Microbial genome dynamics in CNS pathogenesis.

abstract：:Activation of the adenosine A(2A) receptor (A(2A)R) at the time of reperfusion has been shown to reduce ischemia-reperfusion injury in peripheral tissues and spinal cord. In this study we show that treating mice with the A(2A)R agonist, 4-{3-[6-amino-9-(5-cyclopropylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-pu...

journal_title：Neuroscience

authors： Li Y,Oskouian RJ,Day YJ,Rieger JM,Liu L,Kern JA,Linden J

更新日期：2006-09-15 00:00:00

abstract：OBJECTIVE:The spontaneous action potential of isolated sinoatrial node (SAN) cells is regulated by a coupled-clock system of two clocks: the calcium clock and membrane clock. However, it remains unclear whether calcium clock inhibitors have a direct effect on the membrane clock. The purpose of this study was to investi...

journal_title：Neuroscience

authors： Chen Q,Chen JQ,Zhu PL,Wu HL,Xie XT,Dong Y,Xiang GJ,Chen MY,Li Y,Zhang JC

更新日期：2020-05-01 00:00:00

abstract：:Previous attempts to reproduce striatonigral degeneration, the core pathology underlying Parkinsonism in multiple system atrophy, have been impeded by interactions in the neurotoxins used to replicate striatal and nigral degeneration in rodents. To overcome these interactions, we have developed a new model of striaton...

journal_title：Neuroscience

authors： Ghorayeb I,Fernagut PO,Hervier L,Labattu B,Bioulac B,Tison F

更新日期：2002-01-01 00:00:00

abstract：:Extracellular recordings were made from serotonergic neurons of the rat dorsal raphe nucleus in a slice preparation. In the presence of phenylephrine (3 microM) to restore the pacemaker activity of otherwise silent serotonergic neurons, superfusion with the 5-hydroxytryptamine1A agonist ipsapirone depressed the firing...

journal_title：Neuroscience

authors： Haj-Dahmane S,Hamon M,Lanfumey L

更新日期：1991-01-01 00:00:00

abstract：:Accumulating evidences indicate that ceramide is closely involved in apoptotic cell death in neurodegenerative disorders and aging. We examined ceramide levels in the cerebrospinal fluid (CSF) or brain tissues from patients with neurodegenerative disorders and the mechanism of how intra- and extracellular ceramide was...

journal_title：Neuroscience

authors： Satoi H,Tomimoto H,Ohtani R,Kitano T,Kondo T,Watanabe M,Oka N,Akiguchi I,Furuya S,Hirabayashi Y,Okazaki T

更新日期：2005-01-01 00:00:00

abstract：:Motor execution and imagery (ME and MI), as the basic abilities of human beings, have been considered to be effective strategies in motor skill learning and motor abilities rehabilitation. Neuroimaging studies have revealed several critical regions from functional activation for ME as well as MI. Recently, investigati...

journal_title：Neuroscience

authors： Xu L,Zhang H,Hui M,Long Z,Jin Z,Liu Y,Yao L

更新日期：2014-03-07 00:00:00

abstract：:In order to develop another selective marker for cholinergic cell bodies and fibres, we have raised a highly specific polyclonal antibody against a peptide derived from the C-terminus of a recently cloned putative vesicular acetylcholine transporter. This antibody recognizes the vesicular acetylcholine transporter pro...

journal_title：Neuroscience

authors： Roghani A,Shirzadi A,Butcher LL,Edwards RH

更新日期：1998-02-01 00:00:00

abstract：:We describe the immunocytochemical distribution of adenosine A1 receptors in the rat hippocampus. Adenosine A1 receptor-like immunoreactivity was seen on the cell soma and dendrites of pyramidal cells and the cell soma and proximal part of dendrites of granule cells, but not on glial cells. Developmentally, adenosine ...

journal_title：Neuroscience

authors： Ochiishi T,Saitoh Y,Yukawa A,Saji M,Ren Y,Shirao T,Miyamoto H,Nakata H,Sekino Y

更新日期：1999-01-01 00:00:00

abstract：:A small surgical lesion of the parietal cortex induces an increase in the expression of several messenger RNAs varying from 172 to 980% in the entire homolateral cerebral cortex, as detected by quantitative in situ hybridization histochemistry. The messenger RNAs encoding the immediate early genes of the leucine zippe...

journal_title：Neuroscience

authors： Jacobs O,Van Bree L,Mailleux P,Zhang F,Schiffmann SN,Halleux P,Albala N,Vanderhaeghen JJ

