Abstract：
:γ oscillations (30-120 Hz) are generated intrinsically within local networks in the mammalian olfactory bulb (OB). The OB directly receives peripheral input from olfactory sensory neurons (OSNs) that can respond to nasal airflow, and centrifugal input from neuromodulatory systems whose activities are affected by the behavioral states of animal. How peripheral and centrifugal input dynamically modulate γ oscillations is unclear. By simultaneously recording respiration signal and local field potentials (LFPs) in the OB of freely moving mice throughout at least one sleep-wake cycle, we observed that γ oscillations were highest during awake exploratory (AE) state, and successively lower during awake resting (AR) state, rapid eye movement (REM) and non-REM (NREM) sleep. γ activity was further enhanced when animals were exposed to stress condition, which indicated that behavioral states may modulate γ oscillations. Moreover, γ amplitude was phase-locked to respiration-entrained rhythms (RR). RR-high γ (55-120 Hz) coupling strength was strongest during AR state, while RR-low γ (30-55 Hz) coupling strength was strongest during REM sleep. However, in the absence of nasal respiratory input, γ oscillations dramatically decreased or disappeared, and γ power was no longer modulated by behavioral states. Conversely, hippocampal γ oscillations were not altered by nasal respiratory input. These results reveal that nasal respiratory input is necessary for the generation and modulation of γ oscillations in the OB, suggesting that nasal respiration may modulate neural activity and further influence olfactory function.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Zhuang L,Zhang B,Qin Z,Wang Pdoi
10.1016/j.neuroscience.2018.12.011subject
Has Abstractpub_date
2019-02-01 00:00:00pages
218-230eissn
0306-4522issn
1873-7544pii
S0306-4522(18)30820-0journal_volume
398pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:Development and differentiation of basal forebrain-derived cholinergic neurons were studied using a new technique that combines dissociated cell cultures with organotypic slice cultures. Slices of cerebral cortex or entire forebrain hemispheres were taken from early postnatal rat pups and maintained as organotypic cul...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(97)00067-5
更新日期：1997-10-01 00:00:00
abstract：:Several isoforms of integrin subunits are expressed in Schwann cells and mediate Schwann cell interactions with axons. Here, we identify α6 and β1 integrins as heterodimeric proteins expressed in Schwann cells and define their functions in axonal regeneration. α6 and β1 integrins are induced in Schwann cells in the sc...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2017.11.046
更新日期：2018-02-10 00:00:00
abstract：:The rat brain was examined immunocytochemically for estrogen-dependent changes of oxytocin immunoreactivity at the light microscopical level. Ovariectomized rats were treated with subcutaneous silastic implants with estradiol, or empty implants as controls for 2 days (short term treatment). Another group of rats was i...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(88)90022-x
更新日期：1988-04-01 00:00:00
abstract：:Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons and leads to death a few years after symptom onset. Despite its high morbidity and mortality, its underlying pathogenic mechanisms still remain poorly understood. Although there is increasing evidence for sign...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2020.07.047
更新日期：2020-12-01 00:00:00
abstract：:Ketamine is a dissociative anesthetic with complex actions on the CNS. We investigated here the effects of ketamine anesthesia on somatosensory processing in the rat spinal cord, thalamus, and cerebral cortex, using the quantitative 2-deoxyglucose mapping technique. Unanesthetized or ketamine-anesthetized male Sprague...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2004.01.039
更新日期：2004-01-01 00:00:00
abstract：:High densities of mRNAs for three rhythm-related genes, rPeriod1 (rPer1), rPer2, and rClock, which share high homology in Drosophila and mice, were found in the hypothalamic suprachiasmatic nucleus (SCN). The SCN, however, is not the only brain region that expresses these genes. To understand the distributions and pos...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(03)00004-6
更新日期：2003-01-01 00:00:00
abstract：:In this study, we describe a model of opiate sensitization characterized by a brief schedule of treatment with repeated morphine administrations. In this model, we investigated the changes produced by repeated morphine treatment on dopamine transmission at the level of the two major terminal dopaminergic areas, the do...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00466-7
更新日期：1999-05-01 00:00:00
