Abstract：
:Activity-regulated, cytoskeletal-associated protein (Arc) is an immediate early gene induced in excitatory circuits following behavioral episodes. Arc mRNA is targeted to activated regions of the dendrite after long-term potentiation (LTP) of the dentate gyrus, a process dependent on NMDA receptor activation. We used post-embedding immunogold electron microscopy (EM) to test whether synaptic Arc expression patterns are selectively modified by plasticity. Consistent with previous light microscopic observations, Arc protein was rapidly induced in the dentate gyrus following LTP-producing stimulation of the perforant path and was detectable in granule cell nuclei, somata and dendrites after two hours of high frequency stimulation. Post-embedding EM revealed Arc immunogold labeling in three times as many spines in the middle molecular layer of the stimulated dentate gyrus than in either the ipsilateral outer molecular layer or the contralateral middle and outer molecular layers. This upregulation did not occur with low frequency stimulation of the perforant path. Therefore Arc protein localization may be a powerful tool to isolate recently activated dendritic spines.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Moga DE,Calhoun ME,Chowdhury A,Worley P,Morrison JH,Shapiro MLdoi
10.1016/j.neuroscience.2004.02.004keywords:
subject
Has Abstractpub_date
2004-01-01 00:00:00pages
7-11issue
1eissn
0306-4522issn
1873-7544pii
S0306452204001150journal_volume
125pub_type
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