Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia.

Abstract:

:Microglia are the prime cellular sources of reactive oxygen species (ROS) in the central nervous system (CNS). Chronic activation of microglia has been linked to aging-associated neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) since they produce excessive amounts of ROS for a prolonged duration leading to oxidative stress. The present study was aimed at investigating the expression and role of Sirtuin 3 (Sirt3), a protein deacetylase which is implicated in regulating cellular ROS levels. It has been shown that Sirt3 reduces cellular ROS levels by deacetylating forkhead box O 3a (Foxo3a), a transcription factor which transactivates antioxidant genes, catalase (Cat) and manganese superoxide dismutase (mnSod). In the present study, Sirt3 immunoreactivity was localized in the ameboid microglial cells distributed in the corpus callosum (CC) of the early postnatal rat brain and diminished in the ramified microglial cells in the CC of the adult rat brain. A marked induction of Sirt3 expression was seen in lipopolysaccharide (LPS)-activated microglia in vivo and in vitro as well as in adult rat brains subjected to traumatic brain injury (TBI). Knockdown of Sirt3 in microglia led to an increase in the cellular and mitochondrial ROS and decrease in the expression of antioxidant, mnSod which is indicative of the function of Sirt3 in ROS regulation in microglia. Conversely, Sirt3 overexpression led to increase in the expression of antioxidants Cat and mnSod. Further, increase in the expression and nuclear translocation of Foxo3a was observed following Sirt3 overexpression, suggesting that Sirt3 regulates ROS by inducing the expression of antioxidants via activation of Foxo3a. The above results point to an antioxidant defense mechanism presented by Sirt3 through the activation of Foxo3a, in microglia.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Rangarajan P,Karthikeyan A,Lu J,Ling EA,Dheen ST

doi

10.1016/j.neuroscience.2015.10.048

subject

Has Abstract

pub_date

2015-12-17 00:00:00

pages

398-414

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(15)00967-7

journal_volume

311

pub_type

杂志文章
  • Cyclic AMP reduces adhesion of isolated neuronal growth cones from developing rat forebrain to an astrocytic cell line from embryonic mouse striatum.

    abstract::We have recently shown that isolated neuronal growth cones from developing rat forebrain possess an appreciable activity of adenylate cyclase, producing cyclic adenosine monophosphate, which can be stimulated by various neurotransmitter receptor agonists and by forskolin [Lockerbie R. O., Hervé D., Blanc G., Tassin J....

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90191-7

    authors: Lockerbie RO,Autillo-Touati A,Araud D,Seite R,Chneiweiss H,Glowinski J,Prochiantz A

    更新日期:1989-01-01 00:00:00

  • Role of lateral and feedback connections in primary visual cortex in the processing of spatiotemporal regularity - a TMS study.

    abstract::Our human visual system exploits spatiotemporal regularity to interpret incoming visual signals. With a dynamic stimulus sequence of four collinear bars (predictors) appearing consecutively toward the fovea, followed by a target bar with varying contrasts, we have previously found that this predictable spatiotemporal ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.01.027

    authors: Roebuck H,Bourke P,Guo K

    更新日期:2014-03-28 00:00:00

  • Functional Dissociations of the Left Anterior and Posterior Occipitotemporal Cortex for Semantic and Non-semantic Phonological Access.

    abstract::Previous studies have identified the ventral and dorsal brain regions that respectively support semantic and non-semantic phonological access. Nevertheless, the specific role of the left occipitotemporal cortex (lOTC) in the two pathways of phonological access is ambiguous. To address that question, the present study ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.01.024

    authors: Dong J,Lu C,Chen C,Li H,Liu X,Mei L

    更新日期:2020-03-15 00:00:00

  • Cell-type specific distribution of chloride transporters in the rat suprachiasmatic nucleus.

    abstract::The suprachiasmatic nucleus (SCN) is a circadian oscillator and biological clock. Cell-to-cell communication is important for synchronization among SCN neuronal oscillators and the great majority of SCN neurons use GABA as a neurotransmitter, the principal inhibitory neurotransmitter in the adult CNS. Acting via the i...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.11.040

    authors: Belenky MA,Sollars PJ,Mount DB,Alper SL,Yarom Y,Pickard GE

    更新日期:2010-02-17 00:00:00

  • Speech Disfluency-dependent Amygdala Activity in Adults Who Stutter: Neuroimaging of Interpersonal Communication in MRI Scanner Environment.