abstract：:The dopamine D2 receptor (DRD2) and dopamine transporter (DAT) play a regulatory role in dopaminergic neurotransmission and thus play an important role in drug addiction. The prefrontal cortex (PFC), a critical part of the mesencephalic dopaminergic system, is thought to be involved in the development and maintenance ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2019.07.022
更新日期：2019-09-01 00:00:00
abstract：:The distribution of wheatgerm agglutinin-horseradish peroxidase-labelled mossy fibre terminals of internal and external cuneate projections to the cerebellar anterior and posterior lobes were quantitatively analysed in adult rats. Computer-based image analysis mapped the spatial distribution of labelled cuneocerebella...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(97)00081-x
更新日期：1997-09-01 00:00:00
abstract：:When our movement is perturbed by environmental forces, the Long Latency Stretch Reflex (LLSR), generated by a transcortical loop through the primary motor cortex (M1), is the fastest reaction adapted according to our prior intent. We investigated the involvement of the caudal part of the Supplementary Motor Area (SMA...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2013.05.005
更新日期：2013-08-29 00:00:00
abstract：:The analgesic effect of alpha-2 adrenergic receptor (α2AR) agonists, which relieve chronic neuropathic pain, is highly variable among individuals. Here, we used a mouse model of spared nerve injury (SNI) to show that treatment time after the establishment of neuropathic pain was important for the variability in the an...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2020.12.021
更新日期：2020-12-25 00:00:00
abstract：:Monoclonal antibodies to rat striatal choline acetyltransferase were produced by fusion of sensitized mouse lymphocytes with murine plasmacytoma (NS1) cells. Two stable anti-choline acetyltransferase lines were established by limiting dilution cloning. Specificity of antibody was established by the following criteria:...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(83)90229-4
更新日期：1983-11-01 00:00:00
abstract：:In vitro cell cultures are an important tool for obtaining insights into cellular processes in an isolated system and a supplement to in vivo animal experiments. While primary dissociated cultures permit a single homogeneous cell population to be studied, there is a clear need to explore the function of brain cells in...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/j.neuroscience.2015.07.086
更新日期：2015-10-01 00:00:00
abstract：:To clarify the mechanism of yokukansan (TJ-54), a traditional Japanese medicine, against glutamate-mediated excitotoxicity, the effects of TJ-54 on glutamate uptake function were first examined using cultured rat cortical astrocytes. Under thiamine-deficient conditions, the uptake of glutamate into astrocytes, and the...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.02.004
更新日期：2009-04-10 00:00:00
abstract：:Extracellular adenosine 5'-triphosphate (eATP) acts as a neurotransmitter within the retina and brain, activating a range of ionotropic P2X and metabotropic P2Y receptors. In this study, the specific localization of the P2X4 receptor (P2X4-R) subunit was evaluated in the retina using fluorescence immunohistochemistry ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.06.055
更新日期：2014-09-26 00:00:00
abstract：:Interactions between the hippocampus and the prefrontal cortex (PFC) are of major interest in the neurobiology of psychiatric and neurodegenerative disorders and are central to many experimental rodent models. Non-invasive imaging techniques offer a translatable approach to probing this system if homologous features c...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2012.10.032
更新日期：2013-01-03 00:00:00
abstract：:Sensory experience has a profound effect on neocortical neurons. Passive stimulation of whiskers or sensory deprivation from whiskers can induce long-lasting changes in neuronal responses or modify the receptive field in adult animals. We recorded barrel cortical neurons in urethane-anesthetized rats in layers 2/3 or ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.09.057
更新日期：2014-12-05 00:00:00
abstract：:The action of mastoparan (a wasp venom peptide) on "maxi" Ca(2+)-activated K+ channels was studied in excised inside-out patch recordings from cultured bovine chromaffin cells, under normal conditions (160 mM K+ inside, 154 mM Na+ outside). Mastoparan, when applied on the intracellular side of the membrane reduced the...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90456-c
更新日期：1992-10-01 00:00:00
abstract：:The central nervous system responds to diverse neurologic injuries with a vigorous activation of astrocytes. While this phenomenon is found in many different species, its function is obscure. Understanding the molecular profile characteristic of reactive astrocytes should help define their function. The purpose of thi...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/0306-4522(93)90380-x