更新日期：1994-04-01 00:00:00

abstract：:The main action of organophosphorous insecticides is generally believed to be the inhibition of acetylcholinesterase (AChE). However, these compounds also inhibit many other enzymes, any of which may play a role in their toxicity. We tested the neurotoxic mechanism of two organophosphorous insecticides, chlorpyrifos a...

journal_title：Neuroscience

authors： Rush T,Liu XQ,Hjelmhaug J,Lobner D

更新日期：2010-03-31 00:00:00

abstract：:Repeated exposure to the psychostimulant drug, amphetamine, results in a persistent increase in the ability of the drug to elicit behavioral activation.(14,19) The development of sensitized responses to amphetamine involves long-lasting neuroadaptations within defined circuitry.(3,6,12,15,23) The behavioral expression...

journal_title：Neuroscience

authors： Arvanitogiannis A,Sullivan J,Amir S

更新日期：2000-01-01 00:00:00

abstract：:Astrocyte hypertrophy and swelling occur in a variety of pathophysiological conditions, including diseases associated with hyperammonemia. Ammonia is rapidly incorporated into glutamine by glutamine synthetase localized in astrocytes. We tested the hypotheses that (1) 6 h of hyperammonemia (500-600 microM) is adequate...

journal_title：Neuroscience

authors： Willard-Mack CL,Koehler RC,Hirata T,Cork LC,Takahashi H,Traystman RJ,Brusilow SW

更新日期：1996-03-01 00:00:00

abstract：:The effects of muscarinic agonists on GABAergic synaptic transmission were examined using whole-cell patch-clamp recording in chick brain slices containing the lateral spiriform nucleus. Bath application of muscarine (10 microM) both increased the frequency of spontaneous GABAergic postsynaptic currents and reduced th...

journal_title：Neuroscience

authors： Guo J,Chiappinelli VA

更新日期：2001-01-01 00:00:00

abstract：:Arachidonic acid (20:4) is a component of membrane lipids that has been implicated as a messenger both in physiological and pathophysiological processes, including ischemic injury and synaptic plasticity. In order to clarify direct trophic or toxic effects of arachidonic acid on central neurons, primary cultures of ra...

journal_title：Neuroscience

authors： Okuda S,Saito H,Katsuki H

更新日期：1994-12-01 00:00:00

abstract：:Most functional imaging studies of memory retrieval investigate memory for standardized laboratory stimuli. However, naturally acquired autobiographical memories differ from memories of standardized stimuli in important ways. Neuroimaging studies of natural memories may reveal distinctive patterns of brain activation ...

journal_title：Neuroscience

authors： Maddock RJ,Garrett AS,Buonocore MH

更新日期：2001-01-01 00:00:00

abstract：:Excitatory amino acid carrier 1 (EAAC1) is one important subtype of the excitatory amino acid transporters (EAATs), and its absence can increase the vulnerability to oxidative stress in neural tissue. Enhanced expression of EAAC1 can provide neuroprotection in multiple disorders, including ischemia and multiple sclero...

journal_title：Neuroscience

authors： Huang C,Yuan P,Wu J,Huang J

更新日期：2016-04-05 00:00:00

abstract：:In genetically-modified Lmx1b(f/f/p) mice, selective deletion of LMX1B in Pet-1 expressing cells leads to failure of embryonic development of serotonin (5-HT) neurons. As adults, these mice have a decreased hypercapnic ventilatory response and abnormal thermoregulation. This mouse model has been valuable in defining t...

journal_title：Neuroscience

authors： Cerpa V,Gonzalez A,Richerson GB

更新日期：2014-10-24 00:00:00

abstract：:The circadian pacemaker of the suprachiasmatic nuclei is a complex multioscillator system, which controls circadian and seasonal rhythmicity. A number of clock genes have been identified that play a key role in the generation of circadian rhythms. These clock genes are expressed in a circadian manner as has been shown...

journal_title：Neuroscience

authors： Schaap J,Albus H,Eilers PH,Détári L,Meijer JH

更新日期：2001-01-01 00:00:00

abstract：:Agonist-induced endocytosis and recycling of G protein-coupled receptors contributes to desensitization and resensitization of the receptors. In this study, we have used fluorescence immunohistochemistry, confocal microscopy and digital image analysis to quantify the proportion of receptor in the cytoplasm and on the ...