    abstract::Affective states, such as anticipatory anxiety, critically influence speech communication behavior in adults who stutter. However, there is currently little evidence regarding the involvement of the limbic system in speech disfluency during interpersonal communication. We designed this neuroimaging study and experimen...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2018.01.037

    authors: Toyomura A,Fujii T,Yokosawa K,Kuriki S

    更新日期:2018-03-15 00:00:00

  • Animal Use in Neurobiological Research.

    abstract::The fact that neurobiological research is reliant upon laboratory-reared rodents is well known. The following paper discusses this topic broadly, but also aims to highlight other species used in the study of the nervous system and the evolution of animal species usage from the end of World War II through recent invest...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2020.02.049

    authors: Żakowski W

    更新日期:2020-05-01 00:00:00

  • 5-HT3A receptors are required in long-term depression and AMPA receptor internalization.

    abstract::5-Hydroxytrytamine (serotonin) type 3A receptors (5-HT3ARs), as the only ligand-gated ion channels in the serotonin receptor family, are known to regulate neuronal excitation and release of GABA in hippocampal interneurons. However, their physiological role in glutamatergic synaptic plasticity remains unclear. Here, w...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.07.070

    authors: Yu Y,Cao DQ,Xu HY,Sun M,Huang ZL,Yung WH,Lu N,Huang Y

    更新日期:2014-10-10 00:00:00

  • The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth factor-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture.

    abstract::Brain-derived neurotrophic factor, basic fibroblast growth factor and des(1-3)-insulin-like growth factor-1, a brain specific form of insulin-like growth factor-1, were analysed, in the rat, for their influence on survival, morphological growth, and transmitter-specific differentiation of dopaminergic neurons in vitro...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90534-m

    authors: Beck KD,Knüsel B,Hefti F

    更新日期:1993-02-01 00:00:00

  • Insect mouthpart motor patterns: central circuits modified for highly derived appendages?

    abstract::The interrelationships of motor patterns controlling the mouthparts and the salivary gland of the migratory locust were studied in a deafferented preparation activated by the muscarinic agonist pilocarpine. The aim of the study was to check whether motor output of different neuromeres of the suboesophageal ganglion an...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00406-7

    authors: Rast GF,Bräunig P

    更新日期:2001-01-01 00:00:00

  • A brain Na+, K+-ATPase inhibitor (endobain E) enhances norepinephrine release in rat hypothalamus.

    abstract::We have shown that synaptosomal membrane Na+, K+-ATPase activity is stimulated or inhibited by norepinephrine according to the presence or absence of a brain soluble fraction. Gel filtration of such soluble fraction has allowed the separation of two fractions, peaks I and II, able to stimulate and inhibit Na+, K+-ATPa...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00421-7

    authors: Vatta M,Peña C,Fernández B,Rodríguez de Lores Arnaiz G

    更新日期:1999-05-01 00:00:00

  • Zic1 levels regulate mossy fiber neuron position and axon laterality choice in the ventral brain stem.

    abstract::Pontine gray neurons of the brain stem are a major source of mossy fiber (MF) afferents to granule cells of the cerebellum. Achieving this connectivity involves an early regionalization of pontine gray neuron cell bodies within the brainstem pontine nuclei, as well as establishing the proper ratio of crossed versus un...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.02.082

    authors: Dipietrantonio HJ,Dymecki SM

    更新日期:2009-09-01 00:00:00

  • Organotypic brain slice cultures: A review.

    abstract::In vitro cell cultures are an important tool for obtaining insights into cellular processes in an isolated system and a supplement to in vivo animal experiments. While primary dissociated cultures permit a single homogeneous cell population to be studied, there is a clear need to explore the function of brain cells in...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2015.07.086

    authors: Humpel C

    更新日期:2015-10-01 00:00:00

  • Enhancing the salience of dullness: behavioral and pharmacological strategies to facilitate extinction of drug-cue associations in adolescent rats.

    abstract::Extinction of drug-seeking is an integral part of addiction treatment, and can profoundly reverse or ameliorate the harmful consequences of drug use. These consequences may be the most deleterious during adolescence. The studies presented here build from recent evidence that adolescent rats are more resistant to extin...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2010.05.063

    authors: Brenhouse HC,Dumais K,Andersen SL

    更新日期:2010-08-25 00:00:00

  • Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation.

    abstract::Oxytocin (OT) levels in plasma increase during sexual response and are significantly lower in patients with depression. A drug for the treatment of sexual dysfunction, sildenafil, enhances the electrically evoked release of OT from the posterior pituitary. In this study, we showed that sildenafil had an antidepressant...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2011.11.001

    authors: Matsushita H,Matsuzaki M,Han XJ,Nishiki TI,Ohmori I,Michiue H,Matsui H,Tomizawa K