更新日期：1993-05-01 00:00:00
abstract：:The effects of muscarine and nicotine on evoked and spontaneous release of GABA were studied using intracellular and whole-cell patch-clamp recordings from rat midbrain dopamine neurons in an in vitro slice preparation. Muscarine (30 microM) reversibly depressed the pharmacologically isolated inhibitory postsynaptic p...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(99)00579-5
更新日期：2000-01-01 00:00:00
abstract：:Converging evidence in schizophrenia suggests prefrontal cortical neuronal deficits that correlate with exaggerated subcortical dopamine (DA) functions: Excitotoxic lesion of the ventral hippocampus (VH) in neonatal rats is widely considered a putative animal model of schizophrenia as they lead to characteristic post-...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2003.08.016
更新日期：2003-01-01 00:00:00
abstract：:The transmembrane isoform of agrin (Tm-agrin) is the predominant form expressed in the brain but its putative roles in brain development are not well understood. Recent reports have implicated Tm-agrin in the formation and stabilization of filopodia on neurites of immature central and peripheral neurons in culture. In...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2009.06.012
更新日期：2009-09-29 00:00:00
abstract：:The distribution in the rat brain of high affinity nicotinic heteromeric acetylcholine receptors and of low affinity nicotinic, alpha7-containing, homomeric receptors was studied using in vitro light microscopic autoradiography. As ligands, we used [3H]epibatidine, or [125I]epibatidine, and [125I]alpha-bungarotoxin, r...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2003.09.028
更新日期：2004-01-01 00:00:00
abstract：:The generation of long-term potentiation of synaptic transmission in area CA1 of hippocampal slices of the guinea-pig has been examined in solutions containing low concentrations of magnesium ions. It was found that the induction of long-term potentiation is greatly facilitated in slices perfused with 0.1 mM magnesium...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(87)90193-x
更新日期：1987-07-01 00:00:00
abstract：:The development and maintenance of cocaine addiction depend heavily on learned reward-environment associations that can induce drug-seeking behavior and relapse. Understanding the mechanisms underlying these cue-induced conditioned responses is important for relapse prevention. To test whether intracellular responses ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.12.010
更新日期：2015-02-26 00:00:00
abstract：:Stressful life events, especially those that induce fear, can produce a state of anxiety that is useful for avoiding similar fearful and potentially dangerous situations in the future. However, they can also lead to exaggerated states, which over time can produce mental illness. These changing states of readiness vers...
journal_title：Neuroscience
pub_type： 杂志文章,评审
doi：10.1016/j.neuroscience.2012.04.021
更新日期：2013-10-22 00:00:00
abstract：:In stroke-prone spontaneously hypertensive rats (SHRSP/Izm), ischemia induces swelling of astrocytes, a process that subsequently leads to neuronal death. Following ischemic insult, arginine vasopressin (AVP) can induce edema and l-serine released by astrocytes supports the survival of neuronal cells. The purpose of t...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2014.02.039
更新日期：2014-05-16 00:00:00
abstract：:The presence and functional role of vasoactive intestinal peptide in the hamster seminal vesicle were studied by a combination of structural and functional approaches. The use of an immunofluorescence staining technique in both cryostat sections and whole-mount preparations revealed that vasoactive intestinal peptide-...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(94)90307-7
更新日期：1994-04-01 00:00:00
abstract：:Environmental enrichment of laboratory animals leads to multi-faceted changes to physiology, health and disease prognosis. An important and under-appreciated factor in enhancing cognition through environmental manipulation may be improved basic sensory function. Previous studies have highlighted changes in cortical se...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2010.07.029
更新日期：2010-10-13 00:00:00
abstract：:Differential vulnerability in the hindbrain neurons was examined immunohistochemically during hindbrain ischemia in the gerbil. Hindbrain ischemia was produced by extracranial occlusion of the bilateral vertebral arteries just before their entry into the transverse foramen of the cervical vertebra. Local cerebral bloo...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90343-e
更新日期：1993-09-01 00:00:00
