Abstract：
:Alzheimer's disease (AD), the most prominent form of dementia in elderly, is a yet incurable degenerative neurological illness characterized by memory loss. Here, we used an AD rat model to investigate the in vivo efficacy of caprospinol, a disease-modifying steroid developed on the concept that reduced synthesis of 22R-hydroxycholesterol in the AD brain increases beta-amyloid neurotoxicity. Caprospinol treatment of diseased rats attenuated memory impairment, as assessed using Morris watermaze tests. This recovery of cognitive function was accompanied by a reduction in hippocampal amyloid deposits, astrogliosis, neurodegeneration and Tau protein phopshorylation. In parallel studies, caprospinol bioavailability in normal rat forebrain was found to be dependent on the dose and duration of the treatment, demonstrating the ability of the compound to cross the blood-brain barrier. These results position caprospinol as a promising drug candidate for AD treatment.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Lecanu L,Rammouz G,McCourty A,Sidahmed EK,Greeson J,Papadopoulos Vdoi
10.1016/j.neuroscience.2009.10.033subject
Has Abstractpub_date
2010-01-20 00:00:00pages
427-35issue
2eissn
0306-4522issn
1873-7544pii
S0306-4522(09)01717-5journal_volume
165pub_type
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