当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Different voltage-dependent potassium conductances regulate action potential repolarization and excitability in frog myelinated axon.

Different voltage-dependent potassium conductances regulate action potential repolarization and excitability in frog myelinated axon.

Abstract：

:Intracellular microelectrode recordings were used to examine the effects of the potassium channel blockers: 4-aminopyridine, a selective blocker of fast potassium conductances gKf1 and gKf2,13 and tetraethylammonium, a blocker of gKf1, gKf2 and the slow conductance gKs,13 on the repetitive activity of large myelinated axons of frog. The blockers were applied intracellularly by diffusional leak of the agents from the recording microelectrode containing either 4-aminopyridine or a mixture of 4-aminopyridine and tetraethylammonium. A decrease in outward rectification, a measure of the block of the potassium conductances, was evident within 5 min of axon impalement. Within 30 min 80% of maximal blockade was observed during prolonged recording sessions (> 1 h). Parallel with the resistance increase, the action potential duration increased (up to 5 ms). This was attributed to the block of gKf2. The excitability regularly increased, manifested as a train of action potentials (a decrease in accommodation) for a maximum of 200 ms (54 +/- 8 vs 111 +/- 22, 4-aminopyridine vs 4-aminopyridine-tetraethylammonium, respectively, n = 8 and 6, P < 0.006). The presence of 4-aminopyridine-tetraethylammonium in the microelectrodes decreased the spike frequency adaptation (the instantaneous action potential frequency per spike interval number) observed in fibres treated with 4-aminopyridine alone (32 +/- 9 vs 7 +/- 1 Hz; 4-aminopyridine vs 4-aminopyridine-tetraethylammonium, n = 8 and 6, P < 0.04). This effect was attributed to block of gKs by the tetraethylammonium.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Neuroscience

journal_title

Neuroscience

authors

Poulter MO,Padjen AL

doi

10.1016/0306-4522(95)00139-a

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

497-504

issue

2

eissn

0306-4522

issn

1873-7544

pii

0306-4522(95)00139-A

journal_volume

68

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Metabolic activity changes in the rat spinal cord during adjuvant monoarthritis.

    abstract：:The development of chronic pain is associated with activity-dependent plastic changes in neuronal structures in the peripheral and central nervous system. In order to investigate the time-dependent processing of afferent noxious stimuli in the spinal cord we employed the quantitative autoradiographic 2-deoxyglucose te...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00186-4

    authors： Schadrack J,Neto FL,Ableitner A,Castro-Lopes JM,Willoch F,Bartenstein P,Zieglgänsberger W,Tölle TR

    更新日期：1999-01-01 00:00:00

  • Single-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens.

    abstract：:Fetal alcohol spectrum disorders (FASD) constitute a prevalent, yet preventable, developmental disorder worldwide. While a wealth of research demonstrates that altered function of hippocampus (HPC) and prefrontal cortex may underlie behavioral impairments in FASD, only one published paper to date has examined the impa...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.03.046

    authors： Gursky ZH,Spillman EC,Klintsova AY

    更新日期：2020-05-21 00:00:00

  • Activity-dependent regulation of interleukin-1 beta immunoreactivity in the developing rat olfactory bulb.

    abstract：:Interleukin-1beta is a relatively small and abundant polypeptide that plays diverse roles in the central nervous system. In the present study, patterns of interleukin-1beta expression were observed in the olfactory bulbs of rats that had either undergone unilateral closure of the external naris or sham surgery on post...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00093-7

    authors： Lim JH,Brunjes PC

    更新日期：1999-01-01 00:00:00

  • Entorhinal axons project to dentate gyrus in organotypic slice co-culture.

    abstract：:We have demonstrated the formation of entorhinodentate projections by axons arising from explants of embryonic mouse entorhinal cortex or slices of postnatal rat entorhinal area co-cultured in contact with slices of postnatal rat hippocampus in roller tube and static culture. Species-specific markers (Thy-1 alleles an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90530-s

    authors： Li D,Field PM,Starega U,Li Y,Raisman G

    更新日期：1993-02-01 00:00:00

  • Large dense-core vesicle exocytosis from mouse dorsal root ganglion neurons is regulated by neuropeptide Y.

    abstract：:Peptidergic dorsal root ganglion (DRG) neurons transmit sensory and nociceptive information from the periphery to the central nervous system. Their synaptic activity is profoundly affected by neuromodulatory peptides stored and released from large dense-core vesicles (LDCVs). However, the mechanism of peptide secretio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.01.006

    authors： Bost A,Shaib AH,Schwarz Y,Niemeyer BA,Becherer U

    更新日期：2017-03-27 00:00:00

  • Relationship between noise-induced hearing-loss, persistent tinnitus and growth-associated protein-43 expression in the rat cochlear nucleus: does synaptic plasticity in ventral cochlear nucleus suppress tinnitus?

