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Distribution of [3H]diadenosine tetraphosphate binding sites in rat brain.

Abstract：

:The distribution of the diadenosine tetraphosphate high-affinity binding sites has been studied in rat brain by an autoradiographic method using [3H]diadenosine tetraphosphate as the ligand. The binding characteristics are comparable to those described in studies performed on rat brain synaptosomes. White matter is devoid of specific binding. The range of binding site densities in gray matter varies from 3 to 15 fmol/mg of tissue, exhibiting a widespread but heterogeneous distribution. The highest densities correspond to the seventh cranial nerve, medial superior olive, pontine nuclei, glomerular and external plexiform layers of the olfactory bulb, and the granule cell layer of the cerebellar cortex. Intermediate density levels of binding correspond to different cortical areas, several nuclei of the amygdala, and the oriens and pyramidal layers of the hippocampal formation. The localization of diadenosine tetraphosphate binding sites in the brain may provide information on the places where diadenosine polyphosphate compounds can be expected to function in the central nervous system.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Rodríguez-Pascual F,Cortes R,Torres M,Palacios JM,Miras-Portugal MT

doi

10.1016/s0306-4522(96)00424-1

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

247-55

issue

1

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(96)00424-1

journal_volume

77

pub_type

杂志文章

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