Patterned high-frequency stimulation induces a form of long-term depression dependent on GABAA and mACh receptors in the hippocampus.

abstract：:Rats were subjected to 90min of focal ischemia by occluding the left middle cerebral and both common carotid arteries. The dynamic changes in the formation of brain ischemic areas were analyzed by measuring the direct current (DC) potential and reduced nicotinamide adenine dinucleotide (NADH) fluorescence with ultravi...

journal_title：Neuroscience

authors： Naito H,Takeda Y,Danura T,Kass IS,Morita K

更新日期：2013-04-03 00:00:00

abstract：:The hypothesis that electrotonic spread among oxytocinergic neurons contributes to synchronized bursting in the lactating rat leads to the prediction that coupling among oxytocinergic neurons would be stronger and more abundant in lactating than in non-lactating animals. We tested this prediction using, as an index of...

journal_title：Neuroscience

authors： Hatton GI,Yang QZ,Cobbett P

更新日期：1987-06-01 00:00:00

abstract：:Neural injury triggers changes in the expression of a large number of gene families. Particularly interesting are those encoding proteins involved in the generation, propagation or restoration of electric potentials. The expression of the Na+, K+-ATPase subunit isoforms (alpha, beta and gamma) was studied in dorsal ro...

journal_title：Neuroscience

authors： Arteaga MF,Gutiérrez R,Avila J,Mobasheri A,Díaz-Flores L,Martín-Vasallo P

更新日期：2004-01-01 00:00:00

abstract：:Neonatal hypoxic-ischemic encephalopathy is a major cause of mortality and disability in newborns and the only standard approach for treating this condition is therapeutic hypothermia, which shows some limitations. Thus, putative neuroprotective agents have been tested in animal models. The present study evaluated the...

journal_title：Neuroscience

authors： Tassinari ID,Andrade MKG,da Rosa LA,Hoff MLM,Nunes RR,Vogt EL,Fabres RB,Sanches EF,Netto CA,Paz AH,de Fraga LS

更新日期：2020-11-10 00:00:00

abstract：:Niemann-Pick Type C1 (NPC1) is an autosomal recessive disorder characterized by the accumulation of cholesterol and glycosphingolipids. Combination-treatment utilizing cyclodextrin, allopregnanolone and miglustat (CYCLO/ALLO/miglustat) can ameliorate NPC1 disease in a mutant mouse model. The present study was designed...

journal_title：Neuroscience

authors： Hovakimyan M,Maass F,Petersen J,Holzmann C,Witt M,Lukas J,Frech MJ,Hübner R,Rolfs A,Wree A

更新日期：2013-11-12 00:00:00

abstract：:Quantitative autoradiography of [3H]SCH 23390 and [3H](-)-sulpiride binding was performed in the brain of rats of various ages (3, 11 and 24 months) in order to study the changes in D1 and D2 receptor density with age. Binding of [3H]SCH 23390 in the caudate-putamen decreased progressively and markedly at rostral leve...

journal_title：Neuroscience

authors： Morelli M,Mennini T,Cagnotto A,Toffano G,Di Chiara G

更新日期：1990-01-01 00:00:00

abstract：:The cellular transcription factor Fos, product of the immediate early gene c-fos, is induced in secretory neurons of the hypothalamic paraventricular nucleus in response to stress. Recent evidence indicates that the paracrine-acting messenger molecule nitric oxide may be involved in the activation or regulation of c-f...

journal_title：Neuroscience

authors： Amir S,Rackover M,Funk D

更新日期：1997-04-01 00:00:00

abstract：:Acetylcholine (ACh) plays important roles in the modulation of activity and plasticity of primary sensory cortices, thus influencing sensory detection and integration. We examined this in urethane-anesthetized rats, comparing cholinergic modulation of short latency, large amplitude field postsynaptic potentials (fPSPs...

journal_title：Neuroscience

authors： Kuo MC,Rasmusson DD,Dringenberg HC

更新日期：2009-09-29 00:00:00

abstract：:Adrenergic neurons in the C1 region in the ventrolateral medulla oblongata send descending axons into spinal cord which terminate in thoracic and upper lumbar segments, overlapping the distribution of sympathetic preganglionic neurons. The present study was undertaken to determine whether adrenergic fibers synapse dir...

journal_title：Neuroscience

authors： Bernstein-Goral H,Bohn MC

更新日期：1989-01-01 00:00:00

abstract：:We here investigated the effects of neonatal lesions of the entorhinal cortex (EC) in rats on maze learning and on structural alterations of its main projection region, the hippocampus, as well as other regions with anatomical connections to the EC that are involved in maze learning. Since early brain damage is consid...

