The glutamate-based genetic immune hypothesis in obsessive-compulsive disorder. An integrative approach from genes to symptoms.

abstract：:The temporal pattern of distribution of somatostatin receptor was investigated using the somatostatin analogue [125I]Tyr0-DTrp8-somatostatin14 as a ligand and compared with that of somatostatin immunoreactivity during early developmental stages in the spinal cord and the sensory derivatives in rat fetuses. Qualitative...

journal_title：Neuroscience

authors： Maubert E,Slama A,Ciofi P,Viollet C,Tramu G,Dupouy JP,Epelbaum J

更新日期：1994-09-01 00:00:00

abstract：:The regulation of D₃ receptor has not been well documented in diffuse Lewy body disease (DLBD). In this study, a novel D₃-preferring radioligand [(3)H]WC-10 and a D₂-preferring radioligand [(3)H]raclopride were used and the absolute densities of the dopamine D₃ and D₂ receptors were determined in the striatal regions ...

journal_title：Neuroscience

authors： Sun J,Cairns NJ,Perlmutter JS,Mach RH,Xu J

更新日期：2013-09-17 00:00:00

abstract：:Bitter taste serves as an important signal for potentially poisonous compounds in foods to avoid their ingestion. Thousands of compounds are estimated to taste bitter and presumed to activate taste receptor cells expressing bitter taste receptors (Tas2rs) and coupled transduction components including gustducin, phosph...

journal_title：Neuroscience

authors： Yoshida R,Takai S,Sanematsu K,Margolskee RF,Shigemura N,Ninomiya Y

更新日期：2018-01-15 00:00:00

abstract：:We have used the evoked expression of the immediate early gene-encoded proteins (c-Fos, Fos B, Jun B, Jun D, c-Jun and Krox-24) to monitor sensory processing in the hindbrain structures of rats undergoing somatic inflammation. Experiments were performed on freely moving animals that did not experience constraints othe...

journal_title：Neuroscience

authors： Lantéri-Minet M,Weil-Fugazza J,de Pommery J,Menétrey D

更新日期：1994-01-01 00:00:00

abstract：:Dementia, especially Alzheimer's disease, is a rapidly increasing medical condition that presents with enormous challenge for treatment. It is characterized by impairment in memory and cognitive function often accompanied by changes in synaptic transmission and plasticity in relevant brain regions such as the hippocam...

journal_title：Neuroscience

authors： Nashawi H,Bartl T,Bartl P,Novotny L,Oriowo MA,Kombian SB

更新日期：2012-09-18 00:00:00

abstract：:Ecstasy (3,4-methylenedioxymethamphetamine; MDMA) has potent CNS stimulant effects. Besides the acute effects of MDMA, such as psychomotor activation, euphoria, decreased appetite, and hyperthermia, long-term damage of dopaminergic and serotonergic nerve terminals in multiple brain areas have also been reported. Altho...

journal_title：Neuroscience

authors： Alvaro AR,Martins J,Costa AC,Fernandes E,Carvalho F,Ambrósio AF,Cavadas C

更新日期：2008-03-03 00:00:00

abstract：:We investigated the role of cyclic-AMP response element binding protein signaling in the induction of the immediate-early gene c-fos by baroreceptor activation in neurons of the nucleus tractus solitarii of anesthetized rats. Activation of the arterial baroreceptors with sustained hypertension significantly increased ...

journal_title：Neuroscience

authors： Chan JY,Chen WC,Lee HY,Chang TJ,Chan SH

更新日期：1999-01-01 00:00:00

abstract：:Interleukin-1 plays an important role as mediator of endotoxin-induced responses in the brain such as fever, sleep, anorexia, behavioural and neuroendocrine changes. In the present study, interleukin-1 beta immunocytochemistry has been performed at the light and electron microscopic level to study the cellular and sub...

journal_title：Neuroscience

authors： Van Dam AM,Bauer J,Tilders FJ,Berkenbosch F

更新日期：1995-04-01 00:00:00

abstract：:Sensory neurons mediate diabetic peripheral neuropathy. Using a mouse model of diabetic peripheral neuropathy (BKS.Cg-m+/+Lepr(db)/J (db/db) mice) and cultured dorsal root ganglion (DRG) neurons, the present study showed that hyperglycemia downregulated miR-146a expression and elevated interleukin-1 receptor-activated...

journal_title：Neuroscience

authors： Wang L,Chopp M,Szalad A,Zhang Y,Wang X,Zhang RL,Liu XS,Jia L,Zhang ZG

更新日期：2014-02-14 00:00:00

abstract：:Retinal ganglion cell axons of the DBA/2J mouse model of glaucoma, a model characterized by extensive neuroinflammation, preserve synaptic contacts with their subcortical targets for a time after onset of anterograde axonal transport deficits, axon terminal hypertrophy, and cytoskeletal alterations. Though retrograde ...

