Abstract：
:In the neocortex, interaction and cooperation between different areas are important for information processing, which also applies to different areas within one sensory modality. In the temporal cortex of rodents and cats, both the primary auditory cortex (A1) and the anterior auditory field (AAF) have tonotopicity but with a mirrored frequency gradient. However, whether and how A1 modulates the responses in AAF is largely unknown. Here, we functionally identified the locations of A1 and AAF in rats and used an optogenetic approach to manipulate the activity of A1 in vivo. We found that activation of A1 axon terminals in AAF did not change AAF responses, but activating A1 neuronal cell bodies could increase the sound-evoked responses in AAF, as well as decrease the intensity threshold and broaden the frequency bandwidth, while suppressing A1 could cause the opposite effects. Our results suggested that A1 could modulate the general excitability of AAF through indirect pathways, which provides a potential relationship between these two parallel auditory ascending pathways.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Zhang G,Tao C,Zhou C,Yan S,Wang Z,Zhou Y,Xiong Ydoi
10.1016/j.neuroscience.2017.08.019subject
Has Abstractpub_date
2017-10-11 00:00:00pages
157-166eissn
0306-4522issn
1873-7544pii
S0306-4522(17)30585-7journal_volume
361pub_type
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