Genetic differences in hippocampal synaptic plasticity.

abstract：:Organotypic cultures of fetal or early postnatal striatum were used to assess striatal patch formation and maintenance in the presence or absence of dopaminergic and glutamatergic influences. Vibratome-cut slices of the striatum prepared from embryonic day 19 to postnatal day 4 rat pups were maintained in static cultu...

journal_title：Neuroscience

authors： Snyder-Keller A,Costantini LC,Graber DJ

更新日期：2001-01-01 00:00:00

abstract：:Microglia are the prime cellular sources of reactive oxygen species (ROS) in the central nervous system (CNS). Chronic activation of microglia has been linked to aging-associated neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) since they produce excessive amounts of ROS for a p...

journal_title：Neuroscience

authors： Rangarajan P,Karthikeyan A,Lu J,Ling EA,Dheen ST

更新日期：2015-12-17 00:00:00

abstract：:Intracellular microelectrode recordings were used to examine the effects of the potassium channel blockers: 4-aminopyridine, a selective blocker of fast potassium conductances gKf1 and gKf2,13 and tetraethylammonium, a blocker of gKf1, gKf2 and the slow conductance gKs,13 on the repetitive activity of large myelinated...

journal_title：Neuroscience

authors： Poulter MO,Padjen AL

更新日期：1995-09-01 00:00:00

abstract：:Electrophysiological and anatomical studies were carried out in parallel to investigate the ability of lateral geniculate body neurons to regenerate axons damaged by the removal of the primary visual cortex and to innervate graft neurons functionally after transplantation of fetal neocortical tissue to a lesion cavity...

journal_title：Neuroscience

authors： Girman SV

更新日期：1994-06-01 00:00:00

abstract：:Long-term hyperexcitability was found after unilateral, permanent middle cerebral artery occlusion in exofocal neocortical areas of the adult mouse [Mittmann et al. (1998) Neuroscience 85, 15-27]. The aim of the present study was to test the hypothesis in an identical paradigm of ischemia. whether alterations in the d...

journal_title：Neuroscience

authors： Qü M,Mittmann T,Luhmann HJ,Schleicher A,Zilles K

更新日期：1998-07-01 00:00:00

abstract：:In the present study, we investigated whether endoplasmic reticulum (ER) stress is associated with neuronal- and astroglial-death in the hippocampus using LiCl-pilocarpine-induced status epilepticus (SE) rat model. Glucose-related protein (GRP) 78 and protein disulfide isomerase (PDI) expressions were transiently incr...

journal_title：Neuroscience

authors： Ko AR,Kim JY,Hyun HW,Kim JE

更新日期：2015-10-29 00:00:00

abstract：:Rapid eye movement (REM) sleep deprivation elevates noradrenaline level, which upon acting on alpha1-adrenoceptors increases Na-K-ATPase activity; however, the detailed intracellular mechanism of action was unknown. Since membrane integrity is crucial for maintaining Na-K-ATPase activity as well as ionic exchange and ...

journal_title：Neuroscience

authors： Das G,Gopalakrishnan A,Faisal M,Mallick BN

更新日期：2008-07-31 00:00:00

abstract：:Sensory events in the space around us trigger specific motor patterns directed toward or away from the spatial location of the sensory source. Spatially-defined sensorimotor associations are well-known in the visual domain but less so for the auditory modality. In particular no spatially-directed audio-motor associati...

journal_title：Neuroscience

authors： Cattaneo L,Barchiesi G

更新日期：2015-09-24 00:00:00

abstract：:The interrelationships of motor patterns controlling the mouthparts and the salivary gland of the migratory locust were studied in a deafferented preparation activated by the muscarinic agonist pilocarpine. The aim of the study was to check whether motor output of different neuromeres of the suboesophageal ganglion an...

journal_title：Neuroscience

authors： Rast GF,Bräunig P

更新日期：2001-01-01 00:00:00

abstract：:Although neurogenesis in the hippocampus is critical for improvement of depressive behaviors and cognitive functions in neurodegeneration disorders, there is no therapeutic agent available to promote neurogenesis in adult brain following brain ischemic injury. Here we found that i.p. administration of bis(1-oxy-2-pyri...