journal_title：Neuroscience

authors： Smith MA,Plyler ES,Dengler-Crish CM,Meier J,Crish SD

更新日期：2018-10-15 00:00:00

abstract：:We have recently reported on the efficacy of an N-methyl-d-aspartate (NMDA) receptor partial antagonist, S-Methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), in improving outcome following stroke, including reduced infarct size and calcium influx, suppressing the endoplasmic reticulum (ER) stress-induced apoptosi...

journal_title：Neuroscience

authors： Gharibani P,Modi J,Menzie J,Alexandrescu A,Ma Z,Tao R,Prentice H,Wu JY

更新日期：2015-08-06 00:00:00

abstract：:The effects of acute application of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNFalpha) on levels of intracellular Ca(2+) ([Ca(2+)]i) and on whole-cell outward and inward K(+) currents were studied in cultured human microglia. TNFalpha elicited a linear increase in [Ca(2+)]i to a plateau level in micr...

journal_title：Neuroscience

authors： McLarnon JG,Franciosi S,Wang X,Bae JH,Choi HB,Kim SU

更新日期：2001-01-01 00:00:00

abstract：:The effects of excitatory amino acid antagonists on extracellular field potentials in the olfactory bulb produced by lateral olfactory tract stimulation were analysed in vivo. The compounds tested D-2-amino-5-phosphonovalerate, L-(+)2-amino-4-phosphonobutyrate, gamma-D-glutamylglycine, L-glutamic acid diethylester and...

journal_title：Neuroscience

authors： Jacobson I,Butcher S,Hamberger A

更新日期：1986-09-01 00:00:00

abstract：:Repeated induction of a temporary threshold shift (TTS) may result in a permanent threshold shift (PTS) and is thought to be associated with early onset of age-related hearing loss (ARHL). The possibility that a PTS might be induced by administration of repeated TTS-inducing noise exposures (NEs) over a short period d...

journal_title：Neuroscience

authors： Luo Y,Qu T,Song Q,Qi Y,Yu S,Gong S,Liu K,Jiang X

更新日期：2020-03-01 00:00:00

abstract：:In the present study, we analysed the distribution and cellular localization of metabotropic glutamate receptors (1alpha, 2/3, 5) in parabrachial and Kölliker-Fuse nuclei using subtype-specific antisera. Immunolabelling revealed that different nuclei express different sets of metabotropic glutamate receptors. Metabotr...

journal_title：Neuroscience

authors： Guthmann A,Herbert H

更新日期：1999-03-01 00:00:00

abstract：:The aim of this study was to assess whether omega conotoxin fraction GVIA, a potent blocker of N- and L-type voltage-sensitive calcium channels, might interfere with reflex responses (micturition, blood pressure rise in spinal rats) produced by activation of capsaicin-sensitive sensory nerves of the rat urinary bladde...

journal_title：Neuroscience

authors： Maggi CA,Giuliani S,Santicioli P,Tramontana M,Meli A

更新日期：1990-01-01 00:00:00

abstract：:It has previously been reported that the avian H5N1 type of influenza A virus can be detected in neurons and astrocytes of human brains in autopsy cases. However, the underlying neuropathogenicity remains unexplored. In this study, we used differentiated human astrocytic and neuronal cell lines as models to examine th...

journal_title：Neuroscience

authors： Ng YP,Lee SM,Cheung TK,Nicholls JM,Peiris JS,Ip NY

更新日期：2010-07-14 00:00:00

abstract：:Brain ischemia induces a marked response of resident microglia and hematopoietic cells including monocytes/macrophages. The present study was designed to assess the distribution of microglia/macrophages in cerebral ischemia using bone marrow chimera mice known to express enhanced green fluorescent protein (EGFP). At 2...

journal_title：Neuroscience

authors： Tanaka R,Komine-Kobayashi M,Mochizuki H,Yamada M,Furuya T,Migita M,Shimada T,Mizuno Y,Urabe T

更新日期：2003-01-01 00:00:00

abstract：:The sixth lumbar and first sacral spinal cord segments in the rat contain parasympathetic preganglionic neurons which innervate the pelvic viscera. There have been few studies, however, which have specifically considered the distribution of putative peptide neurotransmitters in these cord segments. The present paper d...

journal_title：Neuroscience

authors： Sasek CA,Seybold VS,Elde RP

更新日期：1984-07-01 00:00:00

abstract：:It is now well established that vestibular information plays an important role in spatial memory processes. Although vestibular lesions induce anxiety in humans, this finding remains controversial in rodents. However, it is possible that anxiety-related behavior is associated with spatial memory impairments after vest...

