当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states.

Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states.

Abstract：

:Ghrelin induces orexigenic behavior by activation of growth hormone secretagogue 1 receptors (GHSRs) in the ventral tegmental area (VTA) as well as hypothalamus, suggesting the involvement of mesolimbic dopamine system in the action of ghrelin. The present study aimed to identify neuronal mechanisms by which peripherally administered ghrelin regulates the mesolimbic dopamine system under different food-consumptive states. Ghrelin was administered to rats peripherally (3 nmol, i.v.) as well as locally into the VTA (0.3 nmol). Dopamine in the nucleus accumbens shell (NAc) was measured by microdialysis. Peripheral administration of ghrelin decreased dopamine levels in the NAc when food was removed following ghrelin administration. This inhibitory effect was mediated through GABA(A) and N-methyl-D-aspartate (NMDA) receptors in the VTA. In contrast, when animals consumed food following ghrelin administration, dopamine levels increased robustly. This stimulatory effect was mediated through NMDA receptors, but not through GABA(A) receptors, in the VTA. Importantly, both the inhibitory and stimulatory effects of ghrelin primarily required activation of GHSRs in the VTA. Furthermore, local injection of ghrelin into the VTA induced dopamine release in the NAc and food consumption, supporting the local action of ghrelin in the VTA. In conclusion, peripherally administered ghrelin activates GHSRs in the VTA, and induces bimodal effects on mesolimbic dopamine neurotransmission depending on food-consumptive states.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Kawahara Y,Kawahara H,Kaneko F,Yamada M,Nishi Y,Tanaka E,Nishi A

doi

10.1016/j.neuroscience.2009.03.086

subject

Has Abstract

pub_date

2009-07-07 00:00:00

pages

855-64

issue

3

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(09)00537-5

journal_volume

161

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Somatosensory feedback refines the perception of hand shape with respect to external constraints.

    abstract：:Motor commands issued by the CNS are based upon memories of past experiences with similar objects, the current state of the hand and arm postures, and sensory input. Thus widespread somatosensory information is available to form precise representations of hand shape on which to base motor commands to match a desired p...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.02.047

    authors： Winges SA

    更新日期：2015-05-07 00:00:00

  • Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling.

    abstract：:A systematic line-sampling method is described for counting and mapping myelinated axons in transverse sections of the spinal cord. Its advantages over random sampling of small areas are considered. The technique was applied to quantifying experimental weight-drop contusion injuries of cat spinal cord, from several mo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90150-1

    authors： Blight AR

    更新日期：1983-10-01 00:00:00

  • Fast, synchronous neurotransmitter release: Past, present and future.

    abstract：:This mini-review starts with a summary of the crucial contributions Ricardo Miledi made to our understanding of how the action potential triggers fast, synchronous transmitter release. It then transitions to the discovery of synaptotagmin and its role as the exocytotic Ca2+ sensor at nerve terminals. The final section...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2019.04.030

    authors： Gundersen CB

    更新日期：2020-07-15 00:00:00

  • Effects of gonadectomy on immunoreactivity for choline acetyltransferase in the cortex, hippocampus, and basal forebrain of adult male rats.

    abstract：:Androgens are known to affect cognitive and mnemonic aspects of spatial processing. The cholinergic system is thought to play an important role in cognition and memory, but little is known about the interaction between androgen and cholinergic neurons. The present study focused on the effects of testosterone on the ch...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00513-9

    authors： Nakamura N,Fujita H,Kawata M

    更新日期：2002-01-01 00:00:00

  • Glutamate in some retinal neurons is derived solely from glia.

    abstract：:Glutamate is the most abundant excitatory neurotransmitter in the vertebrate central nervous system. It is widely assumed that neurons using this transmitter derive it from several sources: (i) synthesizing it themselves from alpha-ketoglutarate or aspartate, (ii) synthesize it from glial-derived glutamine, or (iii) t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90249-6

    authors： Pow DV,Robinson SR

    更新日期：1994-05-01 00:00:00

  • Ascending projections from the solitary tract nucleus to the hypothalamus. A Phaseolus vulgaris lectin tracing study in the rat.