journal_title：Neuroscience

authors： Southwell BR,Seybold VS,Woodman HL,Jenkinson KM,Furness JB

更新日期：1998-12-01 00:00:00

abstract：:As seizure propagation within limbic structures is mediated in part by a small area of deep prepiriform cortex (area tempestas), we investigated the role of area tempestas in modulating hippocampal injury induced by systemic kainate administration. Injury was quantitated by counting the numbers of neurons that stained...

journal_title：Neuroscience

authors： Shimosaka S,So YT,Simon RP

更新日期：1994-08-01 00:00:00

abstract：:Current cognitive models suggest that the processing of dynamic facial attributes, including social signals such as gaze direction and facial expression, involves the superior temporal sulcus, whereas the processing of invariant facial structure such as the individuals' identity involves the fusiform face area. Where ...

journal_title：Neuroscience

authors： Iaria G,Fox CJ,Waite CT,Aharon I,Barton JJ

更新日期：2008-08-13 00:00:00

abstract：:Spinules found in brain consist of small invaginations of plasma membranes which enclose membrane evaginations from adjacent cells. Here, we focus on the dynamic properties of the most common type, synaptic spinules, which reside in synaptic terminals. In order to test whether depolarization triggers synaptic spinule ...

journal_title：Neuroscience

authors： Tao-Cheng JH,Dosemeci A,Gallant PE,Miller S,Galbraith JA,Winters CA,Azzam R,Reese TS

更新日期：2009-04-21 00:00:00

abstract：:Major limitations to the pharmacotherapy of Parkinson's disease (PD) are the motor complications resulting from L-DOPA treatment. Abnormal involuntary movements (dyskinesia) affect a majority of the patients after a few years of L-DOPA treatment and can become troublesome and debilitating. Once dyskinesia has debuted,...

journal_title：Neuroscience

authors： Iderberg H,Francardo V,Pioli EY

更新日期：2012-06-01 00:00:00

abstract：:The aged dog brain accumulates beta-amyloid in the form of diffuse senile plaques, which provides a potentially useful in vivo model system for studying the events surrounding the deposition of beta-amyloid. We used postembedding immunocytochemistry at the electron microscopic level to determine the subcellular distri...

journal_title：Neuroscience

authors： Torp R,Head E,Milgram NW,Hahn F,Ottersen OP,Cotman CW

更新日期：2000-01-01 00:00:00

abstract：:Recent electrophysiological investigations in this laboratory have shown that cultured mesopontine serotonergic neurons from neonatal rats evoke serotonergic and/or glutamatergic responses in themselves and in non-serotonergic neurons. Serotonergic nerve terminals in vivo are heterogeneous with respect to vesicle type...

journal_title：Neuroscience

authors： Johnson MD,Yee AG

更新日期：1995-08-01 00:00:00

abstract：:Certain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that re...

journal_title：Neuroscience

authors： Zhu YY,Jing L,Duan TT,Yuan Q,Cao J,Zhou QX,Xu L

更新日期：2013-10-10 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) promotes synaptic plasticity via an enhancement in expression of specific synaptic proteins. Recent results suggest that the neuronal monocarboxylate transporter MCT2 is a postsynaptic protein critically involved in synaptic plasticity and long-term memory. To investigate in vi...

journal_title：Neuroscience

authors： Robinet C,Pellerin L

更新日期：2011-09-29 00:00:00

abstract：:Inhibitory serotonergic and cholecystokinergic mechanisms in the lateral parabrachial nucleus and central GABAergic mechanisms are involved in the regulation of water and NaCl intake. In the present study we investigated if the GABA(A) receptors in the lateral parabrachial nucleus are involved in the control of water,...

journal_title：Neuroscience

authors： Callera JC,Oliveira LB,Barbosa SP,Colombari DS,De Luca LA Jr,Menani JV

更新日期：2005-01-01 00:00:00

abstract：:Neurotrophic factors are known to promote neuronal survival during development and after acute brain injury. Recent data suggest that some neuropeptides also exhibit neurotrophic activities, as shown for the pituitary adenylate cyclase activating polypeptide, which increases the survival of various neuronal population...

journal_title：Neuroscience

authors： Skoglösa Y,Lewén A,Takei N,Hillered L,Lindholm D

更新日期：1999-04-01 00:00:00

abstract：:The neurotransmitter serotonin (5-HT) plays a central role in brain development, regulation of mood, stress reactivity and risk of psychiatric disorders, and thus alterations in 5-HT signaling early in life have critical implications for behavior and mental health across the life span. Drawing on preclinical and emerg...

journal_title：Neuroscience

authors： Brummelte S,Mc Glanaghy E,Bonnin A,Oberlander TF

更新日期：2017-02-07 00:00:00