journal_title：Neuroscience

authors： Shioda N,Han F,Morioka M,Fukunaga K

更新日期：2008-08-26 00:00:00

abstract：:Secretogranin II (chromogranin C), originally described as tyrosine sulfated protein of the anterior pituitary, is present in large dense core vesicles of several endocrine cells and neurons. We raised antisera in rabbits to conjugates of two synthetic peptides (bovine secretogranin 133-151 and rat secretogranin 154-1...

journal_title：Neuroscience

authors： Kirchmair R,Hogue-Angeletti R,Gutierrez J,Fischer-Colbrie R,Winkler H

更新日期：1993-03-01 00:00:00

abstract：:The study of architectonic differentiation in the cortex is advanced by the articulation of objective definitions based on clear features of the cortical architecture. We adopted areal density profiles as a means of sampling the cortex. On the profiles, we isolated and quantified the density of individual cortical lay...

journal_title：Neuroscience

authors： Mackey S,Petrides M

更新日期：2009-03-31 00:00:00

abstract：:We have developed a specific radioimmunoassay for "cerebellin", a 16-amino acid peptide recently isolated from rat cerebellum. In both rat and guinea-pig, cerebellin-like immunoreactivity was highest in the cerebellum but was also present in high concentrations elsewhere in the central nervous system, especially in th...

journal_title：Neuroscience

authors： Burnet PW,Bretherton-Watt D,Ghatei MA,Bloom SR

更新日期：1988-05-01 00:00:00

abstract：:S100A1 and S100B are members of a multigenic family of Ca(2+)-binding proteins of the EF-hand type highly abundant in astrocyte and striated muscle cells that have been implicated in the Ca(2+)-dependent regulation of several intracellular activities including the assembly and disassembly of microtubules and type III ...

journal_title：Neuroscience

authors： Sorci G,Agneletti AL,Donato R

更新日期：2000-01-01 00:00:00

abstract：:The granular layer of the cerebellar cortex consists of densely packed neuronal cells, classified into granule cells and large interneurons. In this study, we provide a comparative survey of large granular layer interneurons in the adult rat cerebellum based on both morphological and neurochemical criteria. To this en...

journal_title：Neuroscience

authors： Geurts FJ,Timmermans J,Shigemoto R,De Schutter E

更新日期：2001-01-01 00:00:00

abstract：:The effects of muscarine and nicotine on evoked and spontaneous release of GABA were studied using intracellular and whole-cell patch-clamp recordings from rat midbrain dopamine neurons in an in vitro slice preparation. Muscarine (30 microM) reversibly depressed the pharmacologically isolated inhibitory postsynaptic p...

journal_title：Neuroscience

authors： Grillner P,Berretta N,Bernardi G,Svensson TH,Mercuri NB

更新日期：2000-01-01 00:00:00

abstract：:Ivane Beritashvili ("Beritoff" in Russian, and often in Western languages) was a major figure in 20th-century neuroscience. Mastering the string galvanometer, he founded the electrophysiology of spinal cord reflexes, showing that inhibition is a distinctly different process from excitation, contrary to the concepts of...

journal_title：Neuroscience

authors： Tsagareli MG,Doty RW

更新日期：2009-10-20 00:00:00

abstract：OBJECTIVE:High-mobility group box 1 (HMGB1), an active receptor for advanced glycation endproducts (RAGE), functions as a potent proinflammatory cytokine-like factor that contributes to the pathogenesis of vasculature. Diabetes mellitus (DM) is associated with accelerated development of both microvascular and macrovasc...

journal_title：Neuroscience

authors： Ye X,Chopp M,Liu X,Zacharek A,Cui X,Yan T,Roberts C,Chen J

更新日期：2011-09-08 00:00:00

abstract：:Intrinsic connectivity networks (ICNs) are composed of spatial components and time courses. The spatial components of ICNs were discovered with moderate-to-high reliability. So far as we know, few studies focused on the reliability of the temporal patterns for ICNs based their individual time courses. The goals of thi...

journal_title：Neuroscience

authors： Wang X,Jiao Y,Tang T,Wang H,Lu Z

更新日期：2013-12-19 00:00:00

abstract：:Cannabinoid ligands have been shown to be anti-nociceptive in animal models of acute and chronic pain by acting at the two known cannabinoid receptors, cannabinoid-1 receptor (CB-1) and cannabinoid-2 receptor (CB-2). A major concern with the use of cannabinoids for pain relief is that they activate receptors at sites ...

