Regulatory factor X1 depresses ApoE-dependent Aβ uptake by miRNA-124 in microglial response to oxidative stress.

abstract：:Neurodegeneration in fetal development of Down syndrome (DS) patients is proposed to result in apparent neuropathological abnormalities and to contribute to the phenotypic characteristics of mental retardation and premature development of Alzheimer disease. In order to identify the aberrant and specific genes involved...

journal_title：Neuroscience

authors： Kadota M,Nishigaki R,Wang CC,Toda T,Shirayoshi Y,Inoue T,Gojobori T,Ikeo K,Rogers MS,Oshimura M

更新日期：2004-01-01 00:00:00

abstract：:In order to investigate neural mechanisms by which the prefrontal cortex adaptively modifies its activities based on past experience, we examined whether or not sensory cortical projections to the medial prefrontal cortex support long-term potentiation (LTP) in rats. Monosynaptic projections from the secondary visual ...

journal_title：Neuroscience

authors： Kim MJ,Chun SK,Kim YB,Mook-Jung I,Jung MW

更新日期：2003-01-01 00:00:00

abstract：:Pathological forms of the microtubule-associated protein tau are involved in a large group of neurodegenerative diseases named tauopathies, including frontotemporal lobar degeneration (FTLD-tau). K369I mutant tau transgenic mice (K3 mice) recapitulate neural and behavioural symptoms of FTLD, including tau aggregates i...

journal_title：Neuroscience

authors： Mo M,Jönsson ME,Mathews MA,Johnstone D,Ke YD,Ittner LM,Balleine BW,Furlong TM,Camp AJ

更新日期：2020-11-21 00:00:00

abstract：:Wobbler mice display forelimb weakness, altered paw positioning, reduced running speed, muscle atrophy and motor neuron loss; co-treatment with glycosaminoglycans and insulin-like growth factor-I counteracts the progression of the disease. Reportedly, treatment with glycosaminoglycans or insulin-like growth factor-I s...

journal_title：Neuroscience

authors： Vergani L,Losa M,Lesma E,Di Giulio AM,Torsello A,Müller EE,Gorio A

更新日期：1999-01-01 00:00:00

abstract：:Rat brain synaptosomes were isolated to study the effects of protein kinase inhibitors (sphingosine, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, N-(6-aminohexyl)-5-chloro-1-naphtalenesulfonamide, staurosporine) on Ca2+-dependent and Ca2+-independent [14C]GABA release. The Ca2+-dependent [14C]GABA re...

journal_title：Neuroscience

authors： Storchak LG,Pozdnyakova NG,Himmelreich NH

更新日期：1998-08-01 00:00:00

abstract：:The cerebral peptidergic caudodorsal cells of the freshwater snail Lymnaea stagnalis control egg laying and egg-laying behaviour by releasing peptides into (1) the haemolymph, from neurohaemal axon terminals in the periphery of the cerebral commissure and (2) the intercellular space of the central nervous system, from...

journal_title：Neuroscience

authors： Schmidt ED,Roubos EW

更新日期：1988-07-01 00:00:00

abstract：:The neural cell adhesion molecule (NCAM) has been implicated in regulating synaptic plasticity mechanisms as well as memory consolidation processes. Attachment of polysialic acid to NCAM (PSA-NCAM) has been reported to down-regulate its adhesive forces, a process hypothesized to be implicated in synapse selection afte...

journal_title：Neuroscience

authors： Markram K,Gerardy-Schahn R,Sandi C

更新日期：2007-02-09 00:00:00

abstract：:In partially denervated skeletal muscle, spared motor fibres sprout, enlarging motor unit size. Neuritogenesis and sprouting are known to depend on the synaptic input to the neurons. This suggests that spared motoneuron reaction to partial muscle denervation might be controlled by primary sensory neurons which directl...

journal_title：Neuroscience

authors： Cuppini R,Ambrogini P,Sartini S

更新日期：1998-05-01 00:00:00

abstract：:Dopamine receptors (DARs) in the nucleus accumbens (NAc) are critical for cocaine's actions but the nature of adaptations in DAR function after repeated cocaine exposure remains controversial. This may be due in part to the fact that different methods used in previous studies measured different DAR pools. In the prese...

journal_title：Neuroscience

authors： Conrad KL,Ford K,Marinelli M,Wolf ME

更新日期：2010-08-11 00:00:00

abstract：:Identification of novel molecules that can induce neuronal differentiation of embryonic stem (ES) cells is essential for deciphering the molecular mechanisms of early development and for exploring cell therapy approaches. Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide ...

journal_title：Neuroscience

authors： Chafai M,Basille M,Galas L,Rostene W,Gressens P,Vaudry H,Gonzalez BJ,Louiset E

