Neurotrophin-3 is a target-derived neurotrophic factor for penile erection-inducing neurons.

abstract：:It has been observed that motor neuron death is induced in adult rats by ventral root avulsion which involves pulling out the spinal cord root. Since motor neurons are reported to be selectively vulnerable to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor-mediated injury in vitro, we investigated chang...

journal_title：Neuroscience

authors： Nagano I,Murakami T,Shiote M,Abe K,Itoyama Y

更新日期：2003-01-01 00:00:00

abstract：:The origin of the corticothalamic projections to the contralateral mediodorsal nucleus, the collateralization of cortical fibers and their synaptic organization in the ipsi- and contralateral mediodorsal nuclei were investigated in adult rats with double retrograde fluorescent and anterograde tracing. After tracer inj...

journal_title：Neuroscience

authors： Négyessy L,Hámori J,Bentivoglio M

更新日期：1998-06-01 00:00:00

abstract：:We investigated in this study the pharmacological properties of AC-3933 (5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-1,6-naphthyridin-2(1H)-one), a novel benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 potently inhibited [3H]-flumazenil binding to rat whole brain membrane with a Ki value of 5....

journal_title：Neuroscience

authors： Hashimoto T,Kiyoshi T,Kohayakawa H,Iwamura Y,Yoshida N

更新日期：2014-01-03 00:00:00

abstract：:The blocking action of recently synthesized benzothiazolamine derivative R56865 was compared with that of dihydropyridine (nimodipine) and diphenylalkylamine (flunarizine) on low-voltage-activated and non-inactivating high-voltage-activated Ca2+ currents. The experiments were carried out on freshly isolated Purkinje n...

journal_title：Neuroscience

authors： Panchenko VA,Krishtal OA,Tegtmeier F,Tsyndrenko AYa

更新日期：1993-06-01 00:00:00

abstract：:The cellular localization of preprosomatostatin mRNA in the rat brain and sensory ganglia has been examined in detail using a newly developed highly sensitive non-radioactive in situ hybridization histochemistry procedure. An alkaline phosphatase labelled anti-sense 30mer oligodeoxynucleotide probe was used for detect...

journal_title：Neuroscience

authors： Kiyama H,Emson PC

更新日期：1990-01-01 00:00:00

abstract：:Many behaviorally relevant sounds, including language, are composed of brief, rapid, repetitive acoustic features. Recent studies suggest that abnormalities in producing and understanding spoken language are correlated with abnormal neural responsiveness to such auditory stimuli at higher auditory levels [Tallal et al...

journal_title：Neuroscience

authors： Bartlett EL,Smith PH

更新日期：2002-01-01 00:00:00

abstract：:The distribution of putative melatonin receptors in the brains of two Old World primates of the superfamily Catarrhina, Cercopithecus aethiops and Papio ursinus, was characterized using 2-[125I]iodomelatonin autoradiography. The specific binding demonstrated a discrete distribution pattern. The median eminence was int...

journal_title：Neuroscience

authors： Stankov B,Capsoni S,Lucini V,Fauteck J,Gatti S,Gridelli B,Biella G,Cozzi B,Fraschini F

更新日期：1993-01-01 00:00:00

abstract：:The excitation of densely packed mammalian central neurons is followed by a substantial transitory elevation of external K+ concentration. This phenomenon may have a different functional significance depending on how the resting membrane conductance mechanisms react to the changes in the gradient of these ions. We hav...

journal_title：Neuroscience

authors： Filippov V,Krishtal O

更新日期：1999-01-01 00:00:00

abstract：:Cytochrome oxidase is the terminal enzyme in the mitochondrial respiratory chain engaged in oxidative metabolism and energy production. In mammals, the holoenzyme is composed of 13 subunits encoded by both nuclear and mitochondrial genomes. The goal of the present study was to compare the effect of afferent impulse bl...

journal_title：Neuroscience

authors： Liu S,Wong-Riley M

更新日期：1995-07-01 00:00:00

abstract：:Three-dimensional changes in the angular orientation of the head were monitored during galvanic vestibular stimulation (GVS) delivered through electrodes implanted bilaterally in the tensor tympani muscle of the guinea-pig middle ear. Bilateral GVS was delivered by passing current between both ears with the anode situ...