journal_title：Neuroscience

authors： Harich S,Kinfe T,Koch M,Schwabe K

更新日期：2008-06-02 00:00:00

abstract：:Brain connectivity studies have reported that functional networks change with older age. We aim to (1) investigate whether electroencephalography (EEG) data can be used to distinguish between individual functional networks of young and old adults; and (2) identify the functional connections that contribute to this cla...

journal_title：Neuroscience

authors： Moezzi B,Pratti LM,Hordacre B,Graetz L,Berryman C,Lavrencic LM,Ridding MC,Keage HAD,McDonnell MD,Goldsworthy MR

更新日期：2019-12-01 00:00:00

abstract：:It is commonly believed that the cell bodies of mammalian sensory neurons are contained within spinal and cranial sensory ganglia associated with the central nervous system or within the central nervous system itself. However, strong circumstantial evidence implies that some sensory neurons are contained entirely with...

journal_title：Neuroscience

authors： Kunze WA,Bornstein JC,Furness JB

更新日期：1995-05-01 00:00:00

abstract：:Membrane currents evoked by iontophoretically applied acetylcholine were recorded from non-dissociated neurons of rat superior cervical ganglion using the whole-cell patch-clamp recording method. Blocking effects produced by a series of specially synthesized organic compounds, the blockers of the open channel of gangl...

journal_title：Neuroscience

authors： Skok VI,Voitenko SV,Kurenniy DE,Brovtsyna NB,Gmiro VE,Kertcer SL

更新日期：1995-08-01 00:00:00

abstract：:Tetramethylpyrazine (TMP) is an active compound extracted from the traditional Chinese medicinal herb Chuanxiong. Recently, it has been reported that TMP enhances neurogenesis, and promotes neural stem cell differentiation toward neurons. However, its molecular basis remains unknown. Topoisomerase IIβ (TopoIIβ) is a n...

journal_title：Neuroscience

authors： Yan Y,Zhao J,Cao C,Jia Z,Zhou N,Han S,Wang Y,Xu Y,Zhao J,Yan Y,Cui H

更新日期：2014-10-10 00:00:00

abstract：:The distribution of the diadenosine tetraphosphate high-affinity binding sites has been studied in rat brain by an autoradiographic method using [3H]diadenosine tetraphosphate as the ligand. The binding characteristics are comparable to those described in studies performed on rat brain synaptosomes. White matter is de...

journal_title：Neuroscience

authors： Rodríguez-Pascual F,Cortes R,Torres M,Palacios JM,Miras-Portugal MT

更新日期：1997-03-01 00:00:00

abstract：:N-Methyl-D-aspartate receptors are fundamental for neuronal plasticity and development in the CNS. Most studies have examined postsynaptic roles of this receptor, but there are also indications for a presynaptic location and function. Here, we provide electrophysiological evidence for the existence of presynaptic N-me...

journal_title：Neuroscience

authors： Berretta N,Jones RS

更新日期：1996-11-01 00:00:00

abstract：:The presence of a widespread endocannabinoid (eCB) system within the nervous system, including the retina, has been demonstrated in recent years. Expression patterns of the cannabinoid receptor type 1 (CB1R) and enzyme fatty acid amide hydrolase (FAAH) are available for rodents, but data for humans and monkeys are sca...

journal_title：Neuroscience

authors： Bouskila J,Burke MW,Zabouri N,Casanova C,Ptito M,Bouchard JF

更新日期：2012-01-27 00:00:00

abstract：:Neonatal posterior cingulate cortex lesions spare the spatial deficits that characterize adult lesions. The present experiments examined the possibility that the anterior cingulate cortex mediates the spared spatial behavior. Rats were given bilateral lesions of the posterior cingulate cortex or anterior plus posterio...

journal_title：Neuroscience

authors： Gonzalez CL,Whishaw IQ,Kolb B

更新日期：2003-01-01 00:00:00

abstract：:Age-dependent, neuronal apoptosis following N-methyl-D-aspartate receptor blockade has been linked to loss of calcium. To further explore this relationship, we examined expression of activated caspase-3, as well as the calcium binding proteins, calbindin-D 28K, calretinin and parvalbumin, following injection of vehicl...

journal_title：Neuroscience

authors： Lema Tomé CM,Bauer C,Nottingham C,Smith C,Blackstone K,Brown L,Hlavaty C,Nelson C,Daker R,Sola R,Miller R,Bryan R,Turner CP

更新日期：2006-09-01 00:00:00

abstract：:The radioligands [3H]SCH 23390 and [3H]spiroperidol were used to label dopamine D1 and D2 receptors, respectively, in rat brain slices. Striatal sections were incubated in one of various concentrations of radioligand in the presence or absence of (+)-butaclamol and the resulting labeling was determined by liquid scint...

