当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Single-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens.

Single-day Postnatal Alcohol Exposure Induces Apoptotic Cell Death and Causes long-term Neuron Loss in Rodent Thalamic Nucleus Reuniens.

Abstract：

:Fetal alcohol spectrum disorders (FASD) constitute a prevalent, yet preventable, developmental disorder worldwide. While a wealth of research demonstrates that altered function of hippocampus (HPC) and prefrontal cortex may underlie behavioral impairments in FASD, only one published paper to date has examined the impact of developmental alcohol exposure (AE) on the region responsible for coordinated prefrontal-hippocampal activity: thalamic nucleus reuniens (Re). In the current study, we used a rodent model of human third trimester AE to examine both the acute and lasting impact of a single-day AE on Re. We administered 5.25 g/kg of ethanol to male and female Long Evans rat pups on postnatal day (PD) 7. We used unbiased stereological estimation to evaluate cell death or cell loss at three time points: 12 h after alcohol administration; 4 days after alcohol administration (i.e., PD11); in adulthood (i.e.,PD 72). AE on PD7 increased apoptotic cell death in Re on PD7, and caused short-term cell loss on PD11. This relationship between short-term cell death versus cell number suggests that alcohol-related cell loss is driven by induction of apoptosis. In adulthood, alcohol-exposed animals displayed permanent cell loss (mediating volume loss in the Re), which included a reduction in neuron number (relative to procedural controls). Both procedural controls and alcohol exposed animals displayed a deficit in non-neuronal cell number relative to typically-developing controls, suggesting that Re cell populations may be vulnerable to early life stress as well as AE in an insult- and cell type-dependent manner.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Gursky ZH,Spillman EC,Klintsova AY

doi

10.1016/j.neuroscience.2020.03.046

subject

Has Abstract

pub_date

2020-05-21 00:00:00

pages

124-134

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(20)30205-0

journal_volume

435

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • The immunohistochemical localization of nine peptides in the sacral parasympathetic nucleus and the dorsal gray commissure in rat spinal cord.

    abstract：:The sixth lumbar and first sacral spinal cord segments in the rat contain parasympathetic preganglionic neurons which innervate the pelvic viscera. There have been few studies, however, which have specifically considered the distribution of putative peptide neurotransmitters in these cord segments. The present paper d...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90175-1

    authors： Sasek CA,Seybold VS,Elde RP

    更新日期：1984-07-01 00:00:00

  • Probenecid protects against cerebral ischemia/reperfusion injury by inhibiting lysosomal and inflammatory damage in rats.

    abstract：:Probenecid has been used for decades to treat gout, and recent studies have revealed it is also a specific inhibitor of the pannexin-1 channel. It has been reported that the pannexin-1 channel is involved in ischemic injury. Here, we investigated the neuroprotective effect and the possible mechanisms of action of prob...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.05.070

    authors： Wei R,Wang J,Xu Y,Yin B,He F,Du Y,Peng G,Luo B

    更新日期：2015-08-20 00:00:00

  • Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.

    abstract：:Alzheimer's disease (AD), the most prominent form of dementia in elderly, is a yet incurable degenerative neurological illness characterized by memory loss. Here, we used an AD rat model to investigate the in vivo efficacy of caprospinol, a disease-modifying steroid developed on the concept that reduced synthesis of 2...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.10.033

    authors： Lecanu L,Rammouz G,McCourty A,Sidahmed EK,Greeson J,Papadopoulos V

    更新日期：2010-01-20 00:00:00

  • Distribution of GABA immunoreactivity in the optic tectum of the frog: a light and electron microscopic study.

    abstract：:GABA immunoreactivity was studied in the optic tectum of the frog, Rana esculenta, by postembedding immunohistochemical methods at the light and electron microscopic levels. Nearly one-third of the total population of tectal cells appeared to be GABA-immunoreactive. The proportion of stained neurons was highest in lay...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90051-o

    authors： Antal M

    更新日期：1991-01-01 00:00:00

  • Ethanol versus lipopolysaccharide-induced hypothermia: involvement of urocortin.

    abstract：:The urocortin1 (Ucn1) neurons of the mid-brain-localized Edinger-Westphal nucleus (EW) are robustly responsive to ethanol (EtOH) administration, and send projections to the dorsal raphe nucleus (DRN), which contains corticotropin-releasing factor type 2 receptors (CRF2) that are responsive to Ucn1. In addition, the DR...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.03.037

    authors： Turek VF,Ryabinin AE

    更新日期：2005-01-01 00:00:00

  • Involvement of cannabinoid receptors in peripheral and spinal morphine analgesia.