    abstract：:Aberrant, lesion-induced neuroplastic changes in the auditory pathway are believed to give rise to the phantom sound of tinnitus. Noise-induced cochlear damage can induce extensive fiber growth and synaptogenesis in the cochlear nucleus, but it is currently unclear if these changes are linked to tinnitus. To address t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.07.056

    authors： Kraus KS,Ding D,Jiang H,Lobarinas E,Sun W,Salvi RJ

    更新日期：2011-10-27 00:00:00

  • Selective inhibition of cyclooxygenase-2 exacerbates methamphetamine-induced dopamine depletion in the striatum in rats.

    abstract：:Neuroinflammatory processes associated with induction of cyclooxygenase (COX) have been implicated in the deleterious events resulting in neurodegeneration. The present study was designed to investigate the impact of acute methamphetamine (MA) administration on COX expression and prostaglandin E2 (PGE(2)) production, ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.09.059

    authors： Zhang X,Dong F,Mayer GE,Bruch DC,Ren J,Culver B

    更新日期：2007-12-19 00:00:00

  • 7beta-hydroxycholesterol reduces the extent of reactive gliosis caused by iron deposition in the hippocampus but does not attenuate the iron-induced seizures in rats.

    abstract：:7beta-Hydroxycholesterol has been previously demonstrated to inhibit astrocytosis in injured cortex or spinal cord of rats. In this study, we explored the inhibitory effects of the liposome containing 7beta-hydroxycholesterol on the reactive astrocytosis caused by the injection of iron into the hippocampus of rats and...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.12.011

    authors： Yao Y,Sun S,Kong Q,Tong E

    更新日期：2006-01-01 00:00:00

  • Hypoxia-inducible Factor 2α Exerts Neuroprotective Effects by Promoting Angiogenesis via the VEGF/Notch Pathway after Intracerebral Hemorrhage Injury in Rats.

    abstract：:Angiogenesis after intracerebral hemorrhage (ICH) injury can effectively alleviate brain damage and improve neurological function. Hypoxia-inducible factor 2α (HIF-2α) is an important angiogenic regulator and exhibits protective effects in several neurological diseases; however, its role in ICH has not yet been report...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.07.010

    authors： Chen H,Xiao H,Gan H,Zhang L,Wang L,Li S,Wang D,Li T,Zhai X,Zhao J

    更新日期：2020-11-10 00:00:00

  • Role of myelin plasticity in oscillations and synchrony of neuronal activity.

    abstract：:Conduction time is typically ignored in computational models of neural network function. Here we consider the effects of conduction delays on the synchrony of neuronal activity and neural oscillators, and evaluate the consequences of allowing conduction velocity (CV) to be regulated adaptively. We propose that CV vari...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.11.007

    authors： Pajevic S,Basser PJ,Fields RD

    更新日期：2014-09-12 00:00:00

  • Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.

    abstract：:Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP) 1 that together form the CGRP receptor. Antagonist antibodie...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.04.046

    authors： Miller S,Liu H,Warfvinge K,Shi L,Dovlatyan M,Xu C,Edvinsson L

    更新日期：2016-07-22 00:00:00

  • Hard-wired feed-forward visual mechanisms of the brain compensate for affine variations in object recognition.

    abstract：:Humans perform object recognition effortlessly and accurately. However, it is unknown how the visual system copes with variations in objects' appearance and the environmental conditions. Previous studies have suggested that affine variations such as size and position are compensated for in the feed-forward sweep of vi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.02.050

    authors： Karimi-Rouzbahani H,Bagheri N,Ebrahimpour R

    更新日期：2017-05-04 00:00:00

  • Blockade of brain histamine metabolism alters methamphetamine-induced expression pattern of stereotypy in mice via histamine H1 receptors.

    abstract：:The administration of methamphetamine (METH, 10 mg/kg, i.p.) to male ICR mice induced stereotyped behavior consisting of nail and/or wood chip biting (86.0%), continuous sniffing (12.0%), head bobbing (1.1%), and circling (1.0%) during the observation period of 1 h. Pretreatment of the mice with metoprine (2, 10, and ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.05.006

    authors： Kitanaka J,Kitanaka N,Tatsuta T,Morita Y,Takemura M

    更新日期：2007-07-13 00:00:00

  • Inhibition of methylphenidate-induced gene expression in the striatum by local blockade of D1 dopamine receptors: interhemispheric effects.

