R56865 as Ca(2+)-channel blocker in Purkinje neurons of rat: comparison with flunarizine and nimodipine.

abstract：:The hippocampus plays an important role in central stress integration. The present study tests the hypothesis that the ventral subiculum, as a principal source of hippocampal efferents, is involved in co-ordination of hypothalamo-pituitary-adrenocortical and behavioural responses to cognitively-processed information. ...

journal_title：Neuroscience

authors： Herman JP,Dolgas CM,Carlson SL

更新日期：1998-09-01 00:00:00

abstract：:Mice provide a highly valuable resource for investigating learning and memory processes; however, many of the established tasks for evaluating learning and memory were developed for rats. Behaviors of mice in these tasks appear to be driven by different motivational factors, and as a result, they often do not perform ...

journal_title：Neuroscience

authors： Pistell PJ,Ingram DK

更新日期：2010-03-10 00:00:00

abstract：:This study used the framework of the referent configuration hypothesis and slow changes in the external conditions during vertical oscillation of a hand-held object to infer the characteristics of hypothetical control variables. The study had two main objectives: (1) to show that hypothetical control variables, namely...

journal_title：Neuroscience

authors： Ambike S,Zhou T,Zatsiorsky VM,Latash ML

更新日期：2015-07-09 00:00:00

abstract：:Microglia, the resident tissue macrophages of the central nervous system, have a highly differentiated morphology and do not express many of the antigens typically associated with other tissue macrophages. Activation of microglia is associated with a change in morphology and an increase in their repertoire of antigen ...

journal_title：Neuroscience

authors： Reid DM,Perry VH,Andersson PB,Gordon S

更新日期：1993-10-01 00:00:00

abstract：:Agonist-induced endocytosis and recycling of G protein-coupled receptors contributes to desensitization and resensitization of the receptors. In this study, we have used fluorescence immunohistochemistry, confocal microscopy and digital image analysis to quantify the proportion of receptor in the cytoplasm and on the ...

journal_title：Neuroscience

authors： Southwell BR,Seybold VS,Woodman HL,Jenkinson KM,Furness JB

更新日期：1998-12-01 00:00:00

abstract：:The N-methyl-D-aspartate channel blocker phencyclidine is known to induce psychotic episodes in normal subjects and exacerbate psychosis in schizophrenics; however, its site of action is not clear. The prefrontal cortex, hippocampus, and basal ganglia are brain regions that appear to play a role in the pathophysiology...

journal_title：Neuroscience

authors： O'Donnell P,Grace AA

更新日期：1998-12-01 00:00:00

abstract：:Windup--the gradual increase of the response--of dorsal horn neurons to repeated activation of primary afferents is an elementary form of short-term plasticity that may mediate central sensitization to pain. In deep dorsal horn neurons of the turtle spinal cord in vitro we report windup of the response to repeated dep...

journal_title：Neuroscience

authors： Russo RE,Hounsgaard J

更新日期：1994-07-01 00:00:00

abstract：:Reg-2 is a secreted protein that is expressed de novo in motoneurons, sympathetic neurons, and dorsal root ganglion (DRG) neurons after nerve injury and which can act as a Schwann cell mitogen. We now show that Reg-2 is also upregulated by DRG neurons in inflammation with a very unusual expression pattern. In a rat mo...

journal_title：Neuroscience

authors： Averill S,Inglis JJ,King VR,Thompson SW,Cafferty WB,Shortland PJ,Hunt SP,Kidd BL,Priestley JV

更新日期：2008-09-09 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective degeneration and death of motoneurons in the spinal cord, brainstem and motor cortex which causes progressive muscle weakness and paralysis. Although the molecular mechanisms causing the disease remain unknown, excitotoxi...

journal_title：Neuroscience

authors： Tolosa L,Mir M,Olmos G,Lladó J

更新日期：2009-02-18 00:00:00

abstract：:In the dog cerebral cortex and spinal cord, [3H]bremazocine and [3H]U69593 both bound with high affinity to an apparent single population of binding sites under kappa-selective conditions. In the cortex similar Bmax values for both radioligands in the saturation studies and the high affinity of the kappa-selective age...

journal_title：Neuroscience

authors： Hunter JC,Birchmore B,Woodruff R,Hughes J

更新日期：1989-01-01 00:00:00

abstract：:The experiments described herein present a method for tracking diffusion of the glucocorticoid receptor agonist RU28362 in brain following i.c.v. drug administration. A useful property of glucocorticoid receptor is that it is primarily cytoplasmic when unbound and rapidly translocates to the nucleus when bound by liga...