    更新日期:2012-01-03 00:00:00

  • "The developmental and functional logic of neuronal circuits": commentary on the Kavli Prize in Neuroscience.

    abstract::The first Kavli Prize in Neuroscience recognizes a confluence of career achievements that together provide a fundamental understanding of how brain and spinal cord circuits are assembled during development and function in the adult. The members of the Kavli Neuroscience Prize Committee have decided to reward three sci...

    journal_title:Neuroscience

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/j.neuroscience.2009.07.047

    authors: Glover JC

    更新日期:2009-11-10 00:00:00

  • Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis.

    abstract::Pathological changes occur in areas of CNS tissue remote from inflammatory lesions in multiple sclerosis (MS) and its animal model experimental allergic encephalomyelitis (EAE). To determine if oxidative stress is a significant contributor to this non-inflammatory pathology, cortex tissues from mice with clinical sign...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2011.04.041

    authors: Castegna A,Palmieri L,Spera I,Porcelli V,Palmieri F,Fabis-Pedrini MJ,Kean RB,Barkhouse DA,Curtis MT,Hooper DC

    更新日期:2011-06-30 00:00:00

  • Differential NR2B subunit expression at dorsal root and ventrolateral funiculus synapses on lumbar motoneurons of neonatal rat.

    abstract::Synapse specific differences in NR2 subunit expression exist in several systems within the mammalian CNS. Here we have studied such differences on motoneurons in the neonatal rat cord using ifenprodil known to inhibit voltage-, use- and glycine-independent responses mediated by NR2B-containing N-methyl-d-aspartate rec...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.12.025

    authors: Shanthanelson M,Mendell LM

    更新日期:2010-03-17 00:00:00

  • Inhibition of transforming growth factor beta-activated kinase 1 confers neuroprotection after traumatic brain injury in rats.

    abstract::The transforming growth factor beta-activated kinase 1 (TAK1), a member of the Mitogen-activated protein kinase kinase kinase family, is characterized as a key regulator in inflammatory and apoptosis signaling pathways. The aim of the present study was to evaluate the role of the TAK1 pathway in experimental traumatic...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.02.022

    authors: Zhang D,Hu Y,Sun Q,Zhao J,Cong Z,Liu H,Zhou M,Li K,Hang C

    更新日期:2013-05-15 00:00:00

  • Differential Activation and Functional Plasticity of Multimodal Areas Associated with Acquired Musical Skill.

    abstract::Training of a musical skill is known to produce a distributed neural representation of the ability to perceive music and perform musical tasks. In the present study we tested the hypothesis that the audiovisual perception of music involves a wider activation of multimodal sensory and sensorimotor structures in the bra...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.08.013

    authors: Srinivasan N,Bishop J,Yekovich R,Rosenfield DB,Helekar SA

    更新日期:2020-10-15 00:00:00

  • GABAA receptors in the mediodorsal thalamus play a crucial role in rat shell-specific acetylcholine-mediated, but not dopamine-mediated, turning behaviour.

    abstract::The role of GABA(A) receptors in the mediodorsal thalamus (mdT) in turning behaviour of rats was studied. Neither the GABA(A) receptor agonist muscimol (50 ng) nor the antagonist bicuculline (200 ng) unilaterally injected into the mdT elicited any behavioural change. Unilateral injection of the acetylcholine receptor ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.02.015

    authors: Ikeda H,Kotani A,Lee J,Koshikawa N,Cools AR

    更新日期:2009-04-10 00:00:00

  • Hypothalamic cocaine- and amphetamine-regulated transcript and corticotrophin releasing factor neurons are stimulated by extracellular volume and osmotic changes.

    abstract::Several studies suggest that hypothalamic cocaine- and amphetamine-regulated transcript (CART) may interact with the hypothalamic-pituitary-adrenal (HPA) axis in the control of neuroendocrine function and may also participate in cardiovascular regulation. Therefore, this study aimed to evaluate, in experimental models...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2011.04.047

    authors: Ruginsk SG,Uchoa ET,Elias LL,Antunes-Rodrigues J,Llewellyn-Smith IJ

    更新日期:2011-07-14 00:00:00

  • Role of central cholinergic receptor sub-types in spatial working memory: a five-arm maze task in mice provides evidence for a functional role of nicotinic receptors in mediating trace access processes.

    abstract::A delayed-matching spatial working memory protocol in a 5-arm maze was used to test the hypothesis of differential roles for central nicotinic and muscarinic cholinergic receptors in mediating task performance. In experiment 1, using a within subjects-repeated design, groups of C57Bl/6 mice, previously trained to crit...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(03)00403-2

    authors: Maviel T,Durkin TP

    更新日期:2003-01-01 00:00:00

  • Selective inhibition of cyclooxygenase-2 exacerbates methamphetamine-induced dopamine depletion in the striatum in rats.

