Emergent Uric Acid Treatment is Synergistic with Mechanical Recanalization in Improving Stroke Outcomes in Male and Female Rats.

abstract：:Hypoglossal (XII) motoneurons innervate extrinsic and intrinsic muscles of the tongue and control behaviors such as suckling, swallowing, breathing or chewing. In young rats, XII motoneurons express V1a vasopressin and oxytocin receptors. Previous studies have shown that activation of these receptors induces direct po...

journal_title：Neuroscience

authors： Wrobel LJ,Reymond-Marron I,Dupré A,Raggenbass M

更新日期：2010-02-03 00:00:00

abstract：:In the present study we examined the effects of normal aging in the hippocampus and cerebellum, as well as behaviors associated with these substrates. A total of 67 CB6F1 hybrid mice were tested at one of five ages (4, 8, 12, 18 or 25 months) on the context pre-exposure facilitation effect (CPFE) modification of fear ...

journal_title：Neuroscience

authors： Kennard JA,Brown KL,Woodruff-Pak DS

更新日期：2013-09-05 00:00:00

abstract：:The identification and characterization of excitatory and inhibitory neurons are significant steps in understanding neural network functions. In this study, we investigated the intrinsic electrophysiological properties of neurons in the prepositus hypoglossi nucleus (PHN), a brainstem structure that is involved in gaz...

journal_title：Neuroscience

authors： Shino M,Kaneko R,Yanagawa Y,Kawaguchi Y,Saito Y

更新日期：2011-12-01 00:00:00

abstract：:In adult rat brain, adenosine A2A receptors and dopamine D2 receptors are known to be located on the same cells where they interact in an antagonistic manner. In the present study we wanted to examine when this situation develops and compared the postnatal ontogeny of the binding of the adenosine A2A receptor agonist ...

journal_title：Neuroscience

authors： Johansson B,Georgiev V,Fredholm BB

更新日期：1997-10-01 00:00:00

abstract：:Endomorphin 2 (EM2) plays essential roles in regulating nociceptive transmission within the spinal dorsal horn, where EM2-immunopositive (EM2-IP) fibers and terminals are densely encountered. However, the origins of these EM2-IP structures are still obscure. Unilateral primary sensory afferents disruption (lumbar 3-6 ...

journal_title：Neuroscience

authors： Hui R,Wang W,Chen T,Lü BC,Li H,Zhang T,Wu SX,Li YQ

更新日期：2010-08-11 00:00:00

abstract：:In mice, microRNAs (miRNAs) are required for embryonic viability, and previous reports implicate miRNA participation in brain cortical neurogenesis. Here, we provide a more comprehensive analysis of miRNA involvement in cortical brain development. To accomplish this we used mice in which Dicer, the RNase III enzyme ne...

journal_title：Neuroscience

authors： McLoughlin HS,Fineberg SK,Ghosh LL,Tecedor L,Davidson BL

更新日期：2012-10-25 00:00:00

abstract：:Types and projections of neurons that received cholinergic, purinergic and other fast excitatory synaptic inputs in myenteric ganglia of the guinea-pig distal colon were identified using combined electrophysiological recording, application of selective antagonists, marker dye filling via the recording microelectrode, ...

journal_title：Neuroscience

authors： Nurgali K,Furness JB,Stebbing MJ

更新日期：2003-01-01 00:00:00

abstract：:Allotetrahydrodeoxycorticosterone (THDOC) belongs to a class of pregnane neurosteroidal compounds that enhance brain inhibition by interacting directly with GABAA signaling, mainly through an increase in tonic inhibitory current. Here, we addressed the role of THDOC in the modulation of interictal- and ictal-like acti...

journal_title：Neuroscience

authors： Herrington R,Lévesque M,Avoli M

更新日期：2014-01-03 00:00:00

abstract：:The present experiments examined the effects of direct intracortical microinjections of the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovaleric acid directly into the insular cortex of rats, before or immediately after training of conditioned taste aversion and the water maze spatial learning task. In ...

journal_title：Neuroscience

authors： Gutiérrez H,Hernández-Echeagaray E,Ramírez-Amaya V,Bermúdez-Rattoni F

更新日期：1999-03-01 00:00:00

abstract：:The neurochemical and behavioural recovery following unilateral and bilateral lesions of the nucleus basalis was investigated in adult male Wistar rats 20 days and 6 months after surgery. The lesions were made by stereotaxic injections of ibotenic acid. Twenty days after surgery there was a statistically significant c...