journal_title：Neuroscience

authors： Kim J

更新日期：2013-12-03 00:00:00

abstract：:Compensatory counter-rotations of the eyes provoked by head turns are commonly attributed to the vestibulo-ocular reflex (VOR). A recent study in guinea pigs demonstrates, however, that this assumption is not always valid. During voluntary head turns, guinea pigs make highly accurate compensatory eye movements that oc...

journal_title：Neuroscience

authors： King WM

更新日期：2013-04-16 00:00:00

abstract：:The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens. Administration of interleukin-1beta did not affect extracellular accumbal dopamine, provoked a modest rise of ho...

journal_title：Neuroscience

authors： Song C,Merali Z,Anisman H

更新日期：1999-01-01 00:00:00

abstract：:We evaluate a novel set-up for scanning functional connectivity in brain slices from the somatosensory cortex of the rat. Upright infrared video microscopy for targeted placement of electrodes is combined with rapid photolysis of bath-applied caged neurotransmitter induced by a xenon flash lamp. Flash photolysis of ca...

journal_title：Neuroscience

authors： Kötter R,Staiger JF,Zilles K,Luhmann HJ

更新日期：1998-09-01 00:00:00

abstract：:Neurons in rat medulla oblongata with Fos immunoreactivity as a marker of synaptic excitation evoked by pentylenetetrazole-induced seizures were compared with cell populations activated by the stimulation of chemoreceptor and baroreceptor afferent pathways. Chemoreceptors were stimulated by placing rats in a hypoxic g...

journal_title：Neuroscience

authors： Kanter RK,Strauss JA,Sauro MD

更新日期：1996-08-01 00:00:00

abstract：:The angular vestibulo-ocular reflex maintains gaze during head movements. It is thought to be mediated by two components: direct and velocity storage pathways. The direct angular vestibulo-ocular reflex is conveyed by a three neuron chain from the labyrinth to the ocular motoneurons. The indirect pathway involves a mo...

journal_title：Neuroscience

authors： Holstein GR,Martinelli GP,Wearne S,Cohen B

更新日期：1999-01-01 00:00:00

abstract：:The first Kavli Prize in Neuroscience recognizes a confluence of career achievements that together provide a fundamental understanding of how brain and spinal cord circuits are assembled during development and function in the adult. The members of the Kavli Neuroscience Prize Committee have decided to reward three sci...

journal_title：Neuroscience

authors： Glover JC

更新日期：2009-11-10 00:00:00

abstract：:Despite an abundance of studies on mechanisms of behavioral sensitization, considerable uncertainty exists as to whether alterations in dopamine neurotransmission underlie the exacerbated behavioral effects of cocaine observed during the early stages of abstinence. One of the factors contributing to the uncertainty an...

journal_title：Neuroscience

authors： Chefer VI,Shippenberg TS

更新日期：2002-01-01 00:00:00

abstract：:FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR. Its association with mental disorders has been identified, but its function in disease development is largely unknown. Long-term potentiation (LTP) is a functiona...

journal_title：Neuroscience

authors： Qiu B,Xu Y,Wang J,Liu M,Dou L,Deng R,Wang C,Williams KE,Stewart RB,Xie Z,Ren W,Zhao Z,Shou W,Liang T,Yong W

更新日期：2019-03-15 00:00:00

abstract：:The antidromic activation of facial nucleus montoneurones has been studied in acute experiments on cats by means of extra- and intracellular recording techniques. Time and amplitude characteristics of separate components of the antidromic action potential and the after--potentials accompanying it have been analyzed. A...

journal_title：Neuroscience

authors： Fanardjian VV,Manvelyan LR,Kasabyan SA

更新日期：1983-08-01 00:00:00

abstract：:The hypocretin/orexin system regulates, among other things, sleep and energy homeostasis. The system is likely regulated by both homeostatic and circadian mechanisms. Little is known about local differences in the regulation of hypocretin activity. The aim of this study was to establish an optimized peptide quantifica...

journal_title：Neuroscience

authors： Justinussen JL,Holm A,Kornum BR

更新日期：2015-12-03 00:00:00

abstract：:The auditory system continuously monitors the environment for irregularities in an automatic, preattentive fashion. This is presumably accomplished by two mechanisms: a sensory mechanism detects a deviant sound on the basis of differential refractoriness of neural populations sensitive to the standard and deviant soun...