    abstract::Neuroinflammatory processes associated with induction of cyclooxygenase (COX) have been implicated in the deleterious events resulting in neurodegeneration. The present study was designed to investigate the impact of acute methamphetamine (MA) administration on COX expression and prostaglandin E2 (PGE(2)) production, ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.09.059

    authors: Zhang X,Dong F,Mayer GE,Bruch DC,Ren J,Culver B

    更新日期:2007-12-19 00:00:00

  • Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases.

    abstract::Mitochondrial defects including reduction of a key mitochondrial tricarboxylic acid cycle enzyme alpha-ketoglutarate-dehydrogenase complex (KGDHC) are characteristic of many neurodegenerative diseases. KGDHC consists of alpha-ketoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (E2k), and dihydrolipoamide de...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.02.071

    authors: Calingasan NY,Ho DJ,Wille EJ,Campagna MV,Ruan J,Dumont M,Yang L,Shi Q,Gibson GE,Beal MF

    更新日期:2008-06-02 00:00:00

  • 5-HT(1A), 5-HT(2A), and 5-HT(2C) receptor mRNA modulation by antidepressant treatment in the chronic mild stress model of depression: sex differences exposed.

    abstract::It is well established that women experience major depression at roughly twice the rate of men. Interestingly, accumulating clinical and experimental evidence shows that the responsiveness of males and females to antidepressant pharmacotherapy, and particularly to tricyclic antidepressants (TCAs), is sex-differentiate...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.03.003

    authors: Pitychoutis PM,Dalla C,Sideris AC,Tsonis PA,Papadopoulou-Daifoti Z

    更新日期:2012-05-17 00:00:00

  • Photolysis of caged inositol 1,4,5-trisphosphate induces action potentials in frog vomeronasal microvillar receptor neurones.

    abstract::To study the effect of inositol 1,4,5-trisphosphate (IP(3)) in isolated frog vomeronasal microvillar receptor neurones, whole-cell recordings were performed with 0.5 microM caged IP(3) dissolved in the pipette solution. IP(3) was released by photolysis of caged IP(3) initiated by a 0.8-ms ultraviolet flash from a xeno...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(03)00115-5

    authors: Gjerstad J,Valen EC,Trotier D,Døving K

    更新日期:2003-01-01 00:00:00

  • Distribution and postnatal ontogeny of adenosine A2A receptors in rat brain: comparison with dopamine receptors.

    abstract::In adult rat brain, adenosine A2A receptors and dopamine D2 receptors are known to be located on the same cells where they interact in an antagonistic manner. In the present study we wanted to examine when this situation develops and compared the postnatal ontogeny of the binding of the adenosine A2A receptor agonist ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00143-7

    authors: Johansson B,Georgiev V,Fredholm BB

    更新日期:1997-10-01 00:00:00

  • Temporospatial coupling of networked synaptic activation of AMPA-type glutamate receptor channels and calcium transients in cultured motoneurons.

    abstract::AMPA-type glutamate receptor (GluR) channels provide fast excitatory synaptic transmission in the CNS, but mediate also cytotoxic insults. It could be shown that AMPA-type GluR channel-mediated chronic excitotoxicity leads to an increased intracellular calcium concentration and plays an important role in neurodegenera...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.07.034

    authors: Jahn K,Grosskreutz J,Haastert K,Ziegler E,Schlesinger F,Grothe C,Dengler R,Bufler J

    更新日期:2006-11-03 00:00:00

  • Stress and the developing adolescent brain.

    abstract::Adolescence is a time of continued brain maturation, particularly in limbic and cortical regions, which undoubtedly plays a role in the physiological and emotional changes coincident with adolescence. An emerging line of research has indicated that stressors experienced during this crucial developmental stage may affe...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2012.10.048

    authors: Eiland L,Romeo RD

    更新日期:2013-09-26 00:00:00

  • Vasoactive intestinal polypeptide/peptide histidine isoleucine immunoreactive neuron systems in the basal hypothalamus of the rat with special reference to the portal vasculature: an immunohistochemical and in situ hybridization study.

    abstract::Using immunohistochemistry and in situ hybridization, we have analysed the distribution of vasoactive intestinal polypeptide (VIP) and peptide histidine isoleucine (PHI) in hypothalamus of male and female Sprague-Dawley rats under normal and experimental conditions. In most cases there was a good overlap between the d...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(91)90310-k

    authors: Ceccatelli S,Fahrenkrug J,Villar MJ,Hökfelt T

    更新日期:1991-01-01 00:00:00