journal_title：Neuroscience

authors： Casamenti F,Di Patre PL,Bartolini L,Pepeu G

更新日期：1988-01-01 00:00:00

abstract：:Early life experiences, particularly the experience with parents, are crucial to phenotypic outcomes in both humans and animals. Although the effects of maternal deprivation on offspring well-being have been studied, paternal deprivation (PD) has received little attention despite documented associations between father...

journal_title：Neuroscience

authors： Tabbaa M,Lei K,Liu Y,Wang Z

更新日期：2017-02-20 00:00:00

abstract：:GABAA-receptors in the brain display a striking structural heterogeneity, which is based on a multiplicity of diverse subunits. The allocation of GABAA-receptor subtypes to identified neurons is essential for an analysis of the functional significance of receptor heterogeneity. Among GABA-receptive neurons, well-chara...

journal_title：Neuroscience

authors： Gao B,Fritschy JM,Benke D,Mohler H

更新日期：1993-06-01 00:00:00

abstract：:In these experiments a large portion of the pelvic ganglion of adult female rats was transplanted into the wall of the urinary bladder of the same animals. The morphology and fine structure of the transplants were studied in whole-mounts and in sections for light and electron microscopy, from two days up to four month...

journal_title：Neuroscience

authors： Gabella G,Uvelius B

更新日期：1998-03-01 00:00:00

abstract：:Previous studies have shown oxidative damage resulting from amyloid Abeta exposure to cultured cells and in murine models. A target of oxidation is 14-3-3 which comprises a group of proteins involved in kinase activation and chaperone activity. The present study shows glycoxidative damage, as revealed with mono and bi...

journal_title：Neuroscience

authors： Santpere G,Puig B,Ferrer I

更新日期：2007-06-08 00:00:00

abstract：:Neurotransmitter release regulation is highly heterogeneous across the brain. The fundamental units of release, individual boutons, are difficult to access and poorly understood. Here we directly activated single boutons on mechanically isolated nucleus tractus solitarius (NTS) neurons to record unitary synaptic event...

journal_title：Neuroscience

authors： Jin YH,Andresen MC

更新日期：2011-10-13 00:00:00

abstract：:Prenatal exposure to the antiepileptic valproic acid (VPA) is associated with an increased risk of autism spectrum disorder (ASD) in humans and is used as an animal model of ASD. The majority of individuals with ASD exhibit adverse reactions to sensory stimuli and auditory dysfunction. Previous studies of animals expo...

journal_title：Neuroscience

authors： Mansour Y,Mangold S,Chosky D,Kulesza RJ Jr

更新日期：2019-01-01 00:00:00

abstract：:How obesity exacerbates migraine and other pain disorders remains unknown. Trigeminal nociceptive processing, crucial in migraine pathophysiology, is abnormal in mice with diet induced obesity. However, it is not known if this is also true in genetic models of obesity. We hypothesized that obese mice, regardless of th...

journal_title：Neuroscience

authors： Rossi HL,Raj NR,Marquez de Prado B,Kuburas A,Luu AKS,Barr GA,Recober A

更新日期：2019-09-01 00:00:00

abstract：:The glomeruli are the first synaptic relay on the olfactory pathway and play a basic role in smell perception. Glomerular degeneration occurs in humans with age and in Alzheimer's disease (AD). The glomeruli heavily express β-amyloid precursor protein (APP), β-secretase (BACE1) and γ-secretase complex. However, extrac...

journal_title：Neuroscience

authors： Cai Y,Xue ZQ,Zhang XM,Li MB,Wang H,Luo XG,Cai H,Yan XX

更新日期：2012-07-26 00:00:00

abstract：:The tissues of the large intestine which receive an innervation by neurons of the major pelvic ganglia were identified following in vivo and in vitro anterograde labelling with the lipophilic tracer 1,1'didodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate in the male rat. The primary target in the gut of major ...

journal_title：Neuroscience

authors： Luckensmeyer GB,Keast JR

更新日期：1998-05-01 00:00:00

abstract：:Long-term treatment with diazepam, a full allosteric modulator of the GABA(A) receptor, results in tolerance to its anticonvulsant effects, whereas an equipotent treatment with the partial allosteric modulator imidazenil does not produce tolerance. Use of subunit-specific antibodies linked to gold particles allowed an...

journal_title：Neuroscience

authors： Pesold C,Caruncho HJ,Impagnatiello F,Berg MJ,Fritschy JM,Guidotti A,Costa E