journal_title：Neuroscience

authors： Francis AB,Pace TW,Ginsberg AB,Rubin BA,Spencer RL

更新日期：2006-09-01 00:00:00

abstract：:The potential of a novel therapeutic approach for treating Parkinson's disease, which involves the transplantation of a transfected human astrocyte cell line SVG-TH, that stably expresses the rate-limiting enzyme for dopamine production, tyrosine hydroxylase, was examined. SVG-TH and untransfected parent cells were gr...

journal_title：Neuroscience

authors： Fitoussi N,Sotnik-Barkai I,Tornatore C,Herzberg U,Yadid G

更新日期：1998-07-01 00:00:00

abstract：:Small (SK) and intermediate (IK) conductance calcium-activated potassium channels are candidate ion channels for the regulation of excitability in nociceptive neurones. We have used unique peptide-directed antisera to describe the immunocytochemical distribution of the known isoforms of these ion channels in dorsal ro...

journal_title：Neuroscience

authors： Mongan LC,Hill MJ,Chen MX,Tate SN,Collins SD,Buckby L,Grubb BD

更新日期：2005-01-01 00:00:00

abstract：:Decreased proteolytic clearance of soluble amyloid β (Aβ) in microglia affects Aβ accumulation on Alzheimer's disease progression. However, the potential molecular mechanism by which microglial Aβ uptake is regulated remains unclear. In this study, we identified a microRNA, miR-124, that was down-regulated in aging wi...

journal_title：Neuroscience

authors： Feng CZ,Yin JB,Yang JJ,Cao L

更新日期：2017-03-06 00:00:00

abstract：:The nucleus of the solitary tract is the site of termination of primary afferent fibers running in the facial, glossopharyngeal and vagus nerves. The present study was performed to map the distribution of glutamatergic axons terminals in the rat nucleus of the solitary tract using immunodetection of vesicular glutamat...

journal_title：Neuroscience

authors： Lachamp P,Crest M,Kessler JP

更新日期：2006-01-01 00:00:00

abstract：:Excessive expression of vascular endothelial growth factor (VEGF) is a common cause of blood-brain barrier (BBB) breakdown that triggers severe complications following traumatic brain injury (TBI). It has been shown that inhibition of VEGF activities may attenuate cerebral edema in pathological conditions. Vascular en...

journal_title：Neuroscience

authors： Zhou Z,Gao S,Li Y,Peng R,Zheng Z,Wei W,Zhao Z,Liu X,Li L,Zhang J

更新日期：2020-07-01 00:00:00

abstract：:Activation of muscarinic acetylcholine receptors (mAChRs) inhibits spinal nociceptive transmission by potentiation of GABAergic tone through M(2), M(3), and M(4) subtypes. To study the signaling mechanisms involved in this unique mAChR action, GABAergic spontaneous inhibitory postsynaptic currents (sIPSCs) of lamina I...

journal_title：Neuroscience

authors： Zhang HM,Chen SR,Cai YQ,Richardson TE,Driver LC,Lopez-Berestein G,Pan HL

更新日期：2009-02-18 00:00:00

abstract：:The innervation of the suprachiasmatic nucleus by serotoninergic fibers has been studied in rats from the 22nd embryonic until the 21st postnatal day. The serotoninergic fibers were detected with the pre-embedding immunocytochemical technique at the electron-microscopic level using antibodies to serotonin. Serotonin-i...

journal_title：Neuroscience

authors： Ugrumov MV,Popov AP,Vladimirov SV,Kasmambetova S,Novodjilova AP,Tramu G

更新日期：1994-01-01 00:00:00

abstract：:In the neocortex, interaction and cooperation between different areas are important for information processing, which also applies to different areas within one sensory modality. In the temporal cortex of rodents and cats, both the primary auditory cortex (A1) and the anterior auditory field (AAF) have tonotopicity bu...

journal_title：Neuroscience

authors： Zhang G,Tao C,Zhou C,Yan S,Wang Z,Zhou Y,Xiong Y

更新日期：2017-10-11 00:00:00

abstract：:The possible involvement of fibroblast growth factor receptor (FGFR) activation in the dorsal root ganglion (DRG) was examined following peripheral nerve injury in the rat. Ligation of the sciatic nerve down-regulated FGFR2, -3 and -4 mRNA; however, the expression of FGFR1 mRNA showed no change. Activation of FGFR was...