journal_title：Neuroscience

authors： Bardo MT,Hammer RP Jr

更新日期：1991-01-01 00:00:00

abstract：:Olvanil ((N-vanillyl)-9-oleamide), a non-pungent transient receptor potential vanilloid type 1 agonist, desensitizes nociceptors and alleviates pain. But its molecular targets and signaling mechanisms are little known. Calcium influx through voltage-activated Ca(2+) channels plays an important role in neurotransmitter...

journal_title：Neuroscience

authors： Wu ZZ,Chen SR,Pan HL

更新日期：2006-08-11 00:00:00

abstract：:Turning in circles is among the behaviors elicited by unilateral cholinergic stimulation of the substantia nigra. Recent studies have shown that microinjection of cholinergic agonists into the substantia nigra pars compacta increases dopamine release and turnover in the striatum of anesthetized rats [Hernández-López e...

journal_title：Neuroscience

authors： Hernández-López S,Góngora-Alfaro JL,Martínez-Fong D,Rosales MG,Aceves J

更新日期：1994-09-01 00:00:00

abstract：:The sec6/8 (exocyst) complex is implicated in targeting of vesicles for regulated exocytosis in various cell types and is believed to play a role in synaptogenesis and brain development. We show that the subunits sec6 and sec8 are present at significant levels in neurons of adult rat brain, and that immunoreactivity f...

journal_title：Neuroscience

authors： Vik-Mo EO,Oltedal L,Hoivik EA,Kleivdal H,Eidet J,Davanger S

更新日期：2003-01-01 00:00:00

abstract：:Brain activities in response to acupuncture have been investigated in multiple studies; however, the neuromechanisms of low- and high-frequency transcutaneous electric acupoint stimulation (TEAS) analgesia are unclear. This work aimed to investigate how brain activity and the analgesic effect changed across 30-min low...

journal_title：Neuroscience

authors： Jiang Y,Liu J,Liu J,Han J,Wang X,Cui C

更新日期：2014-05-30 00:00:00

abstract：:Neuronal activity associated with visual processing of an unfamiliar face gradually diminishes when it is viewed repeatedly. This process, known as repetition suppression (RS), is involved in the acquisition of familiarity. Current models suggest that RS results from interactions between visual information processing ...

journal_title：Neuroscience

authors： Lafontaine MP,Lacourse K,Lina JM,McIntosh AR,Gosselin F,Théoret H,Lippé S

更新日期：2016-06-21 00:00:00

abstract：:The neurotensin/neuromedin N precursor molecule possesses four lysine-arginine dibasic residues which represent potential sites of cleavage by proteolytic maturation enzymes. As shown in the preceding paper, all of these dibasic residues are cleaved to a variable extent in rat brain. The aim of the present study was t...

journal_title：Neuroscience

authors： Woulfe J,Lafortune L,de Nadai F,Kitabgi P,Beaudet A

更新日期：1994-05-01 00:00:00

abstract：:The available data on the innervation of the thoracolumbar fascia (TLF) are inconsistent and partly contradictory. Therefore, the role of the fascia as a potential source of pain in the low back is difficult to assess. In the present study, a quantitative evaluation of calcitonin gene-related peptide (CGRP) and substa...

journal_title：Neuroscience

authors： Tesarz J,Hoheisel U,Wiedenhöfer B,Mense S

更新日期：2011-10-27 00:00:00

abstract：:The effect of lacosamide (LCS), a functionalized molecule with anti-convulsant properties, on ion channels was investigated, with the aid of patch clamp technology and simulation modeling. In NSC-34 neuronal cells, LCS was found to block voltage-gated Na(+) current (INa) in a frequency- and concentration-dependent man...

journal_title：Neuroscience

authors： Huang CW,Hung TY,Wu SN

更新日期：2015-02-26 00:00:00

abstract：:In the present study, in vivo voltammetry was used to monitor changes in dopamine levels in the left and right medial prefrontal cortex of rats exposed to mild physical and psychological stress. These were 2 min of tail-pinch and 15 min exposure to cat odour, respectively. Fourteen male Long Evans rats with bilateral ...

journal_title：Neuroscience

authors： Sullivan RM,Gratton A

更新日期：1998-03-01 00:00:00

abstract：:We have used the evoked expression of the immediate early gene-encoded proteins (c-Fos, Fos B, Jun B, Jun D, c-Jun and Krox-24) to monitor sensory processing in the hindbrain structures of rats undergoing somatic inflammation. Experiments were performed on freely moving animals that did not experience constraints othe...

journal_title：Neuroscience

authors： Lantéri-Minet M,Weil-Fugazza J,de Pommery J,Menétrey D

更新日期：1994-01-01 00:00:00