更新日期：1997-07-01 00:00:00

abstract：:The functional roles of striatonigral neurokinins were studied by analysing the effects of intranigral injections of substance P and neurokinin A on the extracellular levels of dopamine and dihydroxyphenylacetic acid in the striatum, as measured by in vivo microdialysis in rats. An opioid antagonist, naloxone, and a G...

journal_title：Neuroscience

authors： Reid MS,Herrera-Marschitz M,Ungerstedt U

更新日期：1990-01-01 00:00:00

abstract：:The hyperpolarization-activated h channel current (Ih) reported to be present in acutely isolated rat dorsal root ganglion (DRG) neurons is inhibited by Cs+ and ZD7288. It was recently reported that lead (Pb2+) inhibits voltage-gated Ca2+ and K+ channels in DRG neurons but the effect of Pb2+ on Ih has so far not been ...

journal_title：Neuroscience

authors： Dai XQ,Karpinski E,Chen XZ

更新日期：2003-01-01 00:00:00

abstract：:The main objective of the study was to investigate the effects of age and sex differences on locomotor activity, learning and memory in rats. Another objective was to investigate whether repeated elevated plus maze tests induce anxiety in rats. Eighty Wistar rats were divided into eight groups according to their sex, ...

journal_title：Neuroscience

authors： Belviranli M,Atalik KE,Okudan N,Gökbel H

更新日期：2012-12-27 00:00:00

abstract：:In the present study, in vivo voltammetry was used to monitor changes in dopamine levels in the left and right medial prefrontal cortex of rats exposed to mild physical and psychological stress. These were 2 min of tail-pinch and 15 min exposure to cat odour, respectively. Fourteen male Long Evans rats with bilateral ...

journal_title：Neuroscience

authors： Sullivan RM,Gratton A

更新日期：1998-03-01 00:00:00

abstract：:Strong converging evidence indicates that the intermediate and medial part of the hyperstriatum ventrale (IMHV) of the chick forebrain is a site of recognition memory for the learning process of imprinting. Clathrin proteins have been implicated in synaptic plasticity. In the present study we demonstrate for the first...

journal_title：Neuroscience

authors： Solomonia RO,McCabe BJ,Jackson AP,Horn G

更新日期：1997-09-01 00:00:00

abstract：:Animal studies have revealed that chronic stress shifts cognitive strategies from the flexible goal-directed action to the simple and rigid habit action. In addition, stress-induced atrophy in the prefrontal cortex and dorsomedial striatum which are involved in the goal-directed action and hypertrophy of the dorsolate...

journal_title：Neuroscience

authors： Ohira H,Matsunaga M,Kimura K,Murakami H,Osumi T,Isowa T,Fukuyama S,Shinoda J,Yamada J

更新日期：2011-10-13 00:00:00

abstract：:Although intrathecal administration of nociceptin, an endogenous ligand of the opioid receptor-like1 receptor, exhibits an antinociceptive effect in various pain models, cellular mechanisms underlying this action are still unknown. Here, we investigated the effects of nociceptin on excitatory and inhibitory synaptic t...

journal_title：Neuroscience

authors： Luo C,Kumamoto E,Furue H,Chen J,Yoshimura M

更新日期：2002-01-01 00:00:00

abstract：:Working memory for order information is mediated by different cognitive mechanisms that rely on different neural circuits. Here we discuss evidence that order memory involves mechanisms that range from general supervisory processes to process that maintenance fine-grained temporal position information. We suggest that...

journal_title：Neuroscience

authors： Marshuetz C,Smith EE

更新日期：2006-04-28 00:00:00

abstract：:Known to exert an important modulatory influence on the cerebral cortex, the cholinergic neurons of the basal forebrain are modulated in turn by neurotransmitters which may include acetylcholine released from processes of brainstem or forebrain neurons. In the present study, we examined the effect of carbachol, a non-...

journal_title：Neuroscience

authors： Khateb A,Fort P,Williams S,Serafin M,Jones BE,Mühlethaler M

更新日期：1997-11-01 00:00:00

abstract：:Dopamine in the prefrontal cortex plays a critical role in normal cognition throughout the lifespan and has been implicated in the pathophysiology of neuropsychiatric disorders such as schizophrenia and attention deficit disorder. Little is known, however, about the postnatal development of the dopaminergic system in ...

journal_title：Neuroscience

authors： Weickert CS,Webster MJ,Gondipalli P,Rothmond D,Fatula RJ,Herman MM,Kleinman JE,Akil M

更新日期：2007-02-09 00:00:00