Abstract：
:The generation of long-term potentiation of synaptic transmission in area CA1 of hippocampal slices of the guinea-pig has been examined in solutions containing low concentrations of magnesium ions. It was found that the induction of long-term potentiation is greatly facilitated in slices perfused with 0.1 mM magnesium but much less so with 0.5 mM magnesium solution. The long-term potentiation evoked by brief tetanization in 0.1 mM magnesium was prevented following application of the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovalerate. Moreover, the response to tetanization, recorded in the dendritic layer, contained a much greater than normal component blocked by 2-amino-5-phosphonovalerate. The latter represents current through postsynaptic N-methyl-D-aspartate receptor channels, suggesting that the facilitation of long-term potentiation is related to a facilitated opening of these channels. The results support the notion that the generation of long-term potentiation is related to current through N-methyl-D-aspartate receptor channels which is under the control of extracellular magnesium ions.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Huang YY,Wigström H,Gustafsson Bdoi
10.1016/0306-4522(87)90193-xsubject
Has Abstractpub_date
1987-07-01 00:00:00pages
9-16issue
1eissn
0306-4522issn
1873-7544pii
0306-4522(87)90193-Xjournal_volume
22pub_type
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