    abstract：:Psychostimulants change the function of cortico-basal ganglia circuits. Some of these effects are mediated by altered gene regulation in projection neurons of the striatum which participate in these circuits. Psychostimulant-induced changes in gene expression in these neurons are a consequence of excessive stimulation...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.02.017

    authors： Yano M,Beverley JA,Steiner H

    更新日期：2006-06-30 00:00:00

  • Neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamic nucleus in the rat.

    abstract：:The neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamus were demonstrated by electrolytic lesion studies and fluorescent retrograde tracing combined with immunocytochemistry. Three-to-five-day-old rats were used, because the immunoreactivity of neurotensin fibers in anteri...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(88)90102-9

    authors： Fukami K,Kiyama H,Shiotani Y,Tohyama M

    更新日期：1988-09-01 00:00:00

  • Somatostatin and neuropeptide Y in organotypic slice cultures of the rat hippocampus: an immunocytochemical and in situ hybridization study.

    abstract：:The neuronal distributions of somatostatin and neuropeptide Y and their respective mRNAs in hippocampal slice cultures were examined by immunohistochemical staining and in situ hybridization. For the in situ hybridization we used an alkaline phosphatase-labelled oligodeoxynucleotide probe for somatostatin mRNA and an ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90125-l

    authors： Finsen BR,Tønder N,Augood S,Zimmer J

    更新日期：1992-01-01 00:00:00

  • The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro.

    abstract：:The 5-HT(2A) serotonin receptor represents an important molecular target for atypical antipsychotic drugs and for most hallucinogens. In the mammalian cerebral cortex, 5-HT(2A) receptors are enriched in pyramidal neurons, within which 5-HT(2A) receptors are preferentially sorted to the apical dendrites. In primary cor...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00589-x

    authors： Xia Z,Hufeisen SJ,Gray JA,Roth BL

    更新日期：2003-01-01 00:00:00

  • Effects of endogenous and exogenous estrogen exposures in midlife and late-life women on episodic memory and executive functions.

    abstract：:Cognitive aging affects episodic memory and executive functions, and these vulnerable domains are postulated to be modulated by endogenous and exogenous estrogen exposures. In midlife and late-life women without dementia, estrogen effects on cognition can be examined through associations with concentrations of serum e...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2011.05.059

    authors： Henderson VW,Popat RA

    更新日期：2011-09-15 00:00:00

  • Raphe magnus/pallidus neurons regulate tail but not mesenteric arterial blood flow in rats.

    abstract：:In urethane-anesthetized rats with body temperature maintained at 39-40 degrees C, electrical stimulation of raphe magnus/pallidus/parapyramidal region within 0.5 mm of the ventral medullary surface reduced arterial blood flow to the tail cutaneous bed (measured with a chronically implanted Doppler ultrasonic flowmete...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00251-2

    authors： Blessing WW,Nalivaiko E

    更新日期：2001-01-01 00:00:00

  • Glutamate-dependent translational regulation in cultured Bergmann glia cells: involvement of p70S6K.

    abstract：:Glutamate, the main excitatory amino acid transmitter in the vertebrate brain is involved in the dynamic changes in protein repertoire that underlie synaptic plasticity. Activity-dependent differential expression patterns occur not only in neurons but also in glial cells. In fact, a membrane to nuclei signaling has be...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.04.076

    authors： González-Mejia ME,Morales M,Hernández-Kelly LC,Zepeda RC,Bernabé A,Ortega A

    更新日期：2006-09-01 00:00:00

  • Moderate hypoglycemia aggravates effects of hypoxia in hippocampal slices from diabetic rats.

    abstract：:We recorded the effects of hypoxia combined with relative hypoglycemia on pre- and post-synaptic potentials in the CA1 area of slices from 4-month-old control and diabetic (streptozotocin-treated) Wistar rats. In experiments on slices kept in 10 or 4 mM glucose (at 33 degrees C), hypoxia was applied until the pre-syna...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00154-9

    authors： Tekkök SB,Godfraind JM,Krnjević K

    更新日期：2002-01-01 00:00:00

  • Oxytocin/vasopressin-like immunoreactivity is present in the nervous system of hydra.

    abstract：:Nerve cells have been found in hydra, which react with antisera to oxytocin, vasopressin and mesotocin. These nerve cells have a high density in the ectoderm of basal disk and tentacles and lower density in the ectoderm of peduncle, gastric region and hypostome. A very small number of nerve cells occur also in the end...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(82)90241-x

    authors： Grimmelikhuijzen CJ,Dierickx K,Boer GJ

    更新日期：1982-01-01 00:00:00

  • Activation of muscarinic receptors during blockade of GABA(A)-mediated inhibition induces synchronous epileptiform activity in immature rat hippocampus.