    abstract：:The course of the ascending pathways originating from the anterior gustatory and posterior visceral sensory part of the solitary tract nucleus and the topographic organization of the projections to the hypothalamus in the rat were studied with anterogradely transported Phaseolus vulgaris lectin. In general, the poster...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90441-7

    authors： Ter Horst GJ,de Boer P,Luiten PG,van Willigen JD

    更新日期：1989-01-01 00:00:00

  • Importance of D1 and D2 receptors in the dorsal caudate-putamen for the locomotor activity and stereotyped behaviors of preweanling rats.

    abstract：:Dopaminergic compounds often affect the unlearned behaviors of preweanling and adult rats differently, although the brain regions underlying these age-dependent behavioral effects have not been specified. A candidate brain region is the dorsal caudate-putamen (CPu); thus, a goal of the present study was to determine w...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.03.037

    authors： Charntikov S,Der-Ghazarian T,Herbert MS,Horn LR,Widarma CB,Gutierrez A,Varela FA,McDougall SA

    更新日期：2011-06-02 00:00:00

  • Expression of the genes for alpha-type and beta-type calcitonin gene-related peptide during rat embryogenesis.

    abstract：:Throughout rat embryogenesis we analysed the expression patterns of the three mature transcripts generated from the two calcitonin gene-related peptide genes: calcitonin, alpha-calcitonin gene-related peptide, and beta-calcitonin gene-related peptide messenger RNAs. In addition, we examined in parallel the distributio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00730-1

    authors： Terrado J,Gerrikagoitia I,Domínguez L,Raldúa D,Martínez-Millán L,Sarasa M

    更新日期：1999-01-01 00:00:00

  • Dopamine regulates synaptic transmission mediated by cholinergic neurons of the rat retina.

    abstract：:The purpose of this study was to investigate the effect of dopamine on the function of synapses formed by cholinergic neurons derived from the rat retina. We used an experimental culture system in which rat striated muscle cells served as postsynaptic targets for cholinergic neurons of the retina. This culture system ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90104-0

    authors： Yeh HH,Battelle BA,Puro DG

    更新日期：1984-11-01 00:00:00

  • 7beta-hydroxycholesterol reduces the extent of reactive gliosis caused by iron deposition in the hippocampus but does not attenuate the iron-induced seizures in rats.

    abstract：:7beta-Hydroxycholesterol has been previously demonstrated to inhibit astrocytosis in injured cortex or spinal cord of rats. In this study, we explored the inhibitory effects of the liposome containing 7beta-hydroxycholesterol on the reactive astrocytosis caused by the injection of iron into the hippocampus of rats and...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.12.011

    authors： Yao Y,Sun S,Kong Q,Tong E

    更新日期：2006-01-01 00:00:00

  • Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied by their association with cytoskeletal components.

    abstract：:Astrocytic endothelin receptors are involved in the appearance of activated astrocytes upon injury of the brain [Ishikawa N. et al. (1997) Eur. J. Neurosci. 9, 895-901; Koyama Y. et al. (1999) Glia 26, 268-271]. To clarify signal transduction triggered by endothelin receptors, we examined the effects of endothelins on...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00330-4

    authors： Koyama Y,Yoshioka Y,Hashimoto H,Matsuda T,Baba A

    更新日期：2000-01-01 00:00:00

  • Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation.

    abstract：:Inflammation is an important event in ischemic injury. These immune responses begin with the expression of pro-inflammatory genes modulating transcription factors, such as nuclear factor-κB (NF-κB), activator protein-1 (AP-1), and signal transducers and activator of transcription-1 (STAT-1). The 70-kDa heat shock prot...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.11.057

    authors： Kim JY,Yenari MA,Lee JE

    更新日期：2015-02-12 00:00:00

  • Differential signaling of glial cell line-derived neurothrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons.

    abstract：:In the ventral mesencephalon, two neurotrophic factors, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, have been shown previously to have similar effects on the survival of dopaminergic neurons. Here, we compared the signaling mechanisms for brain-derived neurotrophic factor and gli...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00129-3

    authors： Feng L,Wang CY,Jiang H,Oho C,Dugich-Djordjevic M,Mei L,Lu B

    更新日期：1999-01-01 00:00:00

  • Activation of p38 mitogen-activated protein kinase during normal mitosis in the developing retina.

