更新日期：1999-03-01 00:00:00

abstract：:Overexpression of vascular endothelial growth factor (VEGF) is considered the most critical factor in radiation-induced brain injury (RBI). To investigate the role of VEGF and the mechanism underlying microvascular damage in RBI, wild type mice, and transgenic mice overexpressing VEGF derived from astrocytes, were sep...

journal_title：Neuroscience

authors： Zhou D,Huang X,Xie Y,Deng Z,Guo J,Huang H

更新日期：2019-06-01 00:00:00

abstract：:Decreased proteolytic clearance of soluble amyloid β (Aβ) in microglia affects Aβ accumulation on Alzheimer's disease progression. However, the potential molecular mechanism by which microglial Aβ uptake is regulated remains unclear. In this study, we identified a microRNA, miR-124, that was down-regulated in aging wi...

journal_title：Neuroscience

authors： Feng CZ,Yin JB,Yang JJ,Cao L

更新日期：2017-03-06 00:00:00

abstract：:Striatal dopamine receptors become supersensitive when dopaminergic input is removed through either surgical denervation or pharmacological depletion. Although alterations such as increased D2 receptor binding and increased receptor-G protein coupling have been described in supersensitive striatal tissue, their roles ...

journal_title：Neuroscience

authors： Harrison LM,LaHoste GJ

更新日期：2006-01-01 00:00:00

abstract：:Deficits in forepaw adjusting steps in rats have been proposed as a non-drug-induced model of the akinesia associated with Parkinson's disease. The present study examined the relationship between contralateral forepaw adjusting steps and dopamine depletion after medial forebrain bundle lesions with 6-hydroxydopamine. ...

journal_title：Neuroscience

authors： Chang JW,Wachtel SR,Young D,Kang UJ

更新日期：1999-01-01 00:00:00

abstract：:Rat cerebrocortical minislices were incubated with physiological saline in the absence or presence of 5 mM ammonium acetate ("ammonia") and/or inhibitors of osmosensitive amino acid transport: 50 microM niflumic acid and 100 microM N-ethyl-maleimide for 60 min, with medium changes after 20 min and 40 min. The efflux o...

journal_title：Neuroscience

authors： Zielińska M,Hilgier W,Law RO,Goryński P,Albrecht J

更新日期：1999-01-01 00:00:00

abstract：:A role has been suggested for hypothalamic alpha1 adrenoceptors in the acute stress-induced activation of the hypothalamic-pituitary-adrenal axis. Using a polyclonal antiserum against the rat alpha1B adrenergic receptor protein, we have demonstrated alpha1B receptor immunoreactivity in neurons and especially in puncta...

journal_title：Neuroscience

authors： Williams AM,Morilak DA

更新日期：1997-02-01 00:00:00

abstract：:Prior research with a rat model of behavioral therapy [i.e., effort-based reward (EBR) contingency training] suggests that strengthened associations between physical effort and desired outcomes enhance neurobiological indices of resilience. In the current study, male and female Long-Evans rats were exposed to either s...

journal_title：Neuroscience

authors： Kent M,Scott S,Lambert S,Kirk E,Terhune-Cotter B,Thompson B,Neal S,Dozier B,Bardi M,Lambert K

更新日期：2018-08-21 00:00:00

abstract：:Significant alterations in glutamatergic neurotransmission have been reported in major depressive disorder (MDD) that could underlie psychiatric traits. Studies were mainly interested in synaptic dysfunction in the prefrontal cortex, a key structure involved in depressive-like behavior, however hippocampus has been sh...

journal_title：Neuroscience

authors： Dutar P,Tolle V,Kervern M,Carcenac C,Carola V,Gross C,Savasta M,Darmon M,Masson J

更新日期：2019-01-01 00:00:00

abstract：:Age-dependent, neuronal apoptosis following N-methyl-D-aspartate receptor blockade has been linked to loss of calcium. To further explore this relationship, we examined expression of activated caspase-3, as well as the calcium binding proteins, calbindin-D 28K, calretinin and parvalbumin, following injection of vehicl...

journal_title：Neuroscience

authors： Lema Tomé CM,Bauer C,Nottingham C,Smith C,Blackstone K,Brown L,Hlavaty C,Nelson C,Daker R,Sola R,Miller R,Bryan R,Turner CP

更新日期：2006-09-01 00:00:00