    abstract：:The interactions between the cannabinoid and opioid systems for pain modulation are reciprocal. However, the role and the importance of the cannabinoid system in the antinociceptive effects of opioids remain uncertain. We studied these interactions with the goal of highlighting the involvement of the cannabinoid syste...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.12.030

    authors： Desroches J,Bouchard JF,Gendron L,Beaulieu P

    更新日期：2014-03-07 00:00:00

  • Neurochemical and electrophysiological studies on the functional significance of burst firing in serotonergic neurons.

    abstract：:We have previously described a population of 5-hydroxytryptamine neurons which repetitively fires bursts of usually two (but occasionally three or four) action potentials, with a short (<20 ms) interspike interval within a regular low-frequency firing pattern. Here we used a paradigm of electrical stimulation comprisi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00060-9

    authors： Gartside SE,Hajós-Korcsok E,Bagdy E,Hársing LG Jr,Sharp T,Hajós M

    更新日期：2000-01-01 00:00:00

  • Cerebellin-like peptide: tissue distribution in rat and guinea-pig and its release from rat cerebellum, hypothalamus and cerebellar synaptosomes in vitro.

    abstract：:We have developed a specific radioimmunoassay for "cerebellin", a 16-amino acid peptide recently isolated from rat cerebellum. In both rat and guinea-pig, cerebellin-like immunoreactivity was highest in the cerebellum but was also present in high concentrations elsewhere in the central nervous system, especially in th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(88)90262-x

    authors： Burnet PW,Bretherton-Watt D,Ghatei MA,Bloom SR

    更新日期：1988-05-01 00:00:00

  • A correlative physiological and morphological analysis of monosynaptically connected propriospinal axon-motoneuron pairs in the lumbar spinal cord of frogs.

    abstract：:Intracellular stimulation of single propriospinal axons evoked excitatory postsynaptic potentials (EPSPs) in lumbar motoneurons. Mean EPSP amplitudes differed by two orders of magnitude when measured in different connections. After analyzing the distribution of mean amplitudes of 47 single-fiber EPSPs, two populations...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00267-6

    authors： Dityatev A,Birinyi A,Puskár Z,Antal M,Clamann HP

    更新日期：2001-01-01 00:00:00

  • Intranasal administration of TAT-haFGF(₁₄₋₁₅₄) attenuates disease progression in a mouse model of Alzheimer's disease.

    abstract：:Human acidic fibroblast growth factor (haFGF), a neurotrophin-like growth factor in the brain, plays important roles in the development, differentiation and regeneration of brain neurons, which makes it potential to treat Alzheimer's disease (AD). In this study, haFGF(14-154) and TAT-haFGF(14-154) (haFGF(14-154) fused...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.08.003

    authors： Lou G,Zhang Q,Xiao F,Xiang Q,Su Z,Zhang L,Yang P,Yang Y,Zheng Q,Huang Y

    更新日期：2012-10-25 00:00:00

  • Unilateral 6-hydroxydopamine lesion of dopamine neurons and subchronic L-DOPA administration in the adult rat alters the expression of the vesicular GABA transporter in different subsets of striatal neurons and in the substantia nigra, pars reticulata.

    abstract：:The loss of dopamine neurons combined or not with the subsequent administration of L-DOPA in patients with Parkinson's disease or in experimental models of the disease results in altered GABAergic signaling throughout the basal ganglia, including the striatum and the substantia nigra, pars reticulata. However, the mol...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.12.001

    authors： Wang H,Katz J,Dagostino P,Soghomonian JJ

    更新日期：2007-03-16 00:00:00

  • Spinal Circuits Mediate a Stretch Reflex Between the Upper Limbs in Humans.

    abstract：:Inter-limb reflexes play an important role in coordinating behaviors involving different limbs. Previous studies have demonstrated that human elbow muscles express an inter-limb stretch reflex at long-latency (50-100 ms), a timing consistent with a trans-cortical linkage. Here we probe for inter-limb stretch reflexes ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.02.007

    authors： Muraoka T,Kurtzer I

    更新日期：2020-04-01 00:00:00

  • Group II and III metabotropic glutamate receptors and the control of the nucleus reticularis thalami input to rat thalamocortical neurones in vitro.

    abstract：:Intracellular recordings were made from neurones in the thalamic reticular nucleus (TRN) and ventro-basal (VB) thalamus in slices of rat midbrain in vitro. Electrical stimulation of the medial lemniscus or TRN resulted in the generation of complex synaptic potentials containing disynaptic inhibitory post-synaptic pote...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2003.08.014

    authors： Turner JP,Salt TE

    更新日期：2003-01-01 00:00:00

  • Excitatory amino acid receptors in the periaqueductal gray mediate the cardiovascular response evoked by activation of dorsomedial hypothalamic neurons.