journal_title：Neuroscience

authors： Yamanaka H,Obata K,Kobayashi K,Dai Y,Fukuoka T,Noguchi K

更新日期：2007-11-30 00:00:00

abstract：:Somatosensory information from the limbs reaches the contralateral Primary Sensory Cortex (S1) with a delay of 23ms for finger, and 40ms for leg (somatosensory N20/N40). Upon arrival of this input in the cortex, motor evoked potentials (MEPs) elicited by Transcranial Magnetic Stimulation (TMS) are momentarily inhibite...

journal_title：Neuroscience

authors： Ruddy KL,Jaspers E,Keller M,Wenderoth N

更新日期：2016-10-01 00:00:00

abstract：:Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer's disease (AD). Non-invasive diagnostic methods are desirable to identify MCI for early therapeutic interventions. In this study, we proposed a support vector machine (SVM)-based method to discriminate between MCI patien...

journal_title：Neuroscience

authors： Long Z,Jing B,Yan H,Dong J,Liu H,Mo X,Han Y,Li H

更新日期：2016-09-07 00:00:00

abstract：:The dose-limiting side effect of the anti-neoplastic agent, paclitaxel, is a chronic distal symmetrical peripheral neuropathy that produces sensory dysfunction (hypoesthesia and neuropathic pain) but little or no distal motor dysfunction. Similar peripheral neuropathies are seen with chemotherapeutics in the vinca alk...

journal_title：Neuroscience

authors： Xiao WH,Zheng H,Zheng FY,Nuydens R,Meert TF,Bennett GJ

更新日期：2011-12-29 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is the animal model of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that is the most common subtype of Guillain-Barre syndrome (GBS). While neuropathic pain is a common symptom of GBS, its underlying mechanisms remain elusive. Central sensitization, particularly...

journal_title：Neuroscience

authors： Zhang Z,Zhang ZY,Fauser U,Schluesener HJ

更新日期：2008-03-18 00:00:00

abstract：:Nitric oxide is thought to play an important role in multiple forms of use-dependent synaptic plasticity, including that which follows noxious peripheral stimulation. This suggests that development of nociception-induced neuroplasticity should be impaired in transgenic animals lacking the neuronal form of nitric oxide...

journal_title：Neuroscience

authors： Crosby G,Marota JJ,Huang PL

更新日期：1995-12-01 00:00:00

abstract：:The main neuronal population of the striatum is composed of the medium spiny neurones (MSNs). In fact several sub-populations of MSNs can be distinguished according to the striatal compartment (striosomes and matrix) to which they belong, their afferents and their sites of projection, their biochemical markers and the...

journal_title：Neuroscience

authors： Venance L,Glowinski J

更新日期：2003-01-01 00:00:00

abstract：:Increased levels of preproenkephalin mRNA in spinal cord neurons induced by peripheral tissue inflammation were examined using in situ hybridization histochemistry. In addition, in situ hybridization histochemistry was combined with immunocytochemistry to determine whether increases in preproenkephalin mRNA were co-lo...

journal_title：Neuroscience

authors： Noguchi K,Dubner R,Ruda MA

更新日期：1992-01-01 00:00:00

abstract：:Acute stress is known to evoke a discrete pattern of c-fos expression in the brain. The work reported here shows that this pattern is modified in regionally specific ways following repeated stress, and that this can be correlated with changes in telemetered heart rate, core temperature and corticosterone output that o...

journal_title：Neuroscience

authors： Chen X,Herbert J

更新日期：1995-02-01 00:00:00

abstract：:Brain injury can often result in the subsequent appearance of seizures, suggesting an alteration in neural excitability associated with the balance between neuronal excitation and inhibition. The process by which this occurs has yet to be fully elucidated. The specific nature of the changes in excitation and inhibitio...

journal_title：Neuroscience

authors： Ding MC,Lo EH,Stanley GB

更新日期：2008-06-23 00:00:00

abstract：:Lesioning of the mammalian striatum with the excitotoxin quinolinic acid results in a pattern of neuropathology that resembles that of post mortem Huntington's disease brain. Certain neurotrophic factors can rescue degenerating cells in a variety of lesion types, including those produced by neurotoxins. Several neurot...

journal_title：Neuroscience

authors： Alexi T,Venero JL,Hefti F

更新日期：1997-05-01 00:00:00