journal_title：Neuroscience

authors： Machado ML,Lelong-Boulouard V,Smith PF,Freret T,Philoxene B,Denise P,Besnard S

更新日期：2012-08-30 00:00:00

abstract：:Current neurobiological theory of drug use is based on the observation that all addictive drugs induce changes in activity of dopaminergic circuitry, interfering with reward processing, and thus enhancing drug seeking and consumption behaviors. Current theory of drug origins, in contrast, views almost all major drugs ...

journal_title：Neuroscience

authors： Hagen EH,Sullivan RJ,Schmidt R,Morris G,Kempter R,Hammerstein P

更新日期：2009-04-21 00:00:00

abstract：:The purpose of this study was to experimentally investigate the applicability of the equilibrium-point hypothesis to the dynamics of single-joint movements. Subjects were trained to perform relatively slow (movement time 600-1000 ms) or fast (movement time 200-300 ms) single-joint elbow flexion movements against a con...

journal_title：Neuroscience

authors： Latash ML,Gottlieb GL

更新日期：1991-01-01 00:00:00

abstract：:Light-microscope visualization in rat brain of a pattern of distribution of immunoreactivity, which included immunolabeled perikarya and beaded processes, was achieved using an immunoaffinity purified polyclonal antibody, Ab165, which recognizes the amino acid sequence, IRNLRQDRSKYY, found in the mu-opioid binding pro...

journal_title：Neuroscience

authors： Hiller JM,Zhang Y,Bing G,Gioannini TL,Stone EA,Simon EJ

更新日期：1994-10-01 00:00:00

abstract：:Changes in the excitability of the commissural path-CA1 pyramidal cell synapse were studied by varying the interval between the application of a conditioning pulse in the medial septal nucleus and a test pulse in the contralateral hippocampus in freely moving mice. The results showed that septal prestimulation results...

journal_title：Neuroscience

authors： Jeantet Y,Jaffard R

更新日期：1983-01-01 00:00:00

abstract：:The first Kavli Prize in Neuroscience recognizes a confluence of career achievements that together provide a fundamental understanding of how brain and spinal cord circuits are assembled during development and function in the adult. The members of the Kavli Neuroscience Prize Committee have decided to reward three sci...

journal_title：Neuroscience

authors： Glover JC

更新日期：2009-11-10 00:00:00

abstract：:We have previously shown how the Frontal Pole cortex (FPC) neurons play a unique role in both the monitoring and evaluating of self-generated decisions during feedback in a visually cued strategy task. For each trial of this task, a cue instructed one of two strategies: to either stay with the previous goal or shift t...

journal_title：Neuroscience

authors： Mione V,Tsujimoto S,Genovesio A

更新日期：2019-04-15 00:00:00

abstract：:Spreading depression (SD) is a wave of coordinated cellular depolarization that propagates slowly throughout brain tissue. SD has been associated with migraine aura, and related events have been implicated in the enlargement of some brain injuries. Selective disruption of astrocyte oxidative metabolism has previously ...

journal_title：Neuroscience

authors： Seidel JL,Shuttleworth CW

更新日期：2011-09-29 00:00:00

abstract：:Lack of dystrophin in mdx mice leads to muscle fibre degeneration followed by the formation of new myofibres. This degeneration-regeneration event occurs in clusters. It is accompanied by inflammation and remodelling of the intramuscular terminal nerve fibres. Since the growth-associated protein B-50/GAP-43 has been s...

journal_title：Neuroscience

authors： Verzè L,Buffo A,Rossi F,Oestreicher AB,Gispen WH,Strata P

更新日期：1996-02-01 00:00:00

abstract：:The organization of the claustrocortical system was investigated in rat by means of cortical injections of either lectin-conjugated horseradish peroxidase or retrograde fluorescent tracers. The latter were also employed in cat. Evans Blue, Fast Blue, True Blue, Nuclear Yellow and Diamidino Yellow were used in differen...

journal_title：Neuroscience

authors： Minciacchi D,Molinari M,Bentivoglio M,Macchi G

更新日期：1985-11-01 00:00:00

abstract：:The transport of excitatory amino acids (EAA) in CNS is performed by a family of high affinity, sodium dependent carriers. One of these transporters, excitatory amino acid carrier 1 (EAAC1), is known to be regulated by several mechanisms that modify carrier abundance on the plasma membrane. Much less is known on EAAC1...

journal_title：Neuroscience

authors： Bianchi MG,Gazzola GC,Tognazzi L,Bussolati O

更新日期：2008-02-19 00:00:00