    abstract：:Neurons in the region of dorsomedial hypothalamus are involved in the organization of the physiological responses to emotional stress. We have recently shown that the cardiovascular response evoked by activation of dorsomedial hypothalamus neurons is largely dependent on a synaptic relay with the lateral/dorsolateral ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.12.041

    authors： da Silva LG Jr,Menezes RC,Villela DC,Fontes MA

    更新日期：2006-01-01 00:00:00

  • Quantitative study of neuronal degeneration induced by Ricinus toxin and crush of postganglionic nerves in the ciliary ganglion of quail.

    abstract：:The effects of Ricinus toxin on the neurons of the ciliary ganglia were investigated in the quail. The neuronal death and the morphological alterations of the ganglionic cells were assessed following injection of the toxin in the anterior chamber of the eye or after application of the toxin on the postganglionic nerve...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90052-p

    authors： Ciofi Luzzatto A,De Stefano ME,Guidolin D,Paggi P,Toschi G

    更新日期：1991-01-01 00:00:00

  • Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing.

    abstract：:Exercise has been shown to impact brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF); however, mechanisms involved are poorly understood. Two types of BDNF coexist in the brain, the precursor (proBDNF) and its mature product (mBDNF), which preferentially bind specific rec...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.06.032

    authors： Ding Q,Ying Z,Gómez-Pinilla F

    更新日期：2011-09-29 00:00:00

  • Differential involvement of medial prefrontal cortex and basolateral amygdala extracellular signal-regulated kinase in extinction of conditioned taste aversion is dependent on different intervals of extinction following conditioning.

    abstract：:Extinction reflects a decrease in the conditioned response (CR) following non-reinforcement of a conditioned stimulus. Behavioral evidence indicates that extinction involves an inhibitory learning mechanism in which the extinguished CR reappears with presentation of an unconditioned stimulus. However, recent studies o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.08.066

    authors： Lin PY,Wang SP,Tai MY,Tsai YF

    更新日期：2010-11-24 00:00:00

  • Thiamine deficiency in vitro accelerates A-type potassium current inactivation in cerebellar granule neurons.

    abstract：:Thiamine deficiency during embryonic or early postnatal development causes deficits in cerebellum-dependent activities including motor control and procedural memory. Here, we give a detailed description of the changes to A-type current in cultured cerebellar granule neurons exposed to thiamine deficiency in vitro. A-t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.06.053

    authors： Cruz JS,Kushmerick C,Moreira-Lobo DC,Oliveira FA

    更新日期：2012-09-27 00:00:00

  • Diphtheria toxin treatment of Pet-1-Cre floxed diphtheria toxin receptor mice disrupts thermoregulation without affecting respiratory chemoreception.

    abstract：:In genetically-modified Lmx1b(f/f/p) mice, selective deletion of LMX1B in Pet-1 expressing cells leads to failure of embryonic development of serotonin (5-HT) neurons. As adults, these mice have a decreased hypercapnic ventilatory response and abnormal thermoregulation. This mouse model has been valuable in defining t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.08.018

    authors： Cerpa V,Gonzalez A,Richerson GB

    更新日期：2014-10-24 00:00:00

  • Time required for transmitter accumulation inside monoaminergic storage vesicles differs in peripheral and in central systems.

    abstract：:Monoamine storage vesicles accumulate transmitters via an active transport process which presents similar pharmacological and bioenergetic properties in all monoaminergic systems. Using [3H]reserpine, a specific ligand of the vesicular monoamine transporter on isolated storage vesicles, we have determined the molecula...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(88)90207-2

    authors： Scherman D,Boschi G

    更新日期：1988-12-01 00:00:00

  • Potential role of inducible nitric oxide synthase in the sleep-wake states occurrence in old rats.

    abstract：:Extensive evidences now suggest that an association between inducible nitric oxide synthase and oxidative stress takes place during aging. Since the part played by inducible nitric oxide synthase in the sleep impairments associated with aging still remains unexplored, we compared its involvement in old rats (20-24 mon...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.05.064

    authors： Clément P,Sarda N,Cespuglio R,Gharib A

    更新日期：2005-01-01 00:00:00

  • Alterations in glutamate but not GABAA receptor subunit expression as a consequence of epileptiform activity in vitro.

    abstract：:The consequences of epileptiform discharge on the expression of glutamate and GABA receptors were examined by in situ hybridization histochemistry after treatment of rat hippocampal slice cultures with convulsants. Application of 500 microM picrotoxin for two days led to decreases in the messenger RNA levels for the N...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00130-b

    authors： Gerfin-Moser A,Grogg F,Rietschin L,Thompson SM,Streit P

    更新日期：1995-08-01 00:00:00

  • Differential effects of unilateral olfactory deprivation on noradrenergic and cholinergic systems in the main olfactory bulb of the rat.