    abstract：:We investigated the effects of the cholinergic agonist carbachol (25 microM) on the synaptic potentials recorded extracellularly and intracellularly from the CA3 area of immature hippocampal slices of the rat (postnatal days 10-20). In control conditions, carbachol reduced the amplitude of evoked synaptic responses (n...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00338-2

    authors： Psarropoulou C,Dallaire F

    更新日期：1998-02-01 00:00:00

  • Involvement of brain protein kinase C in nitrous oxide-induced antinociception in mice.

    abstract：:Exposure of mice to the anesthetic gas nitrous oxide (N(2)O) produces a marked antinociceptive effect. Protein kinase C is a key regulatory enzyme that may be targeted by general anesthetics. However, a relationship between N(2)O-induced antinociception and protein kinase C has yet to be established. The present study...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.02.001

    authors： Ishikawa M,Matsushita Y,Abe K,Utsunomiya I,Hoshi K,Quock RM,Taguchi K

    更新日期：2006-06-19 00:00:00

  • Expression and localization of the cannabinoid receptor type 1 and the enzyme fatty acid amide hydrolase in the retina of vervet monkeys.

    abstract：:The presence of a widespread endocannabinoid (eCB) system within the nervous system, including the retina, has been demonstrated in recent years. Expression patterns of the cannabinoid receptor type 1 (CB1R) and enzyme fatty acid amide hydrolase (FAAH) are available for rodents, but data for humans and monkeys are sca...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.11.041

    authors： Bouskila J,Burke MW,Zabouri N,Casanova C,Ptito M,Bouchard JF

    更新日期：2012-01-27 00:00:00

  • Restoration of the corticostriatal projection in rat neostriatal grafts: electron microscopic analysis.

    abstract：:The corticostriatal projection in rat neostriatal grafts was studied by using the axonal transport of Phaseolus vulgaris-leucoagglutinin. The neostriatal primodia from 15-18-day embryos were used to make a cell suspension which was implanted unilaterally into the rat neostriatum 3-5 days after kainic acid lesion. Two ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90129-2

    authors： Xu ZC,Wilson CJ,Emson PC

    更新日期：1989-01-01 00:00:00

  • Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia.

    abstract：:Brain ischemia induces a marked response of resident microglia and hematopoietic cells including monocytes/macrophages. The present study was designed to assess the distribution of microglia/macrophages in cerebral ischemia using bone marrow chimera mice known to express enhanced green fluorescent protein (EGFP). At 2...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00954-5

    authors： Tanaka R,Komine-Kobayashi M,Mochizuki H,Yamada M,Furuya T,Migita M,Shimada T,Mizuno Y,Urabe T

    更新日期：2003-01-01 00:00:00

  • Adenosine receptors linked to adenylate cyclase activity in human neuroblastoma cells: modulation during cell differentiation.

    abstract：:In IMR32 neuroblastoma cells, the two adenosine receptor agonists N6-R-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine dose-dependently stimulated membrane adenylate cyclase activity with potencies consistent with the presence of adenosine receptors of the A2-subtype. The S enantiomer of N6-R-phenylisoprop...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(89)90173-5

    authors： Abbracchio MP,Cattabeni F,Clementi F,Sher E

    更新日期：1989-01-01 00:00:00

  • The mossy fiber projection of the nucleus reticularis tegmenti pontis to the flocculus and adjacent ventral paraflocculus in the cat.

    abstract：:The pontine projection of the flocculus and adjacent ventral paraflocculus was investigated with antegrade and retrograde axonal tracer techniques. Injections of horseradish peroxidase into the floccular complex revealed subsets of labeled neurons in the nucleus reticularis tegmenti pontis, the nucleus raphe pontis an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90049-6

    authors： Gerrits NM,Epema AH,Voogd J

    更新日期：1984-03-01 00:00:00

  • Immunohistochemical studies of GABA and parvalbumin in the developing human cerebellum.

    abstract：:The localization of GABA and parvalbumin was studied in the developing cerebellum of human fetuses from 16 to 28 weeks of gestation. The avidin-biotin complex immunohistochemical method combined with silver staining were used to reveal the presence of GABA- and parvalbumin-positive neurons and nerve fibres. As early a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00341-f

    authors： Yu MC,Cho E,Luo CB,Li WW,Shen WZ,Yew DT

    更新日期：1996-01-01 00:00:00