journal_title：Neuroscience

authors： Szycik GR,Stadler J,Brechmann A,Münte TF

更新日期：2013-12-03 00:00:00

abstract：:Although many workers have appreciated the striking cytologic and neurochemical similarities of neostriatum, accumbens and olfactory tubercle, a compelling case for regarding these areas as territories in a striatal complex awaited the arguments made by Heimer and his colleagues based on their investigations of connec...

journal_title：Neuroscience

authors： Zahm DS,Brog JS

更新日期：1992-10-01 00:00:00

abstract：:Adrenalectomy (ADX) abolishes behavioral sensitization to cocaine in DBA/2, but not C57BL/6 inbred mice. The present study tests the hypothesis that this ADX effect on behavioral sensitization in the DBA/2 strain involves changes in midbrain dopamine systems that do not occur in the C57BL/6 strain. For that purpose, w...

journal_title：Neuroscience

authors： de Jong IE,Steenbergen PJ,de Kloet ER

更新日期：2008-05-15 00:00:00

abstract：:Healthy aging is accompanied by neurobiological changes that affect the brain's functional organization and the individual's cognitive abilities. The aim of this study was to investigate the effect of global age-related differences in the cortical white and gray matter on neural activity in three key large-scale netwo...

journal_title：Neuroscience

authors： Marstaller L,Williams M,Rich A,Savage G,Burianová H

更新日期：2015-04-02 00:00:00

abstract：:The ultrastructure of rat neurohypophyses incubated in vitro was studied to investigate secretion-related changes that may be intrinsic to the isolated neurohypophysis and to establish the morphological integrity of this preparation. Neurohypophyses were incubated for 2 h in an in vitro chamber in medium of low (290 m...

journal_title：Neuroscience

authors： Perlmutter LS,Hatton GI,Tweedle CD

更新日期：1984-06-01 00:00:00

abstract：:White matter lesions are common when global cerebral ischemia (GCI) occurs in the elderly, and cause damage to neurological and psychological functions. Remyelination often fails because of the limited recruitment of oligodendrocyte progenitor cells (OPCs) to the demyelinated site or the inefficient differentiation of...

journal_title：Neuroscience

authors： Du B,Liang M,Zheng H,Fan C,Zhang H,Lu X,Du Z,Lian Y,Zhang Y,Bi X

更新日期：2020-07-01 00:00:00

abstract：:Past studies have implicated calcium influx through the N-methyl-D-aspartate class of ionotropic glutamate receptors as a key factor in excitotoxicity. Here, primary cultures of hippocampal neurons were exposed to N-methyl-D-aspartate with or without the L-type calcium channel agonist BayK8644(+/-). Calcium influxes w...

journal_title：Neuroscience

authors： Barger SW

更新日期：1999-03-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis underlies both adaptive and maladaptive responses to stress and may be an important marker of childhood vulnerability to psychopathology, although little is known about genetic variants that influence cortisol reactivity. We therefore examined associations between corticot...

journal_title：Neuroscience

authors： Sheikh HI,Kryski KR,Smith HJ,Hayden EP,Singh SM

更新日期：2013-01-15 00:00:00

abstract：:The midbrain periaqueductal gray matter has been identified as a reflex centre located uppermost in the central organization of diverse defensive reactions. We recently found that when activated, the caudal third of the lateral periaqueductal gray was also capable of provoking a marked increase in cortical blood flow....

journal_title：Neuroscience

authors： Nakai M,Ogata J,Fukui K,Nakai Y,Maeda M

更新日期：1997-07-01 00:00:00

abstract：:Midbrain dopamine neurons in the ventral tegmental area, substantia nigra and retrorubral field play key roles in reward processing, learning and memory, and movement. Within these midbrain regions and admixed with the dopamine neurons, are also substantial populations of GABAergic neurons that regulate dopamine neuro...

journal_title：Neuroscience

authors： Nair-Roberts RG,Chatelain-Badie SD,Benson E,White-Cooper H,Bolam JP,Ungless MA

更新日期：2008-04-09 00:00:00