    abstract：:The lack of environmental olfactory stimulation produced by sensory deprivation causes significant changes in the deprived olfactory bulb. Olfactory transmission in the main olfactory bulb (MOB) is strongly modulated by centrifugal systems. The present report examines the effects of unilateral deprivation on the norad...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.05.046

    authors： Gómez C,Briñón JG,Colado MI,Orio L,Vidal M,Barbado MV,Alonso JR

    更新日期：2006-09-15 00:00:00

  • Input-output relations in the entorhinal cortex-dentate-hippocampal system: evidence for a non-linear transfer of signals.

    abstract：:In the current study we analyzed the input-output relations in the entorhinal-dentate-hippocampal system, a major network involved in long-term memory. In anesthetized guinea pigs, the system was driven by activation of perforant path neurons in the entorhinal cortex (ENT), via presubicular fibers directly stimulated ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.06.001

    authors： Bartesaghi R,Migliore M,Gessi T

    更新日期：2006-09-29 00:00:00

  • The effects of voluntary running exercise coincidence with social isolation after early weaning on monoaminergic axonal development.

    abstract：:The axonal development of serotonin (5-HT)-, noradrenaline (NA)-, or tyrosine hydroxylase (TH)-containing monoaminergic neurons is affected by rearing conditions during the juvenile period. Impaired monoaminergic axonal development is implicated in the pathophysiology of emotional and cognitive dysfunction. On the oth...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.11.020

    authors： Ishikawa J,Ishikawa A

    更新日期：2013-01-29 00:00:00

  • Melatonin generates an outward potassium current in rat suprachiasmatic nucleus neurones in vitro independent of their circadian rhythm.

    abstract：:The present study investigated the membrane mechanisms underlying the inhibitory influence of melatonin on suprachiasmatic nucleus (SCN) neurones in a hypothalamic slice preparation. Perforated-patch recordings were performed to prevent the rapid rundown of spontaneous firing rate as observed during whole cell recordi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00346-3

    authors： van den Top M,Buijs RM,Ruijter JM,Delagrange P,Spanswick D,Hermes ML

    更新日期：2001-01-01 00:00:00

  • Repeated, intermittent exposures to diisopropylfluorophosphate in rats: protracted effects on cholinergic markers, nerve growth factor-related proteins, and cognitive function.

    abstract：:Organophosphates (OPs) pose a constant threat to human health due to their widespread use as pesticides and their potential employment in military and terrorist attacks. The acute toxicity of OPs has been extensively studied; however, the consequences of prolonged or repeated exposure to levels of OPs that produce no ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.12.031

    authors： Terry AV Jr,Buccafusco JJ,Gearhart DA,Beck WD,Middlemore-Risher ML,Truan JN,Schwarz GM,Xu M,Bartlett MG,Kutiyanawala A,Pillai A

    更新日期：2011-03-10 00:00:00

  • Localization of oxytocin receptors in the prairie vole (Microtus ochrogaster) neocortex.

    abstract：:Early experience and social context interact to alter the phenotype of complex social behaviors. These early experiences can also result in alterations to cortical organization and connections. Given the ability of the neuropeptide oxytocin (OT) to modulate social and reproductive behavior, OT is likely involved in th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.02.017

    authors： Duchemin A,Seelke AM,Simmons TC,Freeman SM,Bales KL

    更新日期：2017-04-21 00:00:00

  • The effects of acoustic trauma that can cause tinnitus on spatial performance in rats.

    abstract：:Previous studies have shown that acoustic trauma can disrupt the firing of place cells in the hippocampus and also inhibit hippocampal neurogenesis, suggesting that such trauma might impair spatial memory. In this study, we investigated performance in the alternating T maze and Morris water maze of rats exposed to aco...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.04.052

    authors： Zheng Y,Hamilton E,Begum S,Smith PF,Darlington CL

    更新日期：2011-07-14 00:00:00

  • Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: involvement of BDNF?

    abstract：:Stroke is a leading cause of death and disability in industrialized countries. Although surviving patients exhibit a certain degree of restoration of function attributable to brain plasticity, the majority of stroke survivors has to struggle with persisting deficits. In order to potentiate post-stroke recovery, severa...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.11.054

    authors： Madinier A,Bertrand N,Rodier M,Quirié A,Mossiat C,Prigent-Tessier A,Marie C,Garnier P

    更新日期：2013-02-12 00:00:00