journal_title：Neuroscience

authors： Palmer JA,Higuera ES,Chang L,Chaplan SR

更新日期：2008-07-17 00:00:00

abstract：:The study explored unintentional force changes elicited by removing visual feedback during cyclical, two-finger isometric force production tasks. Subjects performed two types of tasks at 1Hz, paced by an auditory metronome. One - Force task - required cyclical changes in total force while maintaining the sharing, defi...

journal_title：Neuroscience

authors： Reschechtko S,Hasanbarani F,Akulin VM,Latash ML

更新日期：2017-05-14 00:00:00

abstract：:Neurodegeneration in Alzheimer's disease is characterized by a selective loss of particular cell populations. Several recent lines of evidence suggest that beta-amyloid protein directly contributes to the disease's progression and is likely responsible for the observed pattern of neuronal death. We have previously dem...

journal_title：Neuroscience

authors： Pike CJ,Cotman CW

更新日期：1993-09-01 00:00:00

abstract：:Before movement onset, during the reaction time, excitability of M1 is selectively modulated by somatosensory inputs, only in the movement-related muscle. If a similar mechanism operates before the onset of mental movements, then somatosensory afferent inputs are exploited during cognitive representation of movement. ...

journal_title：Neuroscience

authors： Bonassi G,Bisio A,Lagravinese G,Ruggeri P,Bove M,Avanzino L

更新日期：2019-06-15 00:00:00

abstract：:Musculoskeletal pain conditions, particularly those associated with temporomandibular disorders (TMD) affect a large percentage of the population. Identifying mechanisms underlying hyperalgesia could contribute to the development of new treatment strategies for the management of TMD and other muscle pain conditions. I...

journal_title：Neuroscience

authors： Saloman JL,Chung MK,Ro JY

更新日期：2013-03-01 00:00:00

abstract：:How does our mind produce physical, goal-directed action of our body? For about 200years, philosophers and psychologists hypothesized the transformation from mind to body to rely on the anticipation of an action's sensory consequences. Whereas this hypothesis received tremendous support from behavioral experiments, th...

journal_title：Neuroscience

authors： Pfister R,Melcher T,Kiesel A,Dechent P,Gruber O

更新日期：2014-02-14 00:00:00

abstract：:Light-microscope visualization in rat brain of a pattern of distribution of immunoreactivity, which included immunolabeled perikarya and beaded processes, was achieved using an immunoaffinity purified polyclonal antibody, Ab165, which recognizes the amino acid sequence, IRNLRQDRSKYY, found in the mu-opioid binding pro...

journal_title：Neuroscience

authors： Hiller JM,Zhang Y,Bing G,Gioannini TL,Stone EA,Simon EJ

更新日期：1994-10-01 00:00:00

abstract：:High resolution immunogold cytochemistry was used to investigate the subcellular distribution of protein kinase C gamma and delta in Purkinje cells of the rat cerebellum. Postembedding incubation with an antibody raised to a peptide sequence near the C-terminus of protein kinase C gamma resulted in strong labelling al...

journal_title：Neuroscience

authors： Cardell M,Landsend AS,Eidet J,Wieloch T,Blackstad TW,Ottersen OP

更新日期：1998-02-01 00:00:00

abstract：:Exposure of male Syrian hamsters to a short daylength of 8L:16D leads to gonadal regression. This effect of photoperiod was prevented by pinealectomy or chronic exposure of the brain to exogenous melatonin delivered from in-dwelling cannulae. However, the effect of melatonin was dependent on the neural site of applica...

journal_title：Neuroscience

authors： Hastings MH,Walker AP,Roberts AC,Herbert J

更新日期：1988-03-01 00:00:00

abstract：:Early experience and social context interact to alter the phenotype of complex social behaviors. These early experiences can also result in alterations to cortical organization and connections. Given the ability of the neuropeptide oxytocin (OT) to modulate social and reproductive behavior, OT is likely involved in th...

journal_title：Neuroscience

authors： Duchemin A,Seelke AM,Simmons TC,Freeman SM,Bales KL

更新日期：2017-04-21 00:00:00

abstract：:Intracellular recordings were made from submucous plexus neurons of the guinea-pig cecum maintained in vitro. Histamine (0.3-10 microM) produced a dose-dependent membrane depolarization (congruent to 13 mV with 3 microM) in about 28% of the cells tested; most of these cells showed a prominent calcium-activated potassi...

journal_title：Neuroscience

authors： Tokimasa T,Akasu T

更新日期：1989-01-01 00:00:00