更新日期：2011-12-29 00:00:00

abstract：:Rats exposed to repeated unavoidable stress show decreased dopamine output in the nucleus accumbens shell (NAcS) and do not acquire vanilla sugar (VS)-sustained appetitive behavior (VAB). Rats treated with lithium for 3 weeks also show decreased NAcS dopamine output, yet they acquire VAB. Feeding a novel palatable foo...

journal_title：Neuroscience

authors： Gambarana C,Masi F,Leggio B,Grappi S,Nanni G,Scheggi S,De Montis MG,Tagliamonte A

更新日期：2003-01-01 00:00:00

abstract：:Nicotinic stimulation and high K+ depolarization of bovine chromaffin cells cause disassembly of cortical filamentous actin networks. Previous work from our laboratory has demonstrated that disassembly of actin filaments is Ca(2+)-dependent, precedes exocytosis and occurs in cortical areas of low cytoplasmic viscosity...

journal_title：Neuroscience

authors： Vitale ML,Rodríguez Del Castillo A,Trifaró JM

更新日期：1992-11-01 00:00:00

abstract：:Microglial cells exhibit Notch-1 signaling expression which is enhanced upon activation. We reported previously that enhanced Notch-1 expression in activated microglia modulates production of proinflammatory cytokines and nitric oxide (NO). Furthermore, Notch-1 modulates transcription factor nuclear factor-kappa B (NF...

journal_title：Neuroscience

authors： Cao Q,Kaur C,Wu CY,Lu J,Ling EA

更新日期：2011-09-29 00:00:00

abstract：:Excitatory amino acid transporters (EAAT) uptake extracellular glutamate, the major excitatory neurotransmitter in the brain. EAAT type 3 (EAAT3), the main neuronal EAAT, is expressed widely in the CNS. We have shown that the volatile anesthetic isoflurane increases EAAT3 activity and trafficking to the plasma membran...

journal_title：Neuroscience

authors： Lee SN,Li L,Zuo Z

更新日期：2010-12-15 00:00:00

abstract：:Mutations in γ-aminobutyric acid A receptor (GABAA) subunits and sodium channel genes, especially GABRG2 and SCN1A, have been reported to be associated with febrile seizures (FS) and genetic epilepsy with febrile seizures plus (GEFS+). GEFS+ is a well-known family of epileptic syndrome with autosomal dominant inherita...

journal_title：Neuroscience

authors： Li X,Guo S,Liu K,Zhang C,Chang H,Yang W,Rong S,Hu Q,Cui J,Wang F,Sun T

更新日期：2020-07-01 00:00:00

abstract：:Agonist-induced endocytosis and recycling of G protein-coupled receptors contributes to desensitization and resensitization of the receptors. In this study, we have used fluorescence immunohistochemistry, confocal microscopy and digital image analysis to quantify the proportion of receptor in the cytoplasm and on the ...

journal_title：Neuroscience

authors： Southwell BR,Seybold VS,Woodman HL,Jenkinson KM,Furness JB

更新日期：1998-12-01 00:00:00

abstract：:The dopamine D2 receptor (DRD2) and dopamine transporter (DAT) play a regulatory role in dopaminergic neurotransmission and thus play an important role in drug addiction. The prefrontal cortex (PFC), a critical part of the mesencephalic dopaminergic system, is thought to be involved in the development and maintenance ...

journal_title：Neuroscience

authors： Sun Z,Ma Y,Xie L,Huang J,Duan S,Guo R,Xie Y,Lv J,Lin Z,Ma S

更新日期：2019-09-01 00:00:00

abstract：:Human Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32kDa (DARPP-32, also known as PPP1R1B) gene codes for different transcripts that are mainly translated into two DARPP-32 protein isoforms, full length (fl)-DARPP-32 and truncated (t)-DARPP. The t-DARPP lacks the first 36 residues at the N-terminal,...

journal_title：Neuroscience

authors： Straccia M,Carrere J,Rosser AE,Canals JM

更新日期：2016-10-01 00:00:00

abstract：:Activity-regulated, cytoskeletal-associated protein (Arc) is an immediate early gene induced in excitatory circuits following behavioral episodes. Arc mRNA is targeted to activated regions of the dendrite after long-term potentiation (LTP) of the dentate gyrus, a process dependent on NMDA receptor activation. We used ...

journal_title：Neuroscience

authors： Moga DE,Calhoun ME,Chowdhury A,Worley P,Morrison JH,Shapiro ML

更新日期：2004-01-01 00:00:00

abstract：:It is well established that transforming growth factor alpha is involved prenatally in development of the nervous system, but its role in the postnatal brain is less well understood. Here, we document the occurrence of late-onset, morphological and behavioral deficits in the naturally occurring murine mutant, Waved-1 ...