    abstract：:The p38 member of the mitogen-activated protein kinase superfamily is engaged by phosphorylation in response to environmental stress signals, and may have either permissive or inhibitor roles upon cell proliferation. The cell cycle in the proliferative zone of the retina is tightly controlled and proceeds in synchrony...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00096-9

    authors： Campos CB,Bédard PA,Linden R

    更新日期：2002-01-01 00:00:00

  • Restoration of the corticostriatal projection in rat neostriatal grafts: electron microscopic analysis.

    abstract：:The corticostriatal projection in rat neostriatal grafts was studied by using the axonal transport of Phaseolus vulgaris-leucoagglutinin. The neostriatal primodia from 15-18-day embryos were used to make a cell suspension which was implanted unilaterally into the rat neostriatum 3-5 days after kainic acid lesion. Two ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90129-2

    authors： Xu ZC,Wilson CJ,Emson PC

    更新日期：1989-01-01 00:00:00

  • Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection.

    abstract：:Extensive evidence suggests that the reinforcing effects of cocaine involve inhibition of dopamine transporters (DAT) and subsequent increases in dopamine (DA) levels in the striatum. We have previously reported that cocaine inhibits the DAT within 4-5 s of i.v. injection, matching the temporal profile of the behavior...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.03.017

    authors： Yorgason JT,Jones SR,España RA

    更新日期：2011-05-19 00:00:00

  • Gene expression profile analysis of epilepsy-associated gangliogliomas.

    abstract：:Gangliogliomas (GG) constitute the most frequent tumor entity in young patients undergoing surgery for intractable epilepsy. The histological composition of GG, with the presence of dysplastic neurons, corroborates their maldevelopmental origin. However, their histogenesis, the pathogenetic relationship with other dev...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.10.036

    authors： Aronica E,Boer K,Becker A,Redeker S,Spliet WG,van Rijen PC,Wittink F,Breit T,Wadman WJ,Lopes da Silva FH,Troost D,Gorter JA

    更新日期：2008-01-02 00:00:00

  • Overexpression of MicroRNA-9a-5p Ameliorates NLRP1 Inflammasome-mediated Ischemic Injury in Rats Following Ischemic Stroke.

    abstract：:The nucleotide oligomerization domain (NOD)-like receptor (NLR) pyrin domain-containing protein 1 (NLRP1) inflammasome has been shown to contribute to brain injury after ischemic stroke. Our previous study showed that microRNA-9a-5p (miR-9a-5p) ameliorates ischemic injury by regulating neuronal autophagy in rats subje...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.01.008

    authors： Cao Y,Zhang H,Lu X,Wang J,Zhang X,Sun S,Bao Z,Tian W,Ning S,Wang L,Cui L

    更新日期：2020-09-15 00:00:00

  • Memantine Mitigates Oligodendrocyte Damage after Repetitive Mild Traumatic Brain Injury.

    abstract：:Repetitive mild traumatic brain injury (rmTBI; e.g., sports concussions) is common and results in significant cognitive impairment, white matter injury and increased risk of neurodegeneration. Targeted therapies for rmTBI are lacking, though evidence from other injury models indicates that targeting N-methyl-d-asparta...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.10.016

    authors： Ma G,Liu C,Hashim J,Conley G,Morriss N,Meehan WP,Qiu J,Mannix R

    更新日期：2019-11-21 00:00:00

  • Nitric oxide alters proenkephalin and prodynorphin gene expression in hippocampal granule cells.

    abstract：:Application of N-methyl-D-aspartate on to the dendrites of hippocampal granule cells dramatically decreased prodynorphin messenger RNA levels in the affected cells while increasing proenkephalin messenger RNA levels. Sin-1 molsidomine (an agent which releases nitric oxide) and 8-bromo-cyclic GMP were similarly effecti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90423-5

    authors： Johnston HM,Morris BJ

    更新日期：1994-08-01 00:00:00

  • Neonatal manipulation of oxytocin affects expression of estrogen receptor alpha.

    abstract：:In adult females many of the effects of the neuropeptide oxytocin are steroid, and especially estrogen dependent. Here we demonstrate for the first time that neonatal manipulation of oxytocin can affect the expression of estrogen receptor alpha. On the first day of postnatal life male and female prairie voles (Microtu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.08.065

    authors： Yamamoto Y,Carter CS,Cushing BS

    更新日期：2006-01-01 00:00:00

  • Functional development of the vagal and glossopharyngeal nerve-related nuclei in the embryonic rat brainstem: optical mapping with a voltage-sensitive dye.