journal_title：Neuroscience

authors： Burrows RC,Levitt P,Shors TJ

更新日期：2000-01-01 00:00:00

abstract：:Chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to baboons was shown previously to result in a motor syndrome and a pattern of striatal dopaminergic fibre loss similar to those observed in idiopathic Parkinson's disease. In the present study, tyrosine hydroxylase-immunoreactive neurons we...

journal_title：Neuroscience

authors： Varastet M,Riche D,Maziere M,Hantraye P

更新日期：1994-11-01 00:00:00

abstract：:Lack of dystrophin in mdx mice leads to muscle fibre degeneration followed by the formation of new myofibres. This degeneration-regeneration event occurs in clusters. It is accompanied by inflammation and remodelling of the intramuscular terminal nerve fibres. Since the growth-associated protein B-50/GAP-43 has been s...

journal_title：Neuroscience

authors： Verzè L,Buffo A,Rossi F,Oestreicher AB,Gispen WH,Strata P

更新日期：1996-02-01 00:00:00

abstract：:Hearing loss related to aging is the most common sensory disorder among elderly individuals. Macrophage migration inhibitory factor (MIF) is a multi-functional molecule. The aim of this study was to identify the role of MIF in the inner ear. MIF-deficient mice (MIF(-/-) mice) of BALB/c background and wild-type BALB/c ...

journal_title：Neuroscience

authors： Kariya S,Okano M,Maeda Y,Hirai H,Higaki T,Noyama Y,Haruna T,Nishihira J,Nishizaki K

更新日期：2014-10-24 00:00:00

abstract：:The rat neurohypophysis contains a population of microglial cells, the majority of which occupy a pericapillary position in the resting gland. The microglia are immunocytochemically identifiable by the presence of macrophage-associated antigens and resemble microglia of the CNS. Morphometry at light and electron micro...

journal_title：Neuroscience

authors： Pow DV,Perry VH,Morris JF,Gordon S

更新日期：1989-01-01 00:00:00

abstract：:Drinking alcohol during pregnancy is particularly detrimental for the developing brain and may cause a broad spectrum of cognitive and behavioral impairments, collectively known as fetal alcohol spectrum disorder (FASD). While behavioral abnormalities and brain damage have been widely investigated in animal models of ...

journal_title：Neuroscience

authors： Ieraci A,Herrera DG

更新日期：2020-02-10 00:00:00

abstract：:We sought to determine the impact of 17beta-estradiol throughout the hippocampal trisynaptic pathway and to investigate the afferent fiber systems within CA1 and CA3 in detail. To achieve this objective, we utilized multielectrode arrays to simultaneously record the field excitatory postsynaptic potentials from the CA...

journal_title：Neuroscience

authors： Kim MT,Soussou W,Gholmieh G,Ahuja A,Tanguay A,Berger TW,Brinton RD

更新日期：2006-08-11 00:00:00

abstract：:GABA(B) receptors at the cone terminals in bullfrog retina were characterized by immunocytochemical and whole-cell patch clamp techniques in retinal slice preparations. Somata, axons and synaptic terminals (pedicles) of cones were both GABA(B) receptor (GABA(B)R) 1 and GABA(B)R2 immunoreactive. Physiologically, barium...

journal_title：Neuroscience

authors： Liu J,Zhao JW,Du JL,Yang XL

更新日期：2005-01-01 00:00:00

abstract：:In vitro receptor autoradiography was used to localize, quantify and characterize [125I-Tyr8]bradykinin binding sites in all major spinal cord segments of normal rats and animals subjected to various chemical treatments and surgical lesions. [125I-Tyr8]bradykinin specific binding sites were predominantly located to su...

journal_title：Neuroscience

authors： Lopes P,Kar S,Chrétien L,Regoli D,Quirion R,Couture R

更新日期：1995-10-01 00:00:00

abstract：:Light and electron microscopic immunocytochemical methods were used to study the distribution and the morphology of substance P-positive fibers and axon terminals in the dorsal column nuclei of rats and cats, and to determine whether they are part of an ascending input to these nuclei. In rats, substance P-positive fi...

journal_title：Neuroscience

authors： Conti F,De Biasi S,Giuffrida R,Rustioni A

更新日期：1990-01-01 00:00:00

abstract：:Long-term hyperexcitability was found after unilateral, permanent middle cerebral artery occlusion in exofocal neocortical areas of the adult mouse [Mittmann et al. (1998) Neuroscience 85, 15-27]. The aim of the present study was to test the hypothesis in an identical paradigm of ischemia. whether alterations in the d...

journal_title：Neuroscience

authors： Qü M,Mittmann T,Luhmann HJ,Schleicher A,Zilles K

更新日期：1998-07-01 00:00:00