    abstract：:We investigated functional organization of the vagus nerve (N. X)- and glossopharyngeal nerve (N. IX)-related nuclei in the embryonic rat brainstem and compared their development and spatial distribution patterns, using multiple-site optical recording with a fast voltage-sensitive dye, NK2761. Intact brainstem prepara...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.06.019

    authors： Momose-Sato Y,Nakamori T,Sato K

    更新日期：2011-09-29 00:00:00

  • White matter differences between multiple system atrophy (parkinsonian type) and Parkinson's disease: A diffusion tensor image study.

    abstract：:The clinical differential diagnosis between the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD) is difficult in early stages. To identify objective markers for differential diagnosis, we combined the novel tract-based spatial statistics (TBSS) and region of interest (ROI) analyses for...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.07.060

    authors： Ji L,Wang Y,Zhu D,Liu W,Shi J

    更新日期：2015-10-01 00:00:00

  • Co-localization of tyrosine hydroxylase and zebrin II immunoreactivities in Purkinje cells of the mutant mice, tottering and tottering/leaner.

    abstract：:The mutant mice tottering, leaner and the compound heterozygous tottering/leaner exhibit varying degrees of several abnormal neurological phenotypes including petit mal-like epilepsy, ataxia and an intermittent myoclonus-like movement disorder. Aberrant expression of tyrosine hydroxylase in cerebellar Purkinje cells o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00444-0

    authors： Abbott LC,Isaacs KR,Heckroth JA

    更新日期：1996-03-01 00:00:00

  • Quantitative analysis of parvalbumin-immunoreactive cells in the human epileptic hippocampus.

    abstract：:Hippocampal sclerosis is the most frequent pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis. These alterations are accompanied by changes in the expression of a variety of molecules in the sur...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.07.029

    authors： Andrioli A,Alonso-Nanclares L,Arellano JI,DeFelipe J

    更新日期：2007-10-12 00:00:00

  • Pharmacological characterization of ionotropic glutamate receptors in the zebrafish olfactory bulb.

    abstract：:The distribution of N-methyl-D-aspartate- (NMDA) and kainic acid- (KA) sensitive ionotropic glutamate receptors (iGluR) in the zebrafish olfactory bulb was assessed using an activity-dependent labeling method. Olfactory bulbs were incubated with an ion channel permeant probe, agmatine (AGB), and iGluR agonists in vitr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00544-x

    authors： Edwards JG,Michel WC

    更新日期：2003-01-01 00:00:00

  • Acquisition of a novel behavior induces higher levels of Arc mRNA than does overtrained performance.

    abstract：:Arc (also termed activity-regulated cytoskeleton-associated protein or Arg3.1), is an effector immediate early gene whose upregulation has been demonstrated during events of synaptic plasticity. In the present study, the possibility that Arc would be specifically upregulated in rats during the acquisition of a quickly...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00605-4

    authors： Kelly MP,Deadwyler SA

    更新日期：2002-01-01 00:00:00

  • Head movements suggest canal and otolith projections are activated during galvanic vestibular stimulation.

    abstract：:Three-dimensional changes in the angular orientation of the head were monitored during galvanic vestibular stimulation (GVS) delivered through electrodes implanted bilaterally in the tensor tympani muscle of the guinea-pig middle ear. Bilateral GVS was delivered by passing current between both ears with the anode situ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.08.058

    authors： Kim J

    更新日期：2013-12-03 00:00:00

  • Redundancy in ascending and descending pathways mediating head turning elicited by entopenducular stimulation in the cat.

    abstract：:Contraversive turning movements of the head were elicited in alert cats by unilateral electrical stimulation of the entopeduncular nucleus. To determine the relative functional importance of ascending and descending pathways activated by the stimulation, the animals were submitted to thalamocortical or midbrain lesion...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90090-8

    authors： Filion M,Hébert R

    更新日期：1983-09-01 00:00:00

  • Control of slow oscillations in the thalamocortical neuron: a computer model.

    abstract：:We investigated computer models of a single thalamocortical neuron to assess the interaction of intrinsic voltage-sensitive channels and cortical synaptic input in producing the range of oscillation frequencies observed in these cells in vivo. A morphologically detailed model with Hodgkin-Huxley-like ion channels demo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)83006-5

    authors： Lytton WW,Destexhe A,Sejnowski TJ

    更新日期：